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  1. Article ; Online: Using the exploration, preparation, implementation, sustainment (EPIS) framework to assess the cooperative re-engagement controlled trial (CoRECT).

    Elder, Heather / Lang, Simona G / Villanueva, Merceditas / John, Betsey / Roosevelt, Kathleen / Altice, Frederick L / Brady, Kathleen A / Gibson, Briana / Buchelli, Marianne / DeMaria, Alfred / Randall, Liisa M

    Frontiers in public health

    2023  Volume 11, Page(s) 1223149

    Abstract: Background: "Data to Care" (D2C) is a strategy which relies on a combination of public health surveillance data supplemented by clinic data to support continuity of HIV care. The Cooperative Re-Engagement Controlled Trial (CoRECT) was a CDC-sponsored ... ...

    Abstract Background: "Data to Care" (D2C) is a strategy which relies on a combination of public health surveillance data supplemented by clinic data to support continuity of HIV care. The Cooperative Re-Engagement Controlled Trial (CoRECT) was a CDC-sponsored randomized controlled trial of a D2C model, which provided an opportunity to examine the process of implementing an intervention for people with HIV (PWH) who are out-of-care across three public health department jurisdictions. Using the EPIS (Exploration, Preparation, Implementation, Sustainment) framework, we aimed to retrospectively describe the implementation process for each site to provide insights and guidance to inform future D2C activities implemented by public health agencies and their clinical and community partners.
    Methods: After completion of CoRECT, the three (Connecticut, Massachusetts, Philadelphia) trial sites reviewed study protocols and held iterative discussions to describe and compare their processes regarding case identification, interactions with partnering clinics and patients, and sustainability. The EPIS framework provided a structure for comparing key organizational and operational practices and was applied to the entire implementation process.
    Results: The trial sites varied in their implementation processes and the specific elements of the intervention. Factors including prior D2C experience, data management and analytic infrastructure, staff capacity, and relationships with clinic partners informed intervention development and implementation. Additionally, this review identified key lessons learned including to: (1) explore new supplemental sources for public health surveillance data; (2) work with stakeholders representing core functions/components in the early stages of the intervention design process; (3) build flexibility into all components of the follow-up activities; and (4) integrate data sharing, project management, and follow-up activities within existing DPH organizational structure.
    Conclusion: The CoRECT study provides a general blueprint and lessons learned for implementing a D2C intervention for re-engagement in HIV care. Interventions should be tailored to local operational and structural factors, and responsive to evolving clinical and public health practices.
    MeSH term(s) Humans ; Retrospective Studies ; Research Design ; Massachusetts ; Public Health ; HIV Infections/therapy ; HIV Infections/epidemiology ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-12-01
    Publishing country Switzerland
    Document type Review ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1223149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Therapeutic plasma exchange for intractable pruritus secondary to primary sclerosing cholangitis.

    Gibson, Briana / Williams, Lance A / Marques, Marisa B / Pham, Huy P

    Journal of clinical apheresis

    2016  Volume 31, Issue 5, Page(s) 495–496

    MeSH term(s) Cholangitis, Sclerosing/complications ; Cholangitis, Sclerosing/therapy ; Humans ; Plasma Exchange ; Pruritus/etiology ; Pruritus/therapy
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Letter
    ZDB-ID 604912-6
    ISSN 1098-1101 ; 0733-2459
    ISSN (online) 1098-1101
    ISSN 0733-2459
    DOI 10.1002/jca.21436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A machine learning approach to predict mortality due to immune-mediated thrombotic thrombocytopenic purpura.

    Abou-Ismail, Mouhamed Yazan / Zhang, Chong / Presson, Angela P / Chaturvedi, Shruti / Antun, Ana G / Farland, Andrew M / Woods, Ryan / Metjian, Ara / Park, Yara A / de Ridder, Gustaaf / Gibson, Briana / Kasthuri, Raj S / Liles, Darla K / Akwaa, Frank / Clover, Todd / Kreuziger, Lisa Baumann / Sridharan, Meera / Go, Ronald S / McCrae, Keith R /
    Upreti, Harsh Vardhan / Gangaraju, Radhika / Kocher, Nicole K / Zheng, X Long / Raval, Jay S / Masias, Camila / Cataland, Spero R / Johnson, Andrew D / Davis, Elizabeth / Evans, Michael D / Mazepa, Marshall / Lim, Ming Y

    Research and practice in thrombosis and haemostasis

    2024  Volume 8, Issue 3, Page(s) 102388

    Abstract: Background: Mortality due to immune-mediated thrombotic thrombocytopenic purpura (iTTP) remains significant. Predicting mortality risk may potentially help individualize treatment. The French Thrombotic Microangiopathy (TMA) Reference Score has not been ...

