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  1. Article ; Online: Trainees and COVID-19: A Call to Arms.

    Gilbert, Andrea

    The American journal of forensic medicine and pathology

    2020  Volume 41, Issue 3, Page(s) 238

    MeSH term(s) Autopsy/standards ; COVID-19 ; Coronavirus Infections/pathology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/psychology ; Coronavirus Infections/transmission ; Humans ; Internship and Residency ; Pandemics/prevention & control ; Pathology/education ; Pneumonia, Viral/pathology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/psychology ; Pneumonia, Viral/transmission
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Letter
    ZDB-ID 604537-6
    ISSN 1533-404X ; 0195-7910
    ISSN (online) 1533-404X
    ISSN 0195-7910
    DOI 10.1097/PAF.0000000000000561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Trainees and COVID-19 ; A Call to Arms

    Gilbert, Andrea

    American Journal of Forensic Medicine & Pathology

    2020  Volume 41, Issue 3, Page(s) 238–238

    Keywords Pathology and Forensic Medicine ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 604537-6
    ISSN 1533-404X ; 0195-7910
    ISSN (online) 1533-404X
    ISSN 0195-7910
    DOI 10.1097/paf.0000000000000561
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Intracranial Epstein-Barr virus-associated smooth muscle tumor with superimposed cryptococcal infection: A case report.

    Barrett, Kaylyn / Tavakoli, Sam / McGinity, Michael / Gilbert, Andrea

    Medicine

    2022  Volume 101, Issue 9, Page(s) e28806

    Abstract: Rationale: Epstein-Barr virus-associated smooth muscle tumors (EBV-SMT) are rare, virally-induced malignancies that occur almost exclusively in immunocompromised individuals. We report a very rare case of a dura-based EBV-SMT with superimposed local ... ...

    Abstract Rationale: Epstein-Barr virus-associated smooth muscle tumors (EBV-SMT) are rare, virally-induced malignancies that occur almost exclusively in immunocompromised individuals. We report a very rare case of a dura-based EBV-SMT with superimposed local cryptococcal infection.
    Patient concerns: An adult male with a history of untreated acquired immunodeficiency syndrome presented to our hospital with worsening headaches, diarrhea, and diffuse myalgias.
    Diagnoses: Blood cultures were positive for methicillin-resistant Staphylococcus aureus and Cryptococcus neoformans serum antigen. Magnetic resonance imaging revealed 2 adjacent enhancing masses in the right temporal lobe, perilesional edema, and mass effect of the right lateral ventricle. Histological examination and immunohistochemical stains of the surgical specimen were consistent with EBV-SMT. Cryptococcus organisms were identified within the neoplasm.
    Interventions: The patient underwent complete tumor resection, received an extended course of amphotericin and flucytosine, and was restarted on antiretroviral therapy.
    Outcomes: The patient was discharged from the hospital with no focal neurological deficits.
    Lessons: Epstein-Barr virus associated smooth muscle tumors are rare malignancies that occur in immunocompromised patients. Prognosis is largely dependent on immune reconstitution and treatment of concomitant infections.
    MeSH term(s) Adult ; Amphotericin B/therapeutic use ; Antiretroviral Therapy, Highly Active ; Cryptococcus neoformans/isolation & purification ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/pathology ; Flucytosine/therapeutic use ; HIV Infections/drug therapy ; Herpesvirus 4, Human/genetics ; Herpesvirus 4, Human/isolation & purification ; Humans ; Immunocompromised Host ; Magnetic Resonance Imaging/methods ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Opportunistic Infections ; Smooth Muscle Tumor/pathology ; Smooth Muscle Tumor/virology ; Superinfection ; Temporal Lobe/diagnostic imaging
    Chemical Substances Amphotericin B (7XU7A7DROE) ; Flucytosine (D83282DT06)
    Language English
    Publishing date 2022-02-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000028806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correlation of cerebellar granular layer autolysis with ante-mortem systemic acid-base status.

    Agarwal, Apeksha N / Gilbert, Andrea R / Mais, Daniel D

    Cell and tissue banking

    2021  Volume 22, Issue 3, Page(s) 505–509

    Abstract: Research in neuroscience relies heavily upon postmortem human brain tissue. Cerebellar granular layer autolysis (GLA) is a surrogate marker for the quality of such tissue and suitability for molecular analysis. GLA is associated with reduced brain tissue ...

