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  1. Article ; Online: GBV-C: state of the art and future prospects.

    Giret, Maria Teresa Maidana / Kallas, Esper Georges

    Current HIV/AIDS reports

    2012  Volume 9, Issue 1, Page(s) 26–33

    Abstract: The GB virus C is a common non-pathogenic virus, member of the Flaviviridae family with worldwide distribution. Favorable clinical course and reduced mortality among HIV-infected patients was demonstrated by several studies with patients co-infected with ...

    Abstract The GB virus C is a common non-pathogenic virus, member of the Flaviviridae family with worldwide distribution. Favorable clinical course and reduced mortality among HIV-infected patients was demonstrated by several studies with patients co-infected with the GB virus C (GBV-C). This potential benefit of GBV-C has been demonstrated in the pre-HAART and post-HAART eras; however, this effect was not observed in all studies and the discrepancy may be due to changes during the course of HIV infection, characteristic of the cohort, and the degree of therapeutic response. The GBV-C has been found to decrease HIV replication in in vitro models, highlighting the interference of persistent GBV-C viremia. The mechanism of the beneficial effect of GBV-C appears to be mediated by changes in the cellular immune response, and elucidation of putative protective effects of GBV-C in HIV co-infection could potentially identify novel targets for anti-HIV agents.
    MeSH term(s) Coinfection/virology ; Flaviviridae Infections/epidemiology ; Flaviviridae Infections/transmission ; Flaviviridae Infections/virology ; GB virus C/physiology ; HIV Infections/virology ; HIV-1/pathogenicity ; HIV-1/physiology ; Hepatitis, Viral, Human/epidemiology ; Hepatitis, Viral, Human/transmission ; Hepatitis, Viral, Human/virology ; Humans ; Viral Interference/physiology ; Virus Replication
    Language English
    Publishing date 2012-01-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2151206-1
    ISSN 1548-3576 ; 1548-3568
    ISSN (online) 1548-3576
    ISSN 1548-3568
    DOI 10.1007/s11904-011-0109-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Variability of HIV-1 genomes among children and adolescents from São Paulo, Brazil.

    Sanabani, Sabri Saeed / Pessôa, Rodrigo / Soares de Oliveira, Ana Carolina / Martinez, Vanessa Pouza / Giret, Maria Teresa Maidana / de Menezes Succi, Regina Célia / Carvalho, Karina / Tomiyama, Claudia Satiko / Nixon, Douglas F / Sabino, Ester Cerdeira / Kallas, Esper Georges

    PloS one

    2013  Volume 8, Issue 5, Page(s) e62552

    Abstract: Background: Genetic variability is a major feature of the human immunodeficiency virus type 1 (HIV-1) and considered the key factor to frustrating efforts to halt the virus epidemic. In this study, we aimed to investigate the genetic variability of HIV- ... ...

