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  1. Article ; Online: APOC-III: a Gatekeeper in Controlling Triglyceride Metabolism.

    Giammanco, Antonina / Spina, Rossella / Cefalù, Angelo B / Averna, Maurizio

    Current atherosclerosis reports

    2023  Volume 25, Issue 3, Page(s) 67–76

    Abstract: Purpose of review: Apolipoprotein C-III (ApoC-III) is a widely known player in triglyceride metabolism, and it has been recently recognized as a polyhedric factor which may regulate several pathways beyond lipid metabolism by influencing cardiovascular, ...

    Abstract Purpose of review: Apolipoprotein C-III (ApoC-III) is a widely known player in triglyceride metabolism, and it has been recently recognized as a polyhedric factor which may regulate several pathways beyond lipid metabolism by influencing cardiovascular, metabolic, and neurological disease risk. This review summarizes the different functions of ApoC-III and underlines the recent findings related to its multifaceted pathophysiological role.
    Recent findings: The role of ApoC-III has been implicated in HDL metabolism and in the development of atherosclerosis, inflammation, and ER stress in endothelial cells. ApoC-III has been recently considered an important player in insulin resistance mechanisms, lipodystrophy, diabetic dyslipidemia, and postprandial hypertriglyceridemia (PPT). The emerging evidence of the involvement of ApoC-III in the in the pathogenesis of Alzheimer's disease open the way to further study if modification of ApoC-III level slows disease progression. Furthermore, ApoC-III is clearly linked to cardiovascular disease (CVD) risk, and progression of coronary artery disease (CAD) as well as the calcification of aortic valve and recent clinical trials has pointed out the inhibition of ApoC-III as a promising approach to manage hypertriglyceridemia and prevent CVD. Several evidences highlight the role of ApoC-III not only in triglyceride metabolism but also in several cardio-metabolic pathways. Results from recent clinical trials underline that the inhibition of ApoC-III is a promising therapeutical strategy for the management of severe hypertriglyceridemia and in CVD prevention.
    MeSH term(s) Humans ; Apolipoprotein C-III/metabolism ; Coronary Artery Disease/complications ; Endothelial Cells/metabolism ; Hypertriglyceridemia/metabolism ; Lipid Metabolism ; Triglycerides/metabolism
    Chemical Substances Apolipoprotein C-III ; Triglycerides ; APOC3 protein, human
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2057369-8
    ISSN 1534-6242 ; 1523-3804
    ISSN (online) 1534-6242
    ISSN 1523-3804
    DOI 10.1007/s11883-023-01080-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5534: Show issues Location:
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  2. Article ; Online: Sexually Transmitted Diseases: Diagnosis and Control.

    Fasciana, Teresa / Capra, Giuseppina / Lipari, Dario / Firenze, Alberto / Giammanco, Anna

    International journal of environmental research and public health

    2022  Volume 19, Issue 9

    Abstract: Sexually transmitted diseases (STDs)-or sexually transmitted infections (STIs)-are generally acquired through sexual contact [ ... ]. ...

    Abstract Sexually transmitted diseases (STDs)-or sexually transmitted infections (STIs)-are generally acquired through sexual contact [...].
    MeSH term(s) Humans ; Risk Factors ; Sexual Behavior ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/prevention & control
    Language English
    Publishing date 2022-04-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19095293
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  3. Article ; Online: Current and Future Trends in the Laboratory Diagnosis of Sexually Transmitted Infections.

    Caruso, Giorgia / Giammanco, Anna / Virruso, Roberta / Fasciana, Teresa

    International journal of environmental research and public health

    2021  Volume 18, Issue 3

    Abstract: Sexually transmitted infections (STIs) continue to exert a considerable public health and social burden globally, particularly for developing countries. Due to the high prevalence of asymptomatic infections and the limitations of symptom-based (syndromic) ...

    Abstract Sexually transmitted infections (STIs) continue to exert a considerable public health and social burden globally, particularly for developing countries. Due to the high prevalence of asymptomatic infections and the limitations of symptom-based (syndromic) diagnosis, confirmation of infection using laboratory tools is essential to choose the most appropriate course of treatment and to screen at-risk groups. Numerous laboratory tests and platforms have been developed for gonorrhea, chlamydia, syphilis, trichomoniasis, genital mycoplasmas, herpesviruses, and human papillomavirus. Point-of-care testing is now a possibility, and microfluidic and high-throughput omics technologies promise to revolutionize the diagnosis of STIs. The scope of this paper is to provide an updated overview of the current laboratory diagnostic tools for these infections, highlighting their advantages, limitations, and point-of-care adaptability. The diagnostic applicability of the latest molecular and biochemical approaches is also discussed.
    MeSH term(s) Chlamydia Infections ; Clinical Laboratory Techniques ; Gonorrhea ; HIV Infections ; Humans ; Prevalence ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/epidemiology ; Syphilis
    Language English
    Publishing date 2021-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18031038
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  4. Article ; Online: A Comparison of Neural Networks and Center of Gravity in Muon Hit Position Estimation.

