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  1. Article ; Online: Diabetic kidney disease 2.0: the treatment paradigm shifts.

    Gilbert, Richard E

    The lancet. Diabetes & endocrinology

    2019  Volume 7, Issue 11, Page(s) 820–821

    MeSH term(s) Diabetes Mellitus, Type 2 ; Diabetic Nephropathies ; Humans ; Renal Insufficiency ; Sodium-Glucose Transporter 2 Inhibitors
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2019-09-05
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(19)30253-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Finerenone in diabetic kidney disease - So far, so good.

    Gilbert, Richard E

    Journal of diabetes and its complications

    2017  Volume 31, Issue 4, Page(s) 651–652

    MeSH term(s) Diabetes Mellitus, Type 2 ; Diabetic Nephropathies ; Heart Failure ; Humans ; Naphthyridines
    Chemical Substances Naphthyridines ; finerenone
    Language English
    Publishing date 2017-01-20
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1105840-7
    ISSN 1873-460X ; 1056-8727
    ISSN (online) 1873-460X
    ISSN 1056-8727
    DOI 10.1016/j.jdiacomp.2016.12.012
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    Zs.A 2225: Show issues Location:
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  3. Article ; Online: Proximal Tubulopathy: Prime Mover and Key Therapeutic Target in Diabetic Kidney Disease.

    Gilbert, Richard E

    Diabetes

    2017  Volume 66, Issue 4, Page(s) 791–800

    Abstract: The current view of diabetic kidney disease, based on meticulously acquired ultrastructural morphometry and the utility of measuring plasma creatinine and urinary albumin, has been almost entirely focused on the glomerulus. While clearly of great ... ...

    Abstract The current view of diabetic kidney disease, based on meticulously acquired ultrastructural morphometry and the utility of measuring plasma creatinine and urinary albumin, has been almost entirely focused on the glomerulus. While clearly of great importance, changes in the glomerulus are not the major determinant of renal prognosis in diabetes and may not be the primary event in the development of diabetic kidney disease either. Indeed, advances in biomarker discovery and a greater appreciation of tubulointerstitial histopathology and the role of tubular hypoxia in the pathogenesis of chronic kidney disease have given us pause to reconsider the current "glomerulocentric" paradigm and focus attention on the proximal tubule that by virtue of the high energy requirements and reliance on aerobic metabolism render it particularly susceptible to the derangements of the diabetic state. Such findings raise important issues for therapeutic advances specifically targeting the pathophysiological perturbations that develop in this part of the nephron.
    MeSH term(s) Apoptosis ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/physiopathology ; Disease Progression ; Fibrosis ; Humans ; Hypoxia/metabolism ; Hypoxia/physiopathology ; Ischemia/metabolism ; Ischemia/physiopathology ; Kidney Glomerulus/metabolism ; Kidney Glomerulus/physiopathology ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/physiopathology ; Mitochondria/metabolism ; Oxygen Consumption ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/physiopathology
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db16-0796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.175: Show issues Location:
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  4. Article ; Online: SGLT2 inhibitors: β blockers for the kidney?

    Gilbert, Richard E

    The lancet. Diabetes & endocrinology

    2016  Volume 4, Issue 10, Page(s) 814

    Language English
    Publishing date 2016-10
    Publishing country England
    Document type Letter
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(16)30237-6
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  5. Article ; Online: Heart failure: fatal, forgotten, and frequent in type 1 diabetes too.

    Gilbert, Richard E

    The lancet. Diabetes & endocrinology

    2015  Volume 3, Issue 11, Page(s) 832–834

    MeSH term(s) Diabetes Mellitus, Type 1/epidemiology ; Female ; Heart Failure/epidemiology ; Humans ; Male
    Language English
    Publishing date 2015-11
    Publishing country England
    Document type Comment ; Journal Article
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(15)00329-0
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  6. Article ; Online: Reduction in the incidence of myocardial infarction with sodium-glucose linked cotransporter-2 inhibitors: evident and plausible.

