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  1. Article: Dapsone for Recalcitrant Eosinophilic Annular Erythema: A Case Report and Literature Review.

    Wallis, Luke / Gilson, Robert C / Gilson, Robert T

    Dermatology and therapy

    2017  Volume 8, Issue 1, Page(s) 157–163

    Abstract: Eosinophilic annular erythema (EAE) is a rare entity of unknown etiology that is possibly related to a hypersensitivity reaction and presents as annular erythematous plaques with tissue eosinophilia. It is classified as a figurate erythema with a ... ...

    Abstract Eosinophilic annular erythema (EAE) is a rare entity of unknown etiology that is possibly related to a hypersensitivity reaction and presents as annular erythematous plaques with tissue eosinophilia. It is classified as a figurate erythema with a controversial relationship to Wells syndrome (WS) in the literature, where it is generally considered a separate entity or subset based on clinical and histopathologic differences. EAE typically presents with recurrent, erythematous, arcuate, and annular plaques on the trunk and proximal extremities. The course of the disease is often chronic, recurrent, and relapsing. Responses to treatment are variable but are typically best with systemic steroids and antimalarials. We report a patient refractory to other therapies who had a striking response to dapsone.
    Language English
    Publishing date 2017-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2680284-3
    ISSN 2190-9172 ; 2193-8210
    ISSN (online) 2190-9172
    ISSN 2193-8210
    DOI 10.1007/s13555-017-0214-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cell surface GRP78 promotes stemness in normal and neoplastic cells.

    Conner, Clay / Lager, Tyson W / Guldner, Ian H / Wu, Min-Zu / Hishida, Yuriko / Hishida, Tomoaki / Ruiz, Sergio / Yamasaki, Amanda E / Gilson, Robert C / Belmonte, Juan Carlos Izpisua / Gray, Peter C / Kelber, Jonathan A / Zhang, Siyuan / Panopoulos, Athanasia D

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 3474

    Abstract: Reliable approaches to identify stem cell mechanisms that mediate aggressive cancer could have great therapeutic value, based on the growing evidence of embryonic signatures in metastatic cancers. However, how to best identify and target stem-like ... ...

    Abstract Reliable approaches to identify stem cell mechanisms that mediate aggressive cancer could have great therapeutic value, based on the growing evidence of embryonic signatures in metastatic cancers. However, how to best identify and target stem-like mechanisms aberrantly acquired by cancer cells has been challenging. We harnessed the power of reprogramming to examine GRP78, a chaperone protein generally restricted to the endoplasmic reticulum in normal tissues, but which is expressed on the cell surface of human embryonic stem cells and many cancer types. We have discovered that (1) cell surface GRP78 (sGRP78) is expressed on iPSCs and is important in reprogramming, (2) sGRP78 promotes cellular functions in both pluripotent and breast cancer cells (3) overexpression of GRP78 in breast cancer cells leads to an induction of a CD24
    MeSH term(s) Animals ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Differentiation ; Cell Line, Tumor ; Cell Self Renewal ; Cell Transformation, Neoplastic ; Cellular Reprogramming ; Female ; HEK293 Cells ; Heat-Shock Proteins/antagonists & inhibitors ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Lung Neoplasms/pathology ; Lung Neoplasms/secondary ; Mice ; Mice, Knockout ; Neoplastic Stem Cells/cytology ; Neoplastic Stem Cells/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transplantation, Heterologous
    Chemical Substances Heat-Shock Proteins ; RNA, Small Interfering ; Transcription Factors ; molecular chaperone GRP78 (YCYIS6GADR)
    Language English
    Publishing date 2020-02-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-60269-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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