    Aktas, Kadir / Kiisk, Madis / Giammanco, Andrea / Anbarjafari, Gholamreza / Mägi, Märt

    Entropy (Basel, Switzerland)

    2022  Volume 24, Issue 11

    Abstract: The performance of cosmic-ray tomography systems is largely determined by their tracking accuracy. With conventional scintillation detector technology, good precision can be achieved with a small pitch between the elements of the detector array. ... ...

    Abstract The performance of cosmic-ray tomography systems is largely determined by their tracking accuracy. With conventional scintillation detector technology, good precision can be achieved with a small pitch between the elements of the detector array. Improving the resolution implies increasing the number of read-out channels, which in turn increases the complexity and cost of the tracking detectors. As an alternative to that, a scintillation plate detector coupled with multiple silicon photomultipliers could be used as a technically simple solution. In this paper, we present a comparison between two deep-learning-based methods and a conventional Center of Gravity (CoG) algorithm, used to calculate cosmic-ray muon hit positions on the plate detector using the signals from the photomultipliers. In this study, we generated a dataset of muon hits on a detector plate using the Monte Carlo simulation toolkit GEANT4. We demonstrate that two deep-learning-based methods outperform the conventional CoG algorithm by a significant margin. Our proposed algorithm, Fully Connected Network, produces a 0.72 mm average error measured in Euclidean distance between the actual and predicted hit coordinates, showing great improvement in comparison with CoG, which yields 1.41 mm on the same dataset. Additionally, we investigated the effects of different sensor configurations on performance.
    Language English
    Publishing date 2022-11-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e24111659
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  5. Article: Editorial: Special Issue: "

    Fasciana, Teresa / Palermo, Mario / Arrigo, Ignazio / Tricoli, Maria Rita / Diquattro, Orazia / Giammanco, Anna

    Microorganisms

    2023  Volume 11, Issue 10

    Abstract: Legionella ... ...

    Abstract Legionella pneumophila
    Language English
    Publishing date 2023-09-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11102392
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  6. Article: Characterization of

    Tricoli, Maria Rita / Massaro, Chiara / Arrigo, Ignazio / Diquattro, Orazia / Di Bernardo, Francesca / Galia, Elena / Palermo, Mario / Fasciana, Teresa / Giammanco, Anna

    Antibiotics (Basel, Switzerland)

    2024  Volume 13, Issue 1

    Abstract: ... Listeria ... ...

    Abstract Listeria monocytogenes
    Language English
    Publishing date 2024-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics13010057
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  7. Article ; Online: Derivation and validation of a predictive mortality model of in-hospital patients with Acinetobacter baumannii nosocomial infection or colonization.

    Gagliardo, Carola Maria / Noto, Davide / Giammanco, Antonina / Catanzaro, Andrea / Cimino, Maria Concetta / Presti, Rosalia Lo / Tuttolomondo, Antonino / Averna, Maurizio / Cefalù, Angelo Baldassare

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2024  

    Abstract: Purpose: Acinetobacter baumannii (Ab) is a Gram-negative opportunistic bacterium responsible for nosocomial infections or colonizations. It is considered one of the most alarming pathogens due to its multi-drug resistance and due to its mortality rate, ... ...

    Abstract Purpose: Acinetobacter baumannii (Ab) is a Gram-negative opportunistic bacterium responsible for nosocomial infections or colonizations. It is considered one of the most alarming pathogens due to its multi-drug resistance and due to its mortality rate, ranging from 34 to 44,5% of hospitalized patients. The aim of the work is to create a predictive mortality model for hospitalized patient with Ab infection or colonization.
    Methods: A cohort of 140 sequentially hospitalized patients were randomized into a training cohort (TC) (100 patients) and a validation cohort (VC) (40 patients). Statistical bivariate analysis was performed to identify variables discriminating surviving patients from deceased ones in the TC, considering both admission time (T0) and infection detection time (T1) parameters. A custom logistic regression model was created and compared with models obtained from the "status" variable alone (Ab colonization/infection), SAPS II, and APACHE II scores. ROC curves were built to identify the best cut-off for each model.
    Results: Ab infection status, use of penicillin within 90 days prior to ward admission, acidosis, Glasgow Coma Scale, blood pressure, hemoglobin and use of NIV entered the logistic regression model. Our model was confirmed to have a better sensitivity (63%), specificity (85%) and accuracy (80%) than the other models.
    Conclusion: Our predictive mortality model demonstrated to be a reliable and feasible model to predict mortality in Ab infected/colonized hospitalized patients.
    Language English
    Publishing date 2024-04-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-024-04818-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1732: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Erdheim-Chester disease as complex clinical presentation and diagnosis: A case report and concise review of literature.