    Gilbert, Richard E / Connelly, Kim A

    Cardiovascular diabetology

    2019  Volume 18, Issue 1, Page(s) 6

    MeSH term(s) Animals ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/metabolism ; Evidence-Based Medicine ; Humans ; Incidence ; Myocardial Infarction/epidemiology ; Myocardial Infarction/metabolism ; Myocardial Infarction/prevention & control ; Protective Factors ; Risk Assessment ; Risk Factors ; Sodium-Glucose Transporter 2/drug effects ; Sodium-Glucose Transporter 2/metabolism ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Treatment Outcome
    Chemical Substances SLC5A2 protein, human ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2019-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2093769-6
    ISSN 1475-2840 ; 1475-2840
    ISSN (online) 1475-2840
    ISSN 1475-2840
    DOI 10.1186/s12933-019-0812-6
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  7. Article ; Online: Acute kidney injury with sodium-glucose co-transporter-2 inhibitors: A meta-analysis of cardiovascular outcome trials.

    Gilbert, Richard E / Thorpe, Kevin E

    Diabetes, obesity & metabolism

    2019  Volume 21, Issue 8, Page(s) 1996–2000

    Abstract: Three, multicentre, large-scale, randomized, placebo-controlled trials of cardiovascular outcomes with sodium-glucose co-transporter-2 (SGLT2) inhibitors have each shown substantial reductions in rates of hospitalization for heart failure and progression ...

    Abstract Three, multicentre, large-scale, randomized, placebo-controlled trials of cardiovascular outcomes with sodium-glucose co-transporter-2 (SGLT2) inhibitors have each shown substantial reductions in rates of hospitalization for heart failure and progression of chronic kidney disease in people with type 2 diabetes. However, safety concerns remain for this ostensibly paradigm-shifting drug class. In particular, the US Food and Drug Administration has highlighted the risk of acute kidney injury (AKI), a condition associated with high morbidity and mortality. To investigate this further, we conducted a meta-analysis of the three trials to compare the frequency of AKI adverse event reports between participants treated with placebo and those who had received an SGLT2 inhibitor. Rather than an increase, we noted a consistent and robust reduction in the likelihood of AKI among those participants who had been randomized to receive an SGLT2 inhibitor (hazard ratio 0.66, 95% confidence interval 0.54-0.80). We further noted that the reports of AKI were similar in frequency to those of kidney disease progression. The caveats of the non-adjudicated reporting of AKI in the trials notwithstanding, these data suggest that SGLT2 inhibitors may protect vulnerable patients with type 2 diabetes from AKI and that prospective studies to evaluate this additional aspect of kidney protection are warranted.
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Acute Kidney Injury/chemically induced ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/adverse effects ; Kidney/drug effects ; Proportional Hazards Models ; Randomized Controlled Trials as Topic ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Multicenter Studies as Topic
    Chemical Substances Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2019-05-24
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.13754
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    Zs.A 5442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Heart failure in SAVOR-TIMI 53: The hindsight of diabetic retinopathy.

    Gilbert, Richard E

    Journal of diabetes

    2015  Volume 7, Issue 3, Page(s) 304–306

    MeSH term(s) Adamantane/adverse effects ; Adamantane/analogs & derivatives ; Diabetic Nephropathies/complications ; Diabetic Nephropathies/drug therapy ; Dipeptides/adverse effects ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Heart Failure/chemically induced ; Humans
    Chemical Substances Dipeptides ; Dipeptidyl-Peptidase IV Inhibitors ; saxagliptin (9GB927LAJW) ; Adamantane (PJY633525U)
    Language English
    Publishing date 2015-05
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2503337-2
    ISSN 1753-0407 ; 1753-0393
    ISSN (online) 1753-0407
    ISSN 1753-0393
    DOI 10.1111/1753-0407.12249
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    Zs.A 6791: Show issues Location:
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  9. Article ; Online: Preconception SGLT2 or DPP4 inhibitor use and adverse pregnancy outcomes.

