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  1. Article ; Online: Bridging Science and Policy Toward a More Responsive Health Care System Beyond the COVID-19 Pandemic.

    Giannouchos, Theodoros V

    American journal of public health

    2022  Volume 112, Issue 2, Page(s) 197–198

    MeSH term(s) COVID-19 ; Delivery of Health Care ; Health Policy ; Humans ; Pandemics/prevention & control ; SARS-CoV-2
    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2021.306618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Association of the affordable care act with racial and ethnic disparities in uninsured emergency department utilization.

    Ukert, Benjamin / Giannouchos, Theodoros V

    BMC health services research

    2023  Volume 23, Issue 1, Page(s) 1302

    Abstract: Background: Disparities in uninsured emergency department (ED) use are well documented. However, a comprehensive analysis evaluating how the Affordable Care Act (ACA) may have reduced racial and ethnic disparities is lacking. The goal was to assess the ... ...

    Abstract Background: Disparities in uninsured emergency department (ED) use are well documented. However, a comprehensive analysis evaluating how the Affordable Care Act (ACA) may have reduced racial and ethnic disparities is lacking. The goal was to assess the association of the ACA with racial and ethnic disparities in uninsured ED use.
    Methods: This study used data from the Healthcare Cost and Utilization Project (HCUP) State Emergency Department Databases (SEDD) for Georgia, Florida, Massachusetts, and New York from 2011 to 2017. Participants include non-elderly adults between 18 and 64 years old. Outcomes include uninsured rates of ED visits by racial and ethnic groups and stratified by medical urgency using the New York University ED algorithm. Visits were aggregated to year-quarter ED visits per 100,000 population and stratified for non-Hispanic White, non-Hispanic Black, and Hispanic non-elderly adults. Quasi-experimental difference-in-differences and triple differences regression analyses to identify the effect of the ACA and the separate effect of the Medicaid expansion were used comparing uninsured ED visits by race and ethnicity groups pre-post ACA.
    Results: The ACA was associated with a 14% reduction in the rate of uninsured ED visits per 100,000 population (from 10,258 pre-ACA to 8,877 ED visits per 100,000 population post-ACA) overall. The non-Hispanic Black compared to non-Hispanic White disparity decreased by 12.4% (-275.1 ED visits per 100,000) post-ACA. About 60% of the decline in the Black-White disparity was attributed to disproportionate declines in ED visit rates for conditions classified as not-emergent (-93.2 ED visits per 100,000), and primary care treatable/preventable (-64.1 ED visits per 100,000), while the disparity in ED visit rates for injuries and not preventable conditions also declined (-106.57 ED visits per 100,000). All reductions in disparities were driven by the Medicaid expansion. No significant decrease in Hispanic-White disparity was observed.
    Conclusions: The ACA was associated with fewer uninsured ED visits and reduced the Black-White ED disparity, driven mostly by a reduction in less emergent ED visits after the ACA in Medicaid expansion states. Disparities between Hispanic and non-Hispanic White adults did not decline after the ACA. Despite the positive momentum of declining disparities in uninsured ED visits, disparities, especially among Black people, remain.
    MeSH term(s) Adult ; United States ; Humans ; Middle Aged ; Adolescent ; Young Adult ; Patient Protection and Affordable Care Act ; Medically Uninsured ; Medicaid ; Delivery of Health Care ; Emergency Service, Hospital ; Insurance Coverage ; Healthcare Disparities
    Language English
    Publishing date 2023-11-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-023-10168-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Concordance in Medical Urgency Classification of Discharge Diagnoses and Reasons for Visit.

    Giannouchos, Theodoros V / Ukert, Benjamin / Wright, Brad

    JAMA network open

    2024  Volume 7, Issue 1, Page(s) e2350522

    Abstract: Importance: Current policies to divert emergency department (ED) visits for less medically urgent conditions to more cost-effective settings rely on retrospective adjudication of discharge diagnoses. However, patients present to the ED with concerns, ... ...

