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Article ; Conference proceedings: Hyperspektral-Bildgebung bei Plattenepithel-Karzinomen des Kopf-Hals-Bereichs – Klinische Implementation und erste Ergebnisse einer ex-vivo Anwendung

Böhm, Felix / Schwamborn, Carolin / Alperovich, Anna / Zhang, Xiaohan / Giannantonio, Tommaso / Sommer, Fabian / Lingl, Julia / Hoffmann, ThomasK. / Schuler, PatrickJ.

Laryngo-Rhino-Otologie

2023 Volume 102, Issue S 02

Event/congress	94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
Language	German
Publishing date	2023-05-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	96005-6
ISSN	1438-8685 ; 0935-8943 ; 0340-1588
ISSN (online)	1438-8685
ISSN	0935-8943 ; 0340-1588
DOI	10.1055/s-0043-1766510
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Article ; Conference proceedings: Hyperspectral imaging of squamous cell carcinoma of the head and neck – Clinical implementation and initial results of an ex vivo application

Böhm, Felix / Schwamborn, Carolin / Alperovich, Anna / Zhang, Xiaohan / Giannantonio, Tommaso / Sommer, Fabian / Lingl, Julia / Hoffmann, K. Thomas / Schuler, J. Patrick

Laryngo-Rhino-Otologie

2023 Volume 102, Issue S 02

Event/congress	94th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e.V., Bonn, Congress Center Leipzig, 2023-05-17
Language	English
Publishing date	2023-05-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	96005-6
ISSN	1438-8685 ; 0935-8943 ; 0340-1588
ISSN (online)	1438-8685
ISSN	0935-8943 ; 0340-1588
DOI	10.1055/s-0043-1767102
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Article ; Conference proceedings: First results of the ex vivo application and analysis with neural networks in hyperspectral imaging (HSI) of squamous cell carcinoma of head and neck

Schwamborn, Carolin / Böhm, Felix / Alperovich, Anna / Zhang, Xiaohan / Giannantonio, Tommaso / Sommer, Fabian / Hoffmann, ThomasK. / Schuler, PatrickJ.

Laryngo-Rhino-Otologie

2023 Volume 102, Issue S 02

Event/congress	94th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e.V., Bonn, Congress Center Leipzig, 2023-05-17
Language	English
Publishing date	2023-05-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	96005-6
ISSN	1438-8685 ; 0935-8943 ; 0340-1588
ISSN (online)	1438-8685
ISSN	0935-8943 ; 0340-1588
DOI	10.1055/s-0043-1767279
Database	Thieme publisher's database

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Article ; Conference proceedings: Hyperspektral-Bildgebung bei Plattenepithelkarzinomen des Kopf-Hals-Bereichs – Erste Ergebnisse der ex vivo Anwendung und Analyse mit neuronalen Netzwerken

Schwamborn, Carolin / Böhm, Felix / Alperovich, Anna / Zhang, Xiaohan / Giannantonio, Tommaso / Sommer, Fabian / Hoffmann, ThomasK. / Schuler, PatrickJ.

Laryngo-Rhino-Otologie

2023 Volume 102, Issue S 02

Event/congress	94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
Language	German
Publishing date	2023-05-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	96005-6
ISSN	1438-8685 ; 0935-8943 ; 0340-1588
ISSN (online)	1438-8685
ISSN	0935-8943 ; 0340-1588
DOI	10.1055/s-0043-1766669
Database	Thieme publisher's database

In stock of ZB MED Cologne/Königswinter

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Book ; Online: Intra-operative Brain Tumor Detection with Deep Learning-Optimized Hyperspectral Imaging

Giannantonio, Tommaso / Alperovich, Anna / Semeraro, Piercosimo / Atzori, Manfredo / Zhang, Xiaohan / Hauger, Christoph / Freytag, Alexander / Luthman, Siri / Vandebriel, Roeland / Jayapala, Murali / Solie, Lien / de Vleeschouwer, Steven

2023

Abstract: Surgery for gliomas (intrinsic brain tumors), especially when low-grade, is challenging due to the infiltrative nature of the lesion. Currently, no real-time, intra-operative, label-free and wide-field tool is available to assist and guide the surgeon to ...

