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Article ; Online: Assisted human reproduction legislation: Acknowledging the voice of health care professionals.

Schaler, L / Giblin, A / Glover, L E / Wingfield, M

European journal of obstetrics, gynecology, and reproductive biology

2022 Volume 280, Page(s) 28–33

Abstract: Objective: Ireland is one of 5 European countries which currently lacks specific legislation on Assisted Human Reproduction (AHR). Draft legislation was introduced in 2017 and revised in 2022 with a view to enacting legislation this year (2022). This ... ...

Abstract	Objective: Ireland is one of 5 European countries which currently lacks specific legislation on Assisted Human Reproduction (AHR). Draft legislation was introduced in 2017 and revised in 2022 with a view to enacting legislation this year (2022). This study sought to ascertain the views of healthcare professionals to proposed AHR legislation, prior to the implementation of that legislation. Study design: A survey questionnaire based on all clinically relevant aspects of the Irish draft AHR Bill 2017 was distributed to relevant healthcare professionals using an online platform. Results: Over 200 healthcare personnel indicated strong support for the availability of AHR techniques, access to treatment for all patient populations regardless of relationship or gender status, and appropriate legislation and regulation in the field. Views of respondents are at variance with several proposals surrounding surrogacy, with 84 % favouring a pre-birth order to assign parentage from birth, rather than the proposed birth order 6 weeks after birth. The majority also support legislation around international surrogacy. Contrary to the draft Bill, respondents believe that men, as well as women, should be able to use posthumously any stored gametes or embryos belonging to the deceased partner or the couple. While the majority favour altruistic gamete donation, respondents support more generous compensation for donors, such as compensation for time lost at work. Conclusion: This study has uniquely ascertained the views of healthcare professionals to imminent AHR legislation. It is hoped that the results will help inform the national legislation as it nears completion. Similar studies could help other countries, and policy bodies such as ESHRE to frame good legislation in this extremely specialised and complex field.
Language	English
Publishing date	2022-11-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2022.11.007
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Article ; Online: Assisted human reproduction legislation: Listening to the voice of patients.

O'Brien, S / Schaler, L / Giblin, A / Glover, L E / Wingfield, M

European journal of obstetrics, gynecology, and reproductive biology

2023 Volume 284, Page(s) 169–174

Abstract: Objective: Legislation and policies regarding assisted human reproduction (AHR) vary widely across nations and societies. As one of only 5 European countries which currently lacks legislation, Ireland now has a unique opportunity to learn from other ... ...

Abstract	Objective: Legislation and policies regarding assisted human reproduction (AHR) vary widely across nations and societies. As one of only 5 European countries which currently lacks legislation, Ireland now has a unique opportunity to learn from other jurisdictions and introduce AHR law that is reflective of the ongoing myriad developments in this complex field. Draft legislation, initially published in 2017, was revised in 2022 with strong political commitment to enacting in the same year. This study sought to ascertain the views of fertility patients (service users) to the proposed AHR legislation in its current format, prior to its implementation. Study design: A survey questionnaire, previously designed to investigate the attitudes and perceptions of healthcare professionals (HCPs) towards a broad range of issues contained within the draft AHR Bill, was adapted for a patient/service user population. The survey link was distributed via secure email to all patients that had a doctor consult at our fertility clinic in 2020-2021. Results: The survey link was sent to 4420 patients/service users, of whom 1044 (23.6%) responded. A majority had experienced AHR treatment. Service users indicated strong support for AHR regulation and for access to all AHR techniques for all patients, irrespective of relationship or gender status. A majority of respondents disagreed with aspects of the draft bill regarding mandatory counselling, the timing of assignment of parentage in surrogacy, the exclusion of international surrogacy and the exclusion of men from posthumous AHR. Interestingly, the fertility patient cohort were more liberal in their views and opinions regarding AHR than the Irish HCPs previously surveyed. Conclusion: This study demonstrates the views of a large group of AHR patients/service users towards proposed AHR legislation. Many of their views concur with but others differ from those of the drafters of the legislation and from those of healthcare professionals. Consideration of the views of all these groups and a collaborative approach would help ensure that Ireland has AHR legislation that is inclusive and fit for purpose in the 21st century.
MeSH term(s)	Male ; Humans ; Reproductive Techniques, Assisted ; Attitude ; Europe ; Ireland ; Reproduction
Language	English
Publishing date	2023-03-21
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2023.03.020
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Article ; Online: Biogeography of ammonia oxidizers in New England and Gulf of Mexico salt marshes and the potential importance of comammox.

