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Article ; Online: Adenosine A

Abbracchio, Maria P / Ceruti, Stefania / Brambilla, Roberta / Barbieri, Daniela / Camurri, Alessandra / Franceschi, Claudio / Giammarioli, Anna Maria / Jacobson, Kenneth A / Cattabeni, Flaminio / Malorni, Walter

Drug development research

2024 Volume 45, Issue 3-4, Page(s) 379–386

Abstract: We investigated the role of the ... ...

Abstract	We investigated the role of the A
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	604587-x
ISSN	1098-2299 ; 0272-4391
ISSN (online)	1098-2299
ISSN	0272-4391
DOI	10.1002/(sici)1098-2299(199811/12)45:3/4<379::aid-ddr38>3.0.co;2-y
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Article ; Online: [No title information]

Possenti, Valentina / De Castro, Paola / Mistretta, Antonio / Croci, Roberto / Pizzarelli, Scilla / Mattioli, Benedetta / Giammarioli, Anna Maria / Corea, Francesco / Mirra, Marco / Nobile, Annina / Terlizzi, Roberta / Bucciardini, Raffaella

Recenti progressi in medicina

2023 Volume 114, Issue 9, Page(s) 519–520

Title translation	Progetto europeo IMMUNION per sostenere e rafforzare la consapevolezza vaccinale.
MeSH term(s)	Humans ; Immunization Programs
Language	Italian
Publishing date	2023-08-02
Publishing country	Italy
Document type	Journal Article
ZDB-ID	138266-4
ISSN	2038-1840 ; 0034-1193
ISSN (online)	2038-1840
ISSN	0034-1193
DOI	10.1701/4088.40793
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Zs.B 193: Show issues

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Article: Gender issues on occupational safety and health.

Sorrentino, Eugenio / Vona, Rosa / Monterosso, Davide / Giammarioli, Anna Maria

Annali dell'Istituto superiore di sanita

2016 Volume 52, Issue 2, Page(s) 190–197

Abstract: The increasing proportion of women in the workforce raises a range of gender-related questions about the different effects of work-related risks on men and women. Few studies have characterized gender differences across occupations and industries, ... ...

Abstract	The increasing proportion of women in the workforce raises a range of gender-related questions about the different effects of work-related risks on men and women. Few studies have characterized gender differences across occupations and industries, although at this time, the gender sensitive approach is starting to acquire relevance in the field of human preventive medicine. The European Agency for Safety and Health at Work has encouraged a policy of gender equality in all European member states. Italy has adopted European provisions with new specific legislation that integrates the previous laws and introduces the gender differences into the workplace. Despite the fact that gender equal legislation opportunities have been enacted in Italy, their application is delayed by some difficulties. This review examines some of these critical aspects.
MeSH term(s)	Female ; Humans ; Interpersonal Relations ; Male ; Occupational Diseases/epidemiology ; Occupational Health/statistics & numerical data ; Risk Assessment ; Safety ; Sex Factors
Language	English
Publishing date	2016-04
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	950344-4
ISSN	0021-2571
ISSN	0021-2571
DOI	10.4415/ANN_16_02_10
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Zs.A 231: Show issues

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Article: Addressing health inequalities in Europe: key messages from the Joint Action Health Equity Europe (JAHEE).

Archives of public health = Archives belges de sante publique

2023 Volume 81, Issue 1, Page(s) 89

Abstract: Health inequalities within and between Member States of the European Union are widely recognized as a public health problem as they determine a significant share of potentially avoidable mortality and morbidity. After years of growing awareness and ... ...

