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  1. Article ; Online: Treatment of dry age-related macular degeneration: A review.

    Girgis, Shenouda / Lee, Lawrence R

    Clinical & experimental ophthalmology

    2023  Volume 51, Issue 8, Page(s) 835–852

    Abstract: Age-related macular degeneration is a global disease with a significant societal impact. The advent of anti-vascular endothelial growth factor therapy (anti-VEGF) has revolutionised the treatment of neovascular age-related macular degeneration (nAMD). ... ...

    Abstract Age-related macular degeneration is a global disease with a significant societal impact. The advent of anti-vascular endothelial growth factor therapy (anti-VEGF) has revolutionised the treatment of neovascular age-related macular degeneration (nAMD). Dry age-related macular degeneration (dAMD) is being investigated for possible therapeutic options. The therapeutic categories undergoing clinical trials include complement pathway inhibitors, visual cycle modulators, reduction of toxic byproducts, antioxidative therapy, neuroprotective agents, laser therapy, surgical options, gene therapy, stem cell therapy, and miscellaneous treatments. Two intravitreal anti-complement factors (pegcetacoplan and avacincaptad pegol) have recently shown phase 3 clinical trial evidence of a reduction in the growth of geographic atrophy. In this review, we provide an update on treatment options currently undergoing clinical research trials for the management of dAMD and preventing the progression of Geographic Atrophy (GA).
    MeSH term(s) Humans ; Geographic Atrophy/therapy ; Macular Degeneration/drug therapy ; Angiogenesis Inhibitors/therapeutic use ; Intravitreal Injections ; Wet Macular Degeneration/drug therapy
    Chemical Substances Angiogenesis Inhibitors
    Language English
    Publishing date 2023-09-22
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14294
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    Zs.A 1064: Show issues Location:
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  2. Article ; Online: Infant oral mutilation: A response to the subject - 'Infant oral mutilation'.

    Girgis, S / Cheng, L

    British dental journal

    2019  Volume 226, Issue 3, Page(s) 161

    MeSH term(s) Dental Care ; Humans ; Infant ; Self Mutilation
    Language English
    Publishing date 2019-02-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/sj.bdj.2019.142
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    Ul III Zs.143: Show issues Location:
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    Zs.MO 447: Show issues

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  3. Article ; Online: A cautious approach.

    Girgis, S

    British dental journal

    2010  Volume 208, Issue 10, Page(s) 439–440

    MeSH term(s) Bone Density Conservation Agents/adverse effects ; Contraindications ; Diphosphonates/adverse effects ; Humans ; Jaw Diseases/chemically induced ; Osteonecrosis/chemically induced ; Tooth Extraction
    Chemical Substances Bone Density Conservation Agents ; Diphosphonates
    Language English
    Publishing date 2010-05-22
    Publishing country England
    Document type Letter
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/sj.bdj.2010.455
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  4. Article ; Online: Ophthalmic surgery in patients with only one seeing eye: Only eye study 4 (OnES 4).

    Girgis, Shenouda / Whyte, Jonathan P / Shah, Peter / Lee, Graham A

    Clinical & experimental ophthalmology

    2023  

    Language English
    Publishing date 2023-11-28
    Publishing country Australia
    Document type Letter
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14336
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  5. Article ; Online: Only Eye Study 5 (OnES 5): A quantitative study of patient experiences undergoing surgery in their only seeing eye.

    Ngo, Eagle D / Lee, Graham A / Girgis, Shenouda / Shah, Peter

    Clinical & experimental ophthalmology

    2023  Volume 52, Issue 1, Page(s) 121–123

    MeSH term(s) Humans ; Macular Degeneration ; Visual Acuity ; Patient Outcome Assessment
    Language English
    Publishing date 2023-11-14
    Publishing country Australia
    Document type Letter
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14322
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  6. Article ; Online: Incidence and associations of vitreous haemorrhage in proliferative diabetic retinopathy.

    Girgis, Shenouda / Do, Helen Hyun-Jin / Leong, Belinda / Liew, Gerald

    Clinical & experimental ophthalmology

    2023  Volume 52, Issue 1, Page(s) 108–110

    MeSH term(s) Humans ; Diabetic Retinopathy/complications ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/epidemiology ; Vitreous Hemorrhage/diagnosis ; Vitreous Hemorrhage/epidemiology ; Vitreous Hemorrhage/etiology ; Incidence ; Vitreous Body ; Vitrectomy ; Diabetes Mellitus
    Language English
    Publishing date 2023-11-14
    Publishing country Australia
    Document type Letter
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14319
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  7. Article: Injection drug induced septic embolism-A growing concern.

