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Article ; Online: Time-lapse imaging: Morphokinetic analysis of in vitro fertilization outcomes.

Giménez, Carla / Conversa, Laura / Murria, Lucía / Meseguer, Marcos

2023 Volume 120, Issue 2, Page(s) 218–227

Abstract: Time-lapse imaging (TLI) allows continuous monitoring of embryo development without disturbing culture conditions by removing embryos from the incubator. The study of embryo kinetics using TLI has given rise to some new markers for embryo selection that ... ...

Abstract	Time-lapse imaging (TLI) allows continuous monitoring of embryo development without disturbing culture conditions by removing embryos from the incubator. The study of embryo kinetics using TLI has given rise to some new markers for embryo selection that are able to document and evaluate embryo morphology and the timing of developmental events through continuous live image tracking. Time-lapse imaging has emerged as a powerful tool for creating predictive models of in vitro fertilization outcomes. Fourty-seven articles were included in the present review to investigate the current situation of TLI in in vitro fertilization laboratories. Morphokinetics of the embryo during its in vitro development have been described using parameters indicative of the different events capable of predicting the ability to reach blastocyst stage, implantation and pregnancy rates, live birth outcome, and embryo ploidy.
MeSH term(s)	Pregnancy ; Female ; Humans ; Embryo Transfer/methods ; Time-Lapse Imaging/methods ; Fertilization in Vitro/methods ; Embryo Implantation ; Embryonic Development ; Blastocyst ; Embryo Culture Techniques ; Retrospective Studies
Language	English
Publishing date	2023-06-25
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2023.06.015
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Article ; Online: The Effect of Menopause on Vaginal Tissue Mechanics: A Brief Review.

Gimenez, Clara / Alperin, Marianna / De Vita, Raffaella

Journal of biomechanical engineering

2023 Volume 146, Issue 6

Abstract: Often called "the change of life," menopause affects every part of a woman's body. As the sex hormones decrease, the reproductive organs experience the most remarkable changes, with the vagina becoming thinner, drier, and less elastic. Despite the ... ...

Abstract	Often called "the change of life," menopause affects every part of a woman's body. As the sex hormones decrease, the reproductive organs experience the most remarkable changes, with the vagina becoming thinner, drier, and less elastic. Despite the important implications of these changes in genitourinary conditions, there are only a few experimental studies that focus on quantifying the effect of menopause on the mechanical properties of the vagina. These studies are mostly conducted using uniaxial tests on strips of vaginal tissues isolated from rats, rabbits, and sheep and, in only a few cases, from humans. The purpose of this article is to present a systematic review of experimental protocols, methods, and results that are currently published on how menopause alters the mechanical behavior of the vagina. This review will enable new investigators in the biomechanics field to identify important gaps and frame research questions that inform the design of new treatment options for menopausal symptoms.
MeSH term(s)	Humans ; Female ; Rats ; Rabbits ; Animals ; Sheep ; Menopause ; Vagina ; Pelvis ; Biomechanical Phenomena
Language	English
Publishing date	2023-08-05
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	243094-0
ISSN	1528-8951 ; 0148-0731
ISSN (online)	1528-8951
ISSN	0148-0731
DOI	10.1115/1.4063101
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Article ; Online: Evaluating the Use of a CPOE for Chemotherapy Protocols.

Gimenez, C / de Matos Lima, S / Luna, D

Studies in health technology and informatics

2020 Volume 270, Page(s) 1271–1272

Abstract: Chemotherapy drugs are one of the most common causes of serious and fatal medication errors, especially during prescribing, where computerized physician order entry (CPOE) take on importance. This study proposes the description of the post-implementation ...

Abstract	Chemotherapy drugs are one of the most common causes of serious and fatal medication errors, especially during prescribing, where computerized physician order entry (CPOE) take on importance. This study proposes the description of the post-implementation status of a CPOE in a highly specialized hospital between January and June 2018, among patients older than 18 years. Results: a total of 8835 protocols were indicated using the specific CPOE (93% use rate over all protocols) 91% completed the administration, 1.2% were rejected by pharmacy, and 6.8% was canceled. The most frequent cause of rejection by pharmacy and cancellation by oncologist was an inadequate dose. Most of the protocols indicated using the CPOE implemented, with a reject by pharmacy rate of 1.2%, indicates the utility of CPOE as an error prevention strategy.
MeSH term(s)	Antineoplastic Agents ; Antineoplastic Protocols ; Medical Order Entry Systems ; Medication Errors
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2020-06-12
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI200397
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Article ; Online: The subjective feeling of a gap between conceptual and perceptual fluency is interpreted as a metacognitive signal of pastness.

