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Article: Distribución de serotipos de Streptococcus pneumoniae aislados de infecciones invasoras en el Hospital de Niños de Santa Fe.

Mayoral, C / Baroni, M R / Giani, R / Virgolini, S / Zurbriggen, L / Regueira, M

2008 Volume 40, Issue 1, Page(s) 13–16

Abstract: The serotype distribution of Streptococcus pneumoniae varies through time. The introduction of pneumococcal conjugate vaccines showed a decreased prevalence of pneumococcal invasive isolates belonging to serotype 14 and an increase of serotypes not ... ...

Title translation	Serotype distribution of Streptococcus pneumoniae isolated from invasive infections at the Hospital de Niños of Santa Fe.
Abstract	The serotype distribution of Streptococcus pneumoniae varies through time. The introduction of pneumococcal conjugate vaccines showed a decreased prevalence of pneumococcal invasive isolates belonging to serotype 14 and an increase of serotypes not therein included. In 1993, the Hospital de Niños of Santa Fe began surveillance of the serotype distribution of invasive S. pneumoniae disease. In the period 2003-2005, 76 isolates were analysed by studying the correlation between serotype and pathology, age and MIC of penicillin. Serotype 14 was the most frequent followed by serotypes 1, 6B, 18C, 7F, 19 F and 5. Serotype 14 showed a statistically significant correlation with MICs of penicillin ranging from 0,5 to 2 mg/l. Although this serotype was more frequently observed in pneumonia than in meningitis, there was not a significant association with any particular pathology. Serotypes 14 and 1, were prevalent among children under and over 2 years old, respectively. Most of these isolates with MICs of penicillin = 2 mg/l, were from patients with pneumonia and not with meningitis. The serotype distribution was similar to that during the period 1993-99, with the exception of serotypes 18C, 4, 12F and 22F which had never been found before. The emergence of these serotypes makes it essential to continue surveillance to determine which conjugated vaccine formulation would be suitable to prevent the most frequent pneumococcal invasive infections.
MeSH term(s)	Child ; Humans ; Meningitis, Bacterial/microbiology ; Pneumonia, Bacterial/microbiology ; Streptococcus pneumoniae/classification ; Streptococcus pneumoniae/isolation & purification
Language	Spanish
Publishing date	2008-01
Publishing country	Argentina
Document type	English Abstract ; Journal Article
ZDB-ID	731952-6
ISSN	0325-7541
ISSN	0325-7541
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Article ; Online: Role and efficacy of intraoperative evaluation of resection adequacy in conservative breast surgery.

Canavese, G / Ciccarelli, G / Garretti, L / Ponti, A / Bussone, R / Giani, R / Ala, A / Berardengo, E

ISRN oncology

2011 Volume 2011, Page(s) 247385

Abstract: In the present study we considered the histology of 51 patients who have undergone breast conservative surgery and the related 54 re-excisions that were performed in the same surgical procedure or in delayed procedures, in order to evaluate the role of ... ...

Abstract	In the present study we considered the histology of 51 patients who have undergone breast conservative surgery and the related 54 re-excisions that were performed in the same surgical procedure or in delayed procedures, in order to evaluate the role of intraoperative re-excisions in completing tumor removal. In 13% of the cases the re excision obtained the resection of the target lesion. In this study, the occurrence of residual neoplastic lesions in intraoperative re-excisions (24%) is lower than in delayed re-excisions (62%; P = .03). The residual lesions that we could find with definitive histology of re excision specimens are related with lesions with ill defined profile. In 77% of the cases of re excision with tumoral residual the lesion was close to the new resection margin, thus the re-excisions couldn't achieve an adequate ablation of the neoplasm. Invasive or preinvasive nature of the main lesion resected for each case and the approach to the evaluation of the first resection specimen adequacy (surgical or radiological) don't affect the rate of tumoral residual in intraoperative re-excisions. In conclusion, our data are consistent with a low efficacy of intraoperative re excision in obtaining a complete removal of the tumor; intraoperative radiologic evaluation of the first resection specimen is however imperative in defining the effective removal of the target lesion.
Language	English
Publishing date	2011-04-28
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2612994-2
ISSN	2090-567X ; 2090-5661
ISSN (online)	2090-567X
ISSN	2090-5661
DOI	10.5402/2011/247385
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Article: Evaluation of a nested-PCR assay for Streptococcus pneumoniae detection in pediatric patients with community-acquired pneumonia.

