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  1. Article ; Online: p63 orchestrates serine and one carbon metabolism enzymes expression in head and neck cancer

    Angela Cappello / Giulia Tosetti / Artem Smirnov / Carlo Ganini / Xue Yang / Yufang Shi / Ying Wang / Gerry Melino / Francesca Bernassola / Eleonora Candi

    Biology Direct, Vol 18, Iss 1, Pp 1-

    2023  Volume 12

    Abstract: Abstract Background Head and neck squamous cell carcinoma (HNSCC) is characterized by high proliferation and limited differentiation. The altered expression of the p53 family members, and specifically of p63, represents a pivotal event in the ... ...

    Abstract Abstract Background Head and neck squamous cell carcinoma (HNSCC) is characterized by high proliferation and limited differentiation. The altered expression of the p53 family members, and specifically of p63, represents a pivotal event in the pathogenesis of HNSCC. Physiologically, p63 affects metabolism through the direct transactivation of the enzyme hexokinase 2, and subsequently controls the proliferation of epithelial cells; nonetheless, its role in cancer metabolism is still largely unclear. The high energetic demand of cancer and the consequent needs of a metabolic reshape, also involve the serine and glycine catabolic and anabolic pathways, including the one carbon metabolism (OCM), to produce energetic compounds (purines) and to maintain cellular homeostasis (glutathione and S-adenosylmethionine). Results The involvement in serine/glycine starvation by other p53 family members has been reported, including HNSCC. Here, we show that in HNSCC p63 controls the expression of the enzymes regulating the serine biosynthesis and one carbon metabolism. p63 binds the promoter region of genes involved in the serine biosynthesis as well as in the one carbon metabolism. p63 silencing in a HNSCC cell line affects the mRNA and protein levels of these selected enzymes. Moreover, the higher expression of TP63 and its target enzymes, negatively impacts on the overall survival of HNSCC patients. Conclusion These data indicate a direct role of p63 in the metabolic regulation of HNSCC with significant clinical effects.
    Keywords Head and neck cancer ; p53 family ; p63 ; Serine ; One carbon metabolism ; Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Induced myocardial ischemia in candidates to liver transplantation without evidence of heart disease

    Luca Mircoli / Niccolò Bacà / Barbara Antonelli / Lucio Caccamo / Emanuele Cattaneo / Federico Colombo / Clara Dibenedetto / Livia Diehl / Maria Francesca Donato / Andrea Faggiano / Massimo Alberto Iavarone / Pietro Lampertico / Cristina Marenghi / Federico Polli / Edoardo Quarenghi / Fabiola B. Sozzi / Cristina Spaziani / Giulia Tosetti / Carlo Valsecchi /
    Pierluigi Vicardi / Marco Vicenzi / Arianna Zefelippo / Massimiliano Ruscica / Stefano Carugo

    Annals of Medicine, Vol 55, Iss

    2023  Volume 1

    Abstract: AbstractBackground Coronary artery disease (CAD) is associated with perioperative liver transplantation (LT) mortality. In absence of a defined risk algorithm, we aimed to test whether stress echocardiography and coronary computed tomography angiography ( ...

    Abstract AbstractBackground Coronary artery disease (CAD) is associated with perioperative liver transplantation (LT) mortality. In absence of a defined risk algorithm, we aimed to test whether stress echocardiography and coronary computed tomography angiography (CCTA) could detect CAD in end-stage liver disease (ESLD) patients without previous evidence of heart disease.Methods LT candidates ≥30 years underwent a cardiovascular (CV) assessment through stress echocardiography. CCTA was performed in patients ≥50 years with two or more CV risk factors (e.g. diabetes, CAD family history, dyslipidaemia). Coronary angiography (CAG) was scheduled when stress echocardiography and/or CCTA were positive. Sensibility, specificity, positive and negative predictive values of stress echocardiography and CCTA were assessed by numbers of coronary revascularization (true positives) and lack of acute coronary events over a mean follow-up of 3 years (true negatives).Results Stress echocardiography was performed in 273 patients, CCTA in 34 and CAG in 41. Eight patients had critical coronary lesions, and 19 not-critical lesions. Sensitivity, specificity, positive and negative predictive values were 50.0%, 90.2%, 13.3% and 98.4% for stress echocardiography and 100%, 76.7%, 36.4% and 100% for CCTA. Among 163 patients who underwent LT (57.6%), 16 died and 5 had major adverse CV events over a mean follow-up of 3 years.Conclusions A very low prevalence of CAD in a selected population of ESLD at intermediate to high CV risk was found. A screening based on stress echocardiography and CCTA resulted in low incidence of post-LT acute coronary events in ELSD patients. CAD has no impact on mid-term survival.
    Keywords Coronary artery disease ; computed tomography angiography ; end-stage liver disease ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Pediatric Tuberculosis in Italian Children

