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  1. Article ; Online: Understanding the role of 5d electrons in ferromagnetism and spin-based transport properties of K

    Sk, Mukaddar / Ghosh, Saurabh

    RSC advances

    2022  Volume 12, Issue 48, Page(s) 31046–31055

    Abstract: In this article, we have systematically investigated the structural, electronic, magnetic, and spin-based thermoelectric properties of ... ...

    Abstract In this article, we have systematically investigated the structural, electronic, magnetic, and spin-based thermoelectric properties of K
    Language English
    Publishing date 2022-10-31
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra01841a
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  2. Article ; Online: Competing analytical strategies of combining associated SNPs for estimating genetic risks.

    Majumdar, Arunabha / Ghosh, Saurabh

    Journal of genetics

    2022  Volume 101

    Abstract: In genomewide association study (GWAS) of a complex phenotype, a large number of variants, many with small effect sizes, are found to contribute to the variability of the phenotype. Subsequent to the identification of such variants in a GWAS, it is of ... ...

    Abstract In genomewide association study (GWAS) of a complex phenotype, a large number of variants, many with small effect sizes, are found to contribute to the variability of the phenotype. Subsequent to the identification of such variants in a GWAS, it is of interest to estimate the risk jointly conferred by the variants. We propose three different strategies of combining the risk SNPs to calculate an allele dosage score. Using simulations, we evaluate the different measures of allele dosage score with respect to the risk prediction accuracy of a binary trait and the proportion of variance explained for a quantitative trait. For a binary trait, an allele dosage score defined based on log odds ratio performs marginally better than the other two measures. For a quantitative trait, the measure based on the standardized slope coefficient in linear regression of the trait on single-nucleotide polymorphism (SNP) genotypes performs better than the measures using the weights proportional to log
    MeSH term(s) Diabetes Mellitus, Type 2 ; Genome-Wide Association Study/methods ; Genotype ; Humans ; Phenotype ; Polymorphism, Single Nucleotide
    Language English
    Publishing date 2022-02-09
    Publishing country India
    Document type Journal Article
    ZDB-ID 3039-9
    ISSN 0973-7731 ; 0958-8361 ; 0022-1333
    ISSN (online) 0973-7731
    ISSN 0958-8361 ; 0022-1333
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  3. Article ; Online: Competing analytical strategies of combining associated SNPs for estimating genetic risks

    Majumdar, Arunabha / Ghosh, Saurabh

    J Genet. 2022 June, v. 101, no. 1 p.14-14

    2022  

    Abstract: In genomewide association study (GWAS) of a complex phenotype, a large number of variants, many with small effect sizes, are found to contribute to the variability of the phenotype. Subsequent to the identification of such variants in a GWAS, it is of ... ...

    Abstract In genomewide association study (GWAS) of a complex phenotype, a large number of variants, many with small effect sizes, are found to contribute to the variability of the phenotype. Subsequent to the identification of such variants in a GWAS, it is of interest to estimate the risk jointly conferred by the variants. We propose three different strategies of combining the risk SNPs to calculate an allele dosage score. Using simulations, we evaluate the different measures of allele dosage score with respect to the risk prediction accuracy of a binary trait and the proportion of variance explained for a quantitative trait. For a binary trait, an allele dosage score defined based on log odds ratio performs marginally better than the other two measures. For a quantitative trait, the measure based on the standardized slope coefficient in linear regression of the trait on single-nucleotide polymorphism (SNP) genotypes performs better than the measures using the weights proportional to log P-value and the proportion of variance explained. We demonstrate the utility of these measures using a real data on type 2 diabetes and fasting blood sugar level in a south Indian population.
    Keywords alleles ; blood glucose ; noninsulin-dependent diabetes mellitus ; odds ratio ; phenotype ; prediction ; quantitative traits ; regression analysis ; risk ; risk assessment ; single nucleotide polymorphism ; variance
    Language English
    Dates of publication 2022-06
    Size p. 14.
    Publishing place Springer India
    Document type Article ; Online
    ZDB-ID 3039-9
    ISSN 0973-7731 ; 0958-8361 ; 0022-1333
    ISSN (online) 0973-7731
    ISSN 0958-8361 ; 0022-1333
    DOI 10.1007/s12041-021-01349-4
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  4. Article ; Online: Design of high polarization low switching barrier hybrid improper ferroelectric perovskite oxide superlattices.