Mayoral, C / Noroña, M / Baroni, M R / Giani, R / Zalazar, F

Revista Argentina de microbiologia

2005 Volume 37, Issue 4, Page(s) 184–188

Abstract: The aim of the present work was to evaluate the usefulness of a simplified method for DNA extraction coupled to a nested-PCR protocol, based on the amplification of pneumolysin gene fragments for the diagnosis of pneumococcal pneumonia in pediatric ... ...

Abstract	The aim of the present work was to evaluate the usefulness of a simplified method for DNA extraction coupled to a nested-PCR protocol, based on the amplification of pneumolysin gene fragments for the diagnosis of pneumococcal pneumonia in pediatric patients with clinical and radiological evidence of bacterial infection. Bacterial DNA was extracted from sera by boiling and used without further purification in the PCR for the pneumolysin gene. None toxic reagents were used and the necessary steps to obtain the DNA were left at a minimum; furthermore, it overcomes the use of expensive commercial kits for DNA purification. The total procedure can be completed the same day of sampling and, most important, it avoids the use of sophisticated technology. Both in vitro analytical specificity and sensitivity (10 CFU/ml) of the assay were similar to those previously reported. When clinical samples were tested, the rate of positivity was shown to be 83.3% and 71% in pediatric patients with positive (group a) and negative blood cultures (group b), respectively. In group a, DNA detection was successful in samples from children without treatment or with less than 48 h of antibiotic therapy. None amplification was obtained from sera patients with viral infection or in samples from healthy controls. The application of the strategy described in this paper substantially seems to improve the diagnostic process in a determinate group: blood culture-negative children with pneumonia.
MeSH term(s)	Bacteremia/microbiology ; Child, Preschool ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/microbiology ; DNA, Bacterial/blood ; DNA, Bacterial/genetics ; DNA, Bacterial/isolation & purification ; Diagnosis, Differential ; Female ; Humans ; Infant ; Male ; Pneumonia, Bacterial/diagnosis ; Pneumonia, Pneumococcal/diagnosis ; Pneumonia, Pneumococcal/microbiology ; Pneumonia, Viral/diagnosis ; Polymerase Chain Reaction/methods ; Sensitivity and Specificity ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/isolation & purification
Chemical Substances	DNA, Bacterial
Language	English
Publishing date	2005-10
Publishing country	Argentina
Document type	Comparative Study ; Evaluation Studies ; Journal Article
ZDB-ID	731952-6
ISSN	0325-7541
ISSN	0325-7541
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Article: Radiography of the surgical specimen in early stage breast lesions: diagnostic reliability in the analysis of the resection margins.

Ciccarelli, G / Di Virgilio, M R / Menna, S / Garretti, L / Ala, A / Giani, R / Bussone, R / Canavese, G / Berardengo, E

La Radiologia medica

2007 Volume 112, Issue 3, Page(s) 366–376

Abstract: Purpose: The purpose of this study was to evaluate the diagnostic reliability of specimen radiography in the assessment of the status of resection margins in early stage breast lesions.: Materials and methods: The study involved 123 consecutive ... ...

Abstract	Purpose: The purpose of this study was to evaluate the diagnostic reliability of specimen radiography in the assessment of the status of resection margins in early stage breast lesions. Materials and methods: The study involved 123 consecutive patients who underwent breast-conserving surgery for early stage breast lesions. Specimen radiography in the two orthogonal views and with direct magnification was obtained in all cases to assess presence or absence of the lesion, position of the lesion within the surgical specimen and direction in which to extend the excision in cases of lesions located close to the margin. Diagnostic reliability was evaluated for only 102 patients with malignant lesions. Results: Comparison between the radiological and histological diagnoses before immediate reexcision had 66% sensitivity, 86% specificity, 74% positive predictive value and 81% negative predictive value. Definitive histological assessment of margin status, including status after reexcision, was infiltrated margins in 23 patients (23%) and clear margins in 79 patients (77%). Definitive histological assessment in 12/19 patients (63.15%) with intraoperative reexcision, confirmed margin infiltration of the first specimen. Twenty patients (20%) underwent a second surgical procedure. Conclusions: Specimen radiography was reliable in identifying clear margins (74% positive predictive value) and reduced the rate of reintervention from 31% to 20%. Better results will be provided by digital mammographic equipment.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Breast/pathology ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Female ; Humans ; Intraoperative Period ; Mammography ; Mastectomy, Segmental ; Middle Aged ; Predictive Value of Tests ; Reoperation
Language	Italian
Publishing date	2007-04
Publishing country	Italy
Document type	Comparative Study ; Evaluation Studies ; Journal Article
ZDB-ID	205751-7
ISSN	1826-6983 ; 0033-8362
ISSN (online)	1826-6983
ISSN	0033-8362
DOI	10.1007/s11547-007-0147-3
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Article: Familias de la proteína de superficie PspA de Streptococcus pneumoniae. Relación con serotipos y localización.

