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  1. Article ; Online: Radiotracers for positron emission tomography imaging.

    Gillings, Nic

    Magma (New York, N.Y.)

    2012  Volume 26, Issue 1, Page(s) 149–158

    Abstract: The use of positron emission tomography for clinical diagnostics has grown rapidly over the past 2 decades. This growth has mainly been due to advances in scanner technology, and particularly the introduction of the combined PET/CT scanner, and has been ... ...

    Abstract The use of positron emission tomography for clinical diagnostics has grown rapidly over the past 2 decades. This growth has mainly been due to advances in scanner technology, and particularly the introduction of the combined PET/CT scanner, and has been based almost exclusively on one PET radiopharmaceutical ([(18)F]fluorodeoxyglucose), which is broadly applicable to cancer patients. The availability of radiopharmaceuticals and the clinical diagnostic potential of PET has also supported the continued development of the scanner technology. Due to the efforts of many researchers worldwide in the field of radiopharmaceutical sciences, we are now seeing an increasing number of radiopharmaceuticals used for routine clinical diagnostic imaging. This article is intended as a short educational review, giving a brief overview of the design, preparation and use of PET radiopharmaceuticals, with some examples of highly clinically relevant PET tracers.
    MeSH term(s) Humans ; Positron-Emission Tomography ; Radiochemistry ; Radiopharmaceuticals/chemistry
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2012-12-16
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1160826-2
    ISSN 1352-8661 ; 0968-5243
    ISSN (online) 1352-8661
    ISSN 0968-5243
    DOI 10.1007/s10334-012-0356-1
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  2. Article ; Online: A restricted access material for rapid analysis of [(11)C]-labeled radiopharmaceuticals and their metabolites in plasma.

    Gillings, Nic

    Nuclear medicine and biology

    2009  Volume 36, Issue 8, Page(s) 961–965

    Abstract: Introduction: Analysis of the radioactive components in plasma taken during positron emission tomography (PET) measurements is often vital for the correct quantification of the PET data. The described high-performance liquid chromatography (HPLC) method ...

    Abstract Introduction: Analysis of the radioactive components in plasma taken during positron emission tomography (PET) measurements is often vital for the correct quantification of the PET data. The described high-performance liquid chromatography (HPLC) method has been developed to provide a fast, sensitive and robust method for the measurement of plasma samples from PET studies using [(11)C]-labeled radiopharmaceuticals.
    Methods: Unadulterated plasma samples were analyzed directly, following a simple filtration, by the use of a small extraction column, containing a restricted access material, combined with a monolithic analysis column in a column-switching HPLC system.
    Results: Up to 4 ml of plasma was analyzed by this method within 4.5-7 min in a fully automated process. Because of the rapid analysis, a large number of samples could be analyzed during a 90-min PET scan. The extraction column could be used for analysis of up to 500 ml of plasma before replacement was required.
    Conclusions: The described method is fast and robust and the large sample volumes allow for accurate determination of the radioactive components in plasma even at 90 min after injection of a [(11)C]-labeled radiopharmaceutical.
    MeSH term(s) Blood Chemical Analysis/methods ; Carbon Radioisotopes/blood ; Chromatography, High Pressure Liquid/methods ; Humans ; Radiopharmaceuticals/blood ; Reproducibility of Results ; Sensitivity and Specificity ; Ultrafiltration/methods
    Chemical Substances Carbon Radioisotopes ; Radiopharmaceuticals
    Language English
    Publishing date 2009-11
    Publishing country United States
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 1138098-6
    ISSN 1872-9614 ; 0883-2897 ; 0969-8051
    ISSN (online) 1872-9614
    ISSN 0883-2897 ; 0969-8051
    DOI 10.1016/j.nucmedbio.2009.07.004
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  3. Article ; Online: EANM guidance document: dosimetry for first-in-human studies and early phase clinical trials.