Abstract	Health inequalities within and between Member States of the European Union are widely recognized as a public health problem as they determine a significant share of potentially avoidable mortality and morbidity. After years of growing awareness and increasing action taken, a large gap still exists across Europe in terms of policy responses and governance. With the aim to contribute to achieve greater equity in health outcomes, in 2018 a new Joint Action, JAHEE, (Joint Action Health Equity Europe) was funded by the third EU Health Programme, with the main goal of strengthening cooperation between participating countries and of implementing concrete actions to reduce health inequalities. The partnership led by Italy counted 24 countries, conducting actions in five policy domains: monitoring, governance, healthy living environments, health systems and migration, following a three-step implementation approach. Firstly, specific Policy Frameworks for Action (PFA) collecting the available evidence on what practice should be done in each domain were developed. Second, different Country Assessments (CAs) were completed to check the country's adherence to the recommended practice in each domain. The gap between the expected policy response (PFA) and the present policy response (CA) guided the choice of concrete actions to be implemented in JAHEE, many of which are continuing even after the end of JA. Final recommendations based on the best results achieved during JAHEE were elaborated and agreed jointly with the representatives of the involved Ministries of Health. The JAHEE initiative represented an important opportunity for the participating countries to work jointly, and the results show that almost all have increased their level of action and strengthened their capacities to address health inequalities.
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1117688-x
ISSN	2049-3258 ; 0778-7367 ; 0003-9578
ISSN (online)	2049-3258
ISSN	0778-7367 ; 0003-9578
DOI	10.1186/s13690-023-01086-3
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Zs.A 147: Show issues

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Article ; Online: Fibroblast autophagy in fibrotic disorders.

Del Principe, Domenico / Lista, Pasquale / Malorni, Walter / Giammarioli, Anna Maria

The Journal of pathology

2013 Volume 229, Issue 2, Page(s) 208–220

Abstract: Fibrotic disorders are multistage progressive processes that often arise from different causes and are commonly associated with chronic inflammation. Excessive deposition of extracellular matrix is the hallmark of many fibrotic diseases. This may be due ... ...

Abstract	Fibrotic disorders are multistage progressive processes that often arise from different causes and are commonly associated with chronic inflammation. Excessive deposition of extracellular matrix is the hallmark of many fibrotic diseases. This may be due to an excess of fibroblast recruitment and activation, as well as to their differentiation in myofibroblasts. These events may be triggered by cytokines, chemokines and growth factors released by lymphocytes or macrophages. The excessive production of extracellular matrix is apparently due to alterations of metabolic pathways in activated fibroblasts. It has been suggested that a defective autophagy, an important subcellular pathway with multiple homeostatic roles, also recognized as a key component of both innate and acquired immunity, could play a role. In this review we illustrate recent insights in the field, suggesting the possible implication of the immune system in orchestrating the fibrotic response via the modulation of autophagic pathways.
MeSH term(s)	Animals ; Autophagy ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Fibroblasts/immunology ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Fibrosis ; Homeostasis ; Humans ; Signal Transduction
Language	English
Publishing date	2013-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	3119-7
ISSN	1096-9896 ; 0022-3417
ISSN (online)	1096-9896
ISSN	0022-3417
DOI	10.1002/path.4115
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Article ; Online: Modulating the metabolism by trimetazidine enhances myoblast differentiation and promotes myogenesis in cachectic tumor-bearing c26 mice.

Gatta, Lucia / Vitiello, Laura / Gorini, Stefania / Chiandotto, Sergio / Costelli, Paola / Giammarioli, Anna Maria / Malorni, Walter / Rosano, Giuseppe / Ferraro, Elisabetta

Oncotarget

2017 Volume 8, Issue 69, Page(s) 113938–113956

Abstract: Trimetazidine (TMZ) is a metabolic reprogramming agent able to partially inhibit mitochondrial free fatty acid β-oxidation while enhancing glucose oxidation. Here we have found that the metabolic shift driven by TMZ enhances the myogenic potential of ... ...

Abstract	Trimetazidine (TMZ) is a metabolic reprogramming agent able to partially inhibit mitochondrial free fatty acid β-oxidation while enhancing glucose oxidation. Here we have found that the metabolic shift driven by TMZ enhances the myogenic potential of skeletal muscle progenitor cells leading to MyoD, Myogenin, Desmin and the slow isoforms of troponin C and I over-expression. Moreover, similarly to exercise, TMZ stimulates the phosphorylation of the AMP-activated protein kinase (AMPK) and up-regulates the peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC1α), both of which are known to enhance the mitochondrial biogenesis necessary for myoblast differentiation. TMZ also induces autophagy which is required during myoblast differentiation and promotes myoblast alignment which allows cell fusion and myofiber formation. Finally, we found that intraperitoneally administered TMZ (5mg/kg) is able to stimulate myogenesis
Language	English
Publishing date	2017-12-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.23044
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Article ; Online: Exercise-induced skeletal muscle remodeling and metabolic adaptation: redox signaling and role of autophagy.

