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  1. Article: Hypoglossal nerve paresis secondary to anterior approach of upper cervical spine followed by spontaneous recovery.

    Vargas López, Antonio José / González Quarante, Laín Hermes / Gil de Sagredo Del Corral, Oscar Lucas / Montalvo Afonso, Antonio / Fernández Carballal, Carlos

    Journal of spine surgery (Hong Kong)

    2017  Volume 3, Issue 3, Page(s) 481–483

    Abstract: We describe an exceptional complication of cervical spine surgery in a 63-year-old male. He suffered the impact of a beam to the top of his head. During evaluation in the emergency room he reported intense neck pain with no other neurological symptoms or ...

    Abstract We describe an exceptional complication of cervical spine surgery in a 63-year-old male. He suffered the impact of a beam to the top of his head. During evaluation in the emergency room he reported intense neck pain with no other neurological symptoms or findings on physical examination. Spine computed tomography (CT) showed C3 vertebral body fracture that required surgical stabilization. A right side anterior approach to upper cervical spine with C3 corpectomy and placement of iliac bone autograft was performed. After surgery the patient presented dysphagia, dysarthria and limitation tongue mobility to the right side. These findings were consistent with hypoglossal neuropraxia probably related to soft tissue traction generated by the upper part of the self-retaining retractor. After discharge the patient experienced spontaneous improvement of hypoglossal paresis.
    Language English
    Publishing date 2017-10-06
    Publishing country China
    Document type Case Reports
    ZDB-ID 2874556-5
    ISSN 2414-4630 ; 2414-469X
    ISSN (online) 2414-4630
    ISSN 2414-469X
    DOI 10.21037/jss.2017.06.19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Subdural and subarachnoid empyema as a complication of an acute meningococcal meningitis.

    Solís-García, Gonzalo / Darriba Valles, Juan Vicente / Gil de Sagredo Del Corral, Oscar Lucas / Vázquez López, María / Aguado, Alejandra / Saavedra-Lozano, Jesús

    Archives of disease in childhood

    2019  Volume 106, Issue 2, Page(s) 188

    Language English
    Publishing date 2019-10-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2019-318036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.106: Show issues Location:
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  3. Article ; Online: Assessment of the impact of glioma diagnostic reclassification following the new 2016 WHO classification on a series of cases.

    Valera-Melé, Marc / Mateo Sierra, Olga / Sola Vendrell, Emma / Guzmán de Villoria L, Juan Adán / Carvajal Díaz, Lorena / Gil de Sagredo Del Corral, Óscar Lucas / García Leal, Roberto

    Neurocirugia (English Edition)

    2018  Volume 30, Issue 1, Page(s) 19–27

    Abstract: Background and objectives: The aim of this project is to assess diagnostic reclassification based on molecular data over morphology in a series of glial tumours since the introduction of the 2016 WHO classification of brain tumours.: Materials and ... ...

    Title translation Evaluación del impacto del cambio diagnóstico de los gliomas aplicando la nueva clasificación de la OMS de 2016 sobre una serie de casos.
    Abstract Background and objectives: The aim of this project is to assess diagnostic reclassification based on molecular data over morphology in a series of glial tumours since the introduction of the 2016 WHO classification of brain tumours.
    Materials and methods: Retrospective review of glial tumours (oligodendrogliomas and astrocytomas) treated in our centre between January 2012 and June 2016 in which a review of diagnosis was performed when molecular studies were added. Statistical analysis included evaluation of variables of epidemiology, morphology and molecular data (mainly IDH mutation and 1p19q codeletion), diagnostic changes after new classification was considered, and clinical impact in cases of diagnostic reclassification.
    Results: From a total of 147 glial tumours reviewed in our centre, molecular diagnosis was obtained in 74 cases (50.3%). Initial diagnosis changed in 23 cases (31%), and 20 (87%) of them had a prior histological diagnosis of oligodendroglioma (69.6% grade ii and 17.4% grade iii). Only 3 of these 23 cases diagnosis changed from astrocytoma to oligodendroglioma. Among reclassified tumours, there was a common molecular pattern, as findings showed mutant IDH in 16 cases (69.6%) and no codeletion in 20 cases (87%). According to the cell of origin, of the whole group of 27 oligodendrogliomas in our series (reclassified and non-reclassifed), 20 cases (74%) became astrocytomas, despite typical oligodendroglial morphology, due to absence of 1p19q codeletion. There was a trend for diagnosis reclassification in younger patients (<40 years), P=.065, mainly in those with a prior diagnosis of oligodendroglioma, with no statistical differences based on gender or clinical data. Besides, reclassification was more common among tumours with mutant IDH (69.6%), P=.003, than those with wild type IDH. In terms of survival, despite receiving different treatments, no significant changes were detected between reclassified and non-reclassified tumours after a mean follow-up of 16 months, partly related to lower grade of these lesions.
    Conclusions: Within the spectrum of the glial tumours treated in our institution, this new classification including molecular genetics over morphological data has provided marked diagnostic changes. These changes appear mainly in tumours previously diagnosed as oligodendrogliomas and in younger patients, with molecular patterns of mutant IDH and 1p19q codeletion. Although diagnosis reclassification may affect clinic, prognosis or therapeutic management of these tumours, deeper and prospective studies on these specific aspects are needed.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Algorithms ; Astrocytoma/classification ; Astrocytoma/diagnosis ; Astrocytoma/pathology ; Child ; Child, Preschool ; Female ; Glioma/classification ; Glioma/diagnosis ; Glioma/pathology ; Humans ; Infant ; Male ; Middle Aged ; Molecular Diagnostic Techniques ; Oligodendroglioma/classification ; Oligodendroglioma/diagnosis ; Oligodendroglioma/pathology ; Retrospective Studies ; World Health Organization ; Young Adult
    Language Spanish
    Publishing date 2018-10-23
    Document type Journal Article
    ISSN 2529-8496
    ISSN (online) 2529-8496
    DOI 10.1016/j.neucir.2018.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Misdiagnosis of posterior sequestered lumbar disc herniation: report of three cases and review of the literature.

