Article: The effect of spontaneous versus controlled ventilation on the rate of rise of alveolar halothane concentration in dogs.
1977 Volume 56, Issue 1, Page(s) 32–34
Abstract: The rate of rise of the alveolar:inspired halothane concentration (F delta/F1) ratio was measured in dogs breathing spontaneously. These rates were measured at inspired concentrations of 0.3, 1.5, and 4 percent. Initially, FON (FA/F1) ratio was measured ... ...
| Abstract | The rate of rise of the alveolar:inspired halothane concentration (F delta/F1) ratio was measured in dogs breathing spontaneously. These rates were measured at inspired concentrations of 0.3, 1.5, and 4 percent. Initially, FON (FA/F1) ratio was measured in dogs breathing spontaneously. These rates were measured at inspired concentrations of 0.3, 1.5, and 4 percent. Initially FA/F1 rose at similar rates for all 3 concentrations, but a 4 percent, the plateau attained was lower as a result of respiratory depression. In a 2nd group of dogs, FA/FI was measured for inspired concentrations of 0.3, 1.5, 4, and 6 percent during controlled ventilation. FA/FI rose at similar rates at the lower 2 concentrations but at progressively more rapid rates at inspired concentrations of 4 and 6 percent, presumably as a result of circulatory depression. |
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| MeSH term(s) | Animals ; Dogs ; Dose-Response Relationship, Drug ; Halothane/administration & dosage ; Halothane/metabolism ; Pulmonary Alveoli/metabolism ; Respiration ; Respiration, Artificial ; Time Factors |
| Chemical Substances | Halothane (UQT9G45D1P) |
| Language | English |
| Publishing date | 1977-01 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 80032-6 |
| ISSN | 1526-7598 ; 0003-2999 |
| ISSN (online) | 1526-7598 |
| ISSN | 0003-2999 |
| DOI | 10.1213/00000539-197701000-00010 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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