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Article ; Online: Commentary on "The effect of COVID-19 vaccines on sperm parameters: a systematic review and meta-analysis".

Gill, Kamil / Piasecka, Malgorzata

2023 Volume 25, Issue 4, Page(s) 533

MeSH term(s)	Male ; Humans ; COVID-19 Vaccines ; Semen ; COVID-19/prevention & control ; Spermatozoa ; Sperm Count
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-01-02
Publishing country	China
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Comment
ZDB-ID	2075824-8
ISSN	1745-7262 ; 1008-682X
ISSN (online)	1745-7262
ISSN	1008-682X
DOI	10.4103/aja2022110
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Zs.A 5739: Show issues

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Article ; Online: Assessment of the Effectiveness of Treatment of Vascular Lesions within the Facial Skin with a Laser with a Wavelength of 532 nm Based on Photographic Diagnostics with the Use of Polarized Light.

Zawodny, Piotr / Malec, Wiola / Gill, Kamil / Skonieczna-Żydecka, Karolina / Sieńko, Jerzy

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 2

Abstract: Aesthetic medicine is a dynamically developing field of medicine. It has an impact not only on the improvement of the external appearance, but also on health and quality of life. Currently, vascular changes affect many patients and significantly diminish ...

Abstract	Aesthetic medicine is a dynamically developing field of medicine. It has an impact not only on the improvement of the external appearance, but also on health and quality of life. Currently, vascular changes affect many patients and significantly diminish the condition of the skin. The development of modern laser therapy has contributed to the successful management of multiple skin conditions, among them vascular lesions. The aim of our study was to show the efficacy of repetitive 532 nm laser therapy in reducing vascular skin lesions located on the facial area. Observations were possible due to the implementation of System of Skin Analysis. We retrospectively analyzed the records of 120 patients (100 women and 20 men) using "VISIA" Skin Analysis System after 532 nm laser therapy. Treatment with the use of the 532 nm vascular laser turned out to be effective in reducing vascular changes in both women and men. The skin phototypes did not significantly affect the therapy efficacy. Neither the age of patients nor number of laser sessions affect therapy efficacy. 532 nm laser therapy is effective in reducing vascular skin lesions located in the face area.
MeSH term(s)	Male ; Humans ; Female ; Treatment Outcome ; Retrospective Studies ; Quality of Life ; Skin ; Skin Diseases ; Lasers
Language	English
Publishing date	2023-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23021010
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Article ; Online: Low human sperm motility coexists with sperm nuclear DNA damage and oxidative stress in semen.

Gill, Kamil / Machałowski, Tomasz / Harasny, Patryk / Grabowska, Marta / Duchnik, Ewa / Piasecka, Małgorzata

Andrology

2023

Abstract: Background: Low sperm motility, one of the common causes of male infertility, is associated with abnormal sperm quality. Currently, important sperm/semen biomarkers are sperm chromatin status and oxidation-reduction potential (ORP) in semen. Because the ...