Mayoral, Clara / Della Bianca, Mara / Baroni, María Rosa / Giani, Rita / Regueira, Mabel / Zalazar, Fabián

Medicina

2010 Volume 70, Issue 5, Page(s) 437–441

Abstract: PspA, a pneumococcal surface protein, is highly immunogenic and common to all serotypes. Although pspA gene shows a great heterogeneity at the N-terminal region, PspA protein has conserved epytopes which are able to elicit protective cross-reaction ... ...

Title translation	Pneumococcal surface protein A (PspA) families. Relation with serotypes and clinical site of infection.
Abstract	PspA, a pneumococcal surface protein, is highly immunogenic and common to all serotypes. Although pspA gene shows a great heterogeneity at the N-terminal region, PspA protein has conserved epytopes which are able to elicit protective cross-reaction against various serotypes presenting different PspA. In spite of the high polimorfism of the PspA, three majority families can be identified. These properties convert PspA as ideal candidate for the formulation of a pneumococcal vaccine. Investigations of the PspA families were mostly carried out on prevalent serotypes in other countries. The aim of this study was to identify PspA families from Streptococcus pneumoniae isolates of our region as well as to associate them to prevalent serotypes or pathologies. We studied 70 isolates from pediatric patients with invasive infections. PCR was performed using specific primers for each family. In these studies we observed that 60% were PspA family 1, 34% were PspA family 2 and 6% remained unclassified. Serotypes 1 and 5 presented only family 1; serotypes 14, 6B, 19F y 18C showed genes from both families. Family 1 was observed respectively in 60 y 50% of pneumonias and meningitis. The family 2 was identified in 33 and 50% of pneumonias and meningitis. This information about the PspA family distribution could become a valuable contribution to develop an effective regional vaccine using recombinant PspA as immunogen.
MeSH term(s)	Bacterial Proteins/classification ; Bacterial Proteins/immunology ; Electrophoresis, Agar Gel ; Humans ; Membrane Proteins/classification ; Polymerase Chain Reaction ; Serotyping ; Streptococcus pneumoniae/classification
Chemical Substances	Bacterial Proteins ; Membrane Proteins ; pneumococcal surface protein A
Language	Spanish
Publishing date	2010
Publishing country	Argentina
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	411586-7
ISSN	1669-9106 ; 0025-7680 ; 0325-951X
ISSN (online)	1669-9106
ISSN	0025-7680 ; 0325-951X
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Article: Situazione sociodemografica e condizioni di salute della popolazione rom di Milano.

Colombo, Cinzia / Galli, Andrea / Pero, Margherita / Giani, Riccardo / Jucker, Simonetta / Oreste, Pierluigi / Giommarini, Claudia / Aiolfi, Ernestina / Judica, Elda

Epidemiologia e prevenzione

2011 Volume 35, Issue 5-6, Page(s) 282–291

Abstract: Objective: To analyze the socioeconomic and health status of rom a people mainly living in not authorized settlements in Milan.: Design: Evaluation of socioeconomic and healthcare data collected by the mobile unit of Naga, a voluntary association ... ...

