Article ; Online: Drug-induced radiation recall reactions and non-anticancer drugs: A descriptive analysis from VigiBase®.
Fundamental & clinical pharmacology
2023 Volume 37, Issue 3, Page(s) 673–679
Abstract: Radiation recall reactions are inflammatory reactions confined to previously irradiated tissues, often of drug-induced etiology, particularly with anticancer therapies. Other drugs, in particular COVID-19 vaccines, may also be involved. To describe ... ...
| Abstract | Radiation recall reactions are inflammatory reactions confined to previously irradiated tissues, often of drug-induced etiology, particularly with anticancer therapies. Other drugs, in particular COVID-19 vaccines, may also be involved. To describe radiation recall reactions under non-anticancer drugs more precisely, we extracted the cases of radiation recall reactions associated with non-anticancer drugs from WHO pharmacovigilance database VigiBase®. We performed two analyses from this extraction: a global analysis and an analysis focusing on vaccination-related issues. We extracted 120 cases corresponding to 269 drugs, of which 130 were non-anticancer (22 vaccines). Among the non-anticancer drugs, tozinameran was the most reported treatment (4.46% of cases), followed by levofloxacin (2.97%) and folinic acid (2.60%), dexamethasone (2.23), and ChAdOx1 nCoV-19 vaccine and prednisone (1.86% each). Among vaccines, tozinameran (54.55% of cases) was the most reported, followed by ChAdOx1 nCoV-19 (22.73%), HPV and inactivated influenza vaccine (9.09% each), and elasomeran (4.55%). Our study first describes the occurrence of radiation recall reactions during non-anticancer treatment. It also highlights a potential safety signal with COVID-19 vaccines. |
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| MeSH term(s) | Humans ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 ; COVID-19/epidemiology ; COVID-19/prevention & control ; BNT162 Vaccine ; Radiodermatitis ; Influenza Vaccines | |||||
| Chemical Substances | COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; BNT162 Vaccine ; Influenza Vaccines | |||||
| Language | English | |||||
| Publishing date | 2023-01-11 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 639134-5 | |||||
| ISSN | 1472-8206 ; 0767-3981 | |||||
| ISSN (online) | 1472-8206 | |||||
| ISSN | 0767-3981 | |||||
| DOI | 10.1111/fcp.12866 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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