Brouillet, D / Servajean, P / Josa, R / Gimenez, C / Turo, S / Michalland, A H

Cognitive processing

2022 Volume 24, Issue 1, Page(s) 83–94

Abstract: The present study aimed to address the following question: does the discrepancy between an expected word and its readability enhances or impair its memorability? We used an adaptation of the sentence stem paradigm (Whittlesea in J Exp Psycol 19:1235-1253, ...

Abstract	The present study aimed to address the following question: does the discrepancy between an expected word and its readability enhances or impair its memorability? We used an adaptation of the sentence stem paradigm (Whittlesea in J Exp Psycol 19:1235-1253, 1993) and manipulated the perceptual clarity of the words by introducing some Gaussian noise (Reber in Psycol Sci 9:45-48, 1998). The target words were semantically predictable or otherwise (conceptual fluency) or were easy or difficult to read (perceptual fluency). The first experiment was conducted to ensure that the two manipulated factors had an impact on the readability of the words. In particular, results showed that when the words were written against a noisy background their predictability enhanced the judgement of readability. The second experiment aimed to test the hypothesis that recognition would be influenced by the discrepancy between conceptual and perceptual fluency. The results showed that with a noisy background, the predictability of the target words had an impact on recognition judgement; with a clear background, the effect on the recognition judgement was caused by the non-predictability of the target words. Conversely, confidence in judgement increased when the two factors went in the same direction, that is, predictability with clarity and non-predictability with low clarity. The results showed that (a) depending on the task, the effects of conceptual and perceptual fluency did not go in the same direction; (b) the kinds of fluency (conceptual and perceptual) were not independent; and (c) recognition judgements were affected by the gap between conceptual and perceptual fluency.
MeSH term(s)	Humans ; Recognition, Psychology ; Language ; Judgment ; Metacognition ; Emotions
Language	English
Publishing date	2022-12-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2075054-7
ISSN	1612-4790 ; 1612-4782
ISSN (online)	1612-4790
ISSN	1612-4782
DOI	10.1007/s10339-022-01114-0
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Article ; Online: Bilateral localized primary parotid gland amyloidosis: A rare entity with literature review.

Abdelwahed, Mohammed / Kawam, Alae / Gimenez, Cecilia / Rosca, Oana C

Diagnostic cytopathology

2023 Volume 51, Issue 9, Page(s) E255–E258

Abstract: Amyloidosis of the salivary glands is a rare occurrence. Due to non-specific clinical presentation, the diagnosis can be overlooked. Here we present a case of a localized bilateral parotid glands AL kappa-light chain amyloid deposition without systemic ... ...

Abstract	Amyloidosis of the salivary glands is a rare occurrence. Due to non-specific clinical presentation, the diagnosis can be overlooked. Here we present a case of a localized bilateral parotid glands AL kappa-light chain amyloid deposition without systemic involvement, as well as a literature review. Fine needle aspiration (FNA) of a right parotid lesion was performed with rapid on-site evaluation (ROSE). Slides showed characteristic amyloid staining with Congo red and typical Apple-green birefringence under polarized light microscopy. Amyloid in the head and neck can be misinterpreted as other materials such as colloid, keratin, necrosis, hyaline degeneration especially when the condition is not suspected.
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	632710-2
ISSN	1097-0339 ; 8755-1039
ISSN (online)	1097-0339
ISSN	8755-1039
DOI	10.1002/dc.25181
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Conference proceedings ; Online: Legumbres para consumo humano

Mallor Giménez, Cristina

importancia, diversidad y conservación

2020

Abstract: Banco de Germoplasma Hortícola (BGHZ) del ... ...

Abstract	Banco de Germoplasma Hortícola (BGHZ) del CITA
Keywords	Legumbres ; Biodiversidad ; Conservación de recursos genéticos ; Banco de germoplasma ; Agricultura sostenible ; Alimentación humana ; covid19
Language	Spanish
Publishing country	es
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fisiopatologia de los transportadores de glutamato y de glicina: nuevas dianas terapeuticas.