    Abstract Research in neuroscience relies heavily upon postmortem human brain tissue. Cerebellar granular layer autolysis (GLA) is a surrogate marker for the quality of such tissue and suitability for molecular analysis. GLA is associated with reduced brain tissue pH. The aim of this study was to assess correlation of GLA with premortem systemic acid-base status. This is a retrospective study in which 62 consecutive adult autopsy cases were included. Sections of cerebellum were reviewed microscopically for presence of GLA. Autolysis was graded as negative, grade 1, grade 2, and grade 3. Medical records were reviewed for arterial blood gas analysis. Postmortem interval was recorded. 23 of 62 cases showed GLA. Of the 23 patients with autolysis, 22 were acidotic and 1 was alkalotic. Of these 23 cases, 15 had metabolic acidosis, 4 had respiratory acidosis, 3 had combined acidosis and 1 had respiratory alkalosis. There was no statistically significant difference in postmortem interval between the two groups. 10 cases with grade 3 autolysis had mean pH of 7.13, 7 cases with grade 2 autolysis had mean pH of 7.23 and in 6 cases with grade 1 autolysis the mean pH was 7.2. Overall, the mean pH in patients with GLA was 7.19, and in the non-autolytic cases the mean pH was 7.28 (P < 0.05). There was no correlation between the degree of acidosis and severity of autolysis. GLA is associated with premortem systemic acidosis, and premortem systemic alkalosis is associated with the absence of GLA. Premortem acid-base status may serve as an additional quality indicator for assessment of tissue for research.
    MeSH term(s) Adult ; Autolysis ; Autopsy ; Brain ; Cerebellum ; Humans ; Hydrogen-Ion Concentration ; Retrospective Studies
    Language English
    Publishing date 2021-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170897-6
    ISSN 1573-6814 ; 1389-9333
    ISSN (online) 1573-6814
    ISSN 1389-9333
    DOI 10.1007/s10561-021-09900-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Broadening the Age of Incidence of Intracranial Angiomatoid Fibrous Histiocytoma With EWSR1-CREM Fusion: A Case Report.

    Gilbert, Andrea R / Yan, Lei / McDougall, Cameron M

    Journal of neuropathology and experimental neurology

    2020  Volume 79, Issue 11, Page(s) 1244–1246

    MeSH term(s) Brain Neoplasms/epidemiology ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Cyclic AMP Response Element Modulator/genetics ; Histiocytoma, Benign Fibrous/epidemiology ; Histiocytoma, Benign Fibrous/genetics ; Histiocytoma, Benign Fibrous/pathology ; Humans ; Incidence ; Male ; Middle Aged ; Oncogene Proteins, Fusion/genetics ; RNA-Binding Protein EWS/genetics
    Chemical Substances CREM protein, human ; EWSR1 protein, human ; Oncogene Proteins, Fusion ; RNA-Binding Protein EWS ; Cyclic AMP Response Element Modulator (135844-64-3)
    Language English
    Publishing date 2020-10-20
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nlaa114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: COVID-19 Patients With CNS Complications and Neuropathologic Features of Acute Disseminated Encephalomyelitis and Acute Hemorrhagic Leukoencephalopathy.

    Walker, Jamie M / Gilbert, Andrea R / Bieniek, Kevin F / Richardson, Timothy E

    Journal of neuropathology and experimental neurology

    2021  Volume 80, Issue 6, Page(s) 628–631

    MeSH term(s) COVID-19/complications ; COVID-19/diagnostic imaging ; Encephalomyelitis, Acute Disseminated/diagnostic imaging ; Encephalomyelitis, Acute Disseminated/etiology ; Fatal Outcome ; Female ; Humans ; Leukoencephalitis, Acute Hemorrhagic/diagnostic imaging ; Leukoencephalitis, Acute Hemorrhagic/etiology ; Male ; Middle Aged ; Nervous System Diseases/diagnostic imaging ; Nervous System Diseases/etiology
    Language English
    Publishing date 2021-04-19
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nlab036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: When a Tumor Becomes a Legacy: A Collection of Perspectives.

