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  1. Book ; Conference proceedings: Cardiac regeneration and angiogenesis beyond stem cell research

    Gittenberger- De Groot, Adriana C.

    symposium

    (Wiener klinische Wochenschrift ; 119, Suppl. 1)

    2007  

    Institution Society of Coronary Sinus Interventions
    Event/congress Symposium on Cardiac Regeneration and Angiogenesis Beyond Stem Cell Research (2006, Wien)
    Author's details organised by the Society of Coronary Sinus Interventions. Course directors Adriana Gittenberger-de Groot ... [Symposium on Cardiac Regeneration and Angiogenesis Beyond Stem Cell Research , 16th of December 2006, Vienna, Austria]
    Series title Wiener klinische Wochenschrift ; 119, Suppl. 1
    Collection
    Language English
    Size 32 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Wien u.a.
    Publishing country Austria
    Document type Book ; Conference proceedings
    HBZ-ID HT015240259
    Database Catalogue ZB MED Medicine, Health

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    Zs A 902 -119,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Article: Wall Shear Stress Directional Abnormalities in BAV Aortas: Toward a New Hemodynamic Predictor of Aortopathy?

    Grewal, Nimrat / Gittenberger-de Groot, Adriana C

    Frontiers in physiology

    2019  Volume 10, Page(s) 225

    Language English
    Publishing date 2019-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2019.00225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Development and evolution of the metazoan heart.

    Poelmann, Robert E / Gittenberger-de Groot, Adriana C

    Developmental dynamics : an official publication of the American Association of Anatomists

    2019  Volume 248, Issue 8, Page(s) 634–656

    Abstract: The mechanisms of the evolution and development of the heart in metazoans are highlighted, starting with the evolutionary origin of the contractile cell, supposedly the precursor of cardiomyocytes. The last eukaryotic common ancestor is likely a ... ...

    Abstract The mechanisms of the evolution and development of the heart in metazoans are highlighted, starting with the evolutionary origin of the contractile cell, supposedly the precursor of cardiomyocytes. The last eukaryotic common ancestor is likely a combination of several cellular organisms containing their specific metabolic pathways and genetic signaling networks. During evolution, these tool kits diversified. Shared parts of these conserved tool kits act in the development and functioning of pumping hearts and open or closed circulations in such diverse species as arthropods, mollusks, and chordates. The genetic tool kits became more complex by gene duplications, addition of epigenetic modifications, influence of environmental factors, incorporation of viral genomes, cardiac changes necessitated by air-breathing, and many others. We evaluate mechanisms involved in mollusks in the formation of three separate hearts and in arthropods in the formation of a tubular heart. A tubular heart is also present in embryonic stages of chordates, providing the septated four-chambered heart, in birds and mammals passing through stages with first and second heart fields. The four-chambered heart permits the formation of high-pressure systemic and low-pressure pulmonary circulation in birds and mammals, allowing for high metabolic rates and maintenance of body temperature. Crocodiles also have a (nearly) separated circulation, but their resting temperature conforms with the environment. We argue that endothermic ancestors lost the capacity to elevate their body temperature during evolution, resulting in ectothermic modern crocodilians. Finally, a clinically relevant paragraph reviews the occurrence of congenital cardiac malformations in humans as derailments of signaling pathways during embryonic development.
    MeSH term(s) Animals ; Biological Evolution ; Embryonic Development ; Heart/embryology ; Heart Defects, Congenital/etiology ; Humans
    Language English
    Publishing date 2019-05-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1102541-4
    ISSN 1097-0177 ; 1058-8388
    ISSN (online) 1097-0177
    ISSN 1058-8388
    DOI 10.1002/dvdy.45
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 64: Show issues

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  4. Article ; Online: Hemodynamics in Cardiac Development.

    Poelmann, Robert E / Gittenberger-de Groot, Adriana C

    Journal of cardiovascular development and disease

    2018  Volume 5, Issue 4

    Abstract: The beating heart is subject to intrinsic mechanical factors, exerted by contraction of the myocardium (stretch and strain) and fluid forces of the enclosed blood (wall shear stress). The earliest contractions of the heart occur already in the 10-somite ... ...

