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  1. Article ; Online: The Role of Aquaporins in Epileptogenesis-A Systematic Review.

    Bonosi, Lapo / Benigno, Umberto Emanuele / Musso, Sofia / Giardina, Kevin / Gerardi, Rosa Maria / Brunasso, Lara / Costanzo, Roberta / Paolini, Federica / Buscemi, Felice / Avallone, Chiara / Gulino, Vincenzo / Iacopino, Domenico Gerardo / Maugeri, Rosario

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Aquaporins (AQPs) are a family of membrane proteins involved in the transport of water and ions across cell membranes. AQPs have been shown to be implicated in various physiological and pathological processes in the brain, including water homeostasis, ... ...

    Abstract Aquaporins (AQPs) are a family of membrane proteins involved in the transport of water and ions across cell membranes. AQPs have been shown to be implicated in various physiological and pathological processes in the brain, including water homeostasis, cell migration, and inflammation, among others. Epileptogenesis is a complex and multifactorial process that involves alterations in the structure and function of neuronal networks. Recent evidence suggests that AQPs may also play a role in the pathogenesis of epilepsy. In animal models of epilepsy, AQPs have been shown to be upregulated in regions of the brain that are involved in seizure generation, suggesting that they may contribute to the hyperexcitability of neuronal networks. Moreover, genetic studies have identified mutations in AQP genes associated with an increased risk of developing epilepsy. Our review aims to investigate the role of AQPs in epilepsy and seizure onset from a pathophysiological point of view, pointing out the potential molecular mechanism and their clinical implications.
    MeSH term(s) Animals ; Aquaporins/metabolism ; Water/metabolism ; Homeostasis ; Brain/metabolism ; Seizures
    Chemical Substances Aquaporins ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-07-25
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241511923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sonodynamic therapy and magnetic resonance-guided focused ultrasound: new therapeutic strategy in glioblastoma.

    Bonosi, Lapo / Marino, Silvia / Benigno, Umberto Emanuele / Musso, Sofia / Buscemi, Felice / Giardina, Kevin / Gerardi, Rosamaria / Brunasso, Lara / Costanzo, Roberta / Iacopino, Domenico Gerardo / Maugeri, Rosario

    Journal of neuro-oncology

    2023  Volume 163, Issue 1, Page(s) 219–238

    Abstract: Glioblastoma (GB) is one of the most aggressive and difficult-to-treat brain tumors, with a poor prognosis and limited treatment options. In recent years, sonodynamic therapy (SDT) and magnetic resonance focused ultrasound (MRgFUS) have emerged as ... ...

    Abstract Glioblastoma (GB) is one of the most aggressive and difficult-to-treat brain tumors, with a poor prognosis and limited treatment options. In recent years, sonodynamic therapy (SDT) and magnetic resonance focused ultrasound (MRgFUS) have emerged as promising approaches for the treatment of GB. SDT uses ultrasound waves in combination with a sonosensitizer to selectively damage cancer cells, while MRgFUS delivers high-intensity ultrasound waves to precisely target tumor tissue and disrupt the blood-brain barrier to enhance drug delivery. In this review, we explore the potential of SDT as a novel therapeutic strategy for GB. We discuss the principles of SDT, its mechanisms of action, and the preclinical and clinical studies that have investigated its use in Gliomas. We also highlight the challenges, the limitations, and the future perspectives of SDT. Overall, SDT and MRgFUS hold promise as novel and potentially complementary treatment modalities for GB. Further research is needed to optimize their parameters and determine their safety and efficacy in humans, but their potential for selective and targeted tumor destruction makes them an exciting area of investigation in the field of brain cancer therapy.
    MeSH term(s) Humans ; Glioblastoma/diagnostic imaging ; Glioblastoma/therapy ; Glioma/pathology ; Brain Neoplasms/therapy ; Brain Neoplasms/drug therapy ; Brain/pathology ; Magnetic Resonance Spectroscopy ; Cell Line, Tumor
    Language English
    Publishing date 2023-05-14
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-023-04333-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1825: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Role of Mediterranean diet in the development and recurrence of meningiomas: a narrative review.

    Costanzo, Roberta / Simonetta, Irene / Musso, Sofia / Benigno, Umberto Emanuele / Cusimano, Luigi Maria / Giovannini, Evier Andrea / Giardina, Kevin / Abrignani, Vincenzo / Baglio, Irene / Albanese, Alessio / Iacopino, Domenico Gerardo / Maugeri, Rosario / Tuttolomondo, Antonino

    Neurosurgical review

    2023  Volume 46, Issue 1, Page(s) 255

    Abstract: Several studies through the years have proven how an unhealthy nutrition, physical inactivity, sedentary lifestyle, obesity, and smoking represent relevant risk factors in cancer genesis. This study aims to provide an overview about the relationship ... ...