    Swamynadhan, M J / Ghosh, Ayana / Ghosh, Saurabh

    Materials horizons

    2023  Volume 10, Issue 12, Page(s) 5942–5949

    Abstract: Hybrid improper ferroelectricity is a useful tool to design ... ...

    Abstract Hybrid improper ferroelectricity is a useful tool to design ABO
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2744250-0
    ISSN 2051-6355 ; 2051-6347
    ISSN (online) 2051-6355
    ISSN 2051-6347
    DOI 10.1039/d3mh01285a
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  5. Article: Disentangling demand and supply side determinants of post-GFC credit slowdown: an Indian perspective.

    Ghosh, Saurabh / Herwadkar, Snehal / Verma, Radheshyam / Gopalakrishnan, Pawan

    Indian economic review

    2023  , Page(s) 1–23

    Abstract: In an emerging market economy (EME) that depends largely on bank-credit, it is important to decipher whether supply-side or demand-side factors are responsible for a sluggish credit growth phase. A formal empirical analysis using Indian data and a ... ...

    Abstract In an emerging market economy (EME) that depends largely on bank-credit, it is important to decipher whether supply-side or demand-side factors are responsible for a sluggish credit growth phase. A formal empirical analysis using Indian data and a disequilibrium model suggests that demand side factors have majorly contributed to the credit slowdown during the post-GFC period and prior to the pandemic. This could be because of adequate supply of funds, and several concerted policy actions taken by the regulatory authorities to mitigate concerns over the asset quality risks. In contrast, lower investment demand and global supply side bottlenecks have often contributed to demand side weaknesses, suggesting the need for strong policy support to uphold credit demand.
    Language English
    Publishing date 2023-05-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 2658831-6
    ISSN 2520-1778 ; 0019-4670
    ISSN (online) 2520-1778
    ISSN 0019-4670
    DOI 10.1007/s41775-023-00177-w
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  6. Book ; Online: Engineering strong magnetoelectricity using a hexagonal 2D material on electron-doped hexagonal LuFeO$_3$

    Swamynadhan, M. J. / O'Hara, Andrew / Ghosh, Saurabh / Pantelides, Sokrates T.

    2024  

    Abstract: Cubic perovskite-structure ABO$_3$ and A$_{1-x}$A$^{\prime}$$_x$BO$_3$-type oxides have been investigated extensively while their hexagonal-structure versions have received minimal attention, even though they are multiferroic and can form ... ...

    Abstract Cubic perovskite-structure ABO$_3$ and A$_{1-x}$A$^{\prime}$$_x$BO$_3$-type oxides have been investigated extensively while their hexagonal-structure versions have received minimal attention, even though they are multiferroic and can form heterostructures with the manifold hexagonal two-dimensional materials. Hexagonal ferrites of the form RFeO$_3$, where R is yttrium or a rare-earth element such as Lu, Yb, etc., feature coupled ferroelectricity (FE) and weak-ferromagnetism (wFM), exhibiting linear magnetoelectricity. Their only drawback is weak ferromagnetism. In this paper, we employ density-functional-theory (DFT) calculations on hexagonal LuFeO$_3$ ($h$-LFO), targeting its magnetic ordering by electron doping,anticipating spin-disproportionation of the Fe sublattices. Indeed, we show that spin-disproportionation in heavily-electron-doped versions Lu$_{1-x}$Hf$_x$FeO$_3$ ($h$-LHFO), especially for x=1/3 and 1/2, leads to robust out-of-plane collinear ferrimagnetism that is stable at room temperature. Furthermore, the robust ferroelectricity of $h$-LFO persists via a Jahn-Teller metal-to-insulator transition. Finally, we construct a $h$-LHFO/$h$-2D heterostructure, where $h$-2D stands for the FE/FM monolayer MnSTe, and demonstrate strong magnetoelectric coupling, namely manipulation of magnetic skyrmions in MnSTe by an external electric field through the $h$-LHFO polarization, opening up a new realm for magnetoelectric applications.
    Keywords Condensed Matter - Materials Science
    Publishing date 2024-01-26
    Publishing country us
    Document type Book ; Online
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  7. Article ; Online: Multivariate analyses of blood pressure related phenotypes in a longitudinal framework: insights from Genetic Analysis Workshop 18.

