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  1. Book ; Online: Chapter The environmental function analysis: a promising tool to evaluate the coastal zone conservation potential

    Giordano, Laura / Buonocunto, Francesco Paolo / Ferraro, Luciana / Milia, Alfonsa / Mali, Matilda

    (Monitoring of Mediterranean Coastal Areas: Problems and Measurement Techniques)

    2022  

    Series title Monitoring of Mediterranean Coastal Areas: Problems and Measurement Techniques
    Keywords The environment ; Environmental Function Analysis ; Conservation ; Costal zone ; Sustainable Development ; Tyrrhenian Sea
    Language English
    Size 1 electronic resource (10 pages)
    Publisher Firenze University Press
    Publishing place Florence
    Document type Book ; Online
    Note English
    HBZ-ID HT030376221
    ISBN 9791221500301
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Chapter Grain size, nutrients and heavy metals analysis to evaluate natural vs anthropogenic sources in the sea environment (Naples Bay, Eastern Tyrrhenian Sea)

    MILIA, ALFONSA / francesco paolo, buonocunto / Di Leo, Antonella / Ferraro, Luciana / giandomenico, santina / Giordano, Laura / Violante, Crescenzo

    (Monitoring of Mediterranean Coastal Areas: Problems and Measurement Techniques)

    2022  

    Series title Monitoring of Mediterranean Coastal Areas: Problems and Measurement Techniques
    Keywords The environment ; Heavy metals contamination ; Nutrients and grain size ; Submarine delta zone ; Naples Bay ; Tyrrhenian Sea
    Language English
    Size 1 electronic resource (10 pages)
    Publisher Firenze University Press
    Publishing place Florence
    Document type Book ; Online
    Note English
    HBZ-ID HT030376199
    ISBN 9791221500301
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Chapter The offshore environmental impact by Sarno river in Naples bay (South-West Italy)

    Di Leo, Antonella / Giandomenico, Santina / Spada, Lucia / Cardellicchio, Nicola / Buonocunto, Francesco Paolo / Esposito, Eliana / Ferraro, Luciana / Giordano, Laura / Milia, Alfonsa / Violante, Crescenzo

    (Proceedings e report)

    2020  

    Series title Proceedings e report
    Keywords Organic matter ; Naples bay
    Language 0|e
    Size 1 electronic resource (10 pages)
    Publisher Firenze University Press
    Publishing place Florence
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021609459
    ISBN 9788855181471 ; 8855181475
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online: On the KLM properties of a fuzzy DL with Typicality

    Giordano, Laura

    2021  

    Abstract: The paper investigates the properties of a fuzzy logic of typicality. The extension of fuzzy logic with a typicality operator was proposed in recent work to define a fuzzy multipreference semantics for Multilayer Perceptrons, by regarding the deep neural ...

    Abstract The paper investigates the properties of a fuzzy logic of typicality. The extension of fuzzy logic with a typicality operator was proposed in recent work to define a fuzzy multipreference semantics for Multilayer Perceptrons, by regarding the deep neural network as a conditional knowledge base. In this paper, we study its properties. First, a monotonic extension of a fuzzy ALC with typicality is considered (called ALC^FT) and a reformulation the KLM properties of a preferential consequence relation for this logic is devised. Most of the properties are satisfied, depending on the reformulation and on the fuzzy combination functions considered. We then strengthen ALC^FT with a closure construction by introducing a notion of faithful model of a weighted knowledge base, which generalizes the notion of coherent model of a conditional knowledge base previously introduced, and we study its properties.

    Comment: 15 pages
    Keywords Computer Science - Artificial Intelligence ; I.2.4
    Subject code 629
    Publishing date 2021-06-01
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online: From Weighted Conditionals of Multilayer Perceptrons to Gradual Argumentation and Back

    Giordano, Laura

    2021  

    Abstract: A fuzzy multipreference semantics has been recently proposed for weighted conditional knowledge bases, and used to develop a logical semantics for Multilayer Perceptrons, by regarding a deep neural network (after training) as a weighted conditional ... ...

