Artikel ; Online: Ketone bodies in cell physiology and cancer.
American journal of physiology. Cell physiology
2024 Band 326, Heft 3, Seite(n) C948–C963
Abstract: Ketogenic diets (KDs), fasting, or prolonged physical activity elevate serum ketone bodies (KBs) levels, providing an alternative fuel source for the brain and other organs. However, KBs play pleiotropic roles that go beyond their role in energy ... ...
Abstract | Ketogenic diets (KDs), fasting, or prolonged physical activity elevate serum ketone bodies (KBs) levels, providing an alternative fuel source for the brain and other organs. However, KBs play pleiotropic roles that go beyond their role in energy production. KBs can act as signaling metabolites, influence gene expression, proteins' posttranslational modifications (PTMs), inflammation, and oxidative stress. Here, we explore the impact of KBs on mammalian cell physiology, including aging and tissue regeneration. We also concentrate on KBs and cancer, given the extensive evidence that dietary approaches inducing ketosis, including fasting-mimicking diets (FMDs) and KDs, can prevent cancer and affect tumor progression. |
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Mesh-Begriff(e) | Animals ; Humans ; Ketone Bodies/metabolism ; Ketone Bodies/pharmacology ; Neoplasms/metabolism ; Brain/metabolism ; Oxidative Stress ; Cell Physiological Phenomena ; Mammals/metabolism |
Chemische Substanzen | Ketone Bodies |
Sprache | Englisch |
Erscheinungsdatum | 2024-01-08 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article ; Review |
ZDB-ID | 392098-7 |
ISSN | 1522-1563 ; 0363-6143 |
ISSN (online) | 1522-1563 |
ISSN | 0363-6143 |
DOI | 10.1152/ajpcell.00441.2023 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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