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  1. Book ; Online ; E-Book: Standards for ocular toxicology and inflammation

    Gilger, Brian C. / Cook, Cynthia S. / Brown, Michael H.

    2018  

    Author's details Brian C. Gilger, Cynthia S. Cook, Michael H. Brown editors
    Keywords Medicine ; Pharmacology ; Ophthalmology
    Language English
    Size 1 Online-Ressource (ix, 212 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019828183
    ISBN 978-3-319-78364-2 ; 9783319783635 ; 3-319-78364-5 ; 3319783637
    DOI 10.1007/978-3-319-78364-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: How study of naturally occurring ocular disease in animals improves ocular health globally.

    Gilger, Brian C

    Journal of the American Veterinary Medical Association

    2022  Volume 260, Issue 15, Page(s) 1887–1893

    Abstract: In this article, which is part of the Currents in One Health series, the role of naturally occurring ocular disease in animals is reviewed with emphasis on how the understanding of these ocular diseases contributes to one health initiatives, particularly ...

    Abstract In this article, which is part of the Currents in One Health series, the role of naturally occurring ocular disease in animals is reviewed with emphasis on how the understanding of these ocular diseases contributes to one health initiatives, particularly the pathogenesis and treatment of ocular diseases common to animals and humans. Animals spontaneously develop ocular diseases that closely mimic those in humans, especially dry eye disease, herpes virus infection (cats), fungal keratitis (horses), bacterial keratoconjunctivitis, uveitis, and glaucoma. Both uveitis and glaucoma are common in domestic animals and humans, and many similarities exist in pathogenesis, genetics, and response to therapy. Furthermore, the study of inherited retinal disease in animals has particularly epitomized the one health concept, specifically the collaborative efforts of multiple disciplines working to attain optimal health for people and animals. Through this study of retinal disease in dogs, innovative therapies such as gene therapy have been developed. A unique opportunity exists to study ocular disease in shared environments to better understand the interplay between the environment, genetics, and ocular disease in both animals and humans. The companion Currents in One Health by Gilger, AJVR, December 2022, addresses in more detail recent studies of noninfectious immune-mediated animal ocular disease and their role in advancing ocular health globally.
    MeSH term(s) Humans ; Horses ; Cats ; Animals ; Dogs ; Eye ; Uveitis/epidemiology ; Uveitis/therapy ; Uveitis/veterinary ; Glaucoma/veterinary ; Retinal Diseases/veterinary ; Corneal Ulcer/veterinary ; Cat Diseases ; Dog Diseases/epidemiology ; Dog Diseases/therapy ; Horse Diseases/pathology
    Language English
    Publishing date 2022-10-04
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
    DOI 10.2460/javma.22.08.0383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 423: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Developing advanced therapeutics through the study of naturally occurring immune-mediated ocular disease in domestic animals.

    Gilger, Brian C

    American journal of veterinary research

    2022  Volume 83, Issue 11

    Abstract: This review, which is part of the "Currents in One Health" series, describes the importance of the study of immune-mediated ocular disease in the development of innovative therapeutics, such as cell and gene therapy for the eye. Recent examples of cell ... ...

