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  1. Article: Alter Game: A Study Protocol on a Virtual "Serious Game" for Relapse Prevention in Patients With Gambling Disorder.

    Giordano, Rosaria / Donati, Maria Anna / Zamboni, Lorenzo / Fusina, Francesca / Primi, Caterina / Lugoboni, Fabio

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 854088

    Abstract: Cognitive behavioral therapy (CBT) is the most successful protocol in gambling disorder (GD) treatment. However, it presents some weaknesses, especially concerning relapse prevention (RP). RP is one of the most important therapeutic steps, aiming at ... ...

    Abstract Cognitive behavioral therapy (CBT) is the most successful protocol in gambling disorder (GD) treatment. However, it presents some weaknesses, especially concerning relapse prevention (RP). RP is one of the most important therapeutic steps, aiming at managing cravings and to avoid future relapse increasing perceived self-efficacy. Encouraging results come from the blending of psychotherapy and virtual reality (VR), containing gambling cues. The goal of
    Language English
    Publishing date 2022-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.854088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: COVID-19 lockdown: Impact on online gambling, online shopping, web navigation and online pornography.

    Zamboni, Lorenzo / Carli, Silvia / Belleri, Marika / Giordano, Rosaria / Saretta, Giulia / Lugoboni, Fabio

    Journal of public health research

    2021  Volume 10, Issue 1, Page(s) 1759

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-02-15
    Publishing country Italy
    Document type Journal Article
    ISSN 2279-9028
    ISSN 2279-9028
    DOI 10.4081/jphr.2021.1759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Challenges of running a GMP facility for regenerative medicine in a public hospital.

    Viganò, Mariele / Giordano, Rosaria / Lazzari, Lorenza

    Regenerative medicine

    2017  Volume 12, Issue 7, Page(s) 803–813

    Abstract: Advanced therapy medicinal products represent a new generation of medicinal products for regenerative medicine. Since the implementation of the EU regulation for this innovative class of drugs, the academic and hospital institutions have played a central ...

    Abstract Advanced therapy medicinal products represent a new generation of medicinal products for regenerative medicine. Since the implementation of the EU regulation for this innovative class of drugs, the academic and hospital institutions have played a central role in their development and manufacture. For these institutions that are not familiar with the industrial context, being in compliance with the pharmaceutical standards is extremely challenging. This report describes how we dealt with some specific issues during our hospital-based GMP experience. Furthermore, we identify as a future perspective the consistent stimulating contribution that a public entity can ensure for advanced therapy medicinal product development and licensing.
    MeSH term(s) Documentation ; Hospitals, Public/standards ; Humans ; Quality Assurance, Health Care ; Quality Control ; Regenerative Medicine/standards
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2274500-2
    ISSN 1746-076X ; 1746-0751
    ISSN (online) 1746-076X
    ISSN 1746-0751
    DOI 10.2217/rme-2017-0051
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6627: Show issues Location:
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    Zs.MO 629: Show issues

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  4. Article: A flow cytometric assay for the quantification of MSC lysis by peripheral blood mononucleated cells.

    Chieregato, Katia / Bernardi, Martina / Alghisi, Alberta / Giordano, Rosaria / Lazzari, Lorenza / Perbellini, Omar / Rassu, Mario / Ruggeri, Marco / Astori, Giuseppe

    Heliyon

    2021  Volume 7, Issue 2, Page(s) e06036

    Abstract: Mesenchymal stromal cells (MSC) are attractive candidates for the treatment of acute graft versus host disease (aGvHD) or autoimmune disorders. However, mechanisms of MSC recognition remain unclear and there are evidences that MSC are not totally ... ...

