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Article ; Online: Dissipation Function: Nonequilibrium Physics and Dynamical Systems.

Caruso, Salvatore / Giberti, Claudio / Rondoni, Lamberto

2020 Volume 22, Issue 8

Abstract: An exact response theory has recently been developed within the field of Nonequilibrium Molecular Dynamics. Its main ingredient is known as the Dissipation Function, Ω. This quantity determines nonequilbrium properties like thermodynamic potentials do ... ...

Abstract	An exact response theory has recently been developed within the field of Nonequilibrium Molecular Dynamics. Its main ingredient is known as the Dissipation Function, Ω. This quantity determines nonequilbrium properties like thermodynamic potentials do with equilibrium states. In particular, Ω can be used to determine the exact response of particle systems obeying classical mechanical laws, subjected to perturbations of arbitrary size. Under certain conditions, it can also be used to express the response of a single system, in contrast to the standard response theory, which concerns ensembles of identical systems. The dimensions of Ω are those of a rate, hence Ω can be associated with the entropy production rate, provided local thermodynamic equilibrium holds. When this is not the case for a particle system, or generic dynamical systems are considered, Ω can equally be defined, and it yields formal, thermodynamic-like, relations. While such relations may have no physical content, they may still constitute interesting characterizations of the relevant dynamics. Moreover, such a formal approach turns physically relevant, because it allows a deeper analysis of Ω and of response theory than possible in case of fully fledged physical models. Here, we investigate the relation between linear and exact response, pointing out conditions for the validity of the response theory, as well as difficulties and opportunities for the physical interpretation of certain formal results.
Language	English
Publishing date	2020-07-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e22080835
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Article ; Online: Annealed inhomogeneities in random ferromagnets.

Can, Van Hao / Giardinà, Cristian / Giberti, Claudio / van der Hofstad, Remco

Physical review. E

2022 Volume 105, Issue 2-1, Page(s) 24128

Abstract: We consider spin models on complex networks frequently used to model social and technological systems. We study the annealed ferromagnetic Ising model for random networks with either independent edges (Erdős-Rényi) or prescribed degree distributions ( ... ...

Abstract	We consider spin models on complex networks frequently used to model social and technological systems. We study the annealed ferromagnetic Ising model for random networks with either independent edges (Erdős-Rényi) or prescribed degree distributions (configuration model). Contrary to many physical models, the annealed setting is poorly understood and behaves quite differently than the quenched system. In annealed networks with a fluctuating number of edges, the Ising model changes the degree distribution, an aspect previously ignored. For random networks with Poissonian degrees, this gives rise to three distinct annealed critical temperatures depending on the precise model choice, only one of which reproduces the quenched one. In particular, two of these annealed critical temperatures are finite even when the quenched one is infinite because then the annealed graph creates a giant component for all sufficiently small temperatures. We see that the critical exponents in the configuration model with deterministic degrees are the same as the quenched ones, which are the mean-field exponents if the degree distribution has finite fourth moment and power-law-dependent critical exponents otherwise. Remarkably, the annealing for the configuration model with random independent and identically distributed degrees washes away the universality class with power-law critical exponents.
Language	English
Publishing date	2022-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.105.024128
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Article: Combined Effects of Age and Comorbidities on Electrocardiographic Parameters in a Large Non-Selected Population.

Giovanardi, Paolo / Vernia, Cecilia / Tincani, Enrico / Giberti, Claudio / Silipo, Federico / Fabbo, Andrea

Journal of clinical medicine

2022 Volume 11, Issue 13

Abstract: Background: Previous studies have evaluated average electrocardiographic (ECG) values in healthy subjects or specific subpopulations. However, none have evaluated ECG average values in not selected populations, so we examined ECG changes with respect to ... ...

Abstract	Background: Previous studies have evaluated average electrocardiographic (ECG) values in healthy subjects or specific subpopulations. However, none have evaluated ECG average values in not selected populations, so we examined ECG changes with respect to age and sex in a large primary population. Methods: From digitized ECG stored from 2008 to 2021 in the Modena province, 130,471 patients were enrolled. Heart rate, P, QRS and T wave axis, P, QRS and T wave duration, PR interval, QTc, and frontal QRS-T angle were evaluated. Results: All ECG parameters showed a dependence on age, but only some of them with a straight-line correlation: QRS axis (p < 0.001, R2 = 0.991, r = 0.996), PR interval (p < 0.001, R2 = 0.978, r = 0.989), QTc (p < 0.001, R2 = 0.935, r = 0.967), and, in over 51.5 years old, QRS-T angle (p < 0.001, R2 = 0.979, r = 0.956). Differences between females and males and in different clinical settings were observed. Conclusions: ECG changes with ageing are explainable by intrinsic modifications of the heart and thorax and with the appearance of cardiovascular diseases and comorbidities. Age-related reference values were computed and applicable in clinical practice. Significant deviations from mean values and from Z-scores should be investigated.
Language	English
Publishing date	2022-06-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11133737
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Article ; Online: Editorial comment on: The artificial urinary sphincter in patients with spinal cord lesion: description of a modified technique and clinical results.

