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  1. Article ; Online: Dendritic Cell Metabolism and Function in Tumors.

    Giovanelli, Paolo / Sandoval, Tito A / Cubillos-Ruiz, Juan R

    Trends in immunology

    2019  Volume 40, Issue 8, Page(s) 699–718

    Abstract: Dendritic cells (DCs) are fundamental for the initiation and maintenance of immune responses against malignant cells. Despite the unique potential of DCs to elicit robust anticancer immunity, the tumor microenvironment poses a variety of challenges that ... ...

    Abstract Dendritic cells (DCs) are fundamental for the initiation and maintenance of immune responses against malignant cells. Despite the unique potential of DCs to elicit robust anticancer immunity, the tumor microenvironment poses a variety of challenges that hinder competent DC function and consequently inhibit the development of protective immune responses. Here, we discuss recent studies uncovering new molecular pathways and metabolic programs that tumors manipulate in DCs to disturb their homeostasis and evade immune control. We also examine certain state-of-the-art strategies that seek to improve DC function and elicit antitumor responses in hosts with cancer. Understanding and modulating DC metabolism and activity within tumors might help improve the efficacy of T cell-centric immunotherapies.
    MeSH term(s) Amino Acids/metabolism ; Animals ; Cellular Reprogramming ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Disease Susceptibility/immunology ; Energy Metabolism ; Glycolysis ; Humans ; Immunomodulation ; Lipid Metabolism ; Mice ; Neoplasms/etiology ; Neoplasms/metabolism ; Neoplasms/pathology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Oxidative Stress ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Tumor Microenvironment/immunology
    Chemical Substances Amino Acids ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase Type II (EC 1.14.13.39)
    Language English
    Publishing date 2019-07-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2019.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1601: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MG 2: Show issues

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  2. Book: Langenscheidts Handwörterbuch Italienisch / 2

    Giovannelli, Paolo / Frenzel, Walter / Frenzel, Herbert

    1989  

    Collection Langenscheidts Handwörterbuch Italienisch
    Keywords Italienisch ; Wörterbuch ; Deutsch
    Subject Neuhochdeutsch ; Deutsche Sprache ; Hochdeutsch ; Reallexikon ; Sachwörterbuch ; Sprachwörterbuch ; Vokabular ; Vokabularium ; Wörterbücher ; Dictionary ; Italienische Sprache
    Language German ; Italian
    Size 654 S.
    Edition Neubearb., 10. Aufl.
    Publisher Langenscheidt
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT003429648
    ISBN 3-468-04186-1 ; 978-3-468-04186-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 11643 order for loan Magazin

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  3. Book: Langenscheidts Handwörterbuch Italienisch / 1

    Giovannelli, Paolo / Frenzel, Walter / Frenzel, Herbert

    1988  

    Collection Langenscheidts Handwörterbuch Italienisch
    Keywords Italienisch ; Wörterbuch ; Deutsch
    Subject Neuhochdeutsch ; Deutsche Sprache ; Hochdeutsch ; Reallexikon ; Sachwörterbuch ; Sprachwörterbuch ; Vokabular ; Vokabularium ; Wörterbücher ; Dictionary ; Italienische Sprache
    Language German ; Italian
    Size 558 S.
    Edition Neubearb. 1985, 6. Aufl.
    Publisher Langenscheidt
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT003429588
    ISBN 3-468-04181-0 ; 978-3-468-04181-5
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer.

    Crowley, Michael J P / Bhinder, Bhavneet / Markowitz, Geoffrey J / Martin, Mitchell / Verma, Akanksha / Sandoval, Tito A / Chae, Chang-Suk / Yomtoubian, Shira / Hu, Yang / Chopra, Sahil / Tavarez, Diamile A / Giovanelli, Paolo / Gao, Dingcheng / McGraw, Timothy E / Altorki, Nasser K / Elemento, Olivier / Cubillos-Ruiz, Juan R / Mittal, Vivek

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 120

    Abstract: IRE1α-XBP1 signaling is emerging as a central orchestrator of malignant progression and immunosuppression in various cancer types. Employing a computational XBP1s detection method applied to TCGA datasets, we demonstrate that expression of the XBP1s mRNA ...

    Abstract IRE1α-XBP1 signaling is emerging as a central orchestrator of malignant progression and immunosuppression in various cancer types. Employing a computational XBP1s detection method applied to TCGA datasets, we demonstrate that expression of the XBP1s mRNA isoform predicts poor survival in non-small cell lung cancer (NSCLC) patients. Ablation of IRE1α in malignant cells delays tumor progression and extends survival in mouse models of NSCLC. This protective effect is accompanied by alterations in intratumoral immune cell subsets eliciting durable adaptive anti-cancer immunity. Mechanistically, cancer cell-intrinsic IRE1α activation sustains mPGES-1 expression, enabling production of the immunosuppressive lipid mediator prostaglandin E
    MeSH term(s) Animals ; Humans ; Mice ; Carcinoma, Non-Small-Cell Lung/genetics ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; Lung Neoplasms/genetics ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Signal Transduction ; X-Box Binding Protein 1/genetics ; X-Box Binding Protein 1/metabolism
    Chemical Substances Endoribonucleases (EC 3.1.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; X-Box Binding Protein 1 ; ERN1 protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2023-01-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-35584-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function.