    Abstract Importance: Current policies to divert emergency department (ED) visits for less medically urgent conditions to more cost-effective settings rely on retrospective adjudication of discharge diagnoses. However, patients present to the ED with concerns, making it challenging for clinicians.
    Objective: To characterize ED visits based on the medical urgency of the presenting reasons for visit and to explore the concordance between discharge diagnoses and reasons for visit.
    Design, setting, and participants: In this retrospective, cross-sectional study, a nationwide sample of ED visits by adults (aged ≥18 years) in the US from the 2018 and 2019 calendar years' ED data of the National Hospital Ambulatory Medical Care Survey was used. An algorithm to probabilistically assign ED visits into medical urgency categories based on the presenting reason for visit was developed. A 3-step, look-back method was applied using an updated version of the New York University ED algorithm, and a map of all possible discharge diagnoses to the same reasons for visit was developed. Analyses were conducted in July and August 2023.
    Main outcomes and measures: The main outcome was probabilistic medical urgency classification of reasons for visits and discharge diagnoses and their concordance.
    Results: We analyzed 27 068 ED visits (mean age, 48.2% years [95% CI, 47.5%-48.9% years]) representing 190.7 million visits nationwide. Women (mean, 57.0% [95% CI, 55.9%-58.1%]) and patients with public health insurance coverage, including Medicare (mean, 24.9% [95% CI, 21.9%-28.0%]) and Medicaid (mean, 25.1% [95% CI, 21.0%-29.2%]), accounted for the largest share of ED visits, and a mean of 13.2% (95% CI, 11.4%-15.0%) of all visits resulted in a hospital admission. Overall, about 38.5% and 53.9% of all ED visits were classified with 100% and 75% probabilities, respectively, as injury related, emergency care needed, emergent but primary care treatable, nonemergent, or mental health or substance use disorders related based on discharge diagnosis compared with 0.4% and 12.4%, respectively, of all encounters based on patients' reason for visit. Among discharge diagnoses assigned with high certainty to only 1 urgency category using the New York University ED algorithm, between 38.0% (95% CI, 36.3%-39.6%) and 57.4% (95% CI, 56.0%-58.8%) aligned with the probabilistic categorical assignments of their corresponding reasons for visit.
    Conclusions and relevance: In this cross-sectional study of 190.7 million ED visits among adults aged 18 years or older, a smaller percentage of reasons for visit could be prospectively categorized with high accuracy to a specific medical urgency category compared with all visits based on discharge diagnoses, and a limited concordance between reasons for visit and discharge diagnoses was found. Alternative methods are needed to identify the medical necessity of ED encounters more accurately.
    MeSH term(s) United States ; Adult ; Humans ; Aged ; Female ; Adolescent ; Middle Aged ; Cross-Sectional Studies ; Medicare ; Patient Discharge ; Retrospective Studies ; Emergency Medical Services
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.50522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Waning effectiveness of mRNA COVID-19 vaccines against inpatient and emergency department encounters.

    Giannouchos, Theodoros V / Hair, Nicole L / Olatosi, Bankole / Li, Xiaoming

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0300198

    Abstract: In the United States, most real-world estimates of COVID-19 vaccine effectiveness are based on data drawn from large health systems or sentinel populations. More data is needed to understand how the benefits of vaccination may vary across US populations ... ...

    Abstract In the United States, most real-world estimates of COVID-19 vaccine effectiveness are based on data drawn from large health systems or sentinel populations. More data is needed to understand how the benefits of vaccination may vary across US populations with disparate risk profiles and policy contexts. We aimed to provide estimates of mRNA COVID-19 vaccine effectiveness against moderate and severe outcomes of COVID-19 based on state population-level data sources. Using statewide integrated administrative and clinical data and a test-negative case-control study design, we assessed mRNA COVID-19 vaccine effectiveness against SARS-CoV-2-related hospitalizations and emergency department visits among adults in South Carolina. We presented estimates of vaccine effectiveness at discrete time intervals for adults who received one, two or three doses of mRNA COVID-19 vaccine compared to adults who were unvaccinated. We also evaluated changes in vaccine effectiveness over time (waning) for the overall sample and in subgroups defined by age. We showed that while two doses of mRNA COVID-19 vaccine were initially highly effective, vaccine effectiveness waned as time elapsed since the second dose. Compared to protection against hospitalizations, protection against emergency department visits was found to wane more sharply. In all cases, a third dose of mRNA COVID-19 vaccine conferred significant gains in protection relative to waning protection after two doses. Further, over more than 120 days of follow-up, the data revealed relatively limited waning of vaccine effectiveness after a third dose of mRNA COVID-19 vaccine.
    MeSH term(s) Adult ; Humans ; Inpatients ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Case-Control Studies ; SARS-CoV-2/genetics ; Emergency Service, Hospital ; RNA, Messenger
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0300198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Child and Adolescent Anxiety and Depression Prior to and During the COVID-19 Pandemic in the United States.

