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Article ; Online: Time for Well-Powered Controlled Prospective Studies to Test a Causal Role for Herpes Viruses in Alzheimer's Disease Using Antiherpetic Drugs.

Goldschmidt-Clermont, Pascal J / Volinsky, Fred G / LaRosa, Steven P / Gilbert, John R / Periçak-Vance, Margaret A

The journals of gerontology. Series A, Biological sciences and medical sciences

2019 Volume 75, Issue 6, Page(s) 1058–1060

Abstract: Twenty-six phase III studies on Alzheimer's disease are ongoing or have been completed in 2018. Most of these studies are targeting amyloid-beta, its production, polymerization, and/or multiple interactions. None of the amyloid-beta studies seem to ... ...

Abstract	Twenty-six phase III studies on Alzheimer's disease are ongoing or have been completed in 2018. Most of these studies are targeting amyloid-beta, its production, polymerization, and/or multiple interactions. None of the amyloid-beta studies seem to affect positively the clinical outcome of patients with Alzheimer's disease thus far, no matter the advancement of disease. It is time to consider other hypotheses for the pathogenesis of Alzheimer's disease, including the potential role of human herpes viruses (HHV), and especially HHV1 (herpes simplex virus type 1), HHV3 (varicella zoster virus), HHV6A, and HHV7. With this perspective, we review the scientific evidence and make the case for appropriately powered, prospective, randomized, and controlled studies using an anti-HHV drug, to establish a causal role for HHV in Alzheimer's disease.
MeSH term(s)	Alzheimer Disease/etiology ; Alzheimer Disease/virology ; Antiviral Agents/therapeutic use ; Causality ; Herpesviridae ; Herpesviridae Infections/complications ; Herpesviridae Infections/drug therapy ; Humans ; Prospective Studies ; Randomized Controlled Trials as Topic
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2019-05-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glz150
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Article ; Online: Three Brothers With Autism Carry a Stop-Gain Mutation in the HPA-Axis Gene NR3C2.

Cukier, Holly N / Griswold, Anthony J / Hofmann, Natalia K / Gomez, Lissette / Whitehead, Patrice L / Abramson, Ruth K / Gilbert, John R / Cuccaro, Michael L / Dykxhoorn, Derek M / Pericak-Vance, Margaret A

Autism research : official journal of the International Society for Autism Research

2020 Volume 13, Issue 4, Page(s) 523–531

Abstract: Whole exome sequencing and copy-number variant analysis was performed on a family with three brothers diagnosed with autism. Each of the siblings shares an alteration in the nuclear receptor subfamily 3 group C member 2 (NR3C2) gene that is predicted to ... ...

Abstract	Whole exome sequencing and copy-number variant analysis was performed on a family with three brothers diagnosed with autism. Each of the siblings shares an alteration in the nuclear receptor subfamily 3 group C member 2 (NR3C2) gene that is predicted to result in a stop-gain mutation (p.Q919X) in the mineralocorticoid receptor (MR) protein. This variant was maternally inherited and provides further evidence for a connection between the NR3C2 and autism. Interestingly, the NR3C2 gene encodes the MR protein, a steroid hormone-regulated transcription factor that acts in the hypothalamic-pituitary-adrenal axis and has been connected to stress and anxiety, both of which are features often seen in individuals with autism. Autism Res 2020, 13: 523-531. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Given the complexity of the genetics underlying autism, each gene contributes to risk in a relatively small number of individuals, typically less than 1% of all autism cases. Whole exome sequencing of three brothers with autism identified a rare variant in the nuclear receptor subfamily 3 group C member 2 gene that is predicted to strongly interfere with its normal function. This gene encodes the mineralocorticoid receptor protein, which plays a role in how the body responds to stress and anxiety, features that are often elevated in people diagnosed with autism. This study adds further support to the relevance of this gene as a risk factor for autism.
MeSH term(s)	Autism Spectrum Disorder/genetics ; Child, Preschool ; Humans ; Hypothalamo-Hypophyseal System ; Male ; Mutation/genetics ; Pituitary-Adrenal System ; Receptors, Mineralocorticoid/genetics ; Siblings
Chemical Substances	NR3C2 protein, human ; Receptors, Mineralocorticoid
Language	English
Publishing date	2020-02-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2481338-2
ISSN	1939-3806 ; 1939-3792
ISSN (online)	1939-3806
ISSN	1939-3792
DOI	10.1002/aur.2269
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Article ; Online: Novel approach for independent control of brain hypothermia and systemic normothermia: cerebral selective deep hypothermia for refractory cardiac arrest.

