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  1. Article: Post-pregnancy recurrent biliary colic with intraoperative diagnosis of limy bile syndrome.

    Migliore, Marco / Giraudo, Giorgio / Gianotti, Laura / Testa, Valentina / Borghi, Felice

    International journal of surgery case reports

    2021  Volume 83, Page(s) 105976

    Abstract: Introduction: Limy bile syndrome (LBS) is an unusual condition in which gallbladder and/or bile ducts are filled with paste-like radiopaque material with a high calcium carbonate content. It can be rarely associated with PTH disorder and hypercalcemia.!# ...

    Abstract Introduction: Limy bile syndrome (LBS) is an unusual condition in which gallbladder and/or bile ducts are filled with paste-like radiopaque material with a high calcium carbonate content. It can be rarely associated with PTH disorder and hypercalcemia.
    Presentation of case: A 35-year-old woman presented with epigastric and right hypochondrium pain since a few hours. Similar attacks occurred in the past months soon after a pregnancy with vaginal delivery. Laboratory findings were not significant. The abdominal ultrasound highlighted a micro-lithiasis of gallbladder without complications. Considering the recurrent biliary attacks, laparoscopic cholecystectomy was performed with intraoperative diagnosis of LBS. A subsequent endocrinological screening highlighted a normocalcemic hyperparathyroidism associated with Vitamin D deficiency, likely related to the recent pregnancy and not to LBS.
    Discussion: LBS is a rare condition with not clear etiology, frequently associated with cholelithiasis, of which it shares clinical presentation and potential complications. Diagnosis of LBS is based on abdominal X-ray/computed tomography scan, or it could be an intraoperative finding. The gold standard treatment is represented by laparoscopic cholecystectomy. The pregnancy with its related cholestatic phenotype could facilitate the LBS manifestation. An endocrinological screening should be performed to rule out a concomitant calcium metabolism disorder.
    Conclusion: Knowledge of this rare condition could help general surgeons handle it properly.
    Language English
    Publishing date 2021-05-13
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2021.105976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A case of pylephlebitis complicated with liver abscess secondary to cholecystitis.

    Racca, Giulia / D'Agnano, Salvatore / Giraudo, Giorgio / Bracco, Christian / Badinella Martini, Marco / Melchio, Remo / Serraino, Cristina / Fenoglio, Luigi Maria

    Internal and emergency medicine

    2023  Volume 18, Issue 5, Page(s) 1481–1485

    MeSH term(s) Humans ; Liver Abscess/complications ; Liver Diseases/complications ; Cholecystitis/complications
    Language English
    Publishing date 2023-05-24
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-023-03290-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Feasibility of enhanced recovery after surgery program in colorectal surgery during COVID-19 pandemic in Italy: should we change something?

    Borghi, Felice / Pellegrino, Luca / Pruiti, Vincenzo / Donati, Danilo / Giraudo, Giorgio

    Updates in surgery

    2020  Volume 72, Issue 2, Page(s) 319–320

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Enhanced Recovery After Surgery ; Humans ; Intestinal Diseases/surgery ; Italy ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-13
    Publishing country Italy
    Document type Letter
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-020-00827-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Minimally invasive adrenalectomy for large pheochromocytoma: not recommendable yet? Results from a single institution case series.

    Arolfo, Simone / Giraudo, Giuseppe / Franco, Caterina / Parasiliti Caprino, Mirko / Seno, Elisabetta / Morino, Mario

    Langenbeck's archives of surgery

    2021  Volume 407, Issue 1, Page(s) 277–283

    Abstract: Background: Minimally invasive adrenalectomy represents the treatment of choice of pheochromocytoma (PCC). For large or invasive PCCs, an open approach is currently recommended, in order to ensure complete tumor resection, prevent tumor rupture, avoid ... ...

    Abstract Background: Minimally invasive adrenalectomy represents the treatment of choice of pheochromocytoma (PCC). For large or invasive PCCs, an open approach is currently recommended, in order to ensure complete tumor resection, prevent tumor rupture, avoid local recurrence, and limit perioperative hemodynamic instability. The aim of this study is to analyze perioperative outcomes of laparoscopic adrenalectomies (LAs) for large adrenal PCCs.
    Methods: All consecutive LAs for PCC performed at a single institution between 1998 and 2020 were included. Two groups were defined: lesions larger (group 1) and smaller (group 2) than 5 cm. Short-term outcomes were compared in order to find any significant difference between the two groups.
    Outcomes: One hundred fourteen patients underwent LA during the study period: 46 for lesions larger and 68 for lesions smaller than 5 cm. No significant differences were found in patients' characteristics, median operative time, conversion rate, intraoperative hemodynamic and metabolic parameters, postoperative intensive care unit (ICU) admission rate, complications rate, and length of hospital stay. Long-term oncologic outcomes were similar, with a recurrence rate of 5.1% in group 1 vs 3.6% in group 2 (p = 1).
    Conclusion: Minimally invasive adrenalectomy seems to be safe and effective even in large PCC. The recommendation to prefer an open approach for large PCCs should probably be reconsidered.
    MeSH term(s) Adrenal Gland Neoplasms/surgery ; Adrenalectomy ; Humans ; Laparoscopy ; Pheochromocytoma/surgery ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2021-09-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-021-02312-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: "Never Trust to General Impressions, My Boy, but Concentrate Yourself upon Details": An Unusual and Challenging Presentation of Pheochromocytoma.