Abstract	Surgery for gliomas (intrinsic brain tumors), especially when low-grade, is challenging due to the infiltrative nature of the lesion. Currently, no real-time, intra-operative, label-free and wide-field tool is available to assist and guide the surgeon to find the relevant demarcations for these tumors. While marker-based methods exist for the high-grade glioma case, there is no convenient solution available for the low-grade case; thus, marker-free optical techniques represent an attractive option. Although RGB imaging is a standard tool in surgical microscopes, it does not contain sufficient information for tissue differentiation. We leverage the richer information from hyperspectral imaging (HSI), acquired with a snapscan camera in the 468-787 nm range, coupled to a surgical microscope, to build a deep-learning-based diagnostic tool for cancer resection with potential for intra-operative guidance. However, the main limitation of the HSI snapscan camera is the image acquisition time, limiting its widespread deployment in the operation theater. Here, we investigate the effect of HSI channel reduction and pre-selection to scope the design space for the development of cheaper and faster sensors. Neural networks are used to identify the most important spectral channels for tumor tissue differentiation, optimizing the trade-off between the number of channels and precision to enable real-time intra-surgical application. We evaluate the performance of our method on a clinical dataset that was acquired during surgery on five patients. By demonstrating the possibility to efficiently detect low-grade glioma, these results can lead to better cancer resection demarcations, potentially improving treatment effectiveness and patient outcome. Comment: SPIE Photonics West 2023 conference Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis. 18 pages, 11 figures
Keywords	Electrical Engineering and Systems Science - Image and Video Processing ; Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Machine Learning
Subject code	006
Publishing date	2023-02-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Matter bispectrum of large-scale structure with Gaussian and non-Gaussian initial conditions

Lazanu, Andrei / Giannantonio, Tommaso / Schmittfull, Marcel / Shellard, E. P. S.

Halo models, perturbation theory, and a three-shape model

2015

Abstract: We study the matter bispectrum of large-scale structure by comparing the predictions of different perturbative and phenomenological models with the full three-dimensional bispectrum from $N$-body simulations estimated using modal methods. We show that ... ...

Abstract	We study the matter bispectrum of large-scale structure by comparing the predictions of different perturbative and phenomenological models with the full three-dimensional bispectrum from $N$-body simulations estimated using modal methods. We show that among the perturbative approaches, effective field theory succeeds in extending the range of validity furthest on intermediate scales, at the cost of free additional parameters. By studying the halo model, we show that although it is satisfactory in the deeply non-linear regime, it predicts a deficit of power on intermediate scales, worsening at redshifts $z>0$. By comparison with the $N$-body bispectrum on those scales, we show that there is a significant squeezed component underestimated in the halo model. On the basis of these results, we propose a new three-shape model, based on the tree-level, squeezed and constant bispectrum shapes we identified in the halo model; after calibration this fits the simulations on all scales and redshifts of interest. We extend this model further to primordial non-Gaussianity of the local and equilateral types by showing that the same shapes can be used to describe the additional non-Gaussian component in the matter bispectrum. This method provides a HALOFIT-like prototype of the bispectrum that could be used to describe and test parameter dependencies and should be relevant for the bispectrum of weak gravitational lensing and wider applications. Comment: 8 pages, 7 figures; significant new results added and title modified; version published in Phys. Rev. D
Keywords	Astrophysics - Cosmology and Nongalactic Astrophysics
Subject code	612
Publishing date	2015-11-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Matter bispectrum of large-scale structure

Lazanu, Andrei / Giannantonio, Tommaso / Schmittfull, Marcel / Shellard, E. P. S.

Three-dimensional comparison between theoretical models and numerical simulations

2015

Abstract: We study the matter bispectrum of the large-scale structure by comparing different perturbative and phenomenological models with measurements from $N$-body simulations obtained with a modal bispectrum estimator. Using shape and amplitude correlators, we ... ...

