Article ; Online: Assessing the diagnostic accuracy of PCR-based detection of
2017 Volume 7, Issue 6, Page(s) e015008
Abstract: Study design: Detection and serotyping of : Methods: Active surveillance for community-acquired pneumonia (CAP) in hospitalised adults was performed from December 2010 to 2013. Detection of pneumococcal CAP (CAP: Results: NP swab results were ... ...
Abstract | Study design: Detection and serotyping of Methods: Active surveillance for community-acquired pneumonia (CAP) in hospitalised adults was performed from December 2010 to 2013. Detection of pneumococcal CAP (CAP Results: NP swab results were compared against CAP cases where all pneumococcal tests were performed (n=434), or where at least one test was performed (n=1616). CAP Conclusions: While further optimisation may be needed to increase the sensitivity of PCR-based detection, its high specificity suggests there is a value for pneumococcal surveillance. With many laboratories archiving specimens for influenza virus surveillance, this specimen type could provide a non-culture-based method for pneumococcal surveillance. |
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MeSH term(s) | Adult ; Aged ; Canada ; Female ; Humans ; Male ; Middle Aged ; Nasopharynx/microbiology ; Pneumococcal Vaccines/immunology ; Pneumonia, Pneumococcal/microbiology ; Pneumonia, Pneumococcal/prevention & control ; Real-Time Polymerase Chain Reaction/methods ; Real-Time Polymerase Chain Reaction/standards ; Sensitivity and Specificity ; Serotyping ; Streptococcus pneumoniae/immunology ; Streptococcus pneumoniae/isolation & purification ; Young Adult |
Chemical Substances | Pneumococcal Vaccines |
Language | English |
Publishing date | 2017-06-08 |
Publishing country | England |
Document type | Journal Article ; Validation Study |
ZDB-ID | 2599832-8 |
ISSN | 2044-6055 ; 2044-6055 |
ISSN (online) | 2044-6055 |
ISSN | 2044-6055 |
DOI | 10.1136/bmjopen-2016-015008 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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