    Ray, Joel G / Harel, Ziv / Gilbert, Richard E / Wald, Ron / Berger, Howard / Park, Alison L

    Diabetes research and clinical practice

    2023  Volume 205, Page(s) 110946

    Abstract: Aims: To compare preconception use of sodium-glucose cotransporter-2 (SGLT2i) and dipeptidyl peptidase-4 (DPP4i) inhibitors to sulfonylurea agents, and associated peri-conceptional A1c concentration, and risk of pregnancy loss and congenital anomalies.!# ...

    Abstract Aims: To compare preconception use of sodium-glucose cotransporter-2 (SGLT2i) and dipeptidyl peptidase-4 (DPP4i) inhibitors to sulfonylurea agents, and associated peri-conceptional A1c concentration, and risk of pregnancy loss and congenital anomalies.
    Methods: This population-based cohort study used administrative datasets for all of Ontario, Canada, and included women eligible for free medication coverage and who achieved a recognized pregnancy from April 2007-November 2021. Exposure was a SGLT2i, DPP4i or sulfonylurea (referent) dispensed at least 90 days preconception. Study outcomes included differences in periconceptional A1c; miscarriage, induced abortion, or stillbirth; and any congenital anomaly - the latter two outcomes assessed using propensity score overlap weighting.
    Results: The mean (SD) periconceptional A1c was 8.1 % (2.0) among those prescribed any sulfonylurea, compared with 8.3 % (2.0) with a DPP4i and 7.8 % (1.6) with any SGLT2i. The risk of pregnancy loss was lowest among those exclusively prescribed a SGLT2i (relative risk [RR] 0.51, 95 % CI 0.22 to 0.91). Risk of a congenital anomaly at birth did not differ significantly comparing DPP4i or SGLT2i to sulfonylurea agents.
    Conclusions: Neither SGLT2i nor DPP4i use before pregnancy was associated with a difference in A1c, or a higher risk of selective adverse outcomes, compared to sulfonylureas. Future larger studies are required, including assessment of medication use after conception, during the critical period of embryogenesis.
    MeSH term(s) Infant, Newborn ; Pregnancy ; Female ; Humans ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Cohort Studies ; Diabetes Mellitus, Type 2/drug therapy ; Glycated Hemoglobin ; Pregnancy Outcome ; Sodium-Glucose Transporter 2/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Hypoglycemic Agents/therapeutic use ; Sulfonylurea Compounds/therapeutic use ; Retrospective Studies
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors ; Glycated Hemoglobin ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors ; Hypoglycemic Agents ; Sulfonylurea Compounds
    Language English
    Publishing date 2023-10-07
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2023.110946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2047: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: The perils of clinical trials.

    Gilbert, Richard E

    Kidney international

    2014  Volume 85, Issue 4, Page(s) 745–747

    Abstract: When the maximal reabsorptive capacity for glucose is lowered by blockade of the activity of sodium-glucose cotransporter-2 (SGLT2), glucosuria occurs in proportion to the plasma glucose and glomerular filtration rate. Accordingly, the modest, 0.44%, ... ...

    Abstract When the maximal reabsorptive capacity for glucose is lowered by blockade of the activity of sodium-glucose cotransporter-2 (SGLT2), glucosuria occurs in proportion to the plasma glucose and glomerular filtration rate. Accordingly, the modest, 0.44%, hemoglobin A1c reduction found by Kohan et al. in diabetic patients with relatively good glycemic control and chronic kidney disease stage 3 treated with an SGLT2 inhibitor might have been anticipated. The 0.32% fall in hemoglobin A1c in the placebo group, however, seems less expected.
    MeSH term(s) Benzhydryl Compounds ; Diabetes Mellitus, Type 2/drug therapy ; Diabetic Nephropathies/blood ; Female ; Glucosides/therapeutic use ; Humans ; Male
    Chemical Substances Benzhydryl Compounds ; Glucosides ; dapagliflozin (1ULL0QJ8UC)
    Language English
    Publishing date 2014-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/ki.2013.406
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    Zs.A 797: Show issues Location:
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