Abstract	We study the matter bispectrum of the large-scale structure by comparing different perturbative and phenomenological models with measurements from $N$-body simulations obtained with a modal bispectrum estimator. Using shape and amplitude correlators, we directly compare simulated data with theoretical models over the full three-dimensional domain of the bispectrum, for different redshifts and scales. We review and investigate the main perturbative methods in the literature that predict the one-loop bispectrum: standard perturbation theory, effective field theory, resummed Lagrangian and renormalised perturbation theory, calculating the latter also at two loops for some triangle configurations. We find that effective field theory (EFT) succeeds in extending the range of validity furthest into the mildly nonlinear regime, albeit at the price of free extra parameters requiring calibration on simulations. For the more phenomenological halo model, we confirm that despite its validity in the deeply nonlinear regime it has a deficit of power on intermediate scales, which worsens at higher redshifts; this issue is ameliorated, but not solved, by combined halo-perturbative models. We show from simulations that in this transition region there is a strong squeezed bispectrum component that is significantly underestimated in the halo model at earlier redshifts. We thus propose a phenomenological method for alleviating this deficit, which we develop into a simple phenomenological "three-shape" benchmark model based on the three fundamental shapes we have obtained from studying the halo model. When calibrated on the simulations, this three-shape benchmark model accurately describes the bispectrum on all scales and redshifts considered, providing a prototype bispectrum HALOFIT-like methodology that could be used to describe and test parameter dependencies. Comment: 50 pages, 23 figures, published version
Keywords	Astrophysics - Cosmology and Nongalactic Astrophysics
Subject code	612
Publishing date	2015-10-14
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Detection of Cross-Correlation between Gravitational Lensing and γ Rays.

Ammazzalorso, S / Gruen, D / Regis, M / Camera, S / Ando, S / Fornengo, N / Bechtol, K / Bridle, S L / Choi, A / Eifler, T F / Gatti, M / MacCrann, N / Omori, Y / Samuroff, S / Sheldon, E / Troxel, M A / Zuntz, J / Carrasco Kind, M / Annis, J /

Avila, S / Bertin, E / Brooks, D / Burke, D L / Carnero Rosell, A / Carretero, J / Castander, F J / Costanzi, M / da Costa, L N / De Vicente, J / Desai, S / Diehl, H T / Dietrich, J P / Doel, P / Everett, S / Flaugher, B / Fosalba, P / García-Bellido, J / Gaztanaga, E / Gerdes, D W / Giannantonio, T / Goldstein, D A / Gruendl, R A / Gutierrez, G / Hollowood, D L / Honscheid, K / James, D J / Jarvis, M / Jeltema, T / Kent, S / Kuropatkin, N / Lahav, O / Li, T S / Lima, M / Maia, M A G / Marshall, J L / Melchior, P / Menanteau, F / Miquel, R / Ogando, R L C / Palmese, A / Plazas, A A / Romer, A K / Roodman, A / Rykoff, E S / Sánchez, C / Sanchez, E / Scarpine, V / Serrano, S / Sevilla-Noarbe, I / Smith, M / Soares-Santos, M / Sobreira, F / Suchyta, E / Swanson, M E C / Tarle, G / Thomas, D / Vikram, V / Zhang, Y

Physical review letters

2020 Volume 124, Issue 10, Page(s) 101102

Abstract: In recent years, many γ-ray sources have been identified, yet the unresolved component hosts valuable information on the faintest emission. In order to extract it, a cross-correlation with gravitational tracers of matter in the Universe has been shown to ...

Abstract	In recent years, many γ-ray sources have been identified, yet the unresolved component hosts valuable information on the faintest emission. In order to extract it, a cross-correlation with gravitational tracers of matter in the Universe has been shown to be a promising tool. We report here the first identification of a cross-correlation signal between γ rays and the distribution of mass in the Universe probed by weak gravitational lensing. We use data from the Dark Energy Survey Y1 weak lensing data and the Fermi Large Area Telescope 9-yr γ-ray data, obtaining a signal-to-noise ratio of 5.3. The signal is mostly localized at small angular scales and high γ-ray energies, with a hint of correlation at extended separation. Blazar emission is likely the origin of the small-scale effect. We investigate implications of the large-scale component in terms of astrophysical sources and particle dark matter emission.
Language	English
Publishing date	2020-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.124.101102
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Article ; Online: Dark Energy Survey Year 1 Results: Cosmological Constraints from Cluster Abundances, Weak Lensing, and Galaxy Correlations.