Abstract	Background: Low sperm motility, one of the common causes of male infertility, is associated with abnormal sperm quality. Currently, important sperm/semen biomarkers are sperm chromatin status and oxidation-reduction potential (ORP) in semen. Because the association between sperm motility and these biomarkers is still not fully clarified, our study was designed to verify the distribution and risk of sperm DNA fragmentation (SDF) and oxidative stress in semen in asthenozoospermic men. Materials and methods: This study was carried out on discharged sperm cells of asthenozoospermic men (isolated asthenozoospermia or coexisted with reduced sperm number and/or morphology), nonasthenozoospermic men (reduced total sperm count and/or sperm morphology) (experimental groups) and normozoospermic men (proven and presumed fertility) (control group). Basic semen analysis was evaluated according to the 6th edition of the World Health Organization manual guidelines. SDF was assessed using the sperm chromatin dispersion test, while static(s) ORP in semen was measured by means of a MiOXSYS analyser. Results: The men from the asthenozoospermic group had lower basic semen parameters than those from the control and nonasthenozoospermic groups. In men with poor sperm motility SDF and sORP, prevalence and risk for > 20% SDF (high level of DNA damage) and for > 1.37 sORP (oxidative stress) were significantly higher than those of control and nonasthenozoospermic subjects. The risk for sperm DNA damage and oxidative stress in asthenozoospermic men was over 10-fold higher and almost 6-fold higher than those in control subjects and almost or over 3-fold higher than those in nonasthenozoospermic men. Conclusions and discussion: Poor human sperm motility coexisted with low basic sperm quality. Sperm DNA damage and oxidative stress in semen were much more frequent in asthenozoospermia. These abnormalities can decrease the sperm fertilizing capability under both natural and medically assisted reproduction conditions. Thus, in asthenozoospermia, the evaluation of sperm chromatin status and oxidation-reduction potential in semen is justified and inevitable, and the appropriate antioxidant therapy can be suggested.
Language	English
Publishing date	2023-11-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2696108-8
ISSN	2047-2927 ; 2047-2919
ISSN (online)	2047-2927
ISSN	2047-2919
DOI	10.1111/andr.13556
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Article ; Online: The role of the intrinsic pathway of apoptosis in human ejaculated sperm damage under a state of scrotal heat stress.

Budzinska, Marta / Kamieniczna, Marzena / Wojnar, Lukasz / Gill, Kamil / Piasecka, Malgorzata / Kups, Michal / Fraczek, Monika

Journal of assisted reproduction and genetics

2023 Volume 41, Issue 1, Page(s) 99–108

Abstract: Purpose: The study aimed to determine the associations among standard sperm characteristics and oxidative/apoptotic markers in ejaculated sperm of men exposed to prolonged scrotal hyperthermia of either environmental or clinical origin.: Methods: The ...

Abstract	Purpose: The study aimed to determine the associations among standard sperm characteristics and oxidative/apoptotic markers in ejaculated sperm of men exposed to prolonged scrotal hyperthermia of either environmental or clinical origin. Methods: The original study design included four research groups: professional drivers (n = 54), infertile men with varicocele (n = 78), infertile men not exposed to prolonged genital heat stress (n = 37), and fertile individuals serving as the control group (n = 29). Standard semen analysis was performed according to the 5th WHO laboratory manual. The following oxidative and apoptotic parameters of sperm were investigated: mitochondrial superoxide anion generation (MitoSOX Red dye), phosphatidylserine externalization (Annexin V binding assay), mitochondrial membrane potential (JC-1 dye), DNA fragmentation (TUNEL/PI assay), and membrane fluidity (merocyanine 540 dye). Results: All the studied groups presented a strong deterioration in routine sperm parameters and a strongly apoptotic phenotype in sperm, characterized by both decreased mitochondrial membrane potential and enhanced DNA fragmentation, regardless of the thermal insult. Significant induction of mitochondrial superoxide anion generation was noted only in the groups exposed to genital heat stress. A positive correlation between the production of superoxide anion in the mitochondrial chain and the level of DNA fragmentation in drivers was also noted. Conclusion: Long-term exposure to scrotal hyperthermia in real-life situations is sufficient to reduce sperm quality in humans. The thermal stress directly induces the oxidative stress cascade in ejaculated sperm, affecting the plasma membrane fluidity, mitochondrial homeostasis, and sperm DNA integrity.
MeSH term(s)	Humans ; Male ; Semen/metabolism ; Superoxides ; Spermatozoa/metabolism ; Apoptosis ; Oxidative Stress ; Infertility, Male/genetics ; Infertility, Male/metabolism ; DNA Fragmentation ; Sperm Motility
Chemical Substances	Superoxides (11062-77-4)
Language	English
Publishing date	2023-12-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1112577-9
ISSN	1573-7330 ; 1058-0468
ISSN (online)	1573-7330
ISSN	1058-0468
DOI	10.1007/s10815-023-02992-9
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Zs.A 1985: Show issues

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Article ; Online: The long-term effects of multidrug immunosuppressive protocols based on calcineurin inhibitors and conversion to rapamycin on the morphology, apoptosis, and proliferation of rat salivary glands.