    Lipsitt, Amanda E / DeForest, Patricia K / Canon, Andrea J / Gilbert, Andrea R / Tomlinson, Gail E

    Journal of palliative medicine

    2021  Volume 24, Issue 10, Page(s) 1572–1574

    MeSH term(s) Humans ; Neoplasms
    Language English
    Publishing date 2021-10-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2021.0138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Inactivation of foodborne pathogens by the synergistic combinations of food processing technologies and food‐grade compounds

    Zhang, Hongchao / Tikekar, Rohan V / Ding, Qiao / Gilbert, Andrea R / Wimsatt, Stratton T

    Comprehensive reviews in food science and food safety. 2020 July, v. 19, no. 4

    2020  

    Abstract: There is a need to develop food processing technologies with enhanced antimicrobial capacity against foodborne pathogens. While considering the challenges of adequate inactivation of pathogenic microorganisms in different food matrices, the emerging ... ...

    Abstract There is a need to develop food processing technologies with enhanced antimicrobial capacity against foodborne pathogens. While considering the challenges of adequate inactivation of pathogenic microorganisms in different food matrices, the emerging technologies are also expected to be sustainable and have a minimum impact on food quality and nutrients. Synergistic combinations of food processing technologies and food‐grade compounds have a great potential to address these needs. During these combined treatments, food processes directly or indirectly interact with added chemicals, intensifying the overall antimicrobial effect. This review provides an overview of the combinations of different thermal or nonthermal processes with a variety of food‐grade compounds that show synergistic antimicrobial effect against pathogenic microorganisms in foods and model systems. Further, we summarize the underlying mechanisms for representative combined treatments that are responsible for the enhanced microbial inactivation. Finally, regulatory issues and challenges for further development and technical transfer of these new approaches at the industrial level are also discussed.
    Keywords antimicrobial properties ; food matrix ; food pathogens ; food processing ; food safety ; heat treatment ; microorganisms ; model food systems ; nonthermal processing ; nutrients ; synergism
    Language English
    Dates of publication 2020-07
    Size p. 2110-2138.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note NALT-AP-4-rerunAP2-fuzzy ; JOURNAL ARTICLE
    ZDB-ID 2185829-9
    ISSN 1541-4337
    ISSN 1541-4337
    DOI 10.1111/1541-4337.12582
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Intrathecal Methotrexate-Induced Necrotizing Myelopathy: A Case Report and Review of Histologic Features.

    Tariq, Hamza / Gilbert, Andrea / Sharkey, Francis E

    Clinical medicine insights. Pathology

    2018  Volume 11, Page(s) 1179555718809071

    Abstract: Central nervous system (CNS) relapse of acute lymphoblastic leukemia (ALL) is associated with a poor prognosis. However, prophylactic measures, including intrathecal (IT) methotrexate, reduce the incidence of CNS relapse in these patients considerably. ... ...

    Abstract Central nervous system (CNS) relapse of acute lymphoblastic leukemia (ALL) is associated with a poor prognosis. However, prophylactic measures, including intrathecal (IT) methotrexate, reduce the incidence of CNS relapse in these patients considerably. Unfortunately, IT methotrexate can cause several neurologic complications, including transverse myelopathy; ie, the development of isolated spinal cord dysfunction over hours or days following the IT infusion of methotrexate, but in the absence of a compressive lesion. Transverse myelopathy following IT methotrexate is a well-established clinical phenomenon, but the histologic features have been described only very rarely. We report the autopsy findings from a 31-year-old man with a history of T-cell ALL who received prophylactic IT methotrexate in anticipation of a bone marrow transplant. Microscopic examination showed transverse necrosis of the thoracic cord, with massive infiltration by macrophages and lymphocytes, and perivascular lymphocytic infiltrates. There was cavitary necrosis of cervical and lumbar spinal cord involving the entire gray matter and focal white matter, as well as extensive subpial vacuolar degeneration of the dorsal and lateral columns.
    Language English
    Publishing date 2018-11-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2578761-5
    ISSN 1179-5557
    ISSN 1179-5557
    DOI 10.1177/1179555718809071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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