Article ; Online: Metastatic colorectal cancer: mechanisms and emerging therapeutics.
Trends in pharmacological sciences
2023 Volume 44, Issue 4, Page(s) 222–236
Abstract: Metastatic colorectal cancer (mCRC) remains a lethal disease with an approximately 14% 5-year survival rate. While early-stage colorectal cancer (CRC) can be cured by surgery with or without adjuvant chemotherapy, mCRC cannot be eradicated due to a large ...
Abstract | Metastatic colorectal cancer (mCRC) remains a lethal disease with an approximately 14% 5-year survival rate. While early-stage colorectal cancer (CRC) can be cured by surgery with or without adjuvant chemotherapy, mCRC cannot be eradicated due to a large burden of disseminated cancer cells comprising therapy-resistant metastasis-competent cells. To address this gap, recent studies have focused on further elucidating the molecular mechanisms underlying colorectal metastasis and recognizing the limitations of available therapeutic interventions. In this review, we discuss newfound factors that regulate CRC cell dissemination and colonization of distant organs, such as genetic mutations, identification of metastasis-initiating cells (MICs), epithelial-mesenchymal transition (EMT), and the tumor microenvironment (TME). We also review current treatments for mCRC, therapeutic regimens undergoing clinical trials, and trending preclinical studies being investigated to target treatment-resistant mCRC. |
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MeSH term(s) | Humans ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Epithelial-Mesenchymal Transition ; Tumor Microenvironment |
Language | English |
Publishing date | 2023-02-23 |
Publishing country | England |
Document type | Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
ZDB-ID | 282846-7 |
ISSN | 1873-3735 ; 0165-6147 |
ISSN (online) | 1873-3735 |
ISSN | 0165-6147 |
DOI | 10.1016/j.tips.2023.01.003 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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