    Sheppard, Sam / Santosa, Endi K / Lau, Colleen M / Violante, Sara / Giovanelli, Paolo / Kim, Hyunu / Cross, Justin R / Li, Ming O / Sun, Joseph C

    Cell reports

    2021  Volume 35, Issue 9, Page(s) 109210

    Abstract: Natural killer (NK) cells are cytotoxic lymphocytes capable of rapid cytotoxicity, cytokine secretion, and clonal expansion. To sustain such energetically demanding processes, NK cells must increase their metabolic capacity upon activation. However, ... ...

    Abstract Natural killer (NK) cells are cytotoxic lymphocytes capable of rapid cytotoxicity, cytokine secretion, and clonal expansion. To sustain such energetically demanding processes, NK cells must increase their metabolic capacity upon activation. However, little is known about the metabolic requirements specific to NK cells in vivo. To gain greater insight, we investigated the role of aerobic glycolysis in NK cell function and demonstrate that their glycolytic rate increases rapidly following viral infection and inflammation, prior to that of CD8
    MeSH term(s) Aerobiosis ; Animals ; CD8-Positive T-Lymphocytes/immunology ; Cell Proliferation ; Clone Cells ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/pathology ; Cytomegalovirus Infections/virology ; Glycolysis ; Homeostasis ; Killer Cells, Natural/immunology ; Lactate Dehydrogenase 5/metabolism ; Mice, Inbred C57BL ; Muromegalovirus/immunology ; Neoplasms/immunology ; Neoplasms/pathology ; Up-Regulation ; Mice
    Chemical Substances Lactate Dehydrogenase 5 (EC 1.1.1.27.-)
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2021.109210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Langenscheidts Handwörterbuch Italienisch / 1

    Giovannelli, Paolo / Frenzel, Walter / Frenzel, Herbert

    1981  

    Collection Langenscheidts Handwörterbuch Italienisch
    Keywords Italienisch ; Wörterbuch ; Deutsch
    Subject Neuhochdeutsch ; Deutsche Sprache ; Hochdeutsch ; Reallexikon ; Sachwörterbuch ; Sprachwörterbuch ; Vokabular ; Vokabularium ; Wörterbücher ; Dictionary ; Italienische Sprache
    Language German ; Italian
    Size 566 S.
    Edition Neubearb. 1972, 14. Aufl.
    Publisher Langenscheidt
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT002248715
    ISBN 3-468-04180-2 ; 978-3-468-04180-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1982 B 507 -1- order for loan Magazin

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  7. Article ; Online: Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer.

    Chae, Chang-Suk / Sandoval, Tito A / Hwang, Sung-Min / Park, Eun Sil / Giovanelli, Paolo / Awasthi, Deepika / Salvagno, Camilla / Emmanuelli, Alexander / Tan, Chen / Chaudhary, Vidyanath / Casado, Julia / Kossenkov, Andrew V / Song, Minkyung / Barrat, Franck J / Holcomb, Kevin / Romero-Sandoval, E Alfonso / Zamarin, Dmitriy / Pépin, David / D'Andrea, Alan D /
    Färkkilä, Anniina / Cubillos-Ruiz, Juan R

    Cancer discovery

    2022  Volume 12, Issue 8, Page(s) 1904–1921

    Abstract: Lysophosphatidic acid (LPA) is a bioactive lipid enriched in the tumor microenvironment of immunosuppressive malignancies such as ovarian cancer. Although LPA enhances the tumorigenic attributes of cancer cells, the immunomodulatory activity of this ... ...