Gimenez, C / Zafra, F / Aragon, C

Revista de neurologia

2018 Volume 67, Issue 12, Page(s) 491–504

Abstract: Introduction: The amino acids glutamate and glycine, apart from their role in protein synthesis, are two fundamental neurotransmitters in the central nervous system of mammals. The first one is ubiquitous and is involved in excitatory pathways of the ... ...

Title translation	Pathophysiology of the glutamate and the glycine transporters: new therapeutic targets.
Abstract	Introduction: The amino acids glutamate and glycine, apart from their role in protein synthesis, are two fundamental neurotransmitters in the central nervous system of mammals. The first one is ubiquitous and is involved in excitatory pathways of the neocortex, the retina and the cerebellum, and the second is involved in inhibitory pathways of brain caudal areas. However, both share their way of acting by integrating into the functioning of glutamate receptors of the NMDA type fundamentals in the regulation of motor, sensory and cognitive systems. Aim: To highlight the need for a fine regulation of glutamate and glycine concentrations in the intracellular and extracellular spaces of the nervous system through the action of very specific transporters for both neurotransmitters located in the plasma membrane of neurons and glial cells. Development: The role of the glutamate and glycine transporters in glutamatergic and glycinergic neurotransmission and in the functioning of the nervous system is described. The pathological consequences of imbalances in these signaling pathways are pointed out. We also describe its involvement in pathologies such as schizophrenia, chronic pain, cerebral ischemia, diseases such as hereditary hyperekplexia and the non-ketotic hyperglycinemia, and neurodegenerative disorders. Conclusions: The knowledge at molecular level of the way of acting of these transporters for glutamate and glycine is allowing the identification and development of new therapeutic strategies for pathologies such as those described above and the development of new drugs.
MeSH term(s)	Amino Acid Transport System X-AG/drug effects ; Amino Acid Transport System X-AG/physiology ; Brain Ischemia/drug therapy ; Brain Ischemia/physiopathology ; Glycine Plasma Membrane Transport Proteins/drug effects ; Glycine Plasma Membrane Transport Proteins/physiology ; Humans ; Neuralgia/drug therapy ; Neuralgia/physiopathology ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/physiopathology ; Schizophrenia/drug therapy ; Schizophrenia/physiopathology ; Stiff-Person Syndrome/drug therapy ; Stiff-Person Syndrome/physiopathology
Chemical Substances	Amino Acid Transport System X-AG ; Glycine Plasma Membrane Transport Proteins
Language	Spanish
Publishing date	2018-12-07
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	1468278-3
ISSN	1576-6578 ; 0210-0010
ISSN (online)	1576-6578
ISSN	0210-0010
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Article ; Online: Improving Waiting Time for Chemotherapy with Ahead-of-Time Drug Preparation.

Descalzo, Juan Marcos / Frutos, Eliana Ludmila / Castro, Javier / Lombardo, Victoria Regia / Gimenez, Cintia / Otero, Paula / Luna, Daniel / Otero, Carlos

Studies in health technology and informatics

2024 Volume 310, Page(s) 144–148

Abstract: Waiting time for chemotherapy infusion is a fundamental factor to measure quality of care. It has been shown that a prolonged waiting time is related to a higher incidence of anticipatory nausea and poor patient adherence to scheduled appointments and ... ...

Abstract	Waiting time for chemotherapy infusion is a fundamental factor to measure quality of care. It has been shown that a prolonged waiting time is related to a higher incidence of anticipatory nausea and poor patient adherence to scheduled appointments and recommended oncology treatment programs. Some chemotherapy regimens can be prepared hours ahead-of-time, due to long stability. We aimed to study the effect of an informatic-led workflow redesign intervention, facilitating workflow changes in the Oncology Pharmacy, on patient waiting time. This intervention included changes on EHR processes and the chemotherapy CPOE. Their main effect was allowing ahead-of-time preparation of selected chemotherapy regimes. We conducted a cross sectional study, comparing waiting times pre and post intervention periods. A total of 4600 programmed chemotherapy episodes were included. We found a 26.5 % decrease in the mean wait time in the post intervention period (p > 0.02). We were able to show a decrease in waiting time and a measurable impact of the intervention. This evaluation produced valuable and actionable data for Oncology units and adds a valuable, Latin American experience to the literature.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Drug Compounding ; Waiting Lists ; Neoplasms/drug therapy ; Antineoplastic Agents/supply & distribution
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2024-01-24
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI230944
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Article ; Online: Regulation of the Glycine Transporter GLYT1 by microRNAs.