To, C / Krause, E / Rozo, E / Wu, H / Gruen, D / Wechsler, R H / Eifler, T F / Rykoff, E S / Costanzi, M / Becker, M R / Bernstein, G M / Blazek, J / Bocquet, S / Bridle, S L / Cawthon, R / Choi, A / Crocce, M / Davis, C / DeRose, J /

Drlica-Wagner, A / Elvin-Poole, J / Fang, X / Farahi, A / Friedrich, O / Gatti, M / Gaztanaga, E / Giannantonio, T / Hartley, W G / Hoyle, B / Jarvis, M / MacCrann, N / McClintock, T / Miranda, V / Pereira, M E S / Park, Y / Porredon, A / Prat, J / Rau, M M / Ross, A J / Samuroff, S / Sánchez, C / Sevilla-Noarbe, I / Sheldon, E / Troxel, M A / Varga, T N / Vielzeuf, P / Zhang, Y / Zuntz, J / Abbott, T M C / Aguena, M / Amon, A / Annis, J / Avila, S / Bertin, E / Bhargava, S / Brooks, D / Burke, D L / Carnero Rosell, A / Carrasco Kind, M / Carretero, J / Chang, C / Conselice, C / da Costa, L N / Davis, T M / Desai, S / Diehl, H T / Dietrich, J P / Everett, S / Evrard, A E / Ferrero, I / Flaugher, B / Fosalba, P / Frieman, J / García-Bellido, J / Gruendl, R A / Gutierrez, G / Hinton, S R / Hollowood, D L / Honscheid, K / Huterer, D / James, D J / Jeltema, T / Kron, R / Kuehn, K / Kuropatkin, N / Lima, M / Maia, M A G / Marshall, J L / Menanteau, F / Miquel, R / Morgan, R / Muir, J / Myles, J / Palmese, A / Paz-Chinchón, F / Plazas, A A / Romer, A K / Roodman, A / Sanchez, E / Santiago, B / Scarpine, V / Serrano, S / Smith, M / Suchyta, E / Swanson, M E C / Tarle, G / Thomas, D / Tucker, D L / Weller, J / Wester, W / Wilkinson, R D

Physical review letters

2021 Volume 126, Issue 14, Page(s) 141301

Abstract: We present the first joint analysis of cluster abundances and auto or cross-correlations of three cosmic tracer fields: galaxy density, weak gravitational lensing shear, and cluster density split by optical richness. From a joint analysis (4×2pt+N) of ... ...

Abstract	We present the first joint analysis of cluster abundances and auto or cross-correlations of three cosmic tracer fields: galaxy density, weak gravitational lensing shear, and cluster density split by optical richness. From a joint analysis (4×2pt+N) of cluster abundances, three cluster cross-correlations, and the auto correlations of the galaxy density measured from the first year data of the Dark Energy Survey, we obtain Ω_{m}=0.305_{-0.038}^{+0.055} and σ_{8}=0.783_{-0.054}^{+0.064}. This result is consistent with constraints from the DES-Y1 galaxy clustering and weak lensing two-point correlation functions for the flat νΛCDM model. Consequently, we combine cluster abundances and all two-point correlations from across all three cosmic tracer fields (6×2pt+N) and find improved constraints on cosmological parameters as well as on the cluster observable-mass scaling relation. This analysis is an important advance in both optical cluster cosmology and multiprobe analyses of upcoming wide imaging surveys.
Language	English
Publishing date	2021-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.126.141301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: DES Y1 results

Muir, J. / Baxter, E. / Miranda, V. / Doux, C. / Ferté, A. / Leonard, C. D. / Huterer, D. / Jain, B. / Lemos, P. / Raveri, M. / Nadathur, S. / Campos, A. / Chen, A. / Dodelson, S. / Elvin-Poole, J. / Lee, S. / Secco, L. F. / Troxel, M. A. / Weaverdyck, N. /