    Stokke, Caroline / Gnesin, Silvano / Tran-Gia, Johannes / Cicone, Francesco / Holm, Søren / Cremonesi, Marta / Blakkisrud, Johan / Wendler, Thomas / Gillings, Nic / Herrmann, Ken / Mottaghy, Felix M / Gear, Jonathan

    European journal of nuclear medicine and molecular imaging

    2024  Volume 51, Issue 5, Page(s) 1268–1286

    Abstract: The numbers of diagnostic and therapeutic nuclear medicine agents under investigation are rapidly increasing. Both novel emitters and novel carrier molecules require careful selection of measurement procedures. This document provides guidance relevant to ...

    Abstract The numbers of diagnostic and therapeutic nuclear medicine agents under investigation are rapidly increasing. Both novel emitters and novel carrier molecules require careful selection of measurement procedures. This document provides guidance relevant to dosimetry for first-in human and early phase clinical trials of such novel agents. The guideline includes a short introduction to different emitters and carrier molecules, followed by recommendations on the methods for activity measurement, pharmacokinetic analyses, as well as absorbed dose calculations and uncertainty analyses. The optimal use of preclinical information and studies involving diagnostic analogues is discussed. Good practice reporting is emphasised, and relevant dosimetry parameters and method descriptions to be included are listed. Three examples of first-in-human dosimetry studies, both for diagnostic tracers and radionuclide therapies, are given.
    MeSH term(s) Humans ; Radiopharmaceuticals/therapeutic use ; Radiometry/methods ; Radionuclide Imaging ; Nuclear Medicine/methods
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2024-02-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-024-06640-x
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  4. Article ; Online: (99m)Tc-aprotinin - optimisation and validation of radiolabelling kits for routine preparation for diagnostic imaging of amyloidosis.

    Denholt, Charlotte / Gillings, Nic

    Journal of labelled compounds & radiopharmaceuticals

    2016  Volume 59, Issue 4, Page(s) 171–174

    Abstract: Technetium-99m aprotinin was prepared from an optimised radiolabelling kit formulation containing aprotinin, alkaline buffer and stannous chloride (reducing agent) and radiolabelled using (99m) Tc-pertechnetate. The labelling was achieved within 25 min, ... ...

    Abstract Technetium-99m aprotinin was prepared from an optimised radiolabelling kit formulation containing aprotinin, alkaline buffer and stannous chloride (reducing agent) and radiolabelled using (99m) Tc-pertechnetate. The labelling was achieved within 25 min, with radiochemical purities of >98%.
    MeSH term(s) Amyloidosis/diagnostic imaging ; Aprotinin/chemistry ; Diagnostic Imaging ; Isotope Labeling/methods ; Radiochemistry ; Technetium/chemistry
    Chemical Substances Technetium (7440-26-8) ; Aprotinin (9087-70-1)
    Language English
    Publishing date 2016-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 196095-7
    ISSN 1099-1344 ; 0362-4803 ; 0022-2135
    ISSN (online) 1099-1344
    ISSN 0362-4803 ; 0022-2135
    DOI 10.1002/jlcr.3381
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  5. Article: Correction: [

    Marner, Lisbeth / Korsholm, Kirsten / Anderberg, Lasse / Lonsdale, Markus N / Jensen, Mads Radmer / Brødsgaard, Eva / Denholt, Charlotte L / Gillings, Nic / Law, Ian / Friberg, Lars

    EJNMMI research

    2023  Volume 13, Issue 1, Page(s) 19

    Language English
    Publishing date 2023-03-01
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2619892-7
    ISSN 2191-219X
    ISSN 2191-219X
    DOI 10.1186/s13550-023-00970-x
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  6. Article ; Online: Stress Hormone Dynamics Are Coupled to Brain Serotonin 4 Receptor Availability in Unmedicated Patients With Major Depressive Disorder: A NeuroPharm Study.

    Vulpius, Gunild M / Köhler-Forsberg, Kristin / Ozenne, Brice / Larsen, Søren V / Nasser, Arafat / Svarer, Claus / Gillings, Nic / Keller, Sune H / Jørgensen, Martin B / Knudsen, Gitte M / Frokjaer, Vibe G

    The international journal of neuropsychopharmacology

    2023  Volume 26, Issue 9, Page(s) 639–648

    Abstract: Background: A prominent finding in major depressive disorder (MDD) is distorted stress hormone dynamics, which is regulated by serotonergic brain signaling. An interesting feature of the cerebral serotonin system is the serotonin 4 receptor (5-HT4R), ... ...