    Ghosh, Saurabh

    Genetic epidemiology

    2014  Volume 38 Suppl 1, Page(s) S63–7

    Abstract: Our working group studied methods for joint analyses of multiple phenotypes using the data provided by Genetic Analysis Workshop 18. Two data sets were available: one containing genotypes obtained from a real human whole-genome sequencing study along ... ...

    Abstract Our working group studied methods for joint analyses of multiple phenotypes using the data provided by Genetic Analysis Workshop 18. Two data sets were available: one containing genotypes obtained from a real human whole-genome sequencing study along with longitudinal measurements on systolic and diastolic blood pressure, age, sex, medication use, and tobacco smoking; and the other a simulated data set using the same set of genotypes and phenotype structure as the real data set. The nine sets of investigators in our working group focused on the statistical challenges posed by association analyses of multivariate phenotypes; they applied a wide spectrum of statistical methods, such as linear mixed models, copula models, and semiparametric regression models for simultaneous analyses of longitudinal data on the two blood pressure phenotypes at the genome-wide level. In this report, we discuss the various strategies explored by the different investigators whose common goal was improving the power to detect association with multivariate phenotypes.
    MeSH term(s) Age Factors ; Blood Pressure/genetics ; Female ; Genome-Wide Association Study ; Humans ; Longitudinal Studies ; Male ; Models, Genetic ; Multivariate Analysis ; Phenotype ; Polymorphism, Single Nucleotide ; Sex Factors ; Smoking
    Language English
    Publishing date 2014-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605785-8
    ISSN 1098-2272 ; 0741-0395
    ISSN (online) 1098-2272
    ISSN 0741-0395
    DOI 10.1002/gepi.21827
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  8. Article ; Online: Acute corneal perforation 1 week following uncomplicated cataract surgery: the implication of undiagnosed dry eye disease and topical NSAIDs.

    Ting, Darren Shu Jeng / Ghosh, Saurabh

    Therapeutic advances in ophthalmology

    2019  Volume 11, Page(s) 2515841419869508

    Abstract: Dry eye disease is a common ocular surface disease in patients who are undergoing cataract surgery. The significance of dry eye disease is often underestimated or overlooked during preoperative assessment of cataract. We report an 80-year-old patient, ... ...

    Abstract Dry eye disease is a common ocular surface disease in patients who are undergoing cataract surgery. The significance of dry eye disease is often underestimated or overlooked during preoperative assessment of cataract. We report an 80-year-old patient, with a background of seropositive rheumatoid arthritis and diabetes, who presented with an acute corneal melt and perforation associated with undiagnosed dry eye disease and use of topical ketorolac 1 week following an uncomplicated cataract surgery. The patient underwent repeated corneal gluing for corneal perforation and was subsequently diagnosed and treated for bilateral moderate-severe dry eye disease. This case highlights the importance of meticulous preoperative assessment and management of the ocular surface, especially in patients with systemic diseases such as rheumatoid arthritis and diabetes prior to cataract surgery. The implication of the use of topical nonsteroidal anti-inflammatory drugs following cataract surgery - which might have contributed to the process of corneal melt in our case - is also discussed.
    Language English
    Publishing date 2019-08-12
    Publishing country United States
    Document type Case Reports
    ISSN 2515-8414
    ISSN (online) 2515-8414
    DOI 10.1177/2515841419869508
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  9. Article ; Online: Central Toxic Keratopathy After Contact Lens Wear and Mechanical Debridement: Clinical Characteristics, and Visual and Corneal Tomographic Outcomes.