    Barbero, Umberto / Matta, Mario / Caprino, Mirko Parasiliti / Maletta, Francesca / Giraudo, Giuseppe / Frea, Simone / De Benedictis, Michele / Maccario, Mauro

    Journal of cardiovascular development and disease

    2021  Volume 8, Issue 6

    Abstract: We present the case of a 45-year-old woman admitted to our unit with acute heart failure and cardiogenic shock, requiring an intra-aortic balloon pump insertion and inotropes and vasopressors infusion. Despite such treatment, the patient developed multi ... ...

    Abstract We present the case of a 45-year-old woman admitted to our unit with acute heart failure and cardiogenic shock, requiring an intra-aortic balloon pump insertion and inotropes and vasopressors infusion. Despite such treatment, the patient developed multi organ failure and intravascular disseminated coagulation with haemolysis. The initial diagnosis of acute myocarditis was subsequently denied by the finding of bilateral adrenal masses by MRI scan, and urine and plasma metanephrines measurements confirmed a pheochromocytoma (PCC). Genetic analysis revealed a mutation in the neurofibromatosis type 1 (NF1) gene, and an accurate physical examination drew attention to small cafè-au-lait spots, usually associated with this syndrome. PCC diagnosis should be promptly considered in patients presenting with unexplained acute heart failure and cardiogenic shock of unknown origin, considering its life-threatening complications and the good prognosis after radical surgery.
    Language English
    Publishing date 2021-06-15
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd8060071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Persistence of Elevated Procalcitonin in a Patient with Coronavirus Disease 2019 Uncovered a Diagnosis of Medullary Thyroid Carcinoma.

    Gianotti, Laura / D'Agnano, Salvatore / Pettiti, Giorgio / Tassone, Francesco / Giraudo, Giorgio / Lauro, Corrado / Lauria, Giuseppe / Del Bono, Valerio / Borretta, Giorgio

    AACE clinical case reports

    2021  Volume 7, Issue 5, Page(s) 288–292

    Abstract: Objective: During the ongoing coronavirus disease 2019 pandemic, procalcitonin (PCT) levels have proven useful in assisting clinicians to diagnose bacterial superinfection. However, in the absence of signs of infection or at the resolution thereof, ... ...

    Abstract Objective: During the ongoing coronavirus disease 2019 pandemic, procalcitonin (PCT) levels have proven useful in assisting clinicians to diagnose bacterial superinfection. However, in the absence of signs of infection or at the resolution thereof, inappropriately and persistently high PCT levels may suggest and reveal the presence of other pathologies. We report a patient with severe acute respiratory syndrome coronavirus 2 pneumonia with initially elevated PCT levels that persisted during recovery, prompting the diagnosis of medullary thyroid carcinoma (MTC).
    Methods: A 43-year-old man presented with a 2-day history of fever, sneezing, sore throat, and dry cough. His PCT was 94 ng/mL (normal value, 0.00-0.10 ng/mL), and he was positive for severe acute respiratory syndrome coronavirus 2 RNA.
    Results: Empirical antibiotic therapy was administered for 7 days, but despite a clinical improvement, serum PCT remained high (84 ng/mL). Serum calcitonin (CTN) was 2120 pg/mL (normal, ≤12 pg/mL). Cytologic examination of thyroid nodules and CTN measurement of the aspiration needle washout confirmed MTC. The patient underwent total thyroidectomy with bilateral cervical lymph node dissection. Lowered CTN (986 pg/mL) and PCT (16 ng/mL) levels were observed 48 hours after surgery. A close follow-up was planned following the results of
    Conclusion: PCT can be a useful biochemical marker of MTC suspicion in patients with inflammatory conditions and persistently elevated PCT, even after resolution. In our case, high levels of PCT in a patient with coronavirus disease 2019 pneumonia without signs of bacterial infection led to MTC diagnosis.
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Case Reports
    ISSN 2376-0605
    ISSN (online) 2376-0605
    DOI 10.1016/j.aace.2021.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Feasibility of enhanced recovery after surgery program in colorectal surgery during COVID-19 pandemic in Italy: should we change something?