Jiménez, Esperanza / Piniella, Dolores / Giménez, Cecilio / Zafra, Francisco

Neurochemical research

2021 Volume 47, Issue 1, Page(s) 138–147

Abstract: The glycine transporter GLYT1 participates in inhibitory and excitatory neurotransmission by controlling the reuptake of this neuroactive substance from synapses. Over the past few years, microRNAs have emerged as potent negative regulators of gene ... ...

Abstract	The glycine transporter GLYT1 participates in inhibitory and excitatory neurotransmission by controlling the reuptake of this neuroactive substance from synapses. Over the past few years, microRNAs have emerged as potent negative regulators of gene expression. In this report, we investigate the possible regulation of GLYT1 by microRNAs. TargetScan software predicted the existence of multiple targets for microRNAs within the 3' UTR of the human GLYT1 (miR-7, miR-30, miR-96, miR-137 and miR-141), and as they are all conserved among mammalian orthologues, their effects on GLYT1 expression were determined experimentally. Dual reporter bioluminescent assays showed that only miR-96 and miR-137 down-regulated expression of the Renilla reporter fused to the 3' UTR of GLYT1. Mutations introduced into the target sequences blocked this inhibitory effect. Consistently, these two microRNAs downregulated the uptake of [
MeSH term(s)	Animals ; Glycine Plasma Membrane Transport Proteins/genetics ; Glycine Plasma Membrane Transport Proteins/metabolism ; Mammals/genetics ; Mammals/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neuroglia/metabolism ; Neurons/metabolism ; Rats ; Synaptic Transmission
Chemical Substances	Glycine Plasma Membrane Transport Proteins ; MIRN137 microRNA, rat ; MIRN96 microRNA, rat ; MicroRNAs ; Slc6a9 protein, rat
Language	English
Publishing date	2021-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	199335-5
ISSN	1573-6903 ; 0364-3190
ISSN (online)	1573-6903
ISSN	0364-3190
DOI	10.1007/s11064-021-03228-x
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Article ; Online: Bio-guided isolation of aromatic abietane diterpenoids from Salvia canariensis as biopesticides in the control of phytopathogenic fungi.

López-Cabeza, Rocío / Rodríguez-Sabina, Samuel / Reyes, Carolina P / Expósito, Daniela G / Giménez, Cristina / Jiménez, Ignacio A / Cabrera, Raimundo / Bazzocchi, Isabel L

Pest management science

2024 Volume 80, Issue 4, Page(s) 2199–2207

Abstract: Background: Biofungicides arise as a promising alternative to the indiscriminate use of harmful synthetic fungicides in crop management.: Results: The present study reports the bio-guided fractionation of an endemic plant from the Canary Islands, ... ...

Abstract	Background: Biofungicides arise as a promising alternative to the indiscriminate use of harmful synthetic fungicides in crop management. Results: The present study reports the bio-guided fractionation of an endemic plant from the Canary Islands, Salvia canariensis against the phytopathogens, Alternaria alternata, Botrytis cinerea, and Fusarium oxysporum. This procedure allowed identifying a series of diterpenoids with an abietane skeleton (1-5), which exhibited remarkable activity against the phytopathogenic fungi assayed. Their structures were established by means of spectroscopic and spectrometric methods, as well as comparison with reported data. Compounds 2 (carnosic acid), 4 (11-acetoxy carnosic acid) and 5 (11,12-diacetoxy carnosic acid) showed significant mycelium growth inhibition (%GI > 50 at 0.1 mg/mL concentration) on all the assayed fungi, and with a potency also higher than the positive control, Fosbel-Plus, a fungicide commonly used in agriculture. A preliminary structure-activity relationship is also discussed. Conclusions: These findings underline the aromatic abietane diterpenoids as promising eco-friendly alternatives to conventional fungicides to use in integrated pest management. © 2024 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
MeSH term(s)	Abietanes/pharmacology ; Abietanes/chemistry ; Fungicides, Industrial/pharmacology ; Salvia/chemistry ; Biological Control Agents ; Fungi
Chemical Substances	salvin (LI791SXT24) ; Abietanes ; Fungicides, Industrial ; Biological Control Agents
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2001705-4
ISSN	1526-4998 ; 1526-498X
ISSN (online)	1526-4998
ISSN	1526-498X
DOI	10.1002/ps.7958
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