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  1. Article ; Online: Inflammasome activation mediated by oxidised low-density lipoprotein in patients with sleep apnoea and early subclinical atherosclerosis.

    Díaz-García, Elena / Sanz-Rubio, David / García-Tovar, Sara / Alfaro, Enrique / Cubero, Pablo / Gil, Ana V / Marin, José M / Cubillos-Zapata, Carolina / García-Río, Francisco

    The European respiratory journal

    2023  Volume 61, Issue 3

    Abstract: Background: Atherosclerosis is a common comorbidity of obstructive sleep apnoea (OSA) patients, caused by the interaction of dyslipidaemia and systemic inflammation. The OSA pro-inflammatory response is mediated by NLRP3 inflammasome activation, which ... ...

    Abstract Background: Atherosclerosis is a common comorbidity of obstructive sleep apnoea (OSA) patients, caused by the interaction of dyslipidaemia and systemic inflammation. The OSA pro-inflammatory response is mediated by NLRP3 inflammasome activation, which requires a priming signal mediated by intermittent hypoxia (IH) and an activation signal provided by soluble stimulus present in plasma. Our objectives were to study oxidised low-density lipoprotein (oxLDL) expression in OSA patients with or without early subclinical atherosclerosis (eSA) as well as its contribution to NLRP3 activation and tissue factor (TF) release.
    Methods: We analysed oxLDL, key components of the NLRP3 inflammasome cascade and TF in plasma and monocytes from OSA patients and non-apnoeic subjects, with or without eSA as determined by increased carotid intima-media thickness without the appearance of atherosclerotic plaques. The oxLDL contribution to NLRP3 inflammasome activation was assessed using
    Results: High levels of oxLDL were identified in plasma from OSA patients, particularly in those with eSA, as well as an overexpression of NLRP3 cascade components and TF. Furthermore,
    Conclusions: OSA patients with eSA exhibit NLRP3 activation by IH and the presence of oxLDL capable of releasing TF, constituting a pathway for the interaction between dyslipidaemia and systemic inflammation in the development of atherosclerotic lesions.
    MeSH term(s) Humans ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein ; Carotid Intima-Media Thickness ; Lipoproteins, LDL/metabolism ; Atherosclerosis/complications ; Inflammation/metabolism ; Sleep Apnea, Obstructive/complications ; Dyslipidemias
    Chemical Substances Inflammasomes ; oxidized low density lipoprotein ; NLR Family, Pyrin Domain-Containing 3 Protein ; Lipoproteins, LDL
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01401-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

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  2. Article ; Online: Inflammation biomarkers in OSA, chronic obstructive pulmonary disease, and chronic obstructive pulmonary disease/OSA overlap syndrome.

    Sanchez-Azofra, Ana / Gu, Wanjun / Masso-Silva, Jorge A / Sanz-Rubio, David / Marin-Oto, Marta / Cubero, Pablo / Gil, Ana V / Moya, Esteban A / Barnes, Laura A / Mesarwi, Omar A / Marin, Traci / Simonson, Tatum S / Crotty Alexander, Laura E / Marin, Jose M / Malhotra, Atul

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2023  Volume 19, Issue 8, Page(s) 1447–1456

    Abstract: Study objectives: The coexistence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) in a single individual, also known as overlap syndrome (OVS), is associated with higher cardiovascular risk and mortality than either OSA ...