    Abstract This review, which is part of the "Currents in One Health" series, describes the importance of the study of immune-mediated ocular disease in the development of innovative therapeutics, such as cell and gene therapy for the eye. Recent examples of cell and gene therapy studies from the author's laboratory are reviewed to emphasize the importance of One Health initiatives in developing innovative therapies for ocular diseases. Spontaneous immune-mediated corneal disease is common in horses, cats, dogs, and humans. Autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) injected subconjunctivally resulted in the resolution of naturally occurring immune-mediated keratitis (IMMK) without adverse effects. These results support that autologous subconjunctival BM-MSC therapy may be a viable treatment alternative for IMMK. Furthermore, the use of subconjunctival MSCs may be an effective method to treat ocular surface immune-mediated diseases in humans and other species, including herpetic stromal keratitis and immunologic dry eye disease. Furthermore, the use of adeno-associated viral (AAV) vectors to deliver the immunosuppressive transgene cDNA of equine interleukin 10 (eqIL-10) or human leukocyte antigen G injected intravitreally was shown to be safe and inhibited the development of uveitis in the experimental autoimmune uveitis rat model. Efficacy and safety studies of ocular gene therapy in models will pave the way for clinical trials in animals with naturally occurring immune-mediated diseases, such as a therapeutic clinical trial for AAV-eqIL-10 in horses with equine recurrent uveitis.
    MeSH term(s) Horses ; Animals ; Humans ; Rats ; Cats ; Dogs ; Animals, Domestic ; Eye ; Mesenchymal Stem Cells ; Keratitis/metabolism ; Keratitis/veterinary ; Uveitis/therapy ; Uveitis/veterinary ; Cat Diseases ; Dog Diseases/metabolism ; Horse Diseases/therapy ; Horse Diseases/metabolism
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 390796-x
    ISSN 1943-5681 ; 0002-9645
    ISSN (online) 1943-5681
    ISSN 0002-9645
    DOI 10.2460/ajvr.22.08.0145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 422: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Therapeutic Applications of Adeno-Associated Virus (AAV) Gene Transfer of HLA-G in the Eye.

    Gilger, Brian C / Hirsch, Matthew L

    International journal of molecular sciences

    2022  Volume 23, Issue 7

    Abstract: The purpose of this paper is to review human leukocyte antigen G (HLA-G) in the eye, its role in immune tolerance, and the potential therapeutic use of AAV gene transfer and expression of HLA-G in various ocular tissues. Several studies are reviewed that ...

    Abstract The purpose of this paper is to review human leukocyte antigen G (HLA-G) in the eye, its role in immune tolerance, and the potential therapeutic use of AAV gene transfer and expression of HLA-G in various ocular tissues. Several studies are reviewed that demonstrate efficacy in animal models of disease, including intracorneal delivery of AAV-HLA-G to treat corneal inflammation and prevent corneal graft rejection, subconjunctival injection of AAV-HLA-G for ocular graft vs. host disease and potentially dry eye disease, and intravitreal injection of AAV-HLA-G to inhibit uveitis. Furthermore, due to the anti-vascular function of HLA-G, AAV-HLA-G may be an effective therapy for posterior ocular diseases, such as neovascular age-related macular degeneration, diabetic retinopathy, and choroidal neovascularization. Therefore, AAV-mediated gene transfer of HLA-G may be an effective treatment for common immune-mediated, inflammatory, and neovascular diseases of the eye.
    MeSH term(s) Animals ; Choroidal Neovascularization/genetics ; Dependovirus/genetics ; Genetic Therapy ; Genetic Vectors/genetics ; HLA-G Antigens/genetics
    Chemical Substances HLA-G Antigens
    Language English
    Publishing date 2022-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23073465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Immune Relevant Models for Ocular Inflammatory Diseases.

    Gilger, Brian C

    ILAR journal

    2018  Volume 59, Issue 3, Page(s) 352–362

    Abstract: Ocular inflammatory diseases, such as dry eye and uveitis, are common, painful, difficult to treat, and may result in vision loss or blindness. Ocular side effects from the use of antiinflammatory drugs (such as corticosteroids or nonsteroidal ... ...