    Luisa Galli / Laura Lancella / Chiara Tersigni / Elisabetta Venturini / Elena Chiappini / Barbara Maria Bergamini / Margherita Codifava / Cristina Venturelli / Giulia Tosetti / Caterina Marabotto / Laura Cursi / Elena Boccuzzi / Silvia Garazzino / Pier Angelo Tovo / Michele Pinon / Daniele Le Serre / Laura Castiglioni / Andrea Lo Vecchio / Alfredo Guarino /
    Eugenia Bruzzese / Giuseppe Losurdo / Elio Castagnola / Grazia Bossi / Gian Luigi Marseglia / Susanna Esposito / Samantha Bosis / Rita Grandolfo / Valentina Fiorito / Piero Valentini / Danilo Buonsenso / Raffaele Domenici / Marco Montesanti / Filippo Maria Salvini / Enrica Riva / Icilio Dodi / Francesca Maschio / Luisa Abbagnato / Elisa Fiumana / Chiara Fornabaio / Patrizia Ballista / Vincenzo Portelli / Gabriella Bottone / Nicola Palladino / Mariella Valenzise / Barbara Vecchi / Maria Di Gangi / Carla Lupi / Alberto Villani / Maurizio de Martino

    International Journal of Molecular Sciences, Vol 17, Iss 6, p

    Epidemiological and Clinical Data from the Italian Register of Pediatric Tuberculosis

    2016  Volume 960

    Abstract: Tuberculosis (TB) is one of the leading causes of death worldwide. Over the last decades, TB has also emerged in the pediatric population. Epidemiologic data of childhood TB are still limited and there is an urgent need of more data on very large cohorts. ...

    Abstract Tuberculosis (TB) is one of the leading causes of death worldwide. Over the last decades, TB has also emerged in the pediatric population. Epidemiologic data of childhood TB are still limited and there is an urgent need of more data on very large cohorts. A multicenter study was conducted in 27 pediatric hospitals, pediatric wards, and public health centers in Italy using a standardized form, covering the period of time between 1 January 2010 and 31 December 2012. Children with active TB, latent TB, and those recently exposed to TB or recently adopted/immigrated from a high TB incidence country were enrolled. Overall, 4234 children were included; 554 (13.1%) children had active TB, 594 (14.0%) latent TB and 3086 (72.9%) were uninfected. Among children with active TB, 481 (86.8%) patients had pulmonary TB. The treatment of active TB cases was known for 96.4% (n = 534) of the cases. Overall, 210 (39.3%) out of these 534 children were treated with three and 216 (40.4%) with four first-line drugs. Second-line drugs where used in 87 (16.3%) children with active TB. Drug-resistant strains of Mycobacterium tuberculosis were reported in 39 (7%) children. Improving the surveillance of childhood TB is important for public health care workers and pediatricians. A non-negligible proportion of children had drug-resistant TB and was treated with second-line drugs, most of which are off-label in the pediatric age. Future efforts should concentrate on improving active surveillance, diagnostic tools, and the availability of antitubercular pediatric formulations, also in low-endemic countries.
    Keywords tuberculosis ; children ; Italian ; register ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 360
    Language English
    Publishing date 2016-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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