Title translation	Sociodemographic and health conditions of the Romá population in Milan.
Abstract	Objective: To analyze the socioeconomic and health status of rom a people mainly living in not authorized settlements in Milan. Design: Evaluation of socioeconomic and healthcare data collected by the mobile unit of Naga, a voluntary association based in Milan, during two years of activity (2009-2010). Healthcare data have been classified using an operational classification. Setting and participants: Settlements located in Milan where rom a people live. Results: 1 142 rom a people living in 14 settlements of Milan (only one authorized) were visited.Mean schooling years were 4.9. The mean number of children per family was 2.8. Of 803 people older than 13 years, 129 had an occupation (16%). 56%of subjetcs older than 12 years were smokers (53% females vs. 59%males); among smokers, 17%were heavy smokers (12%females vs 22% males). The most frequently reported diseases were: respiratory diseases (21%of total diagnoses), disorders of the orthopedic-rheumatologic-traumatology area (13%), gastroenterological diseases (10%) and dental problems (8%). Most residents had no healthcare coverage (94%). Almost all settlements (except the authorized one) had no sanitary facilities, no garbage collection system and were definitely overcrowded. Conclusion: Mild diseases were the most commonly found pathologies, with few chronic diseases reported probably due to difficulties in investigating more complex diseases in the study setting,and to the impossibility to follow the patients over time. Furthermore, the access to healthcare services for diagnostic tests and specialist visits is very very difficult for these patients. Poor living conditions, low educational level, low employment rate, barriers in the access to healthcare services are all risks factors for the health status of rom a people.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Educational Status ; Family Characteristics/ethnology ; Female ; Health Services Accessibility/statistics & numerical data ; Health Status Disparities ; Humans ; Infant ; Italy/epidemiology ; Male ; Medically Uninsured/ethnology ; Medically Uninsured/statistics & numerical data ; Middle Aged ; Morbidity ; Patient Acceptance of Health Care/ethnology ; Patient Acceptance of Health Care/statistics & numerical data ; Poverty Areas ; Roma/statistics & numerical data ; Sanitation/statistics & numerical data ; Smoking/epidemiology ; Socioeconomic Factors ; Unemployment/statistics & numerical data ; Urban Population/statistics & numerical data ; Young Adult
Language	Italian
Publishing date	2011-09
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	1038112-0
ISSN	1120-9763
ISSN	1120-9763
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Zs.A 2748: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Lymphatic mapping in early stage breast cancer: comparison between periareolar and subdermal injection.

Pelosi, E / Baiocco, C / Ala, A / Gay, E / Bello, M / Varetto, T / Giani, R / Bussone, R / Bisi, G

Nuclear medicine communications

2003 Volume 24, Issue 5, Page(s) 519–523

Abstract: The combination of preoperative lymphatic mapping with intra-operative probe detection is becoming the standard procedure for identifying tumour lymphatic spread at the time of initial treatment in breast cancer. There are a number of identification ... ...

Abstract	The combination of preoperative lymphatic mapping with intra-operative probe detection is becoming the standard procedure for identifying tumour lymphatic spread at the time of initial treatment in breast cancer. There are a number of identification techniques for sentinel lymph nodes, but the concordance of the results of a sentinel lymph node biopsy with axillary lymph node dissection did not vary significantly among them. Periareolar (p.a.) injection of tracer is a new procedure specifically studied to overcome some limitations of other techniques; in two groups of patients with early breast cancer we compared the periareolar with the subdermal technique. One hundred and fifty biopsy proven breast cancer patients were consecutively enrolled in this study. This population was divided into two groups: (1) group A, including 100 cancers; lymphatic mapping was performed by s.d. injection of both blue dye and radiotracer; and (2) group B, including 50 cancers; lymphatic mapping was performed with a combination of blue dye injected p.a. and radiotracer injected s.d. For group A, with both techniques we identified one or more SLNs in 100/100 tumours; blue dye detected the SLNs in 99/100 cancers (99%), lymphoscintigraphy in 93/100 cancers (93%). The concordance rate was 92%. For group B, with both techniques we identified one or more SLNs in 49/50 cancers (98%); blue dye detected the SLNs in 48/50, lymphoscintigraphy in 46/50 cancers (92%). The concordance rate was 92%. In the present study p.a. and s.d. injection of blue dye give similar and comparable results. The periareolar technique is simpler and has several advantages over the subdermal technique.
MeSH term(s)	Administration, Cutaneous ; Axilla ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Female ; Humans ; Injections/methods ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Middle Aged ; Neoplasm Staging/methods ; Nipples ; Radionuclide Imaging ; Radiopharmaceuticals ; Reproducibility of Results ; Rosaniline Dyes/administration & dosage ; Sensitivity and Specificity ; Sentinel Lymph Node Biopsy/methods ; Technetium Tc 99m Aggregated Albumin
Chemical Substances	Radiopharmaceuticals ; Rosaniline Dyes ; Technetium Tc 99m Aggregated Albumin ; technetium Tc 99m nanocolloid ; iso-sulfan blue (39N9K8S2A4)
Language	English
Publishing date	2003-04-22
Publishing country	England
Document type	Clinical Trial ; Controlled Clinical Trial ; Journal Article
ZDB-ID	758141-5
ISSN	1473-5628 ; 0143-3636
ISSN (online)	1473-5628
ISSN	0143-3636
DOI	10.1097/00006231-200305000-00006
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Zs.A 1577: Show issues