    Figas, Kristen / Giannouchos, Theodoros V / Crouch, Elizabeth

    Child psychiatry and human development

    2023  

    Abstract: Childhood anxiety and depression have been increasing for years, and evidence suggests the COVID-19 pandemic has exacerbated this trend. However, research has examined anxiety and depression primarily as exclusive conditions, overlooking comorbidity. ... ...

    Abstract Childhood anxiety and depression have been increasing for years, and evidence suggests the COVID-19 pandemic has exacerbated this trend. However, research has examined anxiety and depression primarily as exclusive conditions, overlooking comorbidity. This study examined relationships between the COVID-19 pandemic and anxiety and depression to clarify risk factors for singular and comorbid anxiety and depression in children. Using 2018-2019 and 2020-2021 samples from the National Survey of Children's Health, a nationally representative survey of children aged 0-17 in the United States, associations between the COVID-19 pandemic and child anxiety and depression were examined via survey-weights' adjusted bivariate and multiple regression analyses, controlling for demographic characteristics. The COVID-19 pandemic was associated with higher odds of having comorbid anxiety and depression but not singular anxiety or depression. Female sex, older age, having special healthcare needs, more frequent inability to cover basic needs on family income, and poorer caregiver mental health were associated with having been diagnosed with singular and comorbid anxiety and depression. Children that witnessed or were victims of violence in the neighborhood were also more likely to have comorbid anxiety and depression. Implications for prevention, intervention, and policy are discussed.
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 223895-0
    ISSN 1573-3327 ; 0009-398X
    ISSN (online) 1573-3327
    ISSN 0009-398X
    DOI 10.1007/s10578-023-01536-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction: Association of Medicaid expansion with dental emergency department visits overall and by states' Medicaid dental benefits provision.

    Giannouchos, Theodoros V / Reynolds, Julie / Damiano, Peter / Wright, Brad

    BMC health services research

    2023  Volume 23, Issue 1, Page(s) 694

    Language English
    Publishing date 2023-06-27
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-023-09709-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Suicide and non-fatal self-injury-related emergency department visits among individuals with autism spectrum disorder.

    Giannouchos, Theodoros V / Beverly, Judith / Christodoulou, Ilias / Callaghan, Timothy

    Autism : the international journal of research and practice

    2023  Volume 27, Issue 7, Page(s) 1983–1996

    Abstract: Lay abstract: This study used data for 14.4 million individuals with 43.5 million emergency department visits from all hospitals in the state of New York to explore the association between suicide and non-fatal self-injury-related (self-injury) ... ...

    Abstract Lay abstract: This study used data for 14.4 million individuals with 43.5 million emergency department visits from all hospitals in the state of New York to explore the association between suicide and non-fatal self-injury-related (self-injury) emergency department visits and autism spectrum disorder. Overall, we found that individuals with autism spectrum disorder had more emergency department visits and admissions through the emergency department, more years of emergency department utilization, and higher prevalence of mental health-related comorbidities. Individuals with autism spectrum disorder were also significantly more likely to have at least one self-injury-related emergency department visit compared to those without autism spectrum disorder. These results emphasize the need to raise awareness across both family caregivers and healthcare providers on the increased suicide and self-injury risks that individuals with autism spectrum disorder face and to improve care delivery practices. In addition, effort to promote and increase timely access to mental health care is an urgent priority for individuals with autism spectrum disorder.
    MeSH term(s) Humans ; Autism Spectrum Disorder/epidemiology ; Self-Injurious Behavior/epidemiology ; Suicide ; Hospitalization ; Emergency Service, Hospital
    Language English
    Publishing date 2023-01-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1338513-6
    ISSN 1461-7005 ; 1362-3613
    ISSN (online) 1461-7005
    ISSN 1362-3613
    DOI 10.1177/13623613221150089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Association of Medicaid expansion with dental emergency department visits overall and by states' Medicaid dental benefits provision.