    Abstract Lysophosphatidic acid (LPA) is a bioactive lipid enriched in the tumor microenvironment of immunosuppressive malignancies such as ovarian cancer. Although LPA enhances the tumorigenic attributes of cancer cells, the immunomodulatory activity of this phospholipid messenger remains largely unexplored. Here, we report that LPA operates as a negative regulator of type I interferon (IFN) responses in ovarian cancer. Ablation of the LPA-generating enzyme autotaxin (ATX) in ovarian cancer cells reprogrammed the tumor immune microenvironment, extended host survival, and improved the effects of therapies that elicit protective responses driven by type I IFN. Mechanistically, LPA sensing by dendritic cells triggered PGE2 biosynthesis that suppressed type I IFN signaling via autocrine EP4 engagement. Moreover, we identified an LPA-controlled, immune-derived gene signature associated with poor responses to combined PARP inhibition and PD-1 blockade in patients with ovarian cancer. Controlling LPA production or sensing in tumors may therefore be useful to improve cancer immunotherapies that rely on robust induction of type I IFN.
    Significance: This study uncovers that ATX-LPA is a central immunosuppressive pathway in the ovarian tumor microenvironment. Ablating this axis sensitizes ovarian cancer hosts to various immunotherapies by unleashing protective type I IFN responses. Understanding the immunoregulatory programs induced by LPA could lead to new biomarkers predicting resistance to immunotherapy in patients with cancer. See related commentary by Conejo-Garcia and Curiel, p. 1841. This article is highlighted in the In This Issue feature, p. 1825.
    MeSH term(s) Female ; Humans ; Interferon Type I ; Lysophospholipids/genetics ; Lysophospholipids/metabolism ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Receptors, Lysophosphatidic Acid/genetics ; Receptors, Lysophosphatidic Acid/metabolism ; Tumor Microenvironment
    Chemical Substances Interferon Type I ; Lysophospholipids ; Receptors, Lysophosphatidic Acid ; lysophosphatidic acid (PG6M3969SG)
    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-21-1181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6916: Show issues Location:
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  8. Book ; Collection: Langenscheidts Handwörterbuch Italienisch

    Giovannelli, Paolo / Frenzel, Walter / Frenzel, Herbert

    (Langenscheidts Handwörterbücher)

    1965  

    Series title Langenscheidts Handwörterbücher
    Keywords Italienisch ; Wörterbuch ; Deutsch
    Subject Neuhochdeutsch ; Deutsche Sprache ; Hochdeutsch ; Reallexikon ; Sachwörterbuch ; Sprachwörterbuch ; Vokabular ; Vokabularium ; Wörterbücher ; Dictionary ; Italienische Sprache
    Language German ; Italian
    Dates of publication 1965-9999
    Publisher Langenscheidt
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book ; Collection (display volumes)
    Remark Neueste Ausg.: Handb. A 13 H 61
    HBZ-ID HT001331705
    Database Catalogue ZB MED Medicine, Health

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  9. Article ; Online: IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain.

    Chopra, Sahil / Giovanelli, Paolo / Alvarado-Vazquez, Perla Abigail / Alonso, Sara / Song, Minkyung / Sandoval, Tito A / Chae, Chang-Suk / Tan, Chen / Fonseca, Miriam M / Gutierrez, Silvia / Jimenez, Leandro / Subbaramaiah, Kotha / Iwawaki, Takao / Kingsley, Philip J / Marnett, Lawrence J / Kossenkov, Andrew V / Crespo, Mariano Sanchez / Dannenberg, Andrew J / Glimcher, Laurie H /
    Romero-Sandoval, E Alfonso / Cubillos-Ruiz, Juan R

    Science (New York, N.Y.)

    2019  Volume 365, Issue 6450

    Abstract: Inositol-requiring enzyme 1[α] (IRE1[α])-X-box binding protein spliced (XBP1) signaling maintains endoplasmic reticulum (ER) homeostasis while controlling immunometabolic processes. Yet, the physiological consequences of IRE1α-XBP1 activation in ... ...

    Abstract Inositol-requiring enzyme 1[α] (IRE1[α])-X-box binding protein spliced (XBP1) signaling maintains endoplasmic reticulum (ER) homeostasis while controlling immunometabolic processes. Yet, the physiological consequences of IRE1α-XBP1 activation in leukocytes remain unexplored. We found that induction of prostaglandin-endoperoxide synthase 2 (
    MeSH term(s) Animals ; Cells, Cultured ; Cyclooxygenase 2/genetics ; Dinoprostone/biosynthesis ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; Humans ; Leukocytes/metabolism ; Mice ; Mice, Inbred C57BL ; Myeloid Cells/metabolism ; Pain, Postoperative/genetics ; Pain, Postoperative/metabolism ; Promoter Regions, Genetic ; Prostaglandin-E Synthases/genetics ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction ; Unfolded Protein Response ; Visceral Pain/genetics ; Visceral Pain/metabolism ; X-Box Binding Protein 1/genetics ; X-Box Binding Protein 1/metabolism
    Chemical Substances X-Box Binding Protein 1 ; Cyclooxygenase 2 (EC 1.14.99.1) ; ERN1 protein, human (EC 2.7.11.1) ; Ern1 protein, mouse (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Endoribonucleases (EC 3.1.-) ; Prostaglandin-E Synthases (EC 5.3.99.3) ; Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2019-07-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aau6499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 77: Show issues

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  10. Book: Langenscheidts Handwörterbuch Italienisch

    Frenzel, Walter / Giovanelli, Paolo

    1977  

    Language German ; Italian
    Size 566 S, 8°
    Edition 7. Aufl
    Publisher Langenscheidt
    Publishing place Berlin u.a.
    Document type Book
    ISBN 3468041802 ; 9783468041808
    Database Former special subject collection: coastal and deep sea fishing

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