    Montalvo Afonso, Antonio / Mateo Sierra, Olga / Gil de Sagredo Del Corral, Oscar Lucas / Vargas López, Antonio José / González-Quarante, Lain Hermes / Sola Vendrell, Emma / Romero Martínez, Julia

    Spinal cord series and cases

    2018  Volume 4, Page(s) 61

    Abstract: Introduction: Posterior migration of sequestered disc is an extremely rare event that mimics more common spinal lesions as spinal tumors, making difficult its preoperative diagnosis and appropriate management. We retrospectively reviewed all lumbar disc ...

    Abstract Introduction: Posterior migration of sequestered disc is an extremely rare event that mimics more common spinal lesions as spinal tumors, making difficult its preoperative diagnosis and appropriate management. We retrospectively reviewed all lumbar disc herniations treated by surgery at our institution from 2006 to 2016 to identify cases with posterior sequestered disc fragments and possible misdiagnosis for other spinal lesions. Complementarily, a literature review of misdiagnosed cases of posterior migrated discs was undertaken.
    Case report: Three posterior sequestered lumbar disc cases (one intradural), were found among the 1153 reviewed surgeries. Two of them, presenting with progressive neurological deficit, were respectively misdiagnosed as pseudotumoral lesion and meningioma/neurogenic tumor on MRI. After intraoperative diagnosis and emergent resection, histology confirmed intervertebral disc tissue. The remaining case had an accurate preoperative diagnosis and after an initial conservative management finally underwent surgery because of refractory pain. Full recovery was achieved months after surgical treatment in all cases.
    Discussion: Non-tumoral lesions are the most frequent misdiagnosis of posterior sequestered lumbar disc described in the literature. Early surgical treatment is the standard management due to high incidence of cauda equine syndrome (CES); however, spontaneous regression of posterior sequestered lumbar disc herniations has been recently reported. In conclusion low incidence and similar clinical and radiological features with other more common posterior spinal lesions like hematomas, synovial cyst or abscess turns posterior sequestered disc herniations a diagnosis challenge. Despite high incidence of CES, an initial conservative management should be evaluated in selected patients without neurological deficit and well-controlled pain.
    Language English
    Publishing date 2018-07-06
    Publishing country England
    Document type Journal Article
    ISSN 2058-6124
    ISSN 2058-6124
    DOI 10.1038/s41394-018-0100-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Multinodular and vacuolating neuronal tumor of the cerebrum. A rare entity. New case and review of the literature.

    Gonzalez-Quarante, Lain Hermes / Ruiz-Juretschke, Fernando / Sola Vendrell, Emma / Gil de Sagredo Del Corral, Oscar Lucas / Agarwal, Vijay / Garcia-Leal, Roberto

    Neurocirugia (English Edition)

    2017  Volume 29, Issue 1, Page(s) 44–55

    Abstract: Background: Multinodular and vacuolating neuronal tumor has been recently described and included in the World Health Organization Classification of Tumors of The Central Nervous System, even though its consideration as a true tumor is controversial. ... ...