    Borghi, Felice / Pellegrino, Luca / Pruiti, Vincenzo / Donati, Danilo / Giraudo, Giorgio

    Updates Surg

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #597547
    Database COVID19

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  8. Article ; Online: Feasibility of enhanced recovery after surgery program in colorectal surgery during COVID-19 pandemic in Italy

    Borghi, Felice / Pellegrino, Luca / Pruiti, Vincenzo / Donati, Danilo / Giraudo, Giorgio

    Updates in Surgery

    should we change something?

    2020  Volume 72, Issue 2, Page(s) 319–320

    Keywords Surgery ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-020-00827-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Sutureless Repair for Open Treatment of Inguinal Hernia: Three Techniques in Comparison.

    Baldini, Enke / Lori, Eleonora / Morini, Carola / Palla, Luigi / Coletta, Diego / De Luca, Giuseppe M / Giraudo, Giorgio / Intini, Sergio G / Perotti, Bruno / Sorge, Angelo / Sozio, Giampaolo / Arganini, Marco / Beltrami, Elsa / Pironi, Daniele / Ranalli, Massimo / Saviano, Cecilia / Patriti, Alberto / Usai, Sofia / Vernaccini, Nicola /
    Vittore, Francesco / D'Andrea, Vito / Nardi, Priscilla / Sorrenti, Salvatore / Palumbo, Piergaspare

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: Currently, groin hernia repair is mostly performed with application of mesh prostheses fixed with or without suture. However, views on safety and efficacy of different surgical approaches are still partly discordant. In this multicentre retrospective ... ...

    Abstract Currently, groin hernia repair is mostly performed with application of mesh prostheses fixed with or without suture. However, views on safety and efficacy of different surgical approaches are still partly discordant. In this multicentre retrospective study, three sutureless procedures, i.e., mesh fixation with glue, application of self-gripping mesh, and Trabucco's technique, were compared in 1034 patients with primary unilateral non-complicated inguinal hernia subjected to open anterior surgery. Patient-related features, comorbidities, and drugs potentially affecting the intervention outcomes were also examined. The incidence of postoperative complications, acute and chronic pain, and time until discharge were assessed. A multivariate logistic regression was used to compare the odds ratio of the surgical techniques adjusting for other risk factors. The application of standard/heavy mesh, performed in the Trabucco's technique, was found to significantly increase the odds ratio of hematomas (
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Laparoscopic total mesorectal excision-the Turin experience.

    Morino, M / Giraudo, G

    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer

    2005  Volume 165, Page(s) 167–179

    Abstract: Improved local control and survival rates in the treatment of rectal cancer have been reported after total mesorectal excision (TME). We performed an analysis of TME for rectal cancer by laparoscopic approach during a prospective nonrandomized trial. A ... ...

    Abstract Improved local control and survival rates in the treatment of rectal cancer have been reported after total mesorectal excision (TME). We performed an analysis of TME for rectal cancer by laparoscopic approach during a prospective nonrandomized trial. A prospective consecutive series of 98 laparoscopic total mesorectal excision (LTME) procedures for low and mid-rectal tumors. All patients had a sphincter-saving procedure. Case selection, surgical technique, and clinical and oncological results were reviewed. The distal limit of rectal neoplasm was on average 5.4 cm (range 3-12) from the anal verge. The mean operative time was 192.5 min (range 125-360). The conversion rate was 18.4%. The mean postoperative stay was 11.6 days (range 4-61). The 30-day mortality rate was 1% (1/98) and the overall postoperative morbidity was 18.4% including 10 anastomotic leakages. Concerning long-term oncological results, we evaluated 93 (94.8%) patients with a median follow-up of 46.3 months (range 12-132). During this period, 15.1% (14/93) died of cancer and 7.5% (7/93) are alive with metastatic disease. The port-site metastases rate was 2.1% (2/93). The locoregional pelvic recurrence rate was 2.1% (2/93): 1 stage II at 12 months and 1 stage III at 18 postoperative months, respectively. LTME is a feasible but technically demanding procedure (18.4% conversion rate). Our series confirms the safety of the procedure, while oncological results are at present comparable to the open published series with the limitation of a short follow-up period. Further studies and possibly randomized series will be necessary to evaluate long-term clinical outcome in cancer patients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Digestive System Surgical Procedures/methods ; Female ; Humans ; Laparoscopy ; Male ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Seeding ; Postoperative Complications ; Prospective Studies ; Rectal Neoplasms/mortality ; Rectal Neoplasms/pathology ; Rectal Neoplasms/surgery ; Survival Analysis ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2005
    Publishing country Germany
    Document type Journal Article
    ISSN 0080-0015
    ISSN 0080-0015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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