    Abstract Background: Mortality due to immune-mediated thrombotic thrombocytopenic purpura (iTTP) remains significant. Predicting mortality risk may potentially help individualize treatment. The French Thrombotic Microangiopathy (TMA) Reference Score has not been externally validated in the United States. Recent advances in machine learning technology can help analyze large numbers of variables with complex interactions for the development of prediction models.
    Objectives: To validate the French TMA Reference Score in the United States Thrombotic Microangiopathy (USTMA) iTTP database and subsequently develop a novel mortality prediction tool, the USTMA TTP Mortality Index.
    Methods: We analyzed variables available at the time of initial presentation, including demographics, symptoms, and laboratory findings. We developed our model using gradient boosting machine, a machine learning ensemble method based on classification trees, implemented in the R package gbm.
    Results: In our cohort (
    Conclusion: The USTMA Mortality Index was acceptable for predicting mortality due to acute iTTP in the USTMA registry, but not sensitive enough to rule out death. Identifying patients at high risk of iTTP-related mortality may help individualize care and ultimately improve iTTP survival outcomes. Further studies are needed to provide external validation. Our model is one of many recent examples where machine learning models may show promise in clinical prediction tools in healthcare.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2024.102388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Occult Metastases in Pelvic Lymphadenectomy Specimens From Patients With Urothelial Carcinoma of the Bladder.

    Gordetsky, Jennifer / Gibson, Briana / Stevens, Todd M / Ellenburg, J Luke / Grizzle, William / Rais-Bahrami, Soroush

    Urology

    2016  Volume 94, Page(s) 161–166

    Abstract: Objective: To identify occult metastases within lymph nodes (LNs) reported as negative by routine histologic evaluation. In patients with high-grade, muscle-invasive urothelial carcinoma (UC) of the bladder, pelvic lymphadenectomy during radical ... ...

    Abstract Objective: To identify occult metastases within lymph nodes (LNs) reported as negative by routine histologic evaluation. In patients with high-grade, muscle-invasive urothelial carcinoma (UC) of the bladder, pelvic lymphadenectomy during radical cystectomy demonstrates a survival advantage, increasing with the number of LNs removed, even if negative for metastatic disease. This finding may potentially be explained by the presence of occult metastases.
    Materials and methods: Radical cystectomy specimens with high-grade UC invading the perivesical tissue and negative LNs (pT3N0) between 2000 and 2014 were reviewed. Five levels were cut for each LN block. Two sections were cut per level: 1 stained for hematoxylin and eosin and 1 for AE1/AE3. Micrometastases were defined as tumor deposits >0.2 mm but <2 mm. Isolated tumor cells were defined as ≤0.2 mm. Medical records and survival data were reviewed.
    Results: We identified 21 cases, consisting of 370 lymph nodes. Six of 21 patients (29%) had occult metastases, including 5 occult metastatic UC and 1 occult metastatic prostate adenocarcinoma. There were 10 positive LNs; 2 macrometastases, 2 micrometastases, and 6 with ITCs. Two of 6 patients (33%) had lymphovascular invasion identified in the primary tumor. Kaplan-Meier analysis showed no significant difference in overall survival between the group of patients who remained N0 versus those upstaged due to discovery of occult metastases (P-value = .42).
    Conclusion: In patients with pT3 UC undergoing cystectomy, we demonstrated the presence of occult metastases in 29% of patients. The high percentage of occult metastases present in these cases possibly explains the proven survival advantage of removing "negative" LNs. This finding might also have implications in the histologic evaluation of LNs.
    MeSH term(s) Aged ; Carcinoma, Transitional Cell/secondary ; Carcinoma, Transitional Cell/surgery ; Cystectomy ; Female ; Humans ; Lymph Node Excision ; Lymphatic Metastasis ; Male ; Pelvis ; Retrospective Studies ; Urinary Bladder/pathology ; Urinary Bladder/surgery
    Language English
    Publishing date 2016-05-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2016.03.058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A descriptive analysis of fatal outcomes in immune thrombotic thrombocytopenic purpura in the USTMA TTP Registry.