    Abstract A fuzzy multipreference semantics has been recently proposed for weighted conditional knowledge bases, and used to develop a logical semantics for Multilayer Perceptrons, by regarding a deep neural network (after training) as a weighted conditional knowledge base. This semantics, in its different variants, suggests some gradual argumentation semantics, which are related to the family of the gradual semantics studied by Amgoud and Doder. The relationships between weighted conditional knowledge bases and MLPs extend to the proposed gradual semantics to capture the stationary states of MPs, in agreement with previous results on the relationship between argumentation frameworks and neural networks. The paper also suggests a simple way to extend the proposed semantics to deal attacks/supports by a boolean combination of arguments, based on the fuzzy semantics of weighted conditionals, as well as an approach for defeasible reasoning over a weighted argumentation graph, building on the proposed gradual semantics.

    Comment: 21 pages. arXiv admin note: text overlap with arXiv:2106.00390
    Keywords Computer Science - Artificial Intelligence ; I.2.4
    Subject code 006
    Publishing date 2021-10-07
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Potential New Therapies "ROS-Based" in CLL: An Innovative Paradigm in the Induction of Tumor Cell Apoptosis.

    Sciaccotta, Raffaele / Gangemi, Sebastiano / Penna, Giuseppa / Giordano, Laura / Pioggia, Giovanni / Allegra, Alessandro

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: Chronic lymphocytic leukemia, in spite of recent advancements, is still an incurable disease; the majority of patients eventually acquire resistance to treatment through relapses. In all subtypes of chronic lymphocytic leukemia, the disruption of normal ... ...

    Abstract Chronic lymphocytic leukemia, in spite of recent advancements, is still an incurable disease; the majority of patients eventually acquire resistance to treatment through relapses. In all subtypes of chronic lymphocytic leukemia, the disruption of normal B-cell homeostasis is thought to be mostly caused by the absence of apoptosis. Consequently, apoptosis induction is crucial to the management of this illness. Damaged biological components can accumulate as a result of the oxidation of intracellular lipids, proteins, and DNA by reactive oxygen species. It is possible that cancer cells are more susceptible to apoptosis because of their increased production of reactive oxygen species. An excess of reactive oxygen species can lead to oxidative stress, which can harm biological elements like DNA and trigger apoptotic pathways that cause planned cell death. In order to upset the balance of oxidative stress in cells, recent therapeutic treatments in chronic lymphocytic leukemia have focused on either producing reactive oxygen species or inhibiting it. Examples include targets created in the field of nanomedicine, natural extracts and nutraceuticals, tailored therapy using biomarkers, and metabolic targets. Current developments in the complex connection between apoptosis, particularly ferroptosis and its involvement in epigenomics and alterations, have created a new paradigm.
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13040475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: An ASP approach for reasoning on neural networks under a finitely many-valued semantics for weighted conditional knowledge bases

    Giordano, Laura / Dupré, Daniele Theseider

    2022  

    Abstract: Weighted knowledge bases for description logics with typicality have been recently considered under a "concept-wise" multipreference semantics (in both the two-valued and fuzzy case), as the basis of a logical semantics of MultiLayer Perceptrons (MLPs). ... ...

    Abstract Weighted knowledge bases for description logics with typicality have been recently considered under a "concept-wise" multipreference semantics (in both the two-valued and fuzzy case), as the basis of a logical semantics of MultiLayer Perceptrons (MLPs). In this paper we consider weighted conditional ALC knowledge bases with typicality in the finitely many-valued case, through three different semantic constructions. For the boolean fragment LC of ALC we exploit ASP and "asprin" for reasoning with the concept-wise multipreference entailment under a phi-coherent semantics, suitable to characterize the stationary states of MLPs. As a proof of concept, we experiment the proposed approach for checking properties of trained MLPs. The paper is under consideration for acceptance in TPLP.

    Comment: Paper presented at the 38th International Conference on Logic Programming (ICLP 2022), 16 pages
    Keywords Computer Science - Artificial Intelligence ; 68T27 ; I.2.4
    Subject code 006
    Publishing date 2022-02-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Conservation or development? An environmental function analysis assessment of the Volturno River coastal zone (central Tyrrhenian Sea - Italy)

    Giordano, Laura / Ferraro, Luciana

    Journal of coastal conservation. 2020 Feb., v. 24, no. 1

    2020  

    Abstract: This study allowed to identify several land-use conflicts in the Volturno River Coastal Zone area which extends for about 50 km2 on-land and seaward. The study area was analysed via Environmental Function Analysis involving assessment of specific ... ...