Grabowska, Marta / Kędzierska-Kapuza, Karolina / Kram, Andrzej / Gill, Kamil / Teresiński, Leszek / Sipak, Olimpia / Piasecka, Małgorzata

Pharmacological reports : PR

2023 Volume 75, Issue 5, Page(s) 1240–1253

Abstract: Background: The effect of multidrug immunosuppressive protocols on the salivary glands is still unknown. This study aimed to determine the influence of immunosuppressive regimens based on calcineurin inhibitors (CNIs) and conversion to rapamycin on the ... ...

Abstract	Background: The effect of multidrug immunosuppressive protocols on the salivary glands is still unknown. This study aimed to determine the influence of immunosuppressive regimens based on calcineurin inhibitors (CNIs) and conversion to rapamycin on the morphology, apoptosis, and proliferation of rat salivary glands. Methods: Male rats received cyclosporin A (CsA), tacrolimus (FK-506), mycophenolate mofetil (MMF), rapamycin (Rapa), and prednisone (Pre) according to three-drug protocols: CMP (CsA, MMF, and Pre), CMP/R (CsA, MMF, and Pre with conversion to Rapa), TMP (FK-506, MMF, and Pre), and TMP/R (FK-506, MMF, and Pre with conversion to Rapa). Morphological and immunohistochemical and quantitative analyses of the salivary glands were performed. Results: Structural changes in salivary glands were observed in all experimental groups, especially in the submandibular gland. In the salivary glands, the percentages of collagen fibers and TUNEL-, Ki67- and PCNA-positive cells were higher in the experimental groups vs. the control but were lower in the CMP/R and TMP/R groups vs. the CMP and TMP groups, with the exception of collagen fibers in the parotid gland in the TMP/R group vs. the TMP group. Conclusions: Long-term administration of CNIs in triple regimens and after conversion to rapamycin monotherapy, causes morphological changes in the salivary glands of rats. Immunosuppressive treatment based on CNIs is associated with an increase in collagen accumulation. The effects of the conversion of treatment with CNIs to rapamycin in immunosuppressive protocols in rat salivary glands lead to decreased fibrosis, apoptosis, and proliferation. These changes may possibly prevent abnormalities resulting from the application of CNIs.
MeSH term(s)	Male ; Rats ; Animals ; Calcineurin Inhibitors/pharmacology ; Sirolimus/pharmacology ; Tacrolimus/pharmacology ; Immunosuppressive Agents ; Cyclosporine/pharmacology ; Mycophenolic Acid/pharmacology ; Mycophenolic Acid/therapeutic use ; Apoptosis ; Cell Proliferation
Chemical Substances	Calcineurin Inhibitors ; Sirolimus (W36ZG6FT64) ; Tacrolimus (WM0HAQ4WNM) ; Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D) ; Mycophenolic Acid (HU9DX48N0T)
Language	English
Publishing date	2023-09-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2186248-5
ISSN	2299-5684 ; 1734-1140
ISSN (online)	2299-5684
ISSN	1734-1140
DOI	10.1007/s43440-023-00521-0
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Zs.A 861: Show issues

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Article: Relationship between sperm morphology and sperm DNA dispersion.

Jakubik-Uljasz, Joanna / Gill, Kamil / Rosiak-Gill, Aleksandra / Piasecka, Malgorzata

Translational andrology and urology

2020 Volume 9, Issue 2, Page(s) 405–415

Abstract: Background: The pathogenesis of teratozoospermia (<4% morphologically normal sperm cells) and the relationship between sperm morphological abnormalities and abnormal sperm nuclear DNA fragmentation, which are considered indicators of male fertility, ... ...