    Abou-Ismail, Mouhamed Yazan / Zhang, Chong / Presson, Angela P / Chaturvedi, Shruti / Antun, Ana G / Farland, Andrew M / Woods, Ryan / Metjian, Ara / Park, Yara A / de Ridder, Gustaaf / Gibson, Briana / Kasthuri, Raj S / Liles, Darla K / Akwaa, Frank / Clover, Todd / Baumann Kreuziger, Lisa / Sridharan, Meera / Go, Ronald S / McCrae, Keith R /
    Upreti, Harsh Vardhan / Gangaraju, Radhika / Kocher, Nicole K / Zheng, X Long / Raval, Jay S / Masias, Camila / Cataland, Spero R / Johnson, Andrew D / Davis, Elizabeth / Evans, Michael D / Mazepa, Marshall / Lim, Ming Y

    Blood advances

    2023  Volume 8, Issue 3, Page(s) 620–623

    MeSH term(s) Humans ; Purpura, Thrombotic Thrombocytopenic/epidemiology ; Purpura, Thrombocytopenic, Idiopathic ; Thrombosis ; Registries
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023010807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Race, rituximab, and relapse in TTP.

    Chaturvedi, Shruti / Antun, Ana G / Farland, Andrew M / Woods, Ryan / Metjian, Ara / Park, Yara A / de Ridder, Gustaaf / Gibson, Briana / Kasthuri, Raj S / Liles, Darla K / Akwaa, Frank / Clover, Todd / Baumann Kreuziger, Lisa / Sadler, J Evan / Sridharan, Meera / Go, Ronald S / McCrae, Keith R / Upreti, Harsh Vardhan / Liu, Angela /
    Lim, Ming Y / Gangaraju, Radhika / Zheng, X Long / Raval, Jay S / Masias, Camila / Cataland, Spero R / Johnson, Andrew / Davis, Elizabeth / Evans, Michael D / Mazepa, Marshall A

    Blood

    2022  Volume 140, Issue 12, Page(s) 1335–1344

    Abstract: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is characterized by recurring episodes of thrombotic microangiopathy, causing ischemic organ impairment. Black patients are overrepresented in iTTP cohorts in the United States, but racial ... ...

    Abstract Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is characterized by recurring episodes of thrombotic microangiopathy, causing ischemic organ impairment. Black patients are overrepresented in iTTP cohorts in the United States, but racial disparities in iTTP outcome and response to therapy have not been studied. Using the United States Thrombotic Microangiopathies Consortium iTTP Registry, we evaluated the impact of race on mortality and relapse-free survival (RFS) in confirmed iTTP in the United States from 1995 to 2020. We separately examined the impact of rituximab therapy and presentation with newly diagnosed (de novo) or relapsed iTTP on RFS by race. A total of 645 participants with 1308 iTTP episodes were available for analysis. Acute iTTP mortality did not differ by race. When all episodes of iTTP were included, Black race was associated with shorter RFS (hazard ratio [HR], 1.60; 95% CI, 1.16-2.21); the addition of rituximab to corticosteroids improved RFS in White (HR, 0.37; 95% CI, 0.18-0.73) but not Black patients (HR, 0.96; 95% CI, 0.71-1.31). In de novo iTTP, rituximab delayed relapse, but Black patients had shorter RFS than White patients, regardless of treatment. In relapsed iTTP, rituximab significantly improved RFS in White but not Black patients. Race affects overall relapse risk and response to rituximab in iTTP. Black patients may require closer monitoring, earlier retreatment, and alternative immunosuppression after rituximab treatment. How race, racism, and social determinants of health contribute to the disparity in relapse risk in iTTP deserves further study.
    MeSH term(s) ADAMTS13 Protein ; Adrenal Cortex Hormones ; Humans ; Purpura, Thrombotic Thrombocytopenic/therapy ; Recurrence ; Rituximab/therapeutic use
    Chemical Substances Adrenal Cortex Hormones ; Rituximab (4F4X42SYQ6) ; ADAMTS13 Protein (EC 3.4.24.87)
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022016640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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