    Abstract Mesenchymal stromal cells (MSC) are attractive candidates for the treatment of acute graft versus host disease (aGvHD) or autoimmune disorders. However, mechanisms of MSC recognition remain unclear and there are evidences that MSC are not totally immunoprivileged. Data suggest that MSC undergo apoptosis after infusion in presence of cytotoxic cells and their death could drive immunosuppression. In GvHD patients, that activity was associated with clinical response. It is mandatory to develop an
    Language English
    Publishing date 2021-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2021.e06036
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  5. Article ; Online: Chondrogenic and BMP-4 primings confer osteogenesis potential to human cord blood mesenchymal stromal cells delivered with biphasic calcium phosphate ceramics.

    Brennan, Meadhbh Á / Barilani, Mario / Rusconi, Francesco / de Lima, Julien / Vidal, Luciano / Lavazza, Cristiana / Lazzari, Lorenza / Giordano, Rosaria / Layrolle, Pierre

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 6751

    Abstract: Bone marrow mesenchymal stem/stromal cells (BMSCs) show great promise for bone repair, however they are isolated by an invasive bone marrow harvest and their regenerative potential decreases with age. Conversely, cord blood can be collected non- ... ...

    Abstract Bone marrow mesenchymal stem/stromal cells (BMSCs) show great promise for bone repair, however they are isolated by an invasive bone marrow harvest and their regenerative potential decreases with age. Conversely, cord blood can be collected non-invasively after birth and contains MSCs (CBMSCs) that can be stored for future use. However, whether CBMSCs can replace BMSCs targeting bone repair is unknown. This study evaluates the in vitro osteogenic potential of unprimed, osteogenically primed, or chondrogenically primed CBMSCs and BMSCs and their in vivo bone forming capacity following ectopic implantation on biphasic calcium phosphate ceramics in nude mice. In vitro, alkaline phosphatase (intracellular, extracellular, and gene expression), and secretion of osteogenic cytokines (osteoprotegerin and osteocalcin) was significantly higher in BMSCs compared with CBMSCs, while CBMSCs demonstrated superior chondrogenic differentiation and secretion of interleukins IL-6 and IL-8. BMSCs yielded significantly more cell engraftment and ectopic bone formation compared to CBMSCs. However, priming of CBMSCs with either chondrogenic or BMP-4 supplements led to bone formation by CBMSCs. This study is the first direct quantification of the bone forming abilities of BMSCs and CBMSCs in vivo and, while revealing the innate superiority of BMSCs for bone repair, it provides avenues to induce osteogenesis by CBMSCs.
    MeSH term(s) Adult ; Biomarkers ; Bone Morphogenetic Protein 4/genetics ; Bone Morphogenetic Protein 4/metabolism ; Bone Substitutes ; Cell Differentiation/genetics ; Cells, Cultured ; Chondrogenesis/genetics ; Cytokines/metabolism ; Fetal Blood/cytology ; Humans ; Hydroxyapatites ; Immunohistochemistry ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Osteogenesis/genetics ; Tissue Engineering ; Young Adult
    Chemical Substances BMP4 protein, human ; Biomarkers ; Bone Morphogenetic Protein 4 ; Bone Substitutes ; Cytokines ; Hydroxyapatites ; hydroxyapatite-beta tricalcium phosphate
    Language English
    Publishing date 2021-03-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-86147-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: ASRS Questionnaire and Tobacco Use: Not Just a Cigarette. A Screening Study in an Italian Young Adult Sample.

    Zamboni, Lorenzo / Marchetti, Pierpaolo / Congiu, Alessio / Giordano, Rosaria / Fusina, Francesca / Carli, Silvia / Centoni, Francesco / Verlato, Giuseppe / Lugoboni, Fabio

    International journal of environmental research and public health

    2021  Volume 18, Issue 6

    Abstract: Young adults exhibit greater sensitivity than adults to nicotine reinforcement, and Attention Deficit Hyperactivity Disorder (ADHD) increases the risk for early-onset smoking. We investigated the correlation between ADHD Self-Report Scale (ASRS) scores ... ...

