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  1. Article: Multi-Domain Touchscreen-Based Cognitive Assessment of C57BL/6J Female Mice Shows Whole-Body Exposure to

    Soler, Ivan / Yun, Sanghee / Reynolds, Ryan P / Whoolery, Cody W / Tran, Fionya H / Kumar, Priya L / Rong, Yuying / DeSalle, Matthew J / Gibson, Adam D / Stowe, Ann M / Kiffer, Frederico C / Eisch, Amelia J

    Frontiers in behavioral neuroscience

    2021  Volume 15, Page(s) 722780

    Abstract: Astronauts during interplanetary missions will be exposed to galactic cosmic radiation, including charged particles ... ...

    Abstract Astronauts during interplanetary missions will be exposed to galactic cosmic radiation, including charged particles like
    Language English
    Publishing date 2021-10-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2021.722780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive.

    Yun, Sanghee / Reynolds, Ryan P / Petrof, Iraklis / White, Alicia / Rivera, Phillip D / Segev, Amir / Gibson, Adam D / Suarez, Maiko / DeSalle, Matthew J / Ito, Naoki / Mukherjee, Shibani / Richardson, Devon R / Kang, Catherine E / Ahrens-Nicklas, Rebecca C / Soler, Ivan / Chetkovich, Dane M / Kourrich, Saïd / Coulter, Douglas A / Eisch, Amelia J

    Nature medicine

    2018  Volume 24, Issue 5, Page(s) 658–666

    Abstract: Major depressive disorder (MDD) is considered a 'circuitopathy', and brain stimulation therapies hold promise for ameliorating MDD symptoms, including hippocampal dysfunction. It is unknown whether stimulation of upstream hippocampal circuitry, such as ... ...

    Abstract Major depressive disorder (MDD) is considered a 'circuitopathy', and brain stimulation therapies hold promise for ameliorating MDD symptoms, including hippocampal dysfunction. It is unknown whether stimulation of upstream hippocampal circuitry, such as the entorhinal cortex (Ent), is antidepressive, although Ent stimulation improves learning and memory in mice and humans. Here we show that molecular targeting (Ent-specific knockdown of a psychosocial stress-induced protein) and chemogenetic stimulation of Ent neurons induce antidepressive-like effects in mice. Mechanistically, we show that Ent-stimulation-induced antidepressive-like behavior relies on the generation of new hippocampal neurons. Thus, controlled stimulation of Ent hippocampal afferents is antidepressive via increased hippocampal neurogenesis. These findings emphasize the power and potential of Ent glutamatergic afferent stimulation-previously well-known for its ability to influence learning and memory-for MDD treatment.
    MeSH term(s) Animals ; Antidepressive Agents/therapeutic use ; Behavior, Animal ; Chronic Disease ; Dendrites/pathology ; Dentate Gyrus/pathology ; Entorhinal Cortex/pathology ; Glutamates/metabolism ; HEK293 Cells ; Humans ; Membrane Proteins/deficiency ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Net/metabolism ; Nerve Net/pathology ; Neurogenesis ; Peroxins/deficiency ; Peroxins/metabolism ; Stress, Psychological/complications
    Chemical Substances Antidepressive Agents ; Glutamates ; Membrane Proteins ; Peroxins ; Pex5l protein, mouse
    Language English
    Publishing date 2018-04-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-018-0002-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 39: Show issues

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  3. Article ; Online: Publisher Correction: Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive.

    Yun, Sanghee / Reynolds, Ryan P / Petrof, Iraklis / White, Alicia / Rivera, Phillip D / Segev, Amir / Gibson, Adam D / Suarez, Maiko / DeSalle, Matthew J / Ito, Naoki / Mukherjee, Shibani / Richardson, Devon R / Kang, Catherine E / Ahrens-Nicklas, Rebecca C / Soler, Ivan / Chetkovich, Dane M / Kourrich, Saïd / Coulter, Douglas A / Eisch, Amelia J

    Nature medicine

    2018  Volume 24, Issue 9, Page(s) 1482

    Abstract: In the version of this article originally published, a URL provided in the Methods section was incorrect. The URL had a solidus at the end but should have appeared as http://www.nature.com/authors/policies/image.html. The error has been corrected in the ... ...

    Abstract In the version of this article originally published, a URL provided in the Methods section was incorrect. The URL had a solidus at the end but should have appeared as http://www.nature.com/authors/policies/image.html. The error has been corrected in the PDF and HTML versions of this article.
    Language English
    Publishing date 2018-06-22
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-018-0084-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 39: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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