    Abstract The beating heart is subject to intrinsic mechanical factors, exerted by contraction of the myocardium (stretch and strain) and fluid forces of the enclosed blood (wall shear stress). The earliest contractions of the heart occur already in the 10-somite stage in the tubular as yet unsegmented heart. With development, the looping heart becomes asymmetric providing varying diameters and curvatures resulting in unequal flow profiles. These flow profiles exert various wall shear stresses and as a consequence different expression patterns of shear responsive genes. In this paper we investigate the morphological alterations of the heart after changing the blood flow by ligation of the right vitelline vein in a model chicken embryo and analyze the extended expression in the endocardial cushions of the shear responsive gene Tgfbeta receptor III. A major phenomenon is the diminished endocardial-mesenchymal transition resulting in hypoplastic (even absence of) atrioventricular and outflow tract endocardial cushions, which might be lethal in early phases. The surviving embryos exhibit several cardiac malformations including ventricular septal defects and malformed semilunar valves related to abnormal development of the aortopulmonary septal complex and the enclosed neural crest cells. We discuss the results in the light of the interactions between several shear stress responsive signaling pathways including an extended review of the involved Vegf, Notch, Pdgf, Klf2, eNos, Endothelin and Tgfβ/Bmp/Smad networks.
    Language English
    Publishing date 2018-11-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd5040054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pathogenesis of aortic wall complications in Marfan syndrome.

    Grewal, Nimrat / Gittenberger-de Groot, Adriana C

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

    2018  Volume 33, Page(s) 62–69

    Abstract: Background: Patients with Marfan (MFS) syndrome and patients with a bicuspid aortic valve (BAV) are more prone to develop aortic dilation and dissection compared to persons with a tricuspid aortic valve (TAV). To elucidate potential common as well as ... ...

    Abstract Background: Patients with Marfan (MFS) syndrome and patients with a bicuspid aortic valve (BAV) are more prone to develop aortic dilation and dissection compared to persons with a tricuspid aortic valve (TAV). To elucidate potential common as well as distinct pathways of clinical relevance, we compared the histopathological substrates of aortic pathology.
    Patient and methods: Ascending aortic wall specimen were divided in five groups: BAV (n=36) and TAV (n=23) without and with dilation and non-dilated MFS (n=8). We performed routine histology to study aortic wall features based on the aortic consensus statement. Immunohistological markers for vascular smooth muscle cell (VSMC) maturation, and expression of fibrillin-1 were additionally investigated for the underlying pathogenesis.
    Results: On basis of the routine histology the aorta in MFS was similar to the aorta in dilated TAVs (overall medial degeneration, elastic fiber fragmentation, loss and disorganization, , and VSMC nuclei loss). The other markers aided in clustering the MFS and BAV patients with a significantly lower fibrillin-1 expression as compared to the TAVs (p<0.05), a lower level of differentiated VSMC markers (p<0.05) and elastic fiber thinning.
    Conclusions: Pathogenesis of aortopathy in MFS overlaps with mechanisms seen in BAV and TAV, leading to a so called double hit hypothesis for aortic complications in MFS. The ascending aortic wall in MFS is immature with undifferentiated VSMCs and low levels of fibrillin-1. The immature media becomes even more vulnerable for aortopathy due to other degenerative features which develop probably as a direct consequence of the fibrillin-1 mutation.
    MeSH term(s) Actins/analysis ; Adult ; Aged ; Aorta/chemistry ; Aorta/pathology ; Aortic Aneurysm/etiology ; Aortic Aneurysm/metabolism ; Aortic Aneurysm/pathology ; Aortic Valve/abnormalities ; Aortic Valve/metabolism ; Aortic Valve/pathology ; Bicuspid Aortic Valve Disease ; Biomarkers/analysis ; Biopsy ; Cytoskeletal Proteins/analysis ; Dilatation, Pathologic ; Elastic Tissue/pathology ; Female ; Fibrillin-1/analysis ; Heart Valve Diseases/complications ; Heart Valve Diseases/metabolism ; Heart Valve Diseases/pathology ; Humans ; Immunohistochemistry ; Lamin Type A/analysis ; Male ; Marfan Syndrome/complications ; Marfan Syndrome/metabolism ; Marfan Syndrome/pathology ; Middle Aged ; Muscle Proteins/analysis ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/pathology ; Risk Factors ; Vascular Remodeling ; Young Adult
    Chemical Substances ACTA2 protein, human ; Actins ; Biomarkers ; Cytoskeletal Proteins ; FBN1 protein, human ; Fibrillin-1 ; LMNA protein, human ; Lamin Type A ; Muscle Proteins ; SMTN protein, human ; prelamin A
    Language English
    Publishing date 2018-02-02
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 1134600-0
    ISSN 1879-1336 ; 1054-8807
    ISSN (online) 1879-1336
    ISSN 1054-8807
    DOI 10.1016/j.carpath.2018.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Normal and abnormal development of the aortic valve and ascending aortic wall: a comprehensive overview of the embryology and pathology of the bicuspid aortic valve.