    Abstract Background: Genetic variability is a major feature of the human immunodeficiency virus type 1 (HIV-1) and considered the key factor to frustrating efforts to halt the virus epidemic. In this study, we aimed to investigate the genetic variability of HIV-1 strains among children and adolescents born from 1992 to 2009 in the state of Sao Paulo, Brazil.
    Methodology: Plasma and peripheral blood mononuclear cells (PBMC) were collected from 51 HIV-1-positive children and adolescents on ART followed between September 1992 and July 2009. After extraction, the genetic materials were used in a polymerase chain reaction (PCR) to amplify the viral near full length genomes (NFLGs) from 5 overlapped fragments. NFLGs and partial amplicons were directly sequenced and data were phylogenetically inferred.
    Results: Of the 51 samples studied, the NFLGs and partial fragments of HIV-1 from 42 PBMCs and 25 plasma were successfully subtyped. Results based on proviral DNA revealed that 22 (52.4%) patients were infected with subtype B, 16 (38.1%) were infected with BF1 mosaic variants and 4 (9.5%) were infected with sub-subtype F1. All the BF1 recombinants were unique and distinct from any previously identified unique or circulating recombinant forms in South America. Evidence of dual infections was detected in 3 patients coinfected with the same or distinct HIV-1 subtypes. Ten of the 31 (32.2%) and 12 of the 21 (57.1%) subjects with recovered proviral and plasma, respectively, protease sequences were infected with major mutants resistant to protease inhibitors. The V3 sequences of 14 patients with available sequences from PBMC/or plasma were predicted to be R5-tropic virus except for two patients who harbored an X4 strain.
    Conclusions: The high proportion of HIV-1 BF1 recombinant, coinfection rate and vertical transmission in Brazil merits urgent attention and effective measures to reduce the transmission of HIV among spouses and sex partners.
    MeSH term(s) Adolescent ; Brazil ; Child ; Child, Preschool ; Drug Resistance, Viral/genetics ; Female ; Genetic Variation ; Genome, Viral/genetics ; Genomics ; Genotype ; HIV-1/drug effects ; HIV-1/genetics ; HIV-1/physiology ; Humans ; Leukocytes, Mononuclear/metabolism ; Male ; Mutation ; Viral Tropism/genetics ; Young Adult
    Language English
    Publishing date 2013-05-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0062552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: High human herpesvirus 8 (HHV-8) prevalence, clinical correlates and high incidence among recently HIV-1-infected subjects in Sao Paulo, Brazil.

    Batista, Mariana Dias / Ferreira, Suzete / Sauer, Mariana M / Tomiyama, Helena / Giret, Maria Teresa Maidana / Pannuti, Cláudio S / Diaz, Ricardo S / Sabino, Ester C / Kallas, Esper G

    PloS one

    2009  Volume 4, Issue 5, Page(s) e5613

    Abstract: Background: Human herpesvirus 8 (HHV-8) is the etiological agent for Kaposi Sarcoma, which occurs especially in HIV-infected subjects. HHV-8 infection and its clinical correlates have not been well characterized in recently HIV-1-infected subjects, ... ...

    Abstract Background: Human herpesvirus 8 (HHV-8) is the etiological agent for Kaposi Sarcoma, which occurs especially in HIV-infected subjects. HHV-8 infection and its clinical correlates have not been well characterized in recently HIV-1-infected subjects, especially men who have sex with men (MSM).
    Methodology/ principal findings: We assessed the HHV-8 seroprevalence, clinical correlates, and incidence after one year of follow-up in a cohort of 228 recently HIV-1-infected individuals, of whom 83.6% were MSM, using indirect immunofluorescence assay. The prevalence of HHV-8 infection at the time of cohort enrollment was 25.9% (59/228). In the univariate model, there were significant associations with male gender, black ethnicity, MSM practice, and previous hepatitis B virus and syphilis infections. In the multivariate model we could still demonstrate association with MSM, hepatitis B, and black ethnicity. No differences in mean CD4+ cell counts or HIV viral load according to HHV-8 status were found. In terms of incidence, there were 23/127 (18.1%) seroconversions in the cohort after 1 year.
    Conclusions: HHV-8 is highly prevalent among recently HIV-1-infected subjects. Correlations with other sexually transmitted infections suggest common transmission routes.
    MeSH term(s) Brazil/epidemiology ; CD4 Lymphocyte Count ; Cohort Studies ; Demography ; Female ; HIV Infections/blood ; HIV Infections/complications ; HIV Infections/epidemiology ; HIV Infections/virology ; HIV-1/physiology ; Herpesviridae Infections/blood ; Herpesviridae Infections/complications ; Herpesviridae Infections/epidemiology ; Herpesviridae Infections/virology ; Herpesvirus 8, Human/physiology ; Humans ; Incidence ; Kaplan-Meier Estimate ; Male ; Prevalence
    Language English
    Publishing date 2009-05-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0005613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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