Article ; Online: Human IVIG treatment in a neurological disease model for Enterovirus A71 infection in 28-day-old AG129 mice.
2023 Volume 580, Page(s) 62–72
Abstract: Enterovirus A71 can cause serious neurological disease in young children. Animal models for EV-A71 are needed to evaluate potential antiviral therapies. Existing models have limitations, including lack of lethality or crucial disease signs. Here we ... ...
| Abstract | Enterovirus A71 can cause serious neurological disease in young children. Animal models for EV-A71 are needed to evaluate potential antiviral therapies. Existing models have limitations, including lack of lethality or crucial disease signs. Here we report the development of an EV-A71 model in 28-day-old mice. Virus was serially passaged until it produced consistent lethality and rear-limb paralysis. Onset of disease occurred between days 6-9 post-infection, with mortality following weight loss and neurological signs on days 9-14. In addition, a single administration of human intravenous immunoglobulin at doses of 200, 400 and 800 mg/kg at 4h post-infection was evaluated in the model. Protection from weight loss, neurological signs, and mortality (between 50 and 89%) were observed at doses of 400 mg/kg or greater. Based on these results, IVIG was selected for use as a positive control in this acute model, and suggest that IVIG is a potential therapeutic for EV-A71 infections. |
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| MeSH term(s) | Child ; Humans ; Mice ; Animals ; Child, Preschool ; Immunoglobulins, Intravenous/therapeutic use ; Enterovirus Infections ; Enterovirus ; Enterovirus A, Human ; Nervous System Diseases ; Disease Models, Animal |
| Chemical Substances | Immunoglobulins, Intravenous |
| Language | English |
| Publishing date | 2023-02-04 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, U.S. Gov't, P.H.S. |
| ZDB-ID | 200425-2 |
| ISSN | 1096-0341 ; 0042-6822 |
| ISSN (online) | 1096-0341 |
| ISSN | 0042-6822 |
| DOI | 10.1016/j.virol.2023.02.002 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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