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  1. Article: Metabolic Disorders in Liver Transplant Recipients: The State of the Art.

    Gabrielli, Filippo / Golfieri, Lucia / Nascimbeni, Fabio / Andreone, Pietro / Gitto, Stefano

    Journal of clinical medicine

    2024  Volume 13, Issue 4

    Abstract: Liver transplantation represents a chief therapeutic approach for acute liver failure, end-stage liver disease and hepatocellular carcinoma. Despite witnessing advancements in short- and medium-term survival over recent decades, attributed to refinements ...

    Abstract Liver transplantation represents a chief therapeutic approach for acute liver failure, end-stage liver disease and hepatocellular carcinoma. Despite witnessing advancements in short- and medium-term survival over recent decades, attributed to refinements in surgical techniques and immunosuppressive protocols, long-term mortality remains impervious to modification. Notably, cardiovascular disease emerges as a predominant cause of mortality among liver transplant recipients. This trend is accentuated by the increasing prominence of non-alcoholic steatohepatitis-related cirrhosis as an indication for liver transplantation. Moreover, the administration of immunosuppressive agents is intricately linked to the degradation of the metabolic profile in liver transplant recipients, thereby contributing to the initiation or exacerbation of cardiovascular risk factors, such as hypertension, diabetes, and dyslipidaemia. In addition, the post-liver transplantation period is marked by a decline in lifestyle quality and a failure to acknowledge the psychological distress experienced by patients throughout the transplant process. These factors can precipitate a deterioration in the patient's metabolic profile, exacerbated by suboptimal therapeutic compliance. This narrative review aims to comprehensively address the principal metabolic disorders intricately associated with liver transplantation.
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13041014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Targeted pharmacotherapy for cardiovascular risk reduction in patients with diabetes undergoing liver transplantation: Author's reply.

    Gitto, Stefano / Andreone, Pietro

    European journal of internal medicine

    2020  Volume 80, Page(s) 105

    MeSH term(s) Cardiovascular Diseases/prevention & control ; Diabetes Mellitus/drug therapy ; Follow-Up Studies ; Heart Disease Risk Factors ; Humans ; Liver Transplantation ; Risk Factors
    Language English
    Publishing date 2020-08-05
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2020.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Aging with a Liver Graft: Analysis of Very Long-Term Survivors after Liver Transplantation.

    De Simone, Paolo / Bronzoni, Jessica / Martinelli, Caterina / Ducci, Juri / Campani, Daniela / Gitto, Stefano / Marchetti, Piero / Biancofiore, Giandomenico

    Journal of clinical medicine

    2024  Volume 13, Issue 4

    Abstract: Background: In Italy, data on long-term survivors after liver transplantation are lacking.: Materials and methods: We conducted a hybrid design study on a cohort of 359 adult recipients who received transplants between 1996 and 2002 to identify ... ...

    Abstract Background: In Italy, data on long-term survivors after liver transplantation are lacking.
    Materials and methods: We conducted a hybrid design study on a cohort of 359 adult recipients who received transplants between 1996 and 2002 to identify predictors of survival and the prevalence of co-morbidities among long-term survivors.
    Results: The actuarial (95% CI) patient survival was 96% (94.6-98.3%), 69% (64.2-73.6%), 55% (49.8-59.9%), 42.8% (37.6-47.8%), and 34% (29.2-38.9%) at 1, 5, 10, 15, and 20 years, respectively. The leading causes of death were hepatitis C virus recurrence (24.6%), extrahepatic malignancies (16.9%), infection (14.4%), and hepatocellular carcinoma recurrence (14.4%). The factors associated with the survival probability were younger donor and recipient ages (
    Conclusions: Aging with a liver graft is associated with an increased risk of complications and requires ongoing care to reduce the long-term attrition rate resulting from chronic immunosuppression.
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13041087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Everolimus Mitigates the Risk of Hepatocellular Carcinoma Recurrence after Liver Transplantation.

    De Simone, Paolo / Precisi, Arianna / Lai, Quirino / Ducci, Juri / Campani, Daniela / Marchetti, Piero / Gitto, Stefano

    Cancers

    2024  Volume 16, Issue 7

    Abstract: To obtain long-term data on the use of everolimus in patients who underwent liver transplantation for hepatocellular carcinoma, we conducted a retrospective, single-center analysis of adult recipients transplanted between 2013 and 2021. Patients on ... ...