    Kelson, Michael / Chaudhry, Asaad / Nguyen, Andrew / Girgis, Sameh

    Radiology case reports

    2022  Volume 17, Issue 11, Page(s) 4345–4349

    Abstract: Septic pulmonary embolism is an obstruction of the pulmonary vasculature due to embolization of an infected thrombus. In many instances, the etiology is cardiac in origin, given the increased prevalence of intravenous drug users in the United States. ... ...

    Abstract Septic pulmonary embolism is an obstruction of the pulmonary vasculature due to embolization of an infected thrombus. In many instances, the etiology is cardiac in origin, given the increased prevalence of intravenous drug users in the United States. This condition usually presents with fever, chest pain, dyspnea, and cough. In order to make the diagnosis, it is helpful to utilize tools like the modified Duke criteria when evaluating for infective endocarditis in the context of pulmonary emboli and septic shock. The gold standard method for establishing the diagnosis of this condition involves imaging modalities, including echocardiogram and computed tomography findings. This case report details a 36-year-old male with a history of drug abuse and hepatitis C, who was found to have an isolated vegetation on the pulmonic valve and septic pulmonary embolism. The patient experienced a rapidly deteriorating clinical course, however improved over the course of 2 weeks with supportive measures and appropriate antibiotic treatment. The purpose of this case report is to highlight the uncommon nature of pulmonary valve involvement in patients with infective endocarditis. Moreover, the goal of this report is to recognize the paralleled increase in septic pulmonary emboli with the rising incidence of patients using injectable opioids in the United States.
    Language English
    Publishing date 2022-09-15
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2022.08.057
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  8. Article: Tularemia: The Resurgence of a Diagnostic Challenge and Clinical Dilemma in the United States.

    Kelson, Michael / Burnett, Justin / Girgis, Sameh / Bakr, Mohamed

    Cureus

    2022  Volume 14, Issue 7, Page(s) e27363

    Abstract: Tularemia is a rare, life-threatening zoonotic infection with low, naturally occurring transmission rates in the United States. Classified as a Category A bioterrorism agent, this disease is highly infectious and has the potential to be fatal if left ... ...

    Abstract Tularemia is a rare, life-threatening zoonotic infection with low, naturally occurring transmission rates in the United States. Classified as a Category A bioterrorism agent, this disease is highly infectious and has the potential to be fatal if left untreated. Making the diagnosis is difficult due to the non-specific symptomatology patients present with. Considering the increase in the prevalence of this diagnosis over the past two decades, this condition has the potential to become a public health crisis. This case report details a pediatric patient who was found to have fever, ulceration, and lymphadenopathy on hospital admission. After a prolonged and protracted course of illness, tularemia was diagnosed with laboratory testing. The purpose of this case report is to increase awareness of tularemia as a potential cause of non-specific flu-like symptoms, especially during the summer months. Moreover, our goal is to propose suggestions for healthcare professionals who encounter patients with clinical suspicion of tularemia.
    Language English
    Publishing date 2022-07-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.27363
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  9. Article ; Online: Acute hepatitis following mRNA BNT162b2 COVID-19 vaccination.

    Cheah, Matthew / Girgis, Safwat / Bain, Vincent G

    Canadian liver journal

    2022  Volume 5, Issue 4, Page(s) 535–539

    Abstract: BACKGROUND: ...

    Abstract BACKGROUND:
    Language English
    Publishing date 2022-11-07
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-4444
    ISSN (online) 2561-4444
    DOI 10.3138/canlivj-2022-0014
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  10. Article ; Online: Teclistamab in Relapsed or Refractory Multiple Myeloma. Reply.

    Moreau, Philippe / Girgis, Suzette / Goldberg, Jenna D

    The New England journal of medicine

    2022  Volume 387, Issue 18, Page(s) 1722–1723

    MeSH term(s) Humans ; Multiple Myeloma/drug therapy ; Neoplasm Recurrence, Local/drug therapy ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols ; Antibodies, Bispecific/therapeutic use
    Chemical Substances Antineoplastic Agents ; Antibodies, Bispecific
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2211969
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