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  1. Article ; Online: Correction: Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks.

    Federico, María Belén / Vallerga, María Belén / Radl, Analía / Paviolo, Natalia Soledad / Bocco, José Luis / Giorgio, Marina Di / Soria, Gastón / Gottifredi, Vanesa

    PLoS genetics

    2023  Volume 19, Issue 12, Page(s) e1011094

    Abstract: This corrects the article DOI: 10.1371/journal.pgen.1005792.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pgen.1005792.].
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1011094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Calibration curves by 60Co with low dose rate are different in terms of dose estimation - a comparative study.

    Mendes, Mariana Esposito / Mendonça, Julyanne Conceição Goes de / Hwang, Suy / Giorgio, Marina Di / Lima, Fabiana Farias de / Santos, Neide

    Genetics and molecular biology

    2020  Volume 43, Issue 1, Page(s) e20180370

    Abstract: Biological dosimetry aims to estimate individual absorbed doses due ionizing radiation exposure. The dicentric chromosomes are considered the most specific biomarker for dose estimation. This study aimed to compare calibration curves for linear low ... ...

    Abstract Biological dosimetry aims to estimate individual absorbed doses due ionizing radiation exposure. The dicentric chromosomes are considered the most specific biomarker for dose estimation. This study aimed to compare calibration curves for linear low energy transfer (LET) radiation built from low dose rates and whether they vary in terms of dose estimation. For that we did a search in the literature of all calibration curves produced with low dose rates and we simulated the dose estimation from pre-established dicentric's frequencies. The information on methodologies and cytogenetic results of each study were analyzed. As expected dose rate influence β coefficients, especially at higher doses. However, we have seen that some doses were not statistically different but they should be, because there is a significant association between the productions of dicentrics and dose rate. This comparative study reinforced the robustness of the dicentric assay and its importance in biological dosimetry. We also emphasized that the dose rate was an important factor in dose estimations. Thus, intercomparison exercises should take into account the dose rates of the participating laboratories, because the dose rates might explain why some results of estimated doses fall outside the recommendations.
    Language English
    Publishing date 2020-02-17
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 1445712-x
    ISSN 1678-4685 ; 1415-4757
    ISSN (online) 1678-4685
    ISSN 1415-4757
    DOI 10.1590/1678-4685-GMB-2018-0370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3079: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Key outcome summaries of the scientific programme of the IRPA15 congress.

    Weiss, Wolfgang / Salomaa, Sisko / Giorgio, Marina Di / Boyd, Mike / Thurston, Jim / Takala, John / Tokonami, Shinji / Vaillant, Ludovic / Coates, Roger / Kim, Jong Kyung

    Journal of radiological protection : official journal of the Society for Radiological Protection

    2021  Volume 41, Issue 4

    Abstract: This special issue of JRP includes a selection of research papers and review articles presented at the 15th Congress of the International Radiation Protection Association (IRPA15) as chosen by the scientific committee. All invited journal contributions ... ...

    Abstract This special issue of JRP includes a selection of research papers and review articles presented at the 15th Congress of the International Radiation Protection Association (IRPA15) as chosen by the scientific committee. All invited journal contributions are suitably expanded beyond the initial conference presentations to meet the criteria for a full journal article and include (a) presentation within a comprehensive radiological protection context and (b) additional data/interpretation. Published contributions address a wide spectrum of scientific topics and concepts to further develop the radiation protection (RP) system. They are based on scientific evidence and available experience in a wide spectrum of applications of the protection system. The IRPA is the international voice of the RP profession. It promotes excellence in RP by providing benchmarks of good practice, enhancing professional competence, and encourages the application of the highest standards of professional conduct, skills and knowledge for the benefit of individuals and society. Within the overarching theme of the conference 'Bridging RP Culture and Science-Widening Public Empathy' IRPA15 provided an invaluable opportunity to discuss and strengthen the relations between RP culture and science, and share developing scientific knowledge and related experience in RP among members of the scientific community, between representatives of key international organizations, including ICRP, IAEA, WHO, and NEA but also with the public. Some discussions focused on the rationale of available RP programmes and priorities, with an opportunity to identify and further develop key scientific issues of the current RP system as well as key processes for the interaction between members of the scientific community and society. The scientific programme of IRPA15 included eight topics and four thematic areas. The topical areas were: Underpinning Science; Dosimetry and Measurement; the System of Protection; Standards and Regulation; Practical Implementation-Medical Sector, as well as Industry and Research; Emergency Preparedness and Response; Existing Exposures and Non-ionizing Radiation. The thematic areas addressed were: Ethics; Communication and Public Understanding; RP Culture; Human Capital and Competency.
    MeSH term(s) Communication ; Humans ; Radiation Protection ; Societies
    Language English
    Publishing date 2021-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 639411-5
    ISSN 1361-6498 ; 0952-4746
    ISSN (online) 1361-6498
    ISSN 0952-4746
    DOI 10.1088/1361-6498/ac0802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1886: Show issues Location:
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  4. Article: Genetic and epigenetic features in radiation sensitivity. Part II: implications for clinical practice and radiation protection.