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Article: Sentinel node detection in breast carcinoma.

Pelosi, E / Arena, V / Baudino, B / Bellò, M / Giani, R / Lauro, D / Ala, A / Bussone, R / Bisi, G

Tumori

2002 Volume 88, Issue 3, Page(s) S10–1

Abstract: Aims and background: The standard procedure for the evaluation of axillary nodal involvement in patients with breast cancer is still complete lymph node dissection. However, about 70% of patients are found to be free of metastatic disease while axillary ...

Abstract	Aims and background: The standard procedure for the evaluation of axillary nodal involvement in patients with breast cancer is still complete lymph node dissection. However, about 70% of patients are found to be free of metastatic disease while axillary node dissection may cause significant morbidity. Lymphatic mapping and sentinel lymph node (SLN) biopsy are changing this situation. Methods and study design: In a period of 18 months we studied 201 patients with breast cancer, excluding patients with palpable axillary nodes, tumors > 2.5 cm in diameter, multifocal or multicentric cancer, pregnant patients and patients over 80 years of age. Before surgery 99mTc-labeled colloid and vital blue dye were injected into the breast to identify the SLN. In lymph nodes dissected during surgery the metastatic status was examined by sections at reduced intervals. Only patients with SLNs that were histologically positive for metastases underwent axillary dissection. Results: We localized one or more SLNs in 194 of 201 (96.5%) patients; when both techniques were utilized the success rate was 100%. Histologically, 21% of patient showed SLN metastases (7.8% micrometastases) and 68% of these had metastases also in other axillary nodes. None of the patients with negative SLNs developed metastases during follow-up. Conclusions: At present there is no definite evidence that negative SLN biopsy is invariably correlated with negative axillary status; however, our study and those of others demonstrate that SLN biopsy is an accurate method of axillary staging.
MeSH term(s)	Aged ; Axilla ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Coloring Agents ; Female ; Humans ; Italy ; Lymph Node Excision ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Lymphatic Metastasis ; Middle Aged ; Neoplasm Staging ; Predictive Value of Tests ; Radiopharmaceuticals ; Rosaniline Dyes ; Sentinel Lymph Node Biopsy ; Technetium Tc 99m Aggregated Albumin ; Unnecessary Procedures/statistics & numerical data
Chemical Substances	Coloring Agents ; Radiopharmaceuticals ; Rosaniline Dyes ; Technetium Tc 99m Aggregated Albumin ; technetium Tc 99m nanocolloid ; sulfan blue (FH1929ICIT)
Language	English
Publishing date	2002-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	280962-x
ISSN	2038-2529 ; 0300-8916
ISSN (online)	2038-2529
ISSN	0300-8916
DOI	10.1177/030089160208800323
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Ud II Zs.43: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Sentinel lymph node detection in patients with early-stage breast cancer: comparison of periareolar and subdermal/peritumoral injection techniques.

Pelosi, Ettore / Bellò, Marilena / Giors, Monica / Ala, Ada / Giani, Roberto / Bussone, Riccardo / Bisi, Gianni

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2004 Volume 45, Issue 2, Page(s) 220–225

Abstract: Unlabelled: Periareolar (PA) injection offers several potential advantages over other techniques for visualizing sentinel lymph nodes (SLNs) in patients with early breast cancer. However, few studies have been published on this procedure. This study was ...