Abstract	Background: The pathogenesis of teratozoospermia (<4% morphologically normal sperm cells) and the relationship between sperm morphological abnormalities and abnormal sperm nuclear DNA fragmentation, which are considered indicators of male fertility, have not been elucidated. Our research was designed to determine the prevalence of different sperm DNA fragmentation (SDF) levels in men with teratozoospermia and to establish a discriminating threshold value for SDF in assessing sperm morphology. Methods: Basic semen characteristics and detailed sperm morphological analysis (head, neck, midpiece, and tail defects and excess residual cytoplasm) (WHO, 2010), and the nuclear sperm DNA dispersion test were performed on semen samples obtained from 523 men with teratozoospermia (n=296) and those without teratozoospermia (n=227). Results: Subjects with abnormal sperm morphology had not only lower results for standard sperm characteristics, including detailed sperm morphological abnormalities, but also a higher proportion of sperm cells with SDF Conclusions: The obtained findings demonstrated that: (I) detailed sperm structural defects coexist with abnormal nuclear sperm DNA dispersion, (II) men with teratozoospermia may have a higher risk for sperm DNA damage, (III) the calculated optimal SDF value of 18% measured by the DNA sperm dispersion test is the best criterion to predict normal and abnormal sperm morphology.
Language	English
Publishing date	2020-05-06
Publishing country	China
Document type	Journal Article
ZDB-ID	2851630-8
ISSN	2223-4691 ; 2223-4691 ; 2223-4683
ISSN (online)	2223-4691
ISSN	2223-4691 ; 2223-4683
DOI	10.21037/tau.2020.01.31
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Article ; Online: The long-term effects of rapamycin-based immunosuppressive protocols on the expression of renal aquaporins 1, 2, 3 and 4 water channels in rats.

Grabowska, Marta / Michałek, Katarzyna / Kędzierska-Kapuza, Karolina / Kram, Andrzej / Gill, Kamil / Piasecka, Małgorzata

Histology and histopathology

2021 Volume 36, Issue 4, Page(s) 459–474

Abstract: Background: To this day, the effect of multi-drug immunosuppressive protocols on renal expression of AQPs is unknown. This study aimed to determine the influence of rapamycin-based multi-drug immunosuppressive regimens on the expression of aquaporins ( ... ...

Abstract	Background: To this day, the effect of multi-drug immunosuppressive protocols on renal expression of AQPs is unknown. This study aimed to determine the influence of rapamycin-based multi-drug immunosuppressive regimens on the expression of aquaporins (AQPs) 1, 2, 3, and 4 in the rat kidney. Methods: For 6 months, 24 male Wistar rats were administered immunosuppressants, according to the three-drug protocols used in patients after organ transplantation. The rats were divided into four groups: the control group, the TRP group (tacrolimus, rapamycin, prednisone), the CRP group (cyclosporine A, rapamycin, prednisone), and the MRP group (mycophenolate mofetil, rapamycin, prednisone). Selected red cell indices and total calcium were measured in the blood of rats and quantitative analysis of AQP1, AQP2, AQP3 and AQP4 immunoexpression in the kidneys were performed. Results: In the TRP and CRP groups, a mild increase of mean corpuscular hemoglobin concentration, hematocrit and total calcium were observed. Moreover, decreased expression of AQP1-4 was found in all experimental groups, with the highest decrease in the CRP group. Conclusions: The long-term immunosuppressive treatment using multi-drug protocols decreased AQP1-4 expressions in renal tubules, possibly leading to impaired urine-concentrating ability in rat.
MeSH term(s)	Animals ; Aquaporins/drug effects ; Aquaporins/metabolism ; Cyclosporine/adverse effects ; Cyclosporine/therapeutic use ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Kidney/metabolism ; Mycophenolic Acid/adverse effects ; Mycophenolic Acid/therapeutic use ; Prednisone/adverse effects ; Prednisone/therapeutic use ; Rats ; Rats, Wistar ; Sirolimus/adverse effects ; Sirolimus/therapeutic use ; Water/metabolism
Chemical Substances	Aquaporins ; Immunosuppressive Agents ; Water (059QF0KO0R) ; Cyclosporine (83HN0GTJ6D) ; Mycophenolic Acid (HU9DX48N0T) ; Prednisone (VB0R961HZT) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2021-02-26
Publishing country	Spain
Document type	Journal Article
ZDB-ID	83911-5
ISSN	1699-5848 ; 0213-3911
ISSN (online)	1699-5848
ISSN	0213-3911
DOI	10.14670/HH-18-321
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Article ; Online: Evaluation of selected semen parameters and biomarkers of male infertility - preliminary study.