    Abstract Study objectives: The coexistence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) in a single individual, also known as overlap syndrome (OVS), is associated with higher cardiovascular risk and mortality than either OSA or COPD alone. However, the underlying mechanisms remain unclear. We hypothesized that patients with OVS have elevated systemic inflammatory biomarkers relative to patients with either disease alone, which could explain greater cardiovascular risk observed in OVS.
    Methods: We included 255 participants in the study, 55 with COPD alone, 100 with OSA alone, 50 with OVS, and 50 healthy controls. All participants underwent a home sleep study, spirometry, and a blood draw for high-sensitivity C-reactive protein and total blood count analysis. In a randomly selected subset of 186 participants, inflammatory protein profiling was performed using Bio-Rad Bio-Plex Pro Human Cytokine 27-Plex Assays. Biomarker level differences across groups were identified using a mixed linear model.
    Results: Levels of interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and granulocyte colony stimulating factor (G-CSF) were higher in participants with OVS and COPD compared with healthy controls and participants with OSA. Furthermore, participants with OVS had higher circulating levels of leukocytes and neutrophils than those with COPD, OSA, and controls.
    Conclusions: COPD and OVS are associated with higher systemic inflammation relative to OSA and healthy controls. This work proposes the potential utilization of interleukin 6, granulocyte colony stimulating factor, and high-sensitivity C-reactive protein as screening biomarkers for COPD in patients with OSA. Inflammatory pathways may not fully explain the higher cardiovascular risk observed in OVS, indicating the need for further investigation.
    Citation: Sanchez-Azofra A, Gu W, Masso-Silva JA, et al. Inflammation biomarkers in OSA, chronic obstructive pulmonary disease, and chronic obstructive pulmonary disease/OSA overlap syndrome.
    MeSH term(s) Humans ; C-Reactive Protein ; Interleukin-6 ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea Syndromes/complications ; Pulmonary Disease, Chronic Obstructive/complications ; Inflammation/complications ; Biomarkers ; Autoimmune Diseases/complications ; Granulocyte Colony-Stimulating Factor
    Chemical Substances C-Reactive Protein (9007-41-4) ; Interleukin-6 ; Biomarkers ; Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6590: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Forkhead Box P3 Methylation and Expression in Men with Obstructive Sleep Apnea.

    Sanz-Rubio, David / Sanz, Arianne / Varona, Luis / Bolea, Rosa / Forner, Marta / Gil, Ana V / Cubero, Pablo / Marin-Oto, Marta / Martin-Burriel, Inmaculada / Marin, Jose M

    International journal of molecular sciences

    2020  Volume 21, Issue 6

    Abstract: Background: Epigenetic changes in obstructive sleep apnea (OSA) have been proposed as a mechanism for end-organ vulnerability. In children with OSA, Forkhead Box P3 (FOXP3) DNA methylation were associated with inflammatory biomarkers; however, the ... ...

    Abstract Background: Epigenetic changes in obstructive sleep apnea (OSA) have been proposed as a mechanism for end-organ vulnerability. In children with OSA, Forkhead Box P3 (FOXP3) DNA methylation were associated with inflammatory biomarkers; however, the methylation pattern and its effect in the expression of this gene have not been tested in adults with OSA.
    Methods: Plasma samples from subjects without comorbid conditions other than OSA were analyzed (the Epigenetics Status and Subclinical Atherosclerosis in Obstructive Sleep Apnea (EPIOSA) Study: NCT02131610). In 16 patients with severe OSA (Apnea-Hypopnea Index-AHI- > 30 events/h) and seven matched controls (AHI < 5), methylation of FOXP3 gen was evaluated by PCR of the promoter and by pyrosequencing of the intron 1 Treg-specific demethylated region (TSDR). In another 74 patients with OSA (AHI > 10) and 31 controls, we quantified FOXP3 protein expression by ELISA and gene expression by quantitative real-time PCR. C-reactive protein (CRP) and plasma Treg cells were also evaluated.
    Results: Neither the levels of the promoter nor the TSDR demethylated region were different between controls and patients with OSA, whether they were grouped by normal or high CRP. FOXP3 protein and mRNA expression did not differ between groups.
    Conclusions: FOXP3 methylation or its expression is not altered in adults with OSA, whatever their inflammatory status.
    MeSH term(s) Adult ; Biomarkers ; DNA Methylation ; Epigenesis, Genetic ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Gene Expression Profiling ; Gene Expression Regulation ; Humans ; Male ; Middle Aged ; Sex Factors ; Sleep Apnea, Obstructive/genetics ; Sleep Apnea, Obstructive/metabolism ; Sleep Apnea, Obstructive/physiopathology
    Chemical Substances Biomarkers ; FOXP3 protein, human ; Forkhead Transcription Factors
    Language English
    Publishing date 2020-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21062233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Systemic inflammation and sympathetic activation in gestational diabetes mellitus with obstructive sleep apnea.