    Ting, Darren Shu Jeng / Ghosh, Saurabh

    Eye & contact lens

    2019  Volume 45, Issue 4, Page(s) e15–e23

    Abstract: Objectives: To highlight the clinical characteristics, and visual and corneal tomographic outcomes of central toxic keratopathy (CTK) after contact lens (CL) wear and mechanical debridement.: Methods: A retrospective observational case series with ... ...

    Abstract Objectives: To highlight the clinical characteristics, and visual and corneal tomographic outcomes of central toxic keratopathy (CTK) after contact lens (CL) wear and mechanical debridement.
    Methods: A retrospective observational case series with literature review.
    Results: Four patients (4 eyes) were included in this study; 3 (75%) females, mean age 29.3±8.1 years. The mean follow-up was 13.5±7.5 months. Early central or paracentral stromal opacification, assuming an inverse dome-shaped pattern observed under anterior-segment optical coherence tomography, with corneal flattening (Kmean 40.4±1.3 D) and thinning (mean thinnest pachymetry=404.8±29.4 microns) were observed in all cases. All patients had a recent use of CL wear, with three after mechanical debridement for recurrent corneal erosion syndrome. None of them had any previous laser refractive surgery (LRS). The mean corrected distance visual acuity improved from 20/40 (ranged 20/25-20/50) initially to 20/30 (ranged 20/20-20/40) at final follow-up, and the outcome was not influenced by the use of topical steroids. A mean improvement of corneal flattening (+Kmean 1.2±1.2 D), thinning (+123.5±23.8 microns), and astigmatism (-3.0±2.7 D), via epithelial and stromal remodeling, was observed up to 15 months after CTK. Persisting reduced corneal sensation was noted in all patients at the final follow-up.
    Conclusions: Central toxic keratopathy is not an exclusive complication of LRS, and it may occur after CL wear and mechanical debridement. Our findings are similar to those of LRS-related CTK and toxic peripheral keratopathy. Awareness of the clinical associations and understanding of the clinical course and tomographic characteristics of CTK helps obviate unnecessary investigation and overtreatment. Further studies are required to elucidate the underlying pathogenesis of this rare clinical entity.
    MeSH term(s) Adult ; Contact Lenses, Hydrophilic/adverse effects ; Corneal Opacity/etiology ; Corneal Opacity/physiopathology ; Corneal Opacity/surgery ; Corneal Pachymetry ; Corneal Stroma/pathology ; Corneal Stroma/surgery ; Debridement ; Female ; Follow-Up Studies ; Humans ; Male ; Retrospective Studies ; Slit Lamp Microscopy ; Tomography, Optical Coherence ; Vision Disorders/etiology ; Vision Disorders/physiopathology ; Vision Disorders/surgery ; Visual Acuity/physiology ; Young Adult
    Language English
    Publishing date 2019-06-25
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2103049-2
    ISSN 1542-233X ; 1542-2321
    ISSN (online) 1542-233X
    ISSN 1542-2321
    DOI 10.1097/ICL.0000000000000575
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  10. Article ; Online: Thickness-Dependent Nanoscale Elastic Stiffening of Chemical Vapor Deposited Atomically Thin 2H-MoS

    Meganathan, Kalaiarasan / Mangamma, G / Swaminadhan, M J / Murugan, Vijaykumar / Shinde, Nitin Babu / Ghosh, Saurabh / Eswaran, Senthil Kumar

    The journal of physical chemistry letters

    2024  Volume 15, Issue 15, Page(s) 4206–4211

    Abstract: Understanding the nanoscale elastic-size-effects of atomically thin transition-metal dichalcogenides (TMDs) as a function of thickness underpins the avenue of flexible 2D electronics. In this work, we employed the atomic force acoustic microscopy (AFAM) ... ...

    Abstract Understanding the nanoscale elastic-size-effects of atomically thin transition-metal dichalcogenides (TMDs) as a function of thickness underpins the avenue of flexible 2D electronics. In this work, we employed the atomic force acoustic microscopy (AFAM) technique to investigate the thickness-dependent elastic properties of CVD grown 2H-MoS
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c03512
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