    Abstract Ocular inflammatory diseases, such as dry eye and uveitis, are common, painful, difficult to treat, and may result in vision loss or blindness. Ocular side effects from the use of antiinflammatory drugs (such as corticosteroids or nonsteroidal antiinflammatories) to treat ocular inflammation have prompted development of more specific and safer medications to treat inflammatory and immune-mediated diseases of the eye. To assess the efficacy and safety of these new therapeutics, appropriate immune-relevant animal models of ocular inflammation are needed. Both induced and naturally-occurring models have been described, but the most valuable for translating treatments to the human eye are the animal models of spontaneous, immunologic ocular disease, such as those with dry eye or uveitis. The purpose of this review is to describe common immune-relevant models of dry eye and uveitis with an overview of the immuno-pathogenesis of each disease and reported evaluation of models from small to large animals. We will also review a selected group of naturally-occurring large animal models, equine uveitis and canine dry eye, that have promise to translate into a better understanding and treatment of clinical immune-relevant ocular disease in man.
    MeSH term(s) Animals ; Disease Models, Animal ; Eye Diseases/immunology ; Inflammation/immunology ; Uveitis/immunology
    Language English
    Publishing date 2018-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2192062-X
    ISSN 1930-6180 ; 1084-2020
    ISSN (online) 1930-6180
    ISSN 1084-2020
    DOI 10.1093/ilar/ily002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Advanced Imaging of the Equine Eye.

    Gilger, Brian C

    The Veterinary clinics of North America. Equine practice

    2017  Volume 33, Issue 3, Page(s) 607–626

    Abstract: This article reviews the literature for studies describing advanced imaging of the equine eye as a reference for practitioners to help in the selection of image modalities, describe how to use the instruments, and help interpret the image findings. ... ...

    Abstract This article reviews the literature for studies describing advanced imaging of the equine eye as a reference for practitioners to help in the selection of image modalities, describe how to use the instruments, and help interpret the image findings. Indications for, technique of, and image interpretation of advanced image modalities such as ultrasound, computed tomography, MRI, optical coherence tomography, confocal microscopy, and angiography are reviewed. The article is organized anatomically, not by instrument, so that the reader will be able to quickly research ways to image specific disease entities or anatomic locations that are affecting their equine patients.
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 286049-1
    ISSN 1558-4224 ; 0749-0739
    ISSN (online) 1558-4224
    ISSN 0749-0739
    DOI 10.1016/j.cveq.2017.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 1109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Phase-Dependent Differential In Vitro and Ex Vivo Susceptibility of

    Roberts, Darby / Salmon, Jacklyn / Cubeta, Marc A / Gilger, Brian C

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 10

    Abstract: Fungal keratitis (FK) is an invasive infection of the cornea primarily associated ... ...

    Abstract Fungal keratitis (FK) is an invasive infection of the cornea primarily associated with
    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9100966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Equine ophthalmology

    Gilger, Brian C

    2017  

    Author's details edited by Brian C. Gilger
    MeSH term(s) Horse Diseases ; Eye Diseases/veterinary
    Language English
    Size vii, 671 pages :, illustrations
    Edition Third edition.
    Document type Book
    Note Preceded by: Equine ophthalmology / Brian C. Gilger. 2nd ed. c2011.
    ISBN 9781119047742 ; 9781119047858 ; 9781119047995 ; 1119047749 ; 1119047854 ; 1119047994
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article: Efficacy and safety of suprachoroidal triamcinolone injection in horses with poorly responsive equine recurrent uveitis

    Gagnon, Nicole A / Hartley, Claudia / Gilger, Brian C

    Veterinary ophthalmology. 2021 May, v. 24, no. 3

    2021  

    Abstract: OBJECTIVE: Equine recurrent uveitis (ERU), a chronic, immune‐mediated intraocular inflammatory disease, is a common cause of blindness in horses. The severity and recurrent nature of ERU makes it difficult to treat with current therapeutics leading to a ... ...