Abstract	Unlabelled: Periareolar (PA) injection offers several potential advantages over other techniques for visualizing sentinel lymph nodes (SLNs) in patients with early breast cancer. However, few studies have been published on this procedure. This study was designed to validate PA injection technique and compare it with the subdermal/peritumoral (SD/PT) injection technique. Methods: The study included 324 patients in whom 330 breast cancers (T) had been identified by biopsy. This population was divided in 4 groups: (A) 148 patients (150 T) in whom lymphatic mapping was performed by injecting radiotracer with the SD/PT technique; (B) 59 patients (60 T) in whom lymphatic mapping was performed with a combination of blue dye injected with the PA technique and radiotracer injected with the SD/PT technique; (C) 58 patients (60 T) in whom blue dye was injected subdermally and radiotracer was injected periareolarly; and (D) 59 patients (60 T) in whom both blue dye and radiotracer were injected periareolarly. Results: Concordances in the SLN detection rate between blue dye and radiotracer in groups B, C, and D were 98.1%, 100%, and 100%, respectively. The SLN identification rates with the PA technique were 98.3% and 95%, respectively, for radiotracer and blue dye. With the SD/PT technique, these rates were 90.5% and 88.3%, respectively, for radiotracer and blue dye. At lymphoscintigraphy, SLN visualization required the acquisition of late images (3 h after the injection) in 20% of patients who received PA injections and 39.5% of patients who received SD/PT injections. Conclusion: These findings validate the PA injection technique and underline some of its reported advantages in comparison with the SD/PT technique.
MeSH term(s)	Breast Neoplasms/pathology ; Coloring Agents ; Female ; Humans ; Injections/methods ; Lymph Nodes/pathology ; Lymphoscintigraphy ; Middle Aged ; Nipples ; Radiopharmaceuticals ; Sentinel Lymph Node Biopsy/methods ; Technetium Tc 99m Aggregated Albumin
Chemical Substances	Coloring Agents ; Radiopharmaceuticals ; Technetium Tc 99m Aggregated Albumin ; technetium Tc 99m nanocolloid
Language	English
Publishing date	2004-02
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0161-5505 ; 0097-9058 ; 0022-3123
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 328: Show issues

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Article: Heterogeneity of [3H]-mepyramine binding sites in guinea pig cerebellum and lung.

Dini, S / Caselli, G F / Ferrari, M P / Giani, R / Clavenna, G

Agents and actions

1991 Volume 33, Issue 1-2, Page(s) 181–184

Abstract: The nature of histamine receptors in peripheral tissues is still controversial. However, evidence of heterogeneous classes of binding sites for [3H]-mepyramine are reported in the literature. The aim of our study was, therefore, to investigate the nature ...

Abstract	The nature of histamine receptors in peripheral tissues is still controversial. However, evidence of heterogeneous classes of binding sites for [3H]-mepyramine are reported in the literature. The aim of our study was, therefore, to investigate the nature of this heterogeneity by comparing [3H]-mepyramine binding in a central tissue (cerebellum) and in a peripheral tissue (lung) obtained from guinea pigs and to assess its dependence upon the temperature of incubation. The results revealed that the [3H]-mepyramine interaction in both tissues is temperature-dependent. At 25 degrees C, the interaction between [3H]-mepyramine and the receptors was biphasic in the lung while only a single class of binding site was found in the cerebellum. At 0 degrees C, [3H]-mepyramine interacted with three binding sites in the lung and two in the cerebellum. The behaviour of the reference compounds (clemastine, promethazine and histamine) also supported this temperature-dependence. Moreover, two new compounds (DF 11062 and DF 11113), synthesized in our laboratories and endowed with antihistamine activity, can differentiate between the low affinity site seen at 25 degrees C in the lung and that seen in the cerebellum at 0 degrees C.
MeSH term(s)	Animals ; Benzimidazoles/metabolism ; Binding, Competitive ; Cerebellum/metabolism ; Guinea Pigs ; Histamine Antagonists/metabolism ; Kinetics ; Lung/metabolism ; Male ; Pyridines/metabolism ; Pyrilamine/metabolism ; Radioligand Assay ; Receptors, Histamine/metabolism ; Temperature ; Tritium
Chemical Substances	Benzimidazoles ; Histamine Antagonists ; Pyridines ; Receptors, Histamine ; Tritium (10028-17-8) ; DF 11062 (134092-07-2) ; DF 11113 (134092-08-3) ; Pyrilamine (HPE317O9TL)
Language	English
Publishing date	1991-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80022-3
ISSN	0065-4299
ISSN	0065-4299
DOI	10.1007/bf01993161
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

Order via subito