Giberti, Claudio

European urology

2009 Volume 55, Issue 3, Page(s) 695

MeSH term(s)	Humans ; Spinal Cord Injuries/complications ; Urinary Bladder, Neurogenic/etiology ; Urinary Bladder, Neurogenic/surgery ; Urinary Incontinence, Stress/etiology ; Urinary Incontinence, Stress/surgery ; Urinary Sphincter, Artificial ; Urologic Surgical Procedures/methods
Language	English
Publishing date	2009-03
Publishing country	Switzerland
Document type	Comment ; Editorial
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2008.03.048
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Nonequilibrium two-dimensional Ising model with stationary uphill diffusion.

Colangeli, Matteo / Giardinà, Cristian / Giberti, Claudio / Vernia, Cecilia

Physical review. E

2018 Volume 97, Issue 3-1, Page(s) 30103

Abstract: Usually, in a nonequilibrium setting, a current brings mass from the highest density regions to the lowest density ones. Although rare, the opposite phenomenon (known as "uphill diffusion") has also been observed in multicomponent systems, where it ... ...

Abstract	Usually, in a nonequilibrium setting, a current brings mass from the highest density regions to the lowest density ones. Although rare, the opposite phenomenon (known as "uphill diffusion") has also been observed in multicomponent systems, where it appears as an artificial effect of the interaction among components. We show here that uphill diffusion can be a substantial effect, i.e., it may occur even in single component systems as a consequence of some external work. To this aim we consider the two-dimensional ferromagnetic Ising model in contact with two reservoirs that fix, at the left and the right boundaries, magnetizations of the same magnitude but of opposite signs.We provide numerical evidence that a class of nonequilibrium steady states exists in which, by tuning the reservoir magnetizations, the current in the system changes from "downhill" to "uphill". Moreover, we also show that, in such nonequilibrium setup, the current vanishes when the reservoir magnetization attains a value approaching, in the large volume limit, the magnetization of the equilibrium dynamics, thus establishing a relation between equilibrium and nonequilibrium properties.
Language	English
Publishing date	2018-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.97.030103
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Article ; Online: Advances in stem cell therapy for male stress urinary incontinence.

Gallo, Fabrizio / Ninotta, Gaetano / Schenone, Maurizio / Cortese, Pierluigi / Giberti, Claudio

Expert opinion on biological therapy

2019 Volume 19, Issue 4, Page(s) 293–300

Abstract: Introduction: Among the several options that have been proposed in recent years for the management of male stress urinary incontinence (SUI), stem cell therapy represents a new frontier in treatment. The aim of this paper is to update the current status ...

Abstract	Introduction: Among the several options that have been proposed in recent years for the management of male stress urinary incontinence (SUI), stem cell therapy represents a new frontier in treatment. The aim of this paper is to update the current status of stem cell therapy in animal and human studies for the management of iatrogenic male SUI. Areas covered: A literature review was conducted based on MEDLINE/PubMed searches for English articles using a combination of the following keywords: stem cell therapy, urinary incontinence, prostatectomy, regenerative medicine, mesenchymal stem cells. Expert opinion: The few studies reported in the literature have demonstrated short-term safety and promising results of stem cell therapy in treating male SUI. However, many aspects need to be clarified before stem cell therapy can be introduced into daily urologic practice. In fact, important issues such as the limitations of these studies in terms of small sample sizes and short follow-ups, the incomplete knowledge of the mechanism of action of stem cells, the technical details regarding the delivery method and the best sources of stem cells, the safety risks regarding genomic or epigenetic changes and potential immune reactions in the longer term need to be identified in more stringent clinical trials.
MeSH term(s)	Adipose Tissue/cytology ; Animals ; Humans ; Male ; Muscle, Skeletal/cytology ; Stem Cell Transplantation ; Stem Cells/cytology ; Urinary Incontinence, Stress/pathology ; Urinary Incontinence, Stress/therapy
Language	English
Publishing date	2019-02-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2052501-1
ISSN	1744-7682 ; 1471-2598
ISSN (online)	1744-7682
ISSN	1471-2598
DOI	10.1080/14712598.2019.1578343
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Zs.A 6094: Show issues

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Article ; Online: Mid- to long-term results of the Remeex system for the treatment of female incontinence due to intrinsic sphincter deficiency: A retrospective analysis of the first 50 patients.