    Serednytskyy, Oleksandr / Alonso-Fernández, Alberto / Ribot, Caterina / Herranz, Andrea / Álvarez, Ainhoa / Sánchez, Andrés / Rodríguez, Paula / Gil, Ana V / Pía, Carla / Cubero, José P / Barceló, María / Cerdà, María / Codina, Mercedes / D Peña, Mónica / Barceló, Antònia / Iglesias, Amanda / Morell-Garcia, Daniel / Peña, José A / Giménez, María P /
    Piñas, María C / García-Río, Francisco

    BMC pulmonary medicine

    2022  Volume 22, Issue 1, Page(s) 94

    Abstract: Background: Although some evidence suggests an association between obstructive sleep apnea (OSA) and gestational diabetes mellitus (GDM), its consequences still remain largely unknown. We sought to determine whether OSA is associated with higher ... ...

    Abstract Background: Although some evidence suggests an association between obstructive sleep apnea (OSA) and gestational diabetes mellitus (GDM), its consequences still remain largely unknown. We sought to determine whether OSA is associated with higher inflammation and sympathetic levels in GDM, and to relate them with insulin resistance and perinatal outcomes.
    Methods: OSA was identified by polysomnography and defined as an apnea-hypopnea index of ≥ 5 h
    Results: We included 17 patients with GDM and OSA and 34 without OSA. Women with GDM and OSA had higher normetanephrine concentrations [81 IQR (59-134) vs. 68 (51-81) pg/mL]. No differences in the inflammatory profile were found, while IL-1β was higher in patients with mean nocturnal oxyhemoglobin saturation ≤ 94%. We found positive correlations between increased sympathetic activation and IL-1β, with obstructive apneas, while time in REM showed an inverse relationship with IL-1β and metanephrine. Furthermore, IL-10 was inversely related with time in sleep stages 1-2, and with the arousal index, and it was positively related with time in slow-wave sleep. Significant correlations were also found between IL-1β and insulin resistance. There were no significant differences in neonatal characteristics; however, we found inverse relationships between IL-10 and birth weight (BW), and percentile of BW.
    Conclusions: OSA increased sympathetic activity, and IL-1β concentration was higher in patients with GDM with lower nocturnal oxygenation, all of which were related with obstructive events, and time in REM. Moreover, IL-1β was related with insulin resistance, and IL-10 inversely correlated with neonatal BW.
    MeSH term(s) Diabetes, Gestational ; Female ; Humans ; Infant, Newborn ; Inflammation ; Insulin Resistance/physiology ; Polysomnography ; Pregnancy ; Sleep Apnea, Obstructive
    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-022-01888-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Upper airway and systemic inflammation in obstructive sleep apnoea.

    Vicente, Eugenio / Marin, Jose M / Carrizo, Santiago J / Osuna, Carlos S / González, Ricardo / Marin-Oto, Marta / Forner, Marta / Vicente, Paul / Cubero, Pablo / Gil, Ana V / Soler, Xavier

    The European respiratory journal

    2016  Volume 48, Issue 4, Page(s) 1108–1117

    Abstract: Obstructive sleep apnoea (OSA) is associated with pharyngeal inflammation, but the coexistence of systemic inflammation is controversial. This study investigated whether local and systemic inflammatory biomarkers are related in patients with OSA. An ... ...

    Abstract Obstructive sleep apnoea (OSA) is associated with pharyngeal inflammation, but the coexistence of systemic inflammation is controversial. This study investigated whether local and systemic inflammatory biomarkers are related in patients with OSA. An uncontrolled extension to the study assessed the response to effective treatment.We recruited 89 patients with OSA (apnoea/hypopnoea index (AHI) ≥5 events·h
    MeSH term(s) Adolescent ; Adult ; Anthropometry ; Biomarkers/metabolism ; CD4-Positive T-Lymphocytes/cytology ; Case-Control Studies ; Continuous Positive Airway Pressure ; Female ; Flow Cytometry ; Humans ; Immunoassay ; Inflammation/complications ; Inflammation/physiopathology ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Male ; Middle Aged ; Prospective Studies ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/physiopathology ; Snoring ; Treatment Outcome ; Tumor Necrosis Factor-alpha/metabolism ; Young Adult
    Chemical Substances Biomarkers ; CXCL8 protein, human ; IL6 protein, human ; Interleukin-6 ; Interleukin-8 ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2016-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00234-2016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

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