    Abstract Several studies through the years have proven how an unhealthy nutrition, physical inactivity, sedentary lifestyle, obesity, and smoking represent relevant risk factors in cancer genesis. This study aims to provide an overview about the relationship between meningiomas and food assumption in the Mediterranean diet and whether it can be useful in meningioma prevention or it, somehow, can prevent their recurrence. The authors performed a wide literature search in PubMed and Scopus databases investigating the presence of a correlation between Mediterranean diet and meningiomas. The following MeSH and free text terms were used: "Meningiomas" AND "Diet" and "Brain tumors" AND "diet." Databases' search yielded a total of 749 articles. After duplicate removal, an abstract screening according to the eligibility criteria has been performed and 40 articles were selected. Thirty-one articles were excluded because they do not meet the inclusion criteria. Finally, a total of 9 articles were included in this review. It is widely established the key and protective role that a healthy lifestyle and a balanced diet can have against tumorigenesis. Nevertheless, studies focusing exclusively on the Mediterranean diet are still lacking. Thus, multicentric and/or prospective, randomized studies are mandatory to better assess and determine the impact of food assumptions in meningioma involvement.
    MeSH term(s) Humans ; Diet, Mediterranean ; Meningioma/prevention & control ; Prospective Studies ; Brain Neoplasms ; Meningeal Neoplasms/prevention & control
    Language English
    Publishing date 2023-09-22
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 6907-3
    ISSN 1437-2320 ; 0344-5607
    ISSN (online) 1437-2320
    ISSN 0344-5607
    DOI 10.1007/s10143-023-02128-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1445: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The role of neuronal plasticity in cervical spondylotic myelopathy surgery: functional assessment and prognostic implication.

    Bonosi, Lapo / Musso, Sofia / Cusimano, Luigi Maria / Porzio, Massimiliano / Giovannini, Evier Andrea / Benigno, Umberto Emanuele / Giammalva, Giuseppe Roberto / Gerardi, Rosa Maria / Brunasso, Lara / Costanzo, Roberta / Paolini, Federica / Sciortino, Andrea / Campisi, Benedetta Maria / Giardina, Kevin / Scalia, Gianluca / Iacopino, Domenico Gerardo / Maugeri, Rosario

    Neurosurgical review

    2023  Volume 46, Issue 1, Page(s) 149

    Abstract: Cervical spondylotic myelopathy (CSM) is a degenerative disease representing the most common spinal cord disorder in the adult population. It is characterized by chronic compression leading to neurological dysfunction due to static and dynamic injury of ... ...

    Abstract Cervical spondylotic myelopathy (CSM) is a degenerative disease representing the most common spinal cord disorder in the adult population. It is characterized by chronic compression leading to neurological dysfunction due to static and dynamic injury of the spinal cord in cervical spine. These insidious damage mechanisms can result in the reorganization of cortical and subcortical areas. The cerebral cortex can reorganize due to spinal cord injury and may play a role in preserving neurological function. To date, the gold standard treatment of cervical myelopathy is surgery, comprising anterior, posterior, and combined approaches. However, the complex physiologic recovery processes involving cortical and subcortical neural reorganization following surgery are still inadequately understood. It has been demonstrated that diffusion MRI and functional imaging and techniques, such as transcranial magnetic stimulation (TMS) or functional magnetic resonance imaging (fMRI), can provide new insights into the diagnosis and prognosis of CSM. This review aims to shed light on the state-of-the-art regarding the pattern of cortical and subcortical areas reorganization and recovery before and after surgery in CSM patients, underlighting the critical role of neuroplasticity.
    MeSH term(s) Adult ; Humans ; Prognosis ; Spinal Cord Diseases/surgery ; Spinal Cord Injuries/pathology ; Magnetic Resonance Imaging ; Neuronal Plasticity ; Cervical Vertebrae/surgery ; Cervical Vertebrae/pathology ; Spinal Osteophytosis/diagnosis ; Spinal Osteophytosis/pathology ; Spondylosis/surgery ; Spondylosis/pathology
    Language English
    Publishing date 2023-06-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 6907-3
    ISSN 1437-2320 ; 0344-5607
    ISSN (online) 1437-2320
    ISSN 0344-5607
    DOI 10.1007/s10143-023-02062-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1445: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Relationship Between Mediterranean Diet, Cardiovascular Risk Factors, and Meningiomas: A Retrospective Study.