    Grewal, Nimrat / Gittenberger-de Groot, Adriana C / Lindeman, Jan H / Klautz, Arthur / Driessen, Antoine / Klautz, Robert J M / Poelmann, Robert E

    Annals of cardiothoracic surgery

    2022  Volume 11, Issue 4, Page(s) 380–388

    Abstract: A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac anomaly, in which the valve has only two leaflets, instead of the normal three. Patients with a BAV have an increased risk of aneurysm formation and the development of an aortic ... ...

    Abstract A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac anomaly, in which the valve has only two leaflets, instead of the normal three. Patients with a BAV have an increased risk of aneurysm formation and the development of an aortic dissection. Vascular smooth muscle cells in both the non- and dilated aortic wall are characterized by a maturation defect in all BAV patients, as compared to patients with a tricuspid aortic valve, which can contribute to inherent developmental susceptibility. Besides structural abnormalities of the vascular wall, a turbulent blood flow, caused by bicuspid valve geometry, could expedite the pathological process in the aortic wall, leading to aortopathy. Although the risk for aortopathy is significant, not all BAV patients experience (acute) aortic complications in their lifespan, highlighting the complexity of the pathogenetic process. Recent studies have focused on the embryonic development of semilunar valves and the ascending aortic wall. Their findings highlight that a defect in the embryogenesis could not only explain the development of a malformed aortic valve but also the increased risk for ascending aorta and arch pathology. This review presents an overview of the normal and abnormal development of the aortic valve and the aortic wall: a common defect in early embryogenesis causes the development of a BAV and associated aortopathy.
    Language English
    Publishing date 2022-08-04
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2021-bav-14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The senescence of vascular smooth muscle cells in BAV-associated aortopathy.

    Mohamed, Salah A / Grewal, Nimrat / Gittenberger-de Groot, Adriana C

    Atherosclerosis

    2018  Volume 278, Page(s) 317–318

    MeSH term(s) Aortic Aneurysm, Thoracic ; Aortic Valve/abnormalities ; Bicuspid Aortic Valve Disease ; Heart Valve Diseases ; Humans ; Muscle, Smooth, Vascular
    Language English
    Publishing date 2018-07-31
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2018.07.027
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 226: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Ventricular Septation and Outflow Tract Development in Crocodilians Result in Two Aortas with Bicuspid Semilunar Valves.

    Poelmann, Robert E / Gittenberger-de Groot, Adriana C / Goerdajal, Charissa / Grewal, Nimrat / De Bakker, Merijn A G / Richardson, Michael K

    Journal of cardiovascular development and disease

    2021  Volume 8, Issue 10

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2021-10-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd8100132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The development of the pulmonary vein revisited.

    Gittenberger-de Groot, Adriana C

    International journal of cardiology

    2011  Volume 147, Issue 3, Page(s) 463–464

    MeSH term(s) Animals ; Humans ; Pulmonary Veins/abnormalities ; Pulmonary Veins/growth & development
    Language English
    Publishing date 2011-03-17
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2011.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1673: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: A Systematic Histopathologic Evaluation of Type-A Aortic Dissections Implies a Uniform Multiple-Hit Causation.

    Grewal, Nimrat / Velders, Bart J J / Gittenberger-de Groot, Adriana C / Poelmann, Robert / Klautz, Robert J M / Van Brakel, Thomas J / Lindeman, Jan H N

    Journal of cardiovascular development and disease

    2021  Volume 8, Issue 2

    Abstract: 1) Background: The pathophysiologic basis of an acute type A aortic dissection (TAAD) is largely unknown. In an effort to evaluate vessel wall defects, we systematically studied aortic specimens in TAAD patients. (2) Methods: Ascending aortic wall ... ...

    Abstract (1) Background: The pathophysiologic basis of an acute type A aortic dissection (TAAD) is largely unknown. In an effort to evaluate vessel wall defects, we systematically studied aortic specimens in TAAD patients. (2) Methods: Ascending aortic wall specimens (
    Language English
    Publishing date 2021-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd8020012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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