Giberti, Claudio / Gallo, Fabrizio / Cortese, Pierluigi / Visalli, Francesco

Neurourology and urodynamics

2017 Volume 36, Issue 3, Page(s) 770–773

Abstract: Aims: To retrospectively report our mid- to long-term results following suburethral tension adjustable sling (Remeex system) implantation for stress urinary incontinence (SUI) due to intrinsic sphincter deficiency (ISD).: Methods: Fifty female ... ...

Abstract	Aims: To retrospectively report our mid- to long-term results following suburethral tension adjustable sling (Remeex system) implantation for stress urinary incontinence (SUI) due to intrinsic sphincter deficiency (ISD). Methods: Fifty female patients with severe SUI due to ISD underwent Remeex system positioning between May 2002 and March 2013 (mean follow-up 83.8 months, median follow-up 85.4 months). Before surgery, patients were evaluated by physical examination, translabial ultrasonography, cystoscopy, urodynamics, 1 hr pad test and compilation of quality-of-life questionnaire. Postoperatively, based on the physical examination and pad test, patients were stratified into three groups: (i) Cured: perfectly dry patients at stress test, pad weight 0-1 g; (ii) Improved: patients with mild to moderate incontinence, pad weight 2-50 g; and (iii) Failed: unchanged or worsened patients, pad weight >50 g. Results: At 7-years mean follow-up, 45 (90.0%) patients were cured, three (6.0%) were improved, and two (4.0%) had failed. Concerning the mean total score of the quality-of-life questionnaire, it increased significantly up to 87.1 ± 5.9 with an improvement of 76.9%. Sling tension readjustment was needed in three patients (6%). The incontinence-free survival curve showed that, after sling positioning and tension readjustments, all the cured patients remained continent during all the follow-up. Complications were represented by bacterial cystitis (6%), de novo urgency (10%), persistent urinary retention (6%), and seroma formation (2%). Conclusions: Our 7-year results showed the efficacy of the Remeex procedure in the treatment of SUI due to ISD. These outcomes tended to be confirmed in the mid- to long-term follow-up which would highlight the durability of this technique. Neurourol. Urodynam. 36:770-773, 2017. © 2016 Wiley Periodicals, Inc.
Language	English
Publishing date	2017-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	604904-7
ISSN	1520-6777 ; 0733-2467
ISSN (online)	1520-6777
ISSN	0733-2467
DOI	10.1002/nau.23020
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Article ; Online: A simple non-chaotic map generating subdiffusive, diffusive, and superdiffusive dynamics.

Salari, Lucia / Rondoni, Lamberto / Giberti, Claudio / Klages, Rainer

Chaos (Woodbury, N.Y.)

2015 Volume 25, Issue 7, Page(s) 73113

Abstract: Analytically tractable dynamical systems exhibiting a whole range of normal and anomalous deterministic diffusion are rare. Here, we introduce a simple non-chaotic model in terms of an interval exchange transformation suitably lifted onto the whole real ... ...

Abstract	Analytically tractable dynamical systems exhibiting a whole range of normal and anomalous deterministic diffusion are rare. Here, we introduce a simple non-chaotic model in terms of an interval exchange transformation suitably lifted onto the whole real line which preserves distances except at a countable set of points. This property, which leads to vanishing Lyapunov exponents, is designed to mimic diffusion in non-chaotic polygonal billiards that give rise to normal and anomalous diffusion in a fully deterministic setting. As these billiards are typically too complicated to be analyzed from first principles, simplified models are needed to identify the minimal ingredients generating the different transport regimes. For our model, which we call the slicer map, we calculate all its moments in position analytically under variation of a single control parameter. We show that the slicer map exhibits a transition from subdiffusion over normal diffusion to superdiffusion under parameter variation. Our results may help to understand the delicate parameter dependence of the type of diffusion generated by polygonal billiards. We argue that in different parameter regions the transport properties of our simple model match to different classes of known stochastic processes. This may shed light on difficulties to match diffusion in polygonal billiards to a single anomalous stochastic process.
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1472677-4
ISSN	1089-7682 ; 1054-1500
ISSN (online)	1089-7682
ISSN	1054-1500
DOI	10.1063/1.4926621
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Article: Simultaneous bilateral robotic partial nephrectomy: Case report and critical evaluation of the technique.