Wang, Chih-Hsien / Lin, Yu-Ting / Chou, Heng-Wen / Wang, Yi-Chih / Hwang, Joey-Jen / Gilbert, John R / Chen, Yih-Sharng

BMJ case reports

2017 Volume 2017

Abstract: A 38-year-old man was found unconscious, alone in the driver's seat of his car. The emergency medical team identified his condition as pulseless ventricular tachycardia. Defibrillation was attempted but failed. Extracorporeal membrane oxygenation (ECMO) ... ...

Abstract	A 38-year-old man was found unconscious, alone in the driver's seat of his car. The emergency medical team identified his condition as pulseless ventricular tachycardia. Defibrillation was attempted but failed. Extracorporeal membrane oxygenation (ECMO) was started in the emergency room 52 min after the estimated arrest following the extracorporeal cardiopulmonary resuscitation (ECPR) protocol in our center. The initial prognosis under the standard protocol was <25% chance of survival. A novel adjunctive to our ECPR protocol, cerebral selective deep (<30°C) hypothermia (CSDH), was applied. CSDH adds a second independent femoral access extracorporeal circuit, perfusing cold blood into the patient's common carotid artery. The ECMO and CSDH circuits demonstrated independent control of cerebral and core temperatures. Nasal temperature was lowered to below 30°C for 12 hours while core was maintained at normothermia. The patient was discharged without significant neurological deficit 32 days after the initial arrest.
MeSH term(s)	Adult ; Brugada Syndrome/complications ; Brugada Syndrome/diagnosis ; Brugada Syndrome/therapy ; Cerebrovascular Circulation ; Defibrillators, Implantable ; Electric Countershock ; Extracorporeal Membrane Oxygenation/methods ; Heart Arrest/therapy ; Humans ; Hypothermia, Induced/methods ; Male ; Tachycardia, Ventricular/etiology ; Tachycardia, Ventricular/therapy
Language	English
Publishing date	2017-01-20
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2016-012806
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Article ; Online: Identification of rare noncoding sequence variants in gamma-aminobutyric acid A receptor, alpha 4 subunit in autism spectrum disorder.

Griswold, Anthony J / Van Booven, Derek / Cuccaro, Michael L / Haines, Jonathan L / Gilbert, John R / Pericak-Vance, Margaret A

Neurogenetics

2017 Volume 19, Issue 1, Page(s) 17–26

Abstract: Alterations of the gamma-aminobutyric acid (GABA) signaling system has been strongly linked to the pathophysiology of autism spectrum disorder (ASD). Genetic associations of common variants in GABA receptor subunits, in particular GABRA4 on chromosome ... ...