    Abstract Background: A prominent finding in major depressive disorder (MDD) is distorted stress hormone dynamics, which is regulated by serotonergic brain signaling. An interesting feature of the cerebral serotonin system is the serotonin 4 receptor (5-HT4R), which is lower in depressed relative to healthy individuals and also has been highlighted as a promising novel antidepressant target. Here, we test the novel hypothesis that brain 5-HT4R availability in untreated patients with MDD is correlated with cortisol dynamics, indexed by the cortisol awakening response (CAR). Further, we evaluate if CAR changes with antidepressant treatment, including a selective serotonin reuptake inhibitor, and if pretreatment CAR can predict treatment outcome.
    Methods: Sixty-six patients (76% women) with a moderate to severe depressive episode underwent positron emission tomography imaging with [11C]SB207145 for quantification of brain 5-HT4R binding using BPND as outcome. Serial home sampling of saliva in the first hour from awakening was performed to assess CAR before and after 8 weeks of antidepressant treatment. Treatment outcome was measured by change in Hamilton Depression Rating Scale 6 items.
    Results: In the unmedicated depressed state, prefrontal and anterior cingulate cortices 5-HT4R binding was positively associated with CAR. CAR remained unaltered after 8 weeks of antidepressant treatment, and pretreatment CAR did not significantly predict treatment outcome.
    Conclusions: Our findings highlight a link between serotonergic disturbances in MDD and cortisol dynamics, which likely is involved in disease and treatment mechanisms. Further, our data support 5-HT4R agonism as a promising precision target in patients with MDD and disturbed stress hormone dynamics.
    MeSH term(s) Humans ; Female ; Male ; Depressive Disorder, Major/diagnostic imaging ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Major/metabolism ; Receptors, Serotonin, 5-HT4/metabolism ; Receptors, Serotonin, 5-HT4/therapeutic use ; Hydrocortisone/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Antidepressive Agents/metabolism
    Chemical Substances Receptors, Serotonin, 5-HT4 (158165-40-3) ; Hydrocortisone (WI4X0X7BPJ) ; Antidepressive Agents
    Language English
    Publishing date 2023-08-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440129-0
    ISSN 1469-5111 ; 1461-1457
    ISSN (online) 1469-5111
    ISSN 1461-1457
    DOI 10.1093/ijnp/pyad041
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  7. Article: Fully Automated GMP-Compliant Synthesis of [

    Bratteby, Klas / Denholt, Charlotte Lund / Lehel, Szabolcs / Petersen, Ida Nymann / Madsen, Jacob / Erlandsson, Maria / Ohlsson, Tomas / Herth, Matthias Manfred / Gillings, Nic

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 7

    Abstract: In the struggle to understand and accurately diagnose Parkinson's disease, radiopharmaceuticals and medical imaging techniques have played a major role. By being able to image and quantify the dopamine transporter density, noninvasive diagnostic imaging ... ...

    Abstract In the struggle to understand and accurately diagnose Parkinson's disease, radiopharmaceuticals and medical imaging techniques have played a major role. By being able to image and quantify the dopamine transporter density, noninvasive diagnostic imaging has become the gold standard. In the shift from the first generation of SPECT tracers, the fluorine-18-labeled tracer [
    Language English
    Publishing date 2021-06-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14070601
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  8. Article ; Online: Highlight selection of radiochemistry and radiopharmacy developments by editorial board.