Zuntz, J. / Brout, D. / Choi, A. / Crocce, M. / Davis, T. M. / Gruen, D. / Krause, E. / Lidman, C. / MacCrann, N. / Möller, A. / Prat, J. / Ross, A. J. / Sako, M. / Samuroff, S. / Sáchez, C. / Scolnic, D. / Zhang, B. / Abbott, T. M. C. / Aguena, M. / Allam, S. / Annis, J. / Avila, S. / Bacon, D. / Bertin, E. / Bhargava, S. / Bridle, S. L. / Brooks, D. / Burke, D. L. / Rosell, A. Carnero / Kind, M. Carrasco / Carretero, J. / Cawthon, R. / Costanzi, M. / da Costa, L. N. / Pereira, M. E. S. / Desai, S. / Diehl, H. T. / Dietrich, J. P. / Doel, P. / Estrada, J. / Everett, S. / Evrard, A. E. / Ferrero, I. / Flaugher, B. / Frieman, J. / García-Bellido, J. / Giannantonio, T. / Gruendl, R. A. / Gschwend, J. / Gutierrez, G. / Hinton, S. R. / Hollowood, D. L. / Honscheid, K. / Hoyle, B. / James, D. J. / Jeltema, T. / Kuehn, K. / Kuropatkin, N. / Lahav, O. / Lima, M. / Maia, M. A. G. / Menanteau, F. / Miquel, R. / Morgan, R. / Myles, J. / Palmese, A. / Paz-Chinchón, F. / Plazas, A. A. / Romer, A. K. / Roodman, A. / Sanchez, E. / Scarpine, V. / Serrano, S. / Sevilla-Noarbe, I. / Smith, M. / Suchyta, E. / Swanson, M. E. C. / Tarle, G. / Thomas, D. / To, C. / Tucker, D. L. / Varga, T. N. / Weller, J. / Wilkinson, R. D.

Splitting growth and geometry to test $\Lambda$CDM

2020

Abstract: We analyze Dark Energy Survey (DES) data to constrain a cosmological model where a subset of parameters -- focusing on $\Omega_m$ -- are split into versions associated with structure growth (e.g. $\Omega_m^{\rm grow}$) and expansion history (e.g. $\ ... ...

Abstract	We analyze Dark Energy Survey (DES) data to constrain a cosmological model where a subset of parameters -- focusing on $\Omega_m$ -- are split into versions associated with structure growth (e.g. $\Omega_m^{\rm grow}$) and expansion history (e.g. $\Omega_m^{\rm geo}$). Once the parameters have been specified for the $\Lambda$CDM cosmological model, which includes general relativity as a theory of gravity, it uniquely predicts the evolution of both geometry (distances) and the growth of structure over cosmic time. Any inconsistency between measurements of geometry and growth could therefore indicate a breakdown of that model. Our growth-geometry split approach therefore serves as both a (largely) model-independent test for beyond-$\Lambda$CDM physics, and as a means to characterize how DES observables provide cosmological information. We analyze the same multi-probe DES data as arXiv:1811.02375 : DES Year 1 (Y1) galaxy clustering and weak lensing, which are sensitive to both growth and geometry, as well as Y1 BAO and Y3 supernovae, which probe geometry. We additionally include external geometric information from BOSS DR12 BAO and a compressed Planck 2015 likelihood, and external growth information from BOSS DR12 RSD. We find no significant disagreement with $\Omega_m^{\rm grow}=\Omega_m^{\rm geo}$. When DES and external data are analyzed separately, degeneracies with neutrino mass and intrinsic alignments limit our ability to measure $\Omega_m^{\rm grow}$, but combining DES with external data allows us to constrain both growth and geometric quantities. We also consider a parameterization where we split both $\Omega_m$ and $w$, but find that even our most constraining data combination is unable to separately constrain $\Omega_m^{\rm grow}$ and $w^{\rm grow}$. Relative to $\Lambda$CDM, splitting growth and geometry weakens bounds on $\sigma_8$ but does not alter constraints on $h$. Comment: 35 pages, 18 figures. Updated to match published version
Keywords	Astrophysics - Cosmology and Nongalactic Astrophysics
Subject code	612
Publishing date	2020-10-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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