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  1. AU="Giuliani, Giacomo"
  2. AU="Khan, Azam" AU="Khan, Azam"

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  1. Artikel ; Online: Ketone bodies in cell physiology and cancer.

    Giuliani, Giacomo / Longo, Valter D

    American journal of physiology. Cell physiology

    2024  Band 326, Heft 3, Seite(n) C948–C963

    Abstract: Ketogenic diets (KDs), fasting, or prolonged physical activity elevate serum ketone bodies (KBs) levels, providing an alternative fuel source for the brain and other organs. However, KBs play pleiotropic roles that go beyond their role in energy ... ...

    Abstract Ketogenic diets (KDs), fasting, or prolonged physical activity elevate serum ketone bodies (KBs) levels, providing an alternative fuel source for the brain and other organs. However, KBs play pleiotropic roles that go beyond their role in energy production. KBs can act as signaling metabolites, influence gene expression, proteins' posttranslational modifications (PTMs), inflammation, and oxidative stress. Here, we explore the impact of KBs on mammalian cell physiology, including aging and tissue regeneration. We also concentrate on KBs and cancer, given the extensive evidence that dietary approaches inducing ketosis, including fasting-mimicking diets (FMDs) and KDs, can prevent cancer and affect tumor progression.
    Mesh-Begriff(e) Animals ; Humans ; Ketone Bodies/metabolism ; Ketone Bodies/pharmacology ; Neoplasms/metabolism ; Brain/metabolism ; Oxidative Stress ; Cell Physiological Phenomena ; Mammals/metabolism
    Chemische Substanzen Ketone Bodies
    Sprache Englisch
    Erscheinungsdatum 2024-01-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00441.2023
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Nutrition and dietary restrictions in cancer prevention.

    Mishra, Amrendra / Giuliani, Giacomo / Longo, Valter D

    Biochimica et biophysica acta. Reviews on cancer

    2023  Band 1879, Heft 1, Seite(n) 189063

    Abstract: The composition and pattern of dietary intake have emerged as key factors influencing aging, regeneration, and consequently, healthspan and lifespan. Cancer is one of the major diseases more tightly linked with aging, and age-related mortality. Although ... ...

    Abstract The composition and pattern of dietary intake have emerged as key factors influencing aging, regeneration, and consequently, healthspan and lifespan. Cancer is one of the major diseases more tightly linked with aging, and age-related mortality. Although the role of nutrition in cancer incidence is generally well established, we are far from a consensus on how diet influences tumour development in different tissues. In this review, we will discuss how diet and dietary restrictions affect cancer risk and the molecular mechanisms potentially responsible for their effects. We will cover calorie restriction, intermittent fasting, prolonged fasting, fasting-mimicking diet, time-restricted eating, ketogenic diet, high protein diet, Mediterranean diet, and the vegan and vegetarian diets.
    Mesh-Begriff(e) Humans ; Diet/adverse effects ; Fasting ; Caloric Restriction ; Aging ; Neoplasms/prevention & control
    Sprache Englisch
    Erscheinungsdatum 2023-12-24
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2918802-7
    ISSN 1879-2561 ; 0304-419X
    ISSN (online) 1879-2561
    ISSN 0304-419X
    DOI 10.1016/j.bbcan.2023.189063
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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