    Abstract Young adults exhibit greater sensitivity than adults to nicotine reinforcement, and Attention Deficit Hyperactivity Disorder (ADHD) increases the risk for early-onset smoking. We investigated the correlation between ADHD Self-Report Scale (ASRS) scores and smoking, evaluated the prevalence of ADHD symptomatology (not diagnoses) in smokers and non-smokers and its comorbidity with benzodiazepine and gambling addictions. A total of 389 young adults from 14 schools in Northern Italy fill out a survey and the Adult ADHD Self-Report Scale (ASRS). A total of 15.2% of subjects tested positive at the ASRS, which correlated with smoking; moreover, smokers had twice the probability of testing positive at the ASRS. ADHD symptomatology, especially when comorbid with tobacco abuse, is an important condition to monitor because early nicotine exposure could be a gateway for other addictive behaviors.
    MeSH term(s) Attention Deficit Disorder with Hyperactivity/epidemiology ; Humans ; Italy/epidemiology ; Surveys and Questionnaires ; Tobacco Products ; Tobacco Use ; Tobacco Use Disorder ; Young Adult
    Language English
    Publishing date 2021-03-12
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18062920
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  7. Article ; Online: Role of the blood service in cellular therapy.

    Rebulla, Paolo / Giordano, Rosaria

    Biologicals : journal of the International Association of Biological Standardization

    2012  Volume 40, Issue 3, Page(s) 218–221

    Abstract: Cellular therapy is a novel form of medical or surgical treatment using cells in place of or in addition to traditional chemical drugs. The preparation of cellular products - called advanced therapy medicinal products - ATMP in Europe, requires ... ...

    Abstract Cellular therapy is a novel form of medical or surgical treatment using cells in place of or in addition to traditional chemical drugs. The preparation of cellular products - called advanced therapy medicinal products - ATMP in Europe, requires compliance with good manufacturing practices (GMP). Based on long-term experience in blood component manufacturing, product traceability and hemovigilance, selected blood services may represent ideal settings for the development and experimental use of ATMP. International harmonization of the protocols and procedures for the preparation of ATMP is of paramount importance to facilitate the development of multicenter clinical trials with adequate sample size, which are urgently needed to determine the clinical efficacy of ATMP. This article describes European regulations on cellular therapy and summarizes the activities of the 'Franco Calori' Cell Factory, a GMP unit belonging to the department of regenerative medicine of a large public university hospital, which acquired a certification for the GMP production of ATMP in 2007 and developed nine experimental clinical protocols during 2003-2011.
    MeSH term(s) Blood Safety/methods ; Blood Safety/standards ; Cell- and Tissue-Based Therapy/methods ; Cell- and Tissue-Based Therapy/standards ; Clinical Trials as Topic/methods ; Clinical Trials as Topic/standards ; Europe ; Humans ; Multicenter Studies as Topic/methods ; Multicenter Studies as Topic/standards ; Regenerative Medicine/methods ; Regenerative Medicine/standards
    Language English
    Publishing date 2012-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1017370-5
    ISSN 1095-8320 ; 1045-1056
    ISSN (online) 1095-8320
    ISSN 1045-1056
    DOI 10.1016/j.biologicals.2011.10.007
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 879: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Role of the blood service in cellular therapy

    Rebulla, Paolo / Giordano, Rosaria

    Biologicals. 2012 May, v. 40, no. 3

    2012  

    Abstract: Cellular therapy is a novel form of medical or surgical treatment using cells in place of or in addition to traditional chemical drugs. The preparation of cellular products – called advanced therapy medicinal products – ATMP in Europe, requires ... ...