    Giannouchos, Theodoros V / Reynolds, Julie / Damiano, Peter / Wright, Brad

    BMC health services research

    2023  Volume 23, Issue 1, Page(s) 625

    Abstract: Background: Evidence on the association of Medicaid expansion with dental emergency department (ED) utilization is limited, while even less is known on policy-related changes in dental ED visits by Medicaid programs' dental benefits generosity. The ... ...

    Abstract Background: Evidence on the association of Medicaid expansion with dental emergency department (ED) utilization is limited, while even less is known on policy-related changes in dental ED visits by Medicaid programs' dental benefits generosity. The objective of this study was to estimate the association of Medicaid expansion with changes in dental ED visits overall and by states' benefits generosity.
    Methods: We used the Healthcare Cost and Utilization Project's Fast Stats Database from 2010 to 2015 for non-elderly adults (19 to 64 years of age) across 23 States, 11 of which expanded Medicaid in January 2014 while 12 did not. Difference-in-differences regression models were used to estimate changes in dental-related ED visits overall and further stratified by states' dental benefit coverage in Medicaid between expansion and non-expansion States.
    Results: After 2014, dental ED visits declined by 10.9 [95% confidence intervals (CI): -18.5 to -3.4] visits per 100,000 population quarterly in states that expanded Medicaid compared to non-expansion states. However, the overall decline was concentrated in Medicaid expansion states with dental benefits. In particular, among expansion states, dental ED visits per 100,000 population declined by 11.4 visits (95% CI: -17.9 to -4.9) quarterly in states with dental benefits in Medicaid compared to states with emergency-only or no dental benefits. Significant differences between non-expansion states by Medicaid's dental benefits generosity were not observed [6.3 visits (95% CI: -22.3 to 34.9)].
    Conclusions: Our findings suggest the need to strengthen public health insurance programs with more generous dental benefits to curtail costly dental ED visits.
    MeSH term(s) Adult ; United States ; Humans ; Middle Aged ; Medicaid ; Insurance, Health ; Databases, Factual ; Emergency Service, Hospital ; Health Care Costs
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-023-09488-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Association of Medicaid Expansion With Emergency Department Visits by Medical Urgency.

    Giannouchos, Theodoros V / Ukert, Benjamin / Andrews, Christina

    JAMA network open

    2022  Volume 5, Issue 6, Page(s) e2216913

    Abstract: Importance: Relatively little is known about the association of the Medicaid eligibility expansion under the Patient Protection and Affordable Care Act with emergency department (ED) visits categorized by medical urgency.: Objective: To estimate the ... ...