    Bourguignon, Michel H / Gisone, Pablo A / Perez, Maria R / Michelin, Severino / Dubner, Diana / Giorgio, Marina Di / Carosella, Edgardo D

    European journal of nuclear medicine and molecular imaging

    2005  Volume 32, Issue 3, Page(s) 351–368

    Abstract: Recent progress especially in the field of gene identification and expression has attracted greater attention to the genetic and epigenetic susceptibility to cancer, possibly enhanced by ionising radiation. This issue is especially important for ... ...

    Abstract Recent progress especially in the field of gene identification and expression has attracted greater attention to the genetic and epigenetic susceptibility to cancer, possibly enhanced by ionising radiation. This issue is especially important for radiation therapists since hypersensitive patients may suffer from adverse effects in normal tissues following standard radiation therapy, while normally sensitive patients could receive higher doses of radiation, offering a better likelihood of cure for malignant tumours. Although only a small percentage of individuals are "hypersensitive" to radiation effects, all medical specialists using ionising radiation should be aware of the aforementioned progress in medical knowledge. The present paper, the second of two parts, reviews human disorders known or strongly suspected to be associated with hypersensitivity to ionising radiation. The main tests capable of detecting such pathologies in advance are analysed, and ethical issues regarding genetic testing are considered. The implications for radiation protection of possible hypersensitivity to radiation in a part of the population are discussed, and some guidelines for nuclear medicine professionals are proposed.
    MeSH term(s) Epigenesis, Genetic ; Genetic Diseases, Inborn/diagnosis ; Genetic Diseases, Inborn/etiology ; Genetic Diseases, Inborn/prevention & control ; Genetic Predisposition to Disease/prevention & control ; Humans ; Practice Guidelines as Topic ; Practice Patterns, Physicians' ; Radiation Injuries/diagnosis ; Radiation Injuries/genetics ; Radiation Injuries/prevention & control ; Radiation Protection/methods ; Radiation Tolerance/genetics ; Radiation, Ionizing ; Risk Assessment/methods ; Risk Factors
    Language English
    Publishing date 2005-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 1619-7070 ; 0340-6997
    ISSN (online) 1619-7089
    ISSN 1619-7070 ; 0340-6997
    DOI 10.1007/s00259-004-1731-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Genetic and epigenetic features in radiation sensitivity Part I: cell signalling in radiation response.

    Bourguignon, Michel H / Gisone, Pablo A / Perez, Maria R / Michelin, Severino / Dubner, Diana / Giorgio, Marina Di / Carosella, Edgardo D

    European journal of nuclear medicine and molecular imaging

    2005  Volume 32, Issue 2, Page(s) 229–246

    Abstract: Recent progress especially in the field of gene identification and expression has attracted greater attention to genetic and epigenetic susceptibility to cancer, possibly enhanced by ionising radiation. It has been proposed that the occurrence and ... ...

    Abstract Recent progress especially in the field of gene identification and expression has attracted greater attention to genetic and epigenetic susceptibility to cancer, possibly enhanced by ionising radiation. It has been proposed that the occurrence and severity of the adverse reactions to radiation therapy are also influenced by such genetic susceptibility. This issue is especially important for radiation therapists since hypersensitive patients may suffer from adverse effects in normal tissues following standard radiation therapy, while normally sensitive patients could receive higher doses of radiation offering a better likelihood of cure for malignant tumours. This paper, the first of two parts, reviews the main mechanisms involved in cell response to ionising radiation. DNA repair machinery and cell signalling pathways are considered and their role in radiosensitivity is analysed. The implication of non-targeted and delayed effects in radiosensitivity is also discussed.
    MeSH term(s) Animals ; Bystander Effect/genetics ; Bystander Effect/radiation effects ; Cell Communication/genetics ; Cell Communication/radiation effects ; DNA Damage ; DNA Repair/genetics ; DNA Repair/radiation effects ; Dose-Response Relationship, Radiation ; Epigenesis, Genetic/genetics ; Epigenesis, Genetic/radiation effects ; Humans ; Radiation Dosage ; Radiation Tolerance/genetics ; Radiation, Ionizing
    Language English
    Publishing date 2005-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 1619-7070 ; 0340-6997
    ISSN (online) 1619-7089
    ISSN 1619-7070 ; 0340-6997
    DOI 10.1007/s00259-004-1730-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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