Giberti, Claudio / Gallo, Fabrizio / Schenone, Maurizio / Cortese, Pierluigi

World journal of clinical cases

2014 Volume 2, Issue 6, Page(s) 224–227

Abstract: We report our first simultaneous bilateral robot assisted partial nephrectomy (RAPN) in order to show and critically discuss the feasibility of this procedure. Materials and methods A 69-year-old male patient visited our department due to incidental ... ...

Abstract	We report our first simultaneous bilateral robot assisted partial nephrectomy (RAPN) in order to show and critically discuss the feasibility of this procedure. Materials and methods A 69-year-old male patient visited our department due to incidental finding of bilateral mesorenal small masses (2.5 cm on the right and 3.5 cm on the left) suspicious for malignancy. We started from the right side with patient in flank position. Port placement: 12-mm periumbilical camera port, two 8-mm robotic ports in wide ''V''configuration, additional 12 mm assistant port on the midline between the umbilicus and symphysis pubis. A right unclamping RAPN with sliding clip renorrhaphy was performed. The trocars were removed and the robot undocked. Without interrupting the anesthesiological procedures, the patient was reported in supine position and, after 180 degrees rotation of the surgical bed, was newly placed in contralateral flank position. Using both the previous periumbilical and midline ports, two other 8-mm robotic trocars were placed. The robot was then redocked and RAPN was also performed on the left side using the same previously reported technique. Results Total time: 285 min. Estimated blood losses: 150 cc. Postoperative period: uneventful. Pathological examination: bilateral renal cell carcinoma, negative surgical margins. Conclusions Our experience was encouraging and confirmed the feasibility and safety of this procedure. The planning of our technique was time and cost effective with cosmetic benefit for the patient. However, we think that an appropriate selection of the patients and a skill in robotic renal surgery are advisable before approaching this type of surgery.
Language	English
Publishing date	2014-05-31
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v2.i6.224
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Article: Salvage low-dose-rate brachytherapy for prostate cancer local recurrence after radical prostatectomy: our first three patients.

Gastaldi, Emilio / Gallo, Fabrizio / Chiono, Luciano / Giberti, Claudio

Urologia

2014 Volume 81, Issue 1, Page(s) 46–50

Abstract: Purpose of the study: To present our initial experience with brachytherapy (BT) as a primary salvage procedure for the treatment of prostate cancer (PCa) local recurrence following radical retropubic prostatectomy (RRP).: Methods: From December 2009 ... ...

Abstract	Purpose of the study: To present our initial experience with brachytherapy (BT) as a primary salvage procedure for the treatment of prostate cancer (PCa) local recurrence following radical retropubic prostatectomy (RRP). Methods: From December 2009 to May 2010, three patients underwent salvage BT due to local recurrences of high risk PCa after extrafascial RRP without additional adjuvant therapies. Local recurrence was confirmed by prostate biopsy and the relapse was well defined by endorectal ultrasonography and magnetic resonance imaging. Metastatic screening was negative. The patients were followed-up according to the American Brachytherapy Society guidelines. Results: The median dose delivered to 90% of the local relapse (D90) was 115 Gy. The three patients reached a prostate specific antigen (PSA) nadir value within the first year that remained stable at a mean follow-up of 32 months. As regards morbidity, moderate de novo urgency was reported by only one patient. Conclusions: We think that our data confirms the feasibility and safety of salvage BT as a possible alternative option to external beam radiotherapy (EBRT) for the treatment of locally recurrent PCa in selected patients when performed by experienced centers. However, larger series of patients with longer follow-ups are needed to define the oncologic role of this procedure.
MeSH term(s)	Aged ; Biomarkers, Tumor/blood ; Biopsy ; Brachytherapy/methods ; Humans ; Male ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/radiotherapy ; Neoplasm Recurrence, Local/surgery ; Neoplasm Recurrence, Local/therapy ; Prostate-Specific Antigen/blood ; Prostatectomy/methods ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery ; Prostatic Neoplasms/therapy ; Radiotherapy Dosage ; Salvage Therapy/methods ; Treatment Outcome
Chemical Substances	Biomarkers, Tumor ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2014-01
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	204043-8
ISSN	1724-6075 ; 0391-5603 ; 0376-0057
ISSN (online)	1724-6075
ISSN	0391-5603 ; 0376-0057
DOI	10.5301/urologia.5000034
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