    Abstract Background: Multinodular and vacuolating neuronal tumor has been recently described and included in the World Health Organization Classification of Tumors of The Central Nervous System, even though its consideration as a true tumor is controversial. Patients with these lesions usually present with refractory seizures and inconclusive imaging findings that may be confused with other more common diagnoses such as dysembryoplastic neuroepithelial tumors or low-grade gliomas. Therefore, surgical resection is warranted to reach a pathologic diagnosis and seizure control. To the best of our knowledge, only 16 cases have been published in the English literature.
    Case description: We present the case of a 52-year-old male who presented at our institution with a 2-year-history of absence of seizures. Brain MRI showed a T2-hyperintense lesion with no contrast enhancement affecting his temporal lobe. Temporal craniotomy and microsurgical resection was scheduled. The procedure was uneventful and a grayish, gluey mass was sent for pathologic analysis. The tumor was formed by immature neuronal cells organized in nodules with a vacuolated matrix. A thorough immunohistochemical analysis showed positivity for: Protein Gene Product 9.5. ATRX. OLIG2. SOX10. p16. Nestin. Synaptophysin. The findings were consistent with multinodular and vacuolating neuronal tumor. The patient has been seizure-free after surgery and with no signs of tumor progression.
    Conclusion: We present a thorough review addressing this uncommon tumor along with a description of the 17th reported case of MVNT, a tumor that was described for the first time in 2013. Further studies and case studies are necessary to establish a well-defined morphological and immunohistochemical profile along with knowledge about its natural history.
    MeSH term(s) Biomarkers, Tumor ; Combined Modality Therapy ; Craniotomy ; Diagnosis, Differential ; Glioma/diagnosis ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasms, Nerve Tissue/chemistry ; Neoplasms, Nerve Tissue/diagnostic imaging ; Neoplasms, Nerve Tissue/pathology ; Neoplasms, Nerve Tissue/therapy ; Neuroimaging ; Neuronavigation ; Oligodendroglioma/diagnosis ; Radiotherapy, Adjuvant ; Seizures/etiology ; Temporal Lobe/pathology ; Temporal Lobe/surgery ; Vacuoles
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2017-10-28
    Document type Case Reports ; Journal Article ; Review
    ISSN 2529-8496
    ISSN (online) 2529-8496
    DOI 10.1016/j.neucir.2017.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Angiocentric Glioma in an Elderly Patient: Case Report and Review of the Literature.

    Gonzalez-Quarante, Lain Hermes / Fernández Carballal, Carlos / Agarwal, Vijay / Vargas Lopez, Antonio J / Gil de Sagredo Del Corral, Oscar Lucas / Sola Vendrell, Emma

    World neurosurgery

    2017  Volume 97, Page(s) 755.e5–755.e10

    Abstract: Background: Angiocentric glioma is a very uncommon low-grade tumor, predominantly occurring in pediatric patients, that was first described in 2005 and was codified 2 years later as a new central nervous system primary tumor. We herein report an ... ...

    Abstract Background: Angiocentric glioma is a very uncommon low-grade tumor, predominantly occurring in pediatric patients, that was first described in 2005 and was codified 2 years later as a new central nervous system primary tumor. We herein report an exceptionally rare case of an elderly patient with angiocentric glioma. Only one additional case of angiocentric glioma in a patient older than 65 years has been hitherto reported.
    Case description: An 83-year-old male patient presented at our institution complaining of a 1-month history of progressive weakness of his right hand and difficulty performing fine movements. Magnetic resonance imaging of the brain was performed, and fluid-attenuated inversion recovery and T2-hyperintense diffuse cortico-subcortical lesion were reported. A neuronavigation-guided frontal craniotomy was performed to expose the premotor cortex, motor cortex, Rolandic sulcus, and postcentral gyrus. Intraoperative mapping showed that the tumor was close to the shoulder area. Therefore, only partial resection was safely feasible. Pathology report described astrocytic neoplastic cells affecting mainly the cortex and piamater with the classic finding of subpial palisading, with no endothelial invasion or atypia. Neoplastic cells were positive for glial fibrillary acidic protein, epithelial membrane antigen, Wilms tumor protein-1, P16, and P53. Low proliferative activity was seen (Ki-67 < 2%). Abundant gliovascular structures were also reported.
    Conclusions: Considering the morphologic and immunohistochemical data, the final pathologic diagnosis was angiocentric glioma. Furthermore, a thorough review of the literature was performed with the purpose of updating and summarizing the main clinical, radiologic, and pathologic features of this rare tumor.
    MeSH term(s) Aged, 80 and over ; Brain Neoplasms/classification ; Brain Neoplasms/pathology ; Brain Neoplasms/surgery ; Diagnosis, Differential ; Evidence-Based Medicine ; Glioma/classification ; Glioma/pathology ; Glioma/surgery ; Humans ; Male ; Rare Diseases/pathology ; Rare Diseases/surgery ; Treatment Outcome
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2016.10.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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