    Toyohara, Jun / Vugts, Danielle / Kiss, Oliver C / Todde, Sergio / Li, Xiang-Guo / Liu, Zhibo / Yang, Zhi / Gillings, Nic / Cazzola, Emiliano / Szymanski, Wiktor / Meulen, Nick van der / Reilly, Raymond / Taddei, Carlotta / Schirrmacher, Ralf / Li, Zijing / Lagebo, Yohannes Jorge / Bentaleb, Naoual / Souza Albernaz, Marta de / Lapi, Suzanne /
    Ramogida, Caterina / Mukherjee, Archana / Ajenjo, Javier / Deuther-Conrad, Winnie / Bourdeau, Cécile

    EJNMMI radiopharmacy and chemistry

    2024  Volume 9, Issue 1, Page(s) 42

    Abstract: Background: The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field of radiopharmaceutical development.: Main body: This selection of highlights provides ... ...

    Abstract Background: The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field of radiopharmaceutical development.
    Main body: This selection of highlights provides commentary on 24 different topics selected by each coauthoring Editorial Board member addressing a variety of aspects ranging from novel radiochemistry to first-in-human application of novel radiopharmaceuticals.
    Conclusion: Trends in radiochemistry and radiopharmacy are highlighted. Hot topics cover the entire scope of EJNMMI Radiopharmacy and Chemistry, demonstrating the progress in the research field in many aspects.
    Language English
    Publishing date 2024-05-16
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2365-421X
    ISSN (online) 2365-421X
    DOI 10.1186/s41181-024-00268-w
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  9. Article: [

    Marner, Lisbeth / Korsholm, Kirsten / Anderberg, Lasse / Lonsdale, Markus N / Jensen, Mads Radmer / Brødsgaard, Eva / Denholt, Charlotte L / Gillings, Nic / Law, Ian / Friberg, Lars

    EJNMMI research

    2022  Volume 12, Issue 1, Page(s) 56

    Abstract: Background: Dopamine transporter (DAT) imaging of striatum is clinically used in Parkinson's disease (PD) and neurodegenerative parkinsonian syndromes (PS) especially in the early disease stages. The aim of the present study was to evaluate the ... ...

    Abstract Background: Dopamine transporter (DAT) imaging of striatum is clinically used in Parkinson's disease (PD) and neurodegenerative parkinsonian syndromes (PS) especially in the early disease stages. The aim of the present study was to evaluate the diagnostic performance of the recently developed tracer for DAT imaging [
    Methods: Ninety-eight unselected patients referred for DAT imaging were included prospectively and consecutively and evaluated with [
    Results: Fifty-six of the [
    Conclusions: The high correspondence of [
    Language English
    Publishing date 2022-09-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2619892-7
    ISSN 2191-219X
    ISSN 2191-219X
    DOI 10.1186/s13550-022-00930-x
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  10. Article ; Online: EANM guideline on quality risk management for radiopharmaceuticals.

    Gillings, Nic / Hjelstuen, Olaug / Behe, Martin / Decristoforo, Clemens / Elsinga, Philip H / Ferrari, Valentina / Kiss, Oliver C / Kolenc, Petra / Koziorowski, Jacek / Laverman, Peter / Mindt, Thomas L / Ocak, Meltem / Patt, Marianne / Todde, Sergio / Walte, Almut

    European journal of nuclear medicine and molecular imaging

    2022  Volume 49, Issue 10, Page(s) 3353–3364

    Abstract: This document is intended as a supplement to the EANM "Guidelines on current Good Radiopharmacy Practice (cGRPP)" issued by the Radiopharmacy Committee of the EANM (Gillings et al. in EJNMMI Radiopharm Chem. 6:8, 2021). The aim of the EANM Radiopharmacy ... ...

    Abstract This document is intended as a supplement to the EANM "Guidelines on current Good Radiopharmacy Practice (cGRPP)" issued by the Radiopharmacy Committee of the EANM (Gillings et al. in EJNMMI Radiopharm Chem. 6:8, 2021). The aim of the EANM Radiopharmacy Committee is to provide a document that describes how to manage risks associated with small-scale "in-house" preparation of radiopharmaceuticals, not intended for commercial purposes or distribution.
    MeSH term(s) Humans ; Nuclear Medicine ; Radiopharmaceuticals/adverse effects ; Risk Management
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2022-04-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-022-05738-4
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