    Gagliardo, Carola M / Giammanco, Antonina / Vaglio, Augusto / Pegoraro, Francesco / Cefalù, Angelo B / Averna, Maurizio / Noto, Davide

    Medicine

    2024  Volume 103, Issue 17, Page(s) e37870

    Abstract: Rationale: Erdheim-Chester disease (ECD) is a rare multisystemic disease characterized by the infiltration of multiple organs by foamy CD68 + CD1a-histiocytes. The genetic background consists of gain-of-function somatic mutations in the mitogen- ... ...

    Abstract Rationale: Erdheim-Chester disease (ECD) is a rare multisystemic disease characterized by the infiltration of multiple organs by foamy CD68 + CD1a-histiocytes. The genetic background consists of gain-of-function somatic mutations in the mitogen-activated protein kinase pathway. The purpose of the present paper is to make a contribution to the scientific literature on ECD by reporting our experience with a complex clinical case report, along with a concise review of the literature. We discussed the unusual clinical presentation, the complex diagnostic process and the comparison with other published cases.
    Patient concerns: A 70-year-old man presented with arthralgia due to multiple bone areas of sclerosis, first diagnosed with metastases of a prostatic neoplasm. Sequential thorax-abdomen, femoral and homer contrast-enhanced computed tomography (CT) showed pericardial effusion, pulmonary fibrosis, and perirenal fibrous tissue as "hairy kidneys." He underwent. Three bone biopsies were unsuccessful to reach diagnosis.
    Diagnoses: A xanthelasma biopsy showed histopathological signs compatible with ECD; genetic analysis showed the mutation BRAFV600E.
    Interventions: The patient underwent targeted therapy with vemurafenib (BRAF-inhibitor), discontinued 2 weeks later due to the onset of a diffuse erythematous papular rash on the trunk and limbs.
    Outcomes: At the 1-year follow-up, there was only progression of chronic kidney disease (CKD).
    Lessons: The present case report describes how ECD diagnosis could represent a challenge for clinicians, owing to its heterogeneous clinical presentation. Early diagnosis followed by prompt therapy is essential for modifying the natural history of the disease.
    MeSH term(s) Humans ; Erdheim-Chester Disease/diagnosis ; Erdheim-Chester Disease/genetics ; Male ; Aged ; Proto-Oncogene Proteins B-raf/genetics ; Vemurafenib/therapeutic use
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Vemurafenib (207SMY3FQT) ; BRAF protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article ; Case Reports ; Review
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037870
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.171: Show issues Location:
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  9. Book ; Online: Applying triangular correlation of angular deviation in muon scattering tomography for multi-block materials via GEANT4 simulations

    Topuz, Ahmet Ilker / Kiisk, Madis / Giammanco, Andrea

    2022  

    Abstract: The scattering angle due to the target volume can be split into two interior angles in the tomographic setups based on the muon scattering, and we call this property as the triangular correlation where the sum of these two interior angles is equal to the ...

    Abstract The scattering angle due to the target volume can be split into two interior angles in the tomographic setups based on the muon scattering, and we call this property as the triangular correlation where the sum of these two interior angles is equal to the scattering angle. In this study, we apply this triangular correlation for a multi-block material configuration that consist of concrete, stainless steel, and uranium. By changing the order of this material set, we employ the GEANT4 simulations and we show that the triangular correlation is valid in the multi-block material setups, thereby providing the possibility of supportive information for the coarse prediction of the material order in such configurations.

    Comment: 3 figures, 1 table. arXiv admin note: substantial text overlap with arXiv:2112.00376
    Keywords Physics - Instrumentation and Detectors ; Condensed Matter - Materials Science
    Publishing date 2022-10-25
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Helicobacter pylori

    Giammanco, Anna / Anzalone, Rita / Serra, Nicola / Graceffa, Giuseppa / Vieni, Salvatore / Scibetta, Nunzia / Rea, Teresa / Capra, Giuseppina / Fasciana, Teresa

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: Genetic predisposition, environmental factors, and infectious agents interact in the development of gastric diseases. ...

    Abstract Genetic predisposition, environmental factors, and infectious agents interact in the development of gastric diseases.
    MeSH term(s) Helicobacter pylori ; Helicobacter Infections/complications ; Epstein-Barr Virus Infections/complications ; Herpesvirus 4, Human ; Coinfection ; Stomach Diseases/genetics ; Stomach Diseases/microbiology ; Stomach Diseases/virology ; Genes, p53/genetics ; Mutation ; DNA Methylation ; Microsatellite Instability ; Sicily ; Humans ; Male ; Female ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Logistic Models
    Language English
    Publishing date 2023-04-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24098104
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