Abstract	Alterations of the gamma-aminobutyric acid (GABA) signaling system has been strongly linked to the pathophysiology of autism spectrum disorder (ASD). Genetic associations of common variants in GABA receptor subunits, in particular GABRA4 on chromosome 4p12, with ASD have been replicated by several studies. Moreover, molecular investigations have identified altered transcriptional and translational levels of this gene and protein in brains of ASD individuals. Since the genotyped common variants are likely not the functional variants contributing to the molecular consequences or underlying ASD phenotype, this study aims to examine rare sequence variants in GABRA4, including those outside the protein coding regions of the gene. We comprehensively re-sequenced the entire protein coding and noncoding portions of the gene and putative regulatory sequences in 82 ASD individuals and 55 developmentally typical pediatric controls, all homozygous for the most significant previously associated ASD risk allele (G/G at rs1912960). We identified only a single common, coding variant, and no association of any single marker or set of variants with ASD. Functional annotation of noncoding variants identified several rare variants in putative regulatory sites. Finally, a rare variant unique to ASD cases, in an evolutionary conserved site of the 3'UTR, shows a trend toward decreasing gene expression. Hence, GABRA4 rare variants in noncoding DNA may be variants of modest physiological effects in ASD etiology.
MeSH term(s)	3' Untranslated Regions ; Adolescent ; Adult ; Alleles ; Autism Spectrum Disorder/genetics ; Child ; Child, Preschool ; Chromosomes, Human, Pair 4/genetics ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Polymorphism, Single Nucleotide ; Protein Subunits/genetics ; Receptors, GABA-A/genetics ; White People/genetics ; Young Adult
Chemical Substances	3' Untranslated Regions ; Protein Subunits ; Receptors, GABA-A
Language	English
Publishing date	2017-11-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1339887-8
ISSN	1364-6753 ; 1364-6745
ISSN (online)	1364-6753
ISSN	1364-6745
DOI	10.1007/s10048-017-0529-1
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Article ; Online: Novel approach for independent control of brain hypothermia and systemic normothermia: cerebral selective deep hypothermia for refractory cardiac arrest.

Wang, Chih-Hsien / Lin, Yu-Ting / Chou, Heng-Wen / Wang, Yi-Chih / Hwang, Joey-Jen / Gilbert, John R / Chen, Yih-Sharng

Journal of neurointerventional surgery

2017 Volume 9, Issue 8, Page(s) e32

Abstract	A 38-year-old man was found unconscious, alone in the driver's seat of his car. The emergency medical team identified his condition as pulseless ventricular tachycardia. Defibrillation was attempted but failed. Extracorporeal membrane oxygenation (ECMO) was started in the emergency room 52 min after the estimated arrest following the extracorporeal cardiopulmonary resuscitation (ECPR) protocol in our center. The initial prognosis under the standard protocol was <25% chance of survival. A novel adjunctive to our ECPR protocol, cerebral selective deep (<30°C) hypothermia (CSDH), was applied. CSDH adds a second independent femoral access extracorporeal circuit, perfusing cold blood into the patient's common carotid artery. The ECMO and CSDH circuits demonstrated independent control of cerebral and core temperatures. Nasal temperature was lowered to below 30°C for 12 hours while core was maintained at normothermia. The patient was discharged without significant neurological deficit 32 days after the initial arrest.
Language	English
Publishing date	2017-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/neurintsurg-2016-012806.rep
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Book ; Online: Highly Parallel Sparse Matrix-Matrix Multiplication

Buluç, Aydın / Gilbert, John R.

2010

Abstract: Generalized sparse matrix-matrix multiplication is a key primitive for many high performance graph algorithms as well as some linear solvers such as multigrid. We present the first parallel algorithms that achieve increasing speedups for an unbounded ... ...

Abstract	Generalized sparse matrix-matrix multiplication is a key primitive for many high performance graph algorithms as well as some linear solvers such as multigrid. We present the first parallel algorithms that achieve increasing speedups for an unbounded number of processors. Our algorithms are based on two-dimensional block distribution of sparse matrices where serial sections use a novel hypersparse kernel for scalability. We give a state-of-the-art MPI implementation of one of our algorithms. Our experiments show scaling up to thousands of processors on a variety of test scenarios.
Keywords	Computer Science - Distributed ; Parallel ; and Cluster Computing ; Computer Science - Mathematical Software ; Computer Science - Performance ; Mathematics - Numerical Analysis
Publishing date	2010-06-10
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Linkage of familial essential tremor to chromosome 5q35.

Hicks, James E / Konidari, Ioanna / Scott, Burton L / Stajich, Jeffrey M / Ashley-Koch, Allison E / Gilbert, John R / Scott, William K

Movement disorders : official journal of the Movement Disorder Society

2016 Volume 31, Issue 7, Page(s) 1059–1062

Abstract: Background: Essential tremor is a neurological condition characterized by tremor during voluntary movement. To date, 3 loci linked to familial essential tremor have been identified.: Methods: We examined 48 essential tremor patients in 5 large ... ...