    Abstract Cellular therapy is a novel form of medical or surgical treatment using cells in place of or in addition to traditional chemical drugs. The preparation of cellular products – called advanced therapy medicinal products – ATMP in Europe, requires compliance with good manufacturing practices (GMP). Based on long-term experience in blood component manufacturing, product traceability and hemovigilance, selected blood services may represent ideal settings for the development and experimental use of ATMP. International harmonization of the protocols and procedures for the preparation of ATMP is of paramount importance to facilitate the development of multicenter clinical trials with adequate sample size, which are urgently needed to determine the clinical efficacy of ATMP. This article describes European regulations on cellular therapy and summarizes the activities of the ‘Franco Calori’ Cell Factory, a GMP unit belonging to the department of regenerative medicine of a large public university hospital, which acquired a certification for the GMP production of ATMP in 2007 and developed nine experimental clinical protocols during 2003–2011.
    Keywords blood ; certification ; clinical trials ; compliance ; drugs ; good manufacturing practices ; manufacturing ; medicine ; surgery ; traceability ; Europe
    Language English
    Dates of publication 2012-05
    Size p. 218-221.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1017370-5
    ISSN 1095-8320 ; 1045-1056
    ISSN (online) 1095-8320
    ISSN 1045-1056
    DOI 10.1016/j.biologicals.2011.10.007
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 879: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: A virtual reality craving study in tobacco addiction: The role of non-pharmacological support in tobacco detox therapy.

    Zamboni, Lorenzo / Campagnari, Simone / Giordano, Rosaria / Fusina, Francesca / Carli, Silvia / Congiu, Alessio / Barbon, Isabella / Melchiori, Silvia / Casari, Rebecca / Tedeschi, Elisa / Vesentin, Roberta / Verlato, Giuseppe / Infante, Maurizio Valentino / Lugoboni, Fabio

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 940100

    Abstract: Nicotine addiction is a widespread, worldwide epidemic, causing six million deaths per year. A large variety of treatments for smoking cessation are currently available, including Cytisine, which is a promising drug due to its low cost and high safety ... ...

    Abstract Nicotine addiction is a widespread, worldwide epidemic, causing six million deaths per year. A large variety of treatments for smoking cessation are currently available, including Cytisine, which is a promising drug due to its low cost and high safety levels. Notwithstanding the important amount of research on tobacco addiction treatments, smoking remains one of the most difficult substance use disorders to treat, probably also due to the fact that pharmacological treatment often overlooks other maintaining factors in this addiction, such as sensory impact and cue reactivity. To address this gap in both treatment protocols and scientific literature, we propose a study protocol in which we will compare the effects of combining Cytisine with Nirdosh, a herbal tobacco substitute, to Cytisine only in two groups of patients (C + N and C) who will also undergo exposure to four different virtual reality settings that will assess the importance of environmental cues. We will further assess mood and craving in the two samples, and include a control group taken from the general population. We expect the C + N group to report a more positive mood and a lower sensitivity to tobacco-related environmental cues.
    Language English
    Publishing date 2022-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.940100
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  10. Article ; Online: Process development and validation of expanded regulatory T cells for prospective applications: an example of manufacturing a personalized advanced therapy medicinal product.

    Lavazza, Cristiana / Budelli, Silvia / Montelatici, Elisa / Viganò, Mariele / Ulbar, Francesca / Catani, Lucia / Cannone, Marta Giulia / Savelli, Sara / Groppelli, Elisa / Lazzari, Lorenza / Lemoli, Roberto M / Cescon, Matteo / La Manna, Gaetano / Giordano, Rosaria / Montemurro, Tiziana

    Journal of translational medicine

    2022  Volume 20, Issue 1, Page(s) 14

    Abstract: Background: A growing number of clinical trials have shown that regulatory T (T: Results: The GMP-compliant protocol defined in this work allows at least 4.11 × 10: Conclusions: These results could be of great use for facilities implementing GMP- ... ...

    Abstract Background: A growing number of clinical trials have shown that regulatory T (T
    Results: The GMP-compliant protocol defined in this work allows at least 4.11 × 10
    Conclusions: These results could be of great use for facilities implementing GMP-compliant cell therapy protocols of these cells for different conditions aimed at restoring the T
    MeSH term(s) Cell- and Tissue-Based Therapy ; Graft vs Host Disease ; Humans ; Immune Tolerance ; Prospective Studies ; T-Lymphocytes, Regulatory
    Language English
    Publishing date 2022-01-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-021-03200-x
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