Ferraro, Elisabetta / Giammarioli, Anna Maria / Chiandotto, Sergio / Spoletini, Ilaria / Rosano, Giuseppe

Antioxidants & redox signaling

2014 Volume 21, Issue 1, Page(s) 154–176

Abstract: Significance: Skeletal muscle is a highly plastic tissue. Exercise evokes signaling pathways that strongly modify myofiber metabolism and physiological and contractile properties of skeletal muscle. Regular physical activity is beneficial for health and ...

Abstract	Significance: Skeletal muscle is a highly plastic tissue. Exercise evokes signaling pathways that strongly modify myofiber metabolism and physiological and contractile properties of skeletal muscle. Regular physical activity is beneficial for health and is highly recommended for the prevention of several chronic conditions. In this review, we have focused our attention on the pathways that are known to mediate physical training-induced plasticity. Recent advances: An important role for redox signaling has recently been proposed in exercise-mediated muscle remodeling and peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) activation. Still more currently, autophagy has also been found to be involved in metabolic adaptation to exercise. Critical issues: Both redox signaling and autophagy are processes with ambivalent effects; they can be detrimental and beneficial, depending on their delicate balance. As such, understanding their role in the chain of events induced by exercise and leading to skeletal muscle remodeling is a very complicated matter. Moreover, the study of the signaling induced by exercise is made even more difficult by the fact that exercise can be performed with several different modalities, with this having different repercussions on adaptation. Future directions: Unraveling the complexity of the molecular signaling triggered by exercise on skeletal muscle is crucial in order to define the therapeutic potentiality of physical training and to identify new pharmacological compounds that are able to reproduce some beneficial effects of exercise. In evaluating the effect of new "exercise mimetics," it will also be necessary to take into account the involvement of reactive oxygen species, reactive nitrogen species, and autophagy and their controversial effects.
MeSH term(s)	Animals ; Autophagy/physiology ; Exercise/physiology ; Humans ; Muscle, Skeletal/metabolism ; Oxidation-Reduction ; PPAR gamma/metabolism ; Physical Conditioning, Animal/physiology ; Signal Transduction/physiology
Chemical Substances	PPAR gamma
Language	English
Publishing date	2014-03-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1483836-9
ISSN	1557-7716 ; 1523-0864
ISSN (online)	1557-7716
ISSN	1523-0864
DOI	10.1089/ars.2013.5773
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Article ; Online: Integrating gender medicine into the workplace health and safety policy in the scientific research institutions: a mandatory task.

Giammarioli, Anna Maria / Siracusano, Alessandra / Sorrentino, Eugenio / Bettoni, Monica / Malorni, Walter

Annali dell'Istituto superiore di sanita

2012 Volume 48, Issue 3, Page(s) 311–318

Abstract: Background: Gender medicine is a multi-faceted field of investigation integrating various aspects of psycho-social and biological sciences but it mainly deals with the impact of the gender on human physiology, pathophysiology, and clinical features of ... ...

Abstract	Background: Gender medicine is a multi-faceted field of investigation integrating various aspects of psycho-social and biological sciences but it mainly deals with the impact of the gender on human physiology, pathophysiology, and clinical features of diseases. In Italy, the Decree Law 81/2008 recently introduced the gender issue in the risk assessment at the workplaces. Aims: This review briefly describes our current knowledge on gender medicine and on the Italian legislation in risk management. Conclusions: Public or private scientific institutions should be the first to pay attention to the safety of their workers, who are simultaneously subjected to biological, chemical and physical agents. Main tasks of risk management in scientific research institutions are here analyzed and discussed in a gender perspective.
MeSH term(s)	Academies and Institutes/legislation & jurisprudence ; Academies and Institutes/organization & administration ; European Union ; Female ; Gender Identity ; Health ; Humans ; Italy ; Male ; Occupational Exposure/prevention & control ; Occupational Health/legislation & jurisprudence ; Risk Management ; Safety/legislation & jurisprudence ; Safety/statistics & numerical data ; Stress, Psychological/physiopathology ; Workplace/legislation & jurisprudence ; Workplace/organization & administration
Language	English
Publishing date	2012-09-22
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	950344-4
ISSN	2384-8553 ; 0021-2571
ISSN (online)	2384-8553
ISSN	0021-2571
DOI	10.4415/ANN_12_03_12
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Article ; Online: Defective autophagy in fibroblasts may contribute to fibrogenesis in autoimmune processes.