    Abstract To obtain long-term data on the use of everolimus in patients who underwent liver transplantation for hepatocellular carcinoma, we conducted a retrospective, single-center analysis of adult recipients transplanted between 2013 and 2021. Patients on everolimus-incorporating immunosuppression were matched with those on tacrolimus using an inverse probability of treatment weighting methodology. Two propensity-matched groups of patients were thus compared: 233 (45.6%) receiving everolimus versus 278 (54.4%) on tacrolimus. At a median (interquartile range) follow-up of 4.4 (3.8) years after transplantation, everolimus patients showed a reduced risk of recurrence versus tacrolimus (7.7% versus 16.9%; RR = 0.45;
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16071243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Virological Treatment Monitoring for Chronic Hepatitis B

    Loggi, Elisabetta / Gitto, Stefano / Gabrielli, Filippo / Franchi, Elena / Seferi, Hajrie / Cursaro, Carmela / Andreone, Pietro

    Viruses. 2022 June 24, v. 14, no. 7

    2022  

    Abstract: More than 250 million people worldwide are currently infected with hepatitis B, despite the effectiveness of vaccination and other preventive measures. In terms of treatment, new therapeutic approaches are rapidly developing, promising to achieve the ... ...

    Abstract More than 250 million people worldwide are currently infected with hepatitis B, despite the effectiveness of vaccination and other preventive measures. In terms of treatment, new therapeutic approaches are rapidly developing, promising to achieve the elimination of infected cells and the complete cure of infection. The on-treatment monitoring of these innovative antiviral treatments will require the implementation of new virological tools. Therefore, new biomarkers are being evaluated besides the traditional virological and serological assays in order to obtain information on different steps of the viral replication cycle and to monitor response to therapy more accurately. The purpose of this work is to describe both standard and innovative tools for chronic hepatitis B treatment monitoring, and to analyse their potential and feasibility.
    Keywords biomarkers ; chronic hepatitis B ; vaccination ; virus replication
    Language English
    Dates of publication 2022-0624
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14071376
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Metabolic Disorders After Liver Transplantation.

    Gitto, Stefano / Falcini, Margherita / Marra, Fabio

    Metabolic syndrome and related disorders

    2020  Volume 19, Issue 2, Page(s) 65–69

    Abstract: Early after surgery, liver transplant (LT) recipients often develop weight gain due to an increase of caloric intake and fat mass (without recovery of muscle frame). This modification of body composition together with a negative metabolic impact of ... ...

    Abstract Early after surgery, liver transplant (LT) recipients often develop weight gain due to an increase of caloric intake and fat mass (without recovery of muscle frame). This modification of body composition together with a negative metabolic impact of immunosuppressive drugs leads to a high prevalence of all the main metabolic disorders. Indeed, as expected, transplanted patients show a higher cardiovascular risk in comparison with general population. Notably, seeing the increase of mean age of transplanted population, metabolic disorders represent the true challenge for the transplant community. Considering the lack of evidences or clear indications about prevention, early diagnosis and treatment of metabolic disorders after LT, it would be mandatory to develop targeted further studies on this matter.
    MeSH term(s) Animals ; Body Composition/physiology ; Humans ; Liver Transplantation/adverse effects ; Liver Transplantation/statistics & numerical data ; Metabolic Diseases/diagnosis ; Metabolic Diseases/epidemiology ; Metabolic Diseases/etiology ; Metabolic Diseases/therapy ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Prevalence ; Risk Factors
    Language English
    Publishing date 2020-10-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2151220-6
    ISSN 1557-8518 ; 1540-4196
    ISSN (online) 1557-8518
    ISSN 1540-4196
    DOI 10.1089/met.2020.0068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5950: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression.

    Caligiuri, Alessandra / Gentilini, Alessandra / Pastore, Mirella / Gitto, Stefano / Marra, Fabio

    Cells

    2021  Volume 10, Issue 10

    Abstract: Chronic liver injury of different etiologies may result in hepatic fibrosis, a scar formation process consisting in altered deposition of extracellular matrix. Progression of fibrosis can lead to impaired liver architecture and function, resulting in ... ...

    Abstract Chronic liver injury of different etiologies may result in hepatic fibrosis, a scar formation process consisting in altered deposition of extracellular matrix. Progression of fibrosis can lead to impaired liver architecture and function, resulting in cirrhosis and organ failure. Although fibrosis was previous thought to be an irreversible process, recent evidence convincingly demonstrated resolution of fibrosis in different organs when the cause of injury is removed. In the liver, due to its high regenerative ability, the extent of fibrosis regression and reversion to normal architecture is higher than in other tissues, even in advanced disease. The mechanisms of liver fibrosis resolution can be recapitulated in the following main points: removal of injurious factors causing chronic hepatic damage, elimination, or inactivation of myofibroblasts (through various cell fates, including apoptosis, senescence, and reprogramming), inactivation of inflammatory response and induction of anti-inflammatory/restorative pathways, and degradation of extracellular matrix. In this review, we will discuss the major cellular and molecular mechanisms underlying the regression of fibrosis/cirrhosis and the potential therapeutic approaches aimed at reversing the fibrogenic process.
    MeSH term(s) Animals ; Extracellular Matrix/metabolism ; Humans ; Inflammation/pathology ; Liver Cirrhosis/genetics ; Liver Cirrhosis/pathology ; Liver Cirrhosis/physiopathology ; Myofibroblasts/pathology ; Remission Induction ; Vascular Remodeling
    Language English
    Publishing date 2021-10-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10102759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Primary biliary cholangitis associated with SARS-CoV-2 infection.