Abstract	Background: Essential tremor is a neurological condition characterized by tremor during voluntary movement. To date, 3 loci linked to familial essential tremor have been identified. Methods: We examined 48 essential tremor patients in 5 large essential tremor pedigrees in our data set for genetic linkage using an Affymetrix Axiom array. Linkage analysis was performed using an affecteds-only dominant model in SIMWALK2. To incorporate all genotype information, GERMLINE was used to identify genome segments shared identical-by-descent in pairs of affecteds. Exome sequencing was performed in pedigrees showing evidence of linkage. Results: For one family, chromosomes 5 and 18 showed genome-wide significant linkage to essential tremor. Shared segment analysis excluded the 18p11 candidate region and reduced the 5q35 region by 1 megabase. Exome sequencing did not identify a potential causative variant in this region. Conclusion: A locus on chromosome 5 is linked to essential tremor. Further research is needed to identify a causative variant. © 2016 International Parkinson and Movement Disorder Society.
MeSH term(s)	Chromosomes, Human, Pair 5/genetics ; Essential Tremor/genetics ; Genetic Linkage ; Genetic Loci ; Humans ; Pedigree
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.26582
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Zs.A 2555: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Book: Sparse matrices in MATLAB: design and implementation

Gilbert, John R

(CSL / XEROX Palo Alto Research Center ; 91,4)

1991

Author's details	John R. Gilbert
Series title	CSL / XEROX Palo Alto Research Center ; 91,4
Language	English
Size	47 S., graph. Darst.
Publisher	XEROX Corp., Palo Alto Research Center
Publishing place	Palo Alto, Calif
Document type	Book
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Conference proceedings ; Online: SWAT 90

Gilbert, John R

2nd Scandinavian Workshop on Algorithm Theory, Bergen, Sweden, July 11 - 14, 1990 ; proceedings

(Lecture notes in computer science ; 447)

1990

Institution	SWAT
Event/congress	SWAT (2, 1990.07.11-14, Bergen) ; Scandinavian Workshop on Algorithm Theory (2, 1990.07.11-14, Bergen)
Author's details	J. R. Gilbert ... (eds.)
Series title	Lecture notes in computer science ; 447
Keywords	Combinatorics ; Computer science ; Computer software ; Data structures (Computer science) ; Distribution (Probability theory) ; Statistics ; Algorithmentheorie
Language	English
Size	Online-Ressource (VI, 417 S.)
Publisher	Springer
Publishing place	Berlin u.a.
Document type	Book ; Conference proceedings ; Online
Note	Literaturangaben
ISBN	3540528466 ; 9783540471646 ; 9783540528463 ; 3540471642
DOI	10.1007/3-540-52846-6
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Conference proceedings ; Online: SWAT 90

Gilbert, John R

2nd Scandinavian Workshop on Algorithm Theory, Bergen, Sweden, July 11 - 14, 1990 ; proceedings

(Lecture notes in computer science ; 447)

1990

Institution	SWAT
Event/congress	SWAT (2, 1990.07.11-14, Bergen) ; Scandinavian Workshop on Algorithm Theory (2, 1990.07.11-14, Bergen)
Author's details	J. R. Gilbert ... (eds.)
Series title	Lecture notes in computer science ; 447
Keywords	Combinatorics ; Computer science ; Computer software ; Data structures (Computer science) ; Distribution (Probability theory) ; Statistics ; Algorithmentheorie
Language	English
Size	Online-Ressource (VI, 417 S.)
Publisher	Springer
Publishing place	Berlin u.a.
Document type	Book ; Conference proceedings ; Online
Note	Literaturangaben
ISBN	3540528466 ; 9783540471646 ; 9783540528463 ; 3540471642
DOI	10.1007/3-540-52846-6
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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