    Abstract Importance: Relatively little is known about the association of the Medicaid eligibility expansion under the Patient Protection and Affordable Care Act with emergency department (ED) visits categorized by medical urgency.
    Objective: To estimate the association between state Medicaid expansions and ED visits by the urgency of presenting conditions.
    Design, setting, and participants: This cross-sectional study used the Healthcare Cost and Utilization Project State Emergency Department Databases from January 2011 to December 2017 for 2 states that expanded Medicaid in 2014 (New York and Massachusetts) and 2 states that did not (Florida and Georgia). Difference-in-differences regression models were used to estimate the changes in ED visits overall and further stratified by the urgency of the conditions using an updated version of the New York University ED algorithm between the states that expanded Medicaid and those that did not, before and after the expansion. Data were analyzed between June 7 and December 12, 2021.
    Exposure: State-level Medicaid eligibility expansion.
    Main outcomes and measures: Emergency department visits per 1000 population overall and stratified by medical urgency of the conditions.
    Results: In total, 80.6 million ED visits by 26.0 million individuals were analyzed. Emergency department visits were concentrated among women (59.3%), non-Hispanic Black individuals (28.3%), non-Hispanic White individuals (47.8%), and those aged 18 to 34 years (47.5%) and 35 to 44 years (20.4%). The rates of ED visits increased by a mean of 2.4 visits in nonexpansion states and decreased by a mean of 2.2 visits in expansion states after 2014, resulting in a significant regression-adjusted decrease of 4.7 visits per 1000 population (95% CI, -7.7 to -1.5; P = .003) in expansion states. Most of this decrease was associated with decreases in ED visits by conditions classified as not emergent (-1.5 visits; 95% CI, -2.4 to -0.7; P < .001), primary care treatable (-1.1 visits; 95% CI, -1.6 to -0.5; P < .001), and potentially preventable (-0.3 visits; 95% CI, -0.5 to -0.1; P = .02). No significant changes were observed for ED visits related to injuries and conditions classified as not preventable (-1.4; 95% CI, -3.1 to 0.3; P = .10), as well as for substance use and mental health disorders (0.0; 95% CI, -0.2 to 0.2; P = .94).
    Conclusions and relevance: The findings of this study suggest that Medicaid expansion was associated with decreases in ED visits, for which decreases in ED visits for less medically emergent ED conditions may have been a factor.
    MeSH term(s) Cross-Sectional Studies ; Eligibility Determination ; Emergency Service, Hospital ; Female ; Humans ; Medicaid ; Patient Protection and Affordable Care Act ; United States/epidemiology
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.16913
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  10. Article ; Online: Risk of tizanidine-induced adverse events after concomitant exposure to ciprofloxacin: A cohort study in the U.S.

    Giannouchos, Theodoros V / Gómez-Lumbreras, Ainhoa / Malone, Daniel C

    The American journal of emergency medicine

    2022  Volume 55, Page(s) 147–151

    Abstract: Background: Tizanidine's potent muscle relaxant properties and short onset of action makes it desirable for pain management. However, concomitant use of tizanidine with ciprofloxacin, a strong inhibitor of the P450-CYP1A2 cytochrome metabolic pathway of ...

    Abstract Background: Tizanidine's potent muscle relaxant properties and short onset of action makes it desirable for pain management. However, concomitant use of tizanidine with ciprofloxacin, a strong inhibitor of the P450-CYP1A2 cytochrome metabolic pathway of tizanidine, can result in increased tizanidine plasma levels and associated adverse outcomes, particularly hypotension. The aim of this study was to assess the risk of hypotension with coadministration of tizanidine and ciprofloxacin.
    Methods: An observational nested cohort study of patients 18 years or older on tizanidine was conducted using data from electronic health records from 2000 to 2018 in the US. We estimated the prevalence and risk of hypotension associated with the DDI between tizanidine and ciprofloxacin using multivariable logistic regression models.
    Results: Our analysis included 70,110 encounters of patients on tizanidine across 221 hospitals. Most encounters included females (65.7%), whites (82.4%), with an average age of 56 years (SD 14.9) and an Elixhauser comorbidity index mean of 1.6 (SD 2.3). Ciprofloxacin was co-administered with tizanidine in 2487 encounters (3.6%). Compared to patients who did not receive ciprofloxacin, co-administration of tizanidine and ciprofloxacin was associated with an increased likelihood of hypotension (adjusted odds ratio: 1.43, 95% Confidence Intervals:1.25-1.63, p-value<0.001).
    Conclusions: Our findings suggest that the concomitant use of tizanidine and ciprofloxacin is associated with an elevated risk of hypotension. The prevalence of co-administration of drugs with a documented interaction highlights the need for continuous education across providers to avoid the incidence of DDI related adverse events and further complications and to improve patient outcomes.
    MeSH term(s) Ciprofloxacin/adverse effects ; Clonidine/adverse effects ; Clonidine/analogs & derivatives ; Cohort Studies ; Drug Interactions ; Female ; Humans ; Hypotension/chemically induced ; Hypotension/epidemiology ; Middle Aged
    Chemical Substances Ciprofloxacin (5E8K9I0O4U) ; tizanidine (6AI06C00GW) ; Clonidine (MN3L5RMN02)
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2022.03.008
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