Bernhard, A E / Beltz, J / Giblin, A E / Roberts, B J

ISME communications

2021 Volume 1, Issue 1, Page(s) 9

Abstract: Few studies have focused on broad scale biogeographic patterns of ammonia oxidizers in coastal systems, yet understanding the processes that govern them is paramount to understanding the mechanisms that drive biodiversity, and ultimately impact ecosystem ...

Abstract	Few studies have focused on broad scale biogeographic patterns of ammonia oxidizers in coastal systems, yet understanding the processes that govern them is paramount to understanding the mechanisms that drive biodiversity, and ultimately impact ecosystem processes. Here we present a meta-analysis of 16 years of data of ammonia oxidizer abundance, diversity, and activity in New England (NE) salt marshes and 5 years of data from marshes in the Gulf of Mexico (GoM). Potential nitrification rates were more than 80x higher in GoM compared to NE marshes. However, nitrifier abundances varied between regions, with ammonia-oxidizing archaea (AOA) and comammox bacteria significantly greater in GoM, while ammonia-oxidizing bacteria (AOB) were more than 20x higher in NE than GoM. Total bacterial 16S rRNA genes were also significantly greater in GoM marshes. Correlation analyses of rates and abundance suggest that AOA and comammox are more important in GoM marshes, whereas AOB are more important in NE marshes. Furthermore, ratios of nitrifiers to total bacteria in NE were as much as 80x higher than in the GoM, suggesting differences in the relative importance of nitrifiers between these systems. Communities of AOA and AOB were also significantly different between the two regions, based on amoA sequences and DNA fingerprints (terminal restriction fragment length polymorphism). Differences in rates and abundances may be due to differences in salinity, temperature, and N loading between the regions, and suggest significantly different N cycling dynamics in GoM and NE marshes that are likely driven by strong environmental differences between the regions.
Language	English
Publishing date	2021-03-29
Publishing country	England
Document type	Journal Article
ISSN	2730-6151
ISSN (online)	2730-6151
DOI	10.1038/s43705-021-00008-0
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Article ; Online: Toxicity of

Morón-Oset, Javier / Fischer, Lilly Ks / Carcolé, Mireia / Giblin, Ashling / Zhang, Pingze / Isaacs, Adrian M / Grönke, Sebastian / Partridge, Linda

Life science alliance

2023 Volume 6, Issue 9

Abstract: Hexanucleotide repeat expansions in ... ...

Abstract	Hexanucleotide repeat expansions in the
MeSH term(s)	Animals ; Dipeptides ; C9orf72 Protein ; Peptides ; Genes, Regulator ; Amyotrophic Lateral Sclerosis ; Drosophila ; Skin Neoplasms
Chemical Substances	Dipeptides ; C9orf72 Protein ; Peptides
Language	English
Publishing date	2023-06-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2575-1077
ISSN (online)	2575-1077
DOI	10.26508/lsa.202201739
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Article ; Online: A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer's disease models.

Xu, Dongwei / Vincent, Alec / González-Gutiérrez, Andrés / Aleyakpo, Benjamin / Anoar, Sharifah / Giblin, Ashling / Atilano, Magda L / Adams, Mirjam / Shen, Dunxin / Thoeng, Annora / Tsintzas, Elli / Maeland, Marie / Isaacs, Adrian M / Sierralta, Jimena / Niccoli, Teresa

PLoS genetics

2023 Volume 19, Issue 9, Page(s) e1010893

Abstract: Brains are highly metabolically active organs, consuming 20% of a person's energy at resting state. A decline in glucose metabolism is a common feature across a number of neurodegenerative diseases. Another common feature is the progressive accumulation ... ...