    Bartoli, Alessandra / Gitto, Stefano / Sighinolfi, Pamela / Cursaro, Carmela / Andreone, Pietro

    Journal of hepatology

    2021  Volume 74, Issue 5, Page(s) 1245–1246

    MeSH term(s) Adult ; Aftercare/methods ; Anti-Bacterial Agents/administration & dosage ; Antiviral Agents/administration & dosage ; Autoimmunity ; Biopsy/methods ; COVID-19/complications ; COVID-19/immunology ; COVID-19/physiopathology ; COVID-19/therapy ; Female ; Guillain-Barre Syndrome/diagnosis ; Guillain-Barre Syndrome/etiology ; Hashimoto Disease/diagnosis ; Hashimoto Disease/immunology ; Humans ; Immunoglobulins, Intravenous/administration & dosage ; Liver/pathology ; Liver Cirrhosis, Biliary/blood ; Liver Cirrhosis, Biliary/etiology ; Liver Cirrhosis, Biliary/physiopathology ; Liver Cirrhosis, Biliary/therapy ; Liver Function Tests/methods ; Neurologic Examination/methods ; Respiration, Artificial/methods ; SARS-CoV-2/isolation & purification
    Chemical Substances Anti-Bacterial Agents ; Antiviral Agents ; Immunoglobulins, Intravenous
    Language English
    Publishing date 2021-02-19
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2021.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: From advanced disease to transplantation: an overview of the liver at the time of COVID-19 pandemic.

    Vitale, Giovanni / Gitto, Stefano / Marra, Fabio / Morelli, Maria Cristina

    Internal and emergency medicine

    2021  Volume 17, Issue 1, Page(s) 15–24

    Abstract: In 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also known as coronavirus disease 2019 (COVID-19) disrupted global health, causing hundreds of thousands of deaths worldwide. The liver injury appears to be one of the possible ... ...

    Abstract In 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also known as coronavirus disease 2019 (COVID-19) disrupted global health, causing hundreds of thousands of deaths worldwide. The liver injury appears to be one of the possible systemic manifestations of COVID-19 disease although the mechanisms causing such injury are not entirely clear. At the beginning of the pandemic, patients with chronic diseases, such as liver cirrhosis, or special populations, such as liver transplant recipients, were considered at higher risk of complications and poor clinical outcomes. Thus, the national transplant programmes have been severely hampered by the COVID-19 pandemic. Furthermore, liver transplant patients are potentially more vulnerable to SARS-CoV-2 infection due to immune suppression, ageing, and metabolic or cardiovascular comorbidities. This review analyses the increasing amounts of data collected in recent months concerning liver cirrhosis and liver transplants to understand if this finding is still relevant with respect to COVID-19 manifestations.
    MeSH term(s) COVID-19 ; Humans ; Liver ; Liver Transplantation ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-07-10
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02801-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6673: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Virological Treatment Monitoring for Chronic Hepatitis B.

    Loggi, Elisabetta / Gitto, Stefano / Gabrielli, Filippo / Franchi, Elena / Seferi, Hajrie / Cursaro, Carmela / Andreone, Pietro

    Viruses

    2022  Volume 14, Issue 7

    Abstract: More than 250 million people worldwide are currently infected with hepatitis B, despite the effectiveness of vaccination and other preventive measures. In terms of treatment, new therapeutic approaches are rapidly developing, promising to achieve the ... ...

    Abstract More than 250 million people worldwide are currently infected with hepatitis B, despite the effectiveness of vaccination and other preventive measures. In terms of treatment, new therapeutic approaches are rapidly developing, promising to achieve the elimination of infected cells and the complete cure of infection. The on-treatment monitoring of these innovative antiviral treatments will require the implementation of new virological tools. Therefore, new biomarkers are being evaluated besides the traditional virological and serological assays in order to obtain information on different steps of the viral replication cycle and to monitor response to therapy more accurately. The purpose of this work is to describe both standard and innovative tools for chronic hepatitis B treatment monitoring, and to analyse their potential and feasibility.
    MeSH term(s) Antiviral Agents/therapeutic use ; Hepatitis B/drug therapy ; Hepatitis B Surface Antigens ; Hepatitis B virus/physiology ; Hepatitis B, Chronic/drug therapy ; Humans
    Chemical Substances Antiviral Agents ; Hepatitis B Surface Antigens
    Language English
    Publishing date 2022-06-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14071376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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