    Abstract OBJECTIVE: Equine recurrent uveitis (ERU), a chronic, immune‐mediated intraocular inflammatory disease, is a common cause of blindness in horses. The severity and recurrent nature of ERU makes it difficult to treat with current therapeutics leading to a poor visual prognosis. The suprachoroidal space (SCS), a potential space between the choroid and sclera surrounding the ocular posterior segment, offers a promising alternative site for drug application to the eye. Corticosteroid administration within this space is hypothesized to be safe and effective at controlling intraocular inflammation, especially in horses with poorly responsive ERU. ANIMAL STUDIED: Horses with active, poorly responsive ERU. PROCEDURE(S): A retrospective study was performed with 29 horses (36 total eyes) that received SCS injection of triamcinolone acetonide (TA) with ERU not well controlled with standard uveitis treatment. A standardized ocular inflammation score (OIS) was used to assess inflammation at the time of injection and at follow‐ups. RESULTS: Standardized OIS revealed a significant decrease in ocular inflammation over time after SCS TA administration (p < .004). Adverse effects after injections occurred in <20% of the horses at follow‐up, but some of these effects were attributed to chronic inflammation prior to effective treatment, long‐term topical corticosteroid use, or complications from hospitalization rather than the SCS injections. Most horses (86.7%) in this study remained visual greater than 3 months after SCS injection. CONCLUSIONS: Based on these results, SCS TA injections appear to be a safe and possible effective treatment modality for managing poorly responsive ERU; further clinical study is warranted.
    Keywords adrenal cortex hormones ; blindness ; horses ; inflammation ; ophthalmology ; prognosis ; retrospective studies ; sclera ; therapeutics ; triamcinolone
    Language English
    Dates of publication 2021-05
    Size p. 308-312.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note NAL-AP-2-clean ; JOURNAL ARTICLE
    ZDB-ID 2011043-1
    ISSN 1463-5224 ; 1463-5216
    ISSN (online) 1463-5224
    ISSN 1463-5216
    DOI 10.1111/vop.12887
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Application of Noggin-Coated Electrospun Scaffold in Corneal Wound Healing.

    Mahmood, Nasif / Sefat, Eelya / Roberts, Darby / Gilger, Brian C / Gluck, Jessica M

    Translational vision science & technology

    2023  Volume 12, Issue 8, Page(s) 15

    Abstract: Purpose: The objective of this study is to develop and characterize electrospun corneal bandage infused with Noggin protein and evaluate its therapeutic potential in the treatment of superficial nonhealing corneal ulceration.: Methods: Electrospun ... ...

    Abstract Purpose: The objective of this study is to develop and characterize electrospun corneal bandage infused with Noggin protein and evaluate its therapeutic potential in the treatment of superficial nonhealing corneal ulceration.
    Methods: Electrospun nanofibrous scaffolds were created with different blend ratios of polycaprolactone and gelatin and coated with different concentrations of Noggin protein. Morphologic, mechanical, degradation, and surface chemistry of the developed scaffold was assessed. Biocompatibility of the developed scaffold with corneal epithelial cells was evaluated by looking at cell viability, proliferation, and immunostaining. In vitro wound healing in the presence of Noggin-coated scaffold was evaluated by measuring wound closure rate after scratch.
    Results: Uniform nanofibrous scaffolds coated with Noggin were constructed through optimization of electrospinning parameters and demonstrated mechanical properties better than or similar to commercially available contact lenses used in corneal wound healing. In the presence of Noggin-coated scaffold, corneal epithelial cells showed higher proliferation and wound-healing rate.
    Conclusions: This Noggin-coated electrospun scaffold represents a step toward, expanding treatment options for patients with indolent corneal ulcers.
    Translational relevance: In this study, the feasibility of Noggin-coated electrospun scaffold as a therapeutic for indolent corneal ulcer was evaluated. This study also provides a better perspective for understanding electrospun scaffolds as a tunable platform to infuse topical therapeutics and use as a corneal bandage.
    MeSH term(s) Humans ; Contact Lenses ; Cornea ; Corneal Injuries/therapy ; Epithelial Cells ; Tissue Scaffolds
    Chemical Substances noggin protein (148294-77-3)
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2674602-5
    ISSN 2164-2591 ; 2164-2591
    ISSN (online) 2164-2591
    ISSN 2164-2591
    DOI 10.1167/tvst.12.8.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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