Abstract	Brains are highly metabolically active organs, consuming 20% of a person's energy at resting state. A decline in glucose metabolism is a common feature across a number of neurodegenerative diseases. Another common feature is the progressive accumulation of insoluble protein deposits, it's unclear if the two are linked. Glucose metabolism in the brain is highly coupled between neurons and glia, with glucose taken up by glia and metabolised to lactate, which is then shuttled via transporters to neurons, where it is converted back to pyruvate and fed into the TCA cycle for ATP production. Monocarboxylates are also involved in signalling, and play broad ranging roles in brain homeostasis and metabolic reprogramming. However, the role of monocarboxylates in dementia has not been tested. Here, we find that increasing pyruvate import in Drosophila neurons by over-expression of the transporter bumpel, leads to a rescue of lifespan and behavioural phenotypes in fly models of both frontotemporal dementia and Alzheimer's disease. The rescue is linked to a clearance of late stage autolysosomes, leading to degradation of toxic peptides associated with disease. We propose upregulation of pyruvate import into neurons as potentially a broad-scope therapeutic approach to increase neuronal autophagy, which could be beneficial for multiple dementias.
MeSH term(s)	Humans ; Animals ; Frontotemporal Dementia/genetics ; Alzheimer Disease/genetics ; Neuroglia ; Pyruvic Acid ; Drosophila ; Glucose
Chemical Substances	Pyruvic Acid (8558G7RUTR) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1010893
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Article: Sentinel lymph node biopsies for cutaneous melanoma.

Victoria Giblin, A / Meirion Thomas, J

The American journal of surgical pathology

2006 Volume 30, Issue 3, Page(s) 418–9; author reply 420–1

MeSH term(s)	Humans ; Lymphatic Metastasis/pathology ; Melanoma/mortality ; Melanoma/pathology ; Melanoma/surgery ; Sentinel Lymph Node Biopsy ; Skin Neoplasms/mortality ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery
Language	English
Publishing date	2006-03
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	752964-8
ISSN	1532-0979 ; 0147-5185
ISSN (online)	1532-0979
ISSN	0147-5185
DOI	10.1097/01.pas.0000171000.79976.2f
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Zs.A 1356: Show issues

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Article: Differences in properties of salt marsh sediment between hayed and reference sites.

Greenbaum, A / Giblin, A

The Biological bulletin

2000 Volume 199, Issue 2, Page(s) 225–226

MeSH term(s)	Biomass ; Ecosystem ; Geologic Sediments/analysis ; Massachusetts ; Poaceae ; Seawater/analysis
Language	English
Publishing date	2000-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1268-3
ISSN	1939-8697 ; 0006-3185 ; 0148-9488
ISSN (online)	1939-8697
ISSN	0006-3185 ; 0148-9488
DOI	10.2307/1542911
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Article: Incidence, mortality and survival in cutaneous melanoma.

Giblin, A-V / Thomas, J M

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2007 Volume 60, Issue 1, Page(s) 32–40

Abstract: Cutaneous melanoma remains a challenge despite increased levels of awareness, education and targeted health policies. Worldwide incidence rates for cutaneous melanoma have risen faster than those for any other malignancy in Caucasian populations over the ...

Abstract	Cutaneous melanoma remains a challenge despite increased levels of awareness, education and targeted health policies. Worldwide incidence rates for cutaneous melanoma have risen faster than those for any other malignancy in Caucasian populations over the last 30 years. Despite improving survival rates (defined as the ratio of those who survive the disease against incidence) over this period, mortality rates, generally, have continued to climb. Mortality from melanoma is greater than that caused by all other types of skin cancer, especially in men. In Britain the percentage of increase in the male age standardised mortality rate surpassed that of all other malignancies assessed (1993-2002) by Cancer Research UK. A literature-based study was conducted with review of publications identified through Medline and EMBase, 1980-December 2005, databases. We present a review of the current literature on incidence, mortality and survival rates of melanoma including a discussion on the aetiological factors, behaviour modification associated with public education campaigns and recent health policies and the effect these are having on melanoma figures. It is likely that any fall in mortality rates from melanoma in the near future will be secondary to early detection. Changes resulting from primary prevention are unlikely to be noticeable for several decades.
MeSH term(s)	Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Australasia ; Europe/epidemiology ; Female ; Health Education ; Humans ; Incidence ; Male ; Melanoma/epidemiology ; Melanoma/etiology ; Melanoma/mortality ; Middle Aged ; Sex Distribution ; Skin Neoplasms/epidemiology ; Skin Neoplasms/etiology ; Skin Neoplasms/mortality ; United States/epidemiology
Language	English
Publishing date	2007
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2006.05.008
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Article ; Online: Reducing biting rates of Aedes aegypti with metofluthrin: investigations in time and space.