    Abstract This study allowed to identify several land-use conflicts in the Volturno River Coastal Zone area which extends for about 50 km2 on-land and seaward. The study area was analysed via Environmental Function Analysis involving assessment of specific environmental and socio-economic indicators. These were allocated scores from field surveys, interviews and extensive desktop studies, which included literature data and public territorial geo-databases. Normalised scores allowed production of a conservation/development matrix, enabling to evaluate the potential for conservation, development or conflict fields. The main conflicts were strictly related to urbanization, land reclamation and conservation of pristine areas with increasing anthropic pressure. The study site resulted to be in the conservation/development full conflict field of the matrix, signifying a tendency to high conflict rather than conservation as one might expect. This demonstrated that despite the strong attempt to preserve a pristine environment, the presence of different conflicts of use can hinder both the potential of development and the conservation of the area preventing either to take place. This important result leads to suggest that Environmental Function Analysis may be a potential tool for forthcoming adaptive management strategies in the study area.
    Keywords adaptive management ; anthropogenic activities ; coasts ; interviews ; land restoration ; land use ; rivers ; socioeconomics ; spatial data ; surveys ; urbanization ; Italy ; Tyrrhenian Sea
    Language English
    Dates of publication 2020-02
    Size p. 6.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 2053395-0
    ISSN 1874-7841 ; 1400-0350
    ISSN (online) 1874-7841
    ISSN 1400-0350
    DOI 10.1007/s11852-019-00717-8
    Database NAL-Catalogue (AGRICOLA)

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  9. Book ; Online: Complexity and scalability of defeasible reasoning in many-valued weighted knowledge bases with typicality

    Alviano, Mario / Giordano, Laura / Dupré, Daniele Theseider

    2023  

    Abstract: Weighted knowledge bases for description logics with typicality under a "concept-wise" multi-preferential semantics provide a logical interpretation of MultiLayer Perceptrons. In this context, Answer Set Programming (ASP) has been shown to be suitable ... ...

    Abstract Weighted knowledge bases for description logics with typicality under a "concept-wise" multi-preferential semantics provide a logical interpretation of MultiLayer Perceptrons. In this context, Answer Set Programming (ASP) has been shown to be suitable for addressing defeasible reasoning in the finitely many-valued case, providing a $\Pi^p_2$ upper bound on the complexity of the problem, nonetheless leaving unknown the exact complexity and only providing a proof-of-concept implementation. This paper fulfils the lack by providing a $P^{NP[log]}$-completeness result and new ASP encodings that deal with weighted knowledge bases with large search spaces.

    Comment: 14 pages 4, figures
    Keywords Computer Science - Artificial Intelligence ; 68T27 ; I.2.4
    Publishing date 2023-03-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Targeting Redox Regulation as a Therapeutic Opportunity against Acute Leukemia: Pro-Oxidant Strategy or Antioxidant Approach?

    Allegra, Alessandro / Tonacci, Alessandro / Giordano, Laura / Musolino, Caterina / Gangemi, Sebastiano

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 9

    Abstract: Redox adaptation is essential for human health, as the physiological quantities of non-radical reactive oxygen species operate as the main second messengers to regulate normal redox reactions by controlling several sensors. An abnormal increase reactive ... ...

    Abstract Redox adaptation is essential for human health, as the physiological quantities of non-radical reactive oxygen species operate as the main second messengers to regulate normal redox reactions by controlling several sensors. An abnormal increase reactive oxygen species, called oxidative stress, induces biological injury. For this reason, variations in oxidative stress continue to receive consideration as a possible approach to treat leukemic diseases. However, the intricacy of redox reactions and their effects might be a relevant obstacle; consequently, and alongside approaches aimed at increasing oxidative stress in neoplastic cells, antioxidant strategies have also been suggested for the same purpose. The present review focuses on the molecular processes of anomalous oxidative stress in acute myeloid and acute lymphoblastic leukemias as well as on the oxidative stress-determined pathways implicated in leukemogenic development. Furthermore, we review the effect of chemotherapies on oxidative stress and the possibility that their pharmacological effects might be increased by modifying the intracellular redox equilibrium through a pro-oxidant approach or an antioxidant strategy. Finally, we evaluated the prospect of varying oxidative stress as an efficacious modality to destroy chemoresistant cells using new methodologies. Altering redox conditions may be advantageous for inhibiting genomic variability and the eradication of leukemic clones will promote the treatment of leukemic disease.
    Language English
    Publishing date 2022-08-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11091696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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