    Costanzo, Roberta / Maugeri, Rosario / Simonetta, Irene / Musso, Sofia / Benigno, Umberto Emanuele / Abrignani, Vincenzo / Baglio, Irene / Cusimano, Luigi Maria / Giardina, Kevin / Sciortino, Andrea / Cipollina, Giuseppe / Bonosi, Lapo / Brunasso, Lara / Umana, Giuseppe Emmanuele / DI Bonaventura, Rina / Sturiale, Carmelo Lucio / Iacopino, Domenico Gerardo / Albanese, Alessio / Tuttolomondo, Antonino

    Anticancer research

    2023  Volume 43, Issue 12, Page(s) 5499–5508

    Abstract: Background/aim: The Mediterranean diet may be deemed as the best combination of nutrients to play a protective role against cancer. Previous studies have demonstrated how a healthy lifestyle, and the adherence to the Mediterranean diet might affect the ... ...

    Abstract Background/aim: The Mediterranean diet may be deemed as the best combination of nutrients to play a protective role against cancer. Previous studies have demonstrated how a healthy lifestyle, and the adherence to the Mediterranean diet might affect the onset of most common cancers, focusing less on their relationship with central nervous system (CNS) tumoral pathologies, especially benign ones, such as meningiomas.
    Patients and methods: This was a retrospective multicenter study, involving 52 patients who underwent meningioma resection and a group of 100 subjects not affected by brain tumors. This preliminary study aimed to investigate whether the non-adherence to a dietary pattern, such as the Mediterranean diet, and pre-existing cardiovascular risk factors can affect the onset of cranial meningiomas.
    Results: Patients affected by meningioma had a significantly lower mean Mediterranean Diet Score (MDS), and a similar distribution of the main cardiovascular risk factors.
    Conclusion: A larger patient cohort is required to corroborate our findings. However, these promising results open up a new avenue for further exploration of the role of the Mediterranean diet in the development of meningiomas.
    MeSH term(s) Humans ; Diet, Mediterranean ; Retrospective Studies ; Meningioma/prevention & control ; Risk Factors ; Cardiovascular Diseases/prevention & control ; Heart Disease Risk Factors ; Meningeal Neoplasms/epidemiology
    Language English
    Publishing date 2023-11-29
    Publishing country Greece
    Document type Multicenter Study ; Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Intraoperative Evaluation of Brain-Tumor Microvascularization through MicroV IOUS: A Protocol for Image Acquisition and Analysis of Radiomic Features.

    Giammalva, Giuseppe Roberto / Viola, Anna / Maugeri, Rosario / Giardina, Kevin / Di Bonaventura, Rina / Musso, Sofia / Brunasso, Lara / Cepeda, Santiago / Della Pepa, Giuseppe Maria / Scerrati, Alba / Mantovani, Giorgio / Ferini, Gianluca / Gerardi, Rosa Maria / Pino, Maria Angela / Umana, Giuseppe Emmanuele / Denaro, Luca / Albanese, Alessio / Iacopino, Domenico Gerardo

    Cancers

    2022  Volume 14, Issue 21

    Abstract: Microvascular Doppler (MicroV) is a new-generation Doppler technique developed by Esaote (Esaote s.p.a., Genova, Italy), which is able to visualize small and low-flow vessels through a suppression of interfering signals. MicroV uses advanced filters that ...

    Abstract Microvascular Doppler (MicroV) is a new-generation Doppler technique developed by Esaote (Esaote s.p.a., Genova, Italy), which is able to visualize small and low-flow vessels through a suppression of interfering signals. MicroV uses advanced filters that are able to differentiate tissue artifacts from low-speed blood flows; by exploiting the space-time coherence information, these filters can selectively suppress tissue components, preserving the signal coming from the microvascular flow. This technique is clinically applied to the study of the vascularization of parenchymatous lesions, often with better diagnostic accuracy than color/power Doppler techniques. The aim of this paper is to develop a reproducible protocol for the recording and collection of MicroV intraoperative ultrasound images by the use of a capable intraoperative ultrasound machine and post-processing aimed at evaluation of brain-tumor microvascularization through the analysis of radiomic features. The proposed protocol has been internally validated on eight patients and will be firstly applied to patients affected by WHO grade IV astrocytoma (glioblastoma-GBM) candidates for craniotomy and lesion removal. In a further stage, it will be generally applied to patients with primary or metastatic brain tumors. IOUS is performed before durotomy. Tumor microvascularization is evaluated using the MicroV Doppler technique and IOUS images are recorded, stored, and post-processed. IOUS images are remotely stored on the BraTIoUS database, which will promote international cooperation and multicentric analysis. Processed images and texture radiomic features are analyzed post-operatively using ImageJ, a free scientific image-analysis software based on the Sun-Java platform. Post-processing protocol is further described in-depth. The study of tumor microvascularization through advanced IOUS techniques such as MicroV could represent, in the future, a non-invasive and real-time method for intraoperative predictive evaluation of the tumor features. This evaluation could finally result in a deeper knowledge of brain-tumor behavior and in the on-going adaptation of the surgery with the improvement of surgical outcomes.
    Language English
    Publishing date 2022-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14215335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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