Darbro, Jonathan M / Muzari, M Odwell / Giblin, Arthur / Adamczyk, Rebecca M / Ritchie, Scott A / Devine, Gregor J

Parasites & vectors

2017 Volume 10, Issue 1, Page(s) 69

Abstract: Background: Indoor residual spraying is key to dengue control in Cairns and other parts of northern Queensland, Australia, where Aedes aegypti is prevalent, but the strategy faces challenges with regards to slow application time and, therefore, ... ...

Abstract	Background: Indoor residual spraying is key to dengue control in Cairns and other parts of northern Queensland, Australia, where Aedes aegypti is prevalent, but the strategy faces challenges with regards to slow application time and, therefore, community coverage. A faster potential improvement might be the use of polyethylene netting impregnated with the volatile pyrethroid metofluthrin (SumiOne™). This formulation was assessed in rooms in three houses in Cairns, Australia. One emanator was placed in each room and cages of 10 female Aedes aegypti were exposed at distances of 1 and 3 m. Knockdown and landings on a human hand were counted before metofluthrin exposure and at 10, 30, 60, 90 and 120 min during exposure. In addition, two trials continued over 48 h of exposure to assess the long-term sublethal effects of metofluthrin on caged mosquitoes. Results: Percentage landing rates fell to 0-2.5% in the first 10 min of exposure. Knockdown was most evident between 10 and 30 min (54% at 1 m and 33% at 3 m). Distance from the emanator strongly affected the results: mosquitoes at 3 m exhibited less knockdown and more landings than those at 1 m. As room volume increased, knockdown decreased and the number of landing increased. There is a cumulative mortality and landing inhibition and, for mosquitoes exposed to metofluthrin for > 48 h, mortality was 100% at 1 m and 90% at 3 m. Of those still alive, a small number continued to land and bite. After being removed from metofluthrin-treated rooms, exposed insect cages were found to reducing landing rates for up to 2 h. Conclusions: Despite only moderate levels of knockdown during the initial hours of exposure, metofluthrin emanators were effective in reducing mosquito landing rates, especially within 1 m, even when exposed on an open veranda. The evaluation methods and results described in this paper will help inform the optimal conditions of deployment of metofluthrin emanators. These devices have the potential to reduce contact between humans and urban disease vectors faster than indoor residual spraying so supplement our current arsenal of dengue control tools.
MeSH term(s)	Aedes/drug effects ; Animals ; Australia ; Cyclopropanes/pharmacology ; Female ; Fluorobenzenes/pharmacology ; Insect Bites and Stings/prevention & control ; Insecticides/pharmacology ; Mosquito Control/instrumentation ; Time Factors ; Volatilization
Chemical Substances	Cyclopropanes ; Fluorobenzenes ; Insecticides ; (2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate (WZX356S299)
Language	English
Publishing date	2017-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-017-2004-0
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Article: Dermatologists should exert a greater influence over sentinel lymph node biopsy for melanoma in the U.K.

Thomas, J Meirion / Giblin, A V

The British journal of dermatology

2005 Volume 152, Issue 1, Page(s) 176–177

MeSH term(s)	Humans ; Lymphatic Metastasis ; Melanoma/secondary ; Randomized Controlled Trials as Topic ; Referral and Consultation ; Sentinel Lymph Node Biopsy ; Skin Neoplasms/pathology
Language	English
Publishing date	2005-01
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/j.1365-2133.2005.06405.x
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