Kups, Michal / Gill, Kamil / Rosiak-Gill, Aleksandra / Harasny, Patryk / Machalowski, Tomasz / Grabowska, Marta / Kurzawa, Rafal / Sipak, Olimpia / Piasecka, Malgorzata

F1000Research

2022 Volume 11, Page(s) 591

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-05-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.121622.1
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Article ; Online: Male aging as a causative factor of detrimental changes in human conventional semen parameters and sperm DNA integrity.

Gill, Kamil / Jakubik-Uljasz, Joanna / Rosiak-Gill, Aleksandra / Grabowska, Marta / Matuszewski, Marcin / Piasecka, Malgorzata

The aging male : the official journal of the International Society for the Study of the Aging Male

2020 Volume 23, Issue 5, Page(s) 1321–1332

Abstract: The effect of male aging on fertility potential is controversial and difficult to predict. The aim of our study was to determine the associations between age, basic semen parameters, and sperm DNA fragmentation (SDF). Comparison of four age-dependent ... ...

Abstract	The effect of male aging on fertility potential is controversial and difficult to predict. The aim of our study was to determine the associations between age, basic semen parameters, and sperm DNA fragmentation (SDF). Comparison of four age-dependent groups (men ≤29 years, 30-35 years, 36-40 years, and >40 years) revealed a significant fall in the basic semen characteristics and sperm genomic integrity with age. Receiver operating characteristic (ROC) analysis confirmed that men >29 years had lower semen quality. In the group of men >29 years, the prevalence of men with abnormal semen parameters was higher, and these men had over a threefold higher odds ratio (OR) for abnormal semen parameters. Next, ROC analysis revealed that a threshold of 18% SDF was optimal for discriminating between men with normal and abnormal standard semen parameters. The prevalence of men with >18% SDF was higher in the group of men >29 years than in men ≤29 years. Older men had an almost twofold higher risk for >18% SDF than younger men. Our results suggest that age >29 years may be a causative factor of detrimental changes in semen quality, which may raise the risk for disorders of male fertility potential.
MeSH term(s)	Aged ; Aging ; DNA ; Humans ; Male ; Semen ; Semen Analysis ; Spermatozoa
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2020-05-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2108146-3
ISSN	1473-0790 ; 1368-5538
ISSN (online)	1473-0790
ISSN	1368-5538
DOI	10.1080/13685538.2020.1765330
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Zs.A 5776: Show issues

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Article ; Online: The Effects of Long-Term Immunosuppressive Therapies on the Structure of the Rat Prostate.

Grabowska, Marta / Laszczyńska, Maria / Kędzierska-Kapuza, Karolina / Kram, Andrzej / Gill, Kamil / Piasecka, Małgorzata

International journal of environmental research and public health

2020 Volume 17, Issue 12

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Animals ; Cyclosporine ; Immunosuppressive Agents ; Male ; Prostate ; Rats ; Rats, Wistar ; Tacrolimus
Chemical Substances	Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2020-06-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph17124614
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