Del Principe, Domenico / Vona, Rosa / Giordani, Luciana / Straface, Elisabetta / Giammarioli, Anna Maria

Current pharmaceutical design

2011 Volume 17, Issue 35, Page(s) 3878–3887

Abstract: Fibrosis may represent the final step induced by autoimmune mechanism(s). This may be due to the excess in fibroblast recruitment, activation and differentiation in myofibroblasts. These events may be triggered by cytokines, chemokines and growth factors ...

Abstract	Fibrosis may represent the final step induced by autoimmune mechanism(s). This may be due to the excess in fibroblast recruitment, activation and differentiation in myofibroblasts. These events may be triggered by cytokines, chemokines and growth factors released by lymphocytes or macrophages. Autophagy is an essential conserved homeostatic process that has long been appreciated for cell adaptation to nutrient deprivation. Autophagy is also recognized as an important component of both innate and acquired immunity to pathogens. Recently, dysregulation of autophagy in haematopoietic cells has been suggested to amplify the autoimmune responses. On the other hand, it is possible that defective autophagy in non-haematopoietic cells contributes to the progression to fibrosis. In fibroblasts some alterations in the metabolic pathways and pharmacological data suggest that a defective autophagy could contribute to excess in the production of extracellular matrix by altering the turnover of protein such as collagen. Our goal in this review is to describe the current knowledge on the role of autophagy in the development of fibrotic autoimmune diseases. Further studies could confirm whether agents modulating autophagy may be used in the treatment of these autoimmune diseases.
MeSH term(s)	Animals ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/pathology ; Autoimmune Diseases/physiopathology ; Autophagy/drug effects ; Fibroblasts/drug effects ; Fibroblasts/pathology ; Fibrosis ; Hematopoietic System/drug effects ; Hematopoietic System/physiopathology ; Humans ; Molecular Targeted Therapy ; Scleroderma, Systemic/drug therapy ; Scleroderma, Systemic/pathology
Language	English
Publishing date	2011-08-04
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/138161211798357791
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Zs.A 4714: Show issues

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Article: Dynamics of lipid raft components during lymphocyte apoptosis: the paradigmatic role of GD3.

Malorni, Walter / Giammarioli, Anna Maria / Garofalo, Tina / Sorice, Maurizio

Apoptosis : an international journal on programmed cell death

2007 Volume 12, Issue 5, Page(s) 941–949

Abstract: Several investigations have been carried out since many years in order to precisely address the function of lipid rafts in cell life and death. On the basis of the biochemical nature of lipid rafts, composed by sphingolipids, including gangliosides, ... ...

Abstract	Several investigations have been carried out since many years in order to precisely address the function of lipid rafts in cell life and death. On the basis of the biochemical nature of lipid rafts, composed by sphingolipids, including gangliosides, sphingomyelin, cholesterol and signaling proteins, a plethora of possible interactions with various subcellular structures has been suggested. Their structural and functional role at the plasma membrane as well as in cell organelles such as endoplasmic reticulum and Golgi apparatus has been analyzed in detail in several studies. In particular, a specific activity of lipid rafts has been hypothesized to contribute to cell death by apoptosis. Although detected in various cell types, the role of lipid rafts in apoptosis has however been mostly studied in lymphocytes where the physiological apoptotic program occurs after CD95/Fas triggering. In this review, the possible contribution of lipid rafts to the cascade of events leading to T cell apoptosis after CD95/Fas ligation are summarized. Particular attention has been given to the mitochondrial raft-like microdomains, which may represent preferential sites where some key reactions can take place and can be catalyzed, leading to either survival or death of T cells.
MeSH term(s)	Animals ; Apoptosis/physiology ; Cytoskeleton/metabolism ; Gangliosides/metabolism ; Humans ; Intracellular Membranes/chemistry ; Intracellular Membranes/metabolism ; Lymphocytes/physiology ; Lymphocytes/ultrastructure ; Membrane Microdomains/chemistry ; Membrane Microdomains/metabolism ; Mitochondria/metabolism ; Mitochondria/ultrastructure ; Models, Theoretical
Chemical Substances	Gangliosides ; ganglioside, GD3 (62010-37-1)
Language	English
Publishing date	2007-05
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1452360-7
ISSN	1360-8185
ISSN	1360-8185
DOI	10.1007/s10495-007-0757-1
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