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  1. Article: Companion Animal Model in Translational Oncology; Feline Oral Squamous Cell Carcinoma and Canine Oral Melanoma.

    Giuliano, Antonio

    Biology

    2021  Volume 11, Issue 1

    Abstract: Companion animals with naturally occurring cancers can provide an advantageous model for cancer research and in particular anticancer drug development. Compared to commonly utilized mouse models, companion animals, specifically dogs and cats, share a ... ...

    Abstract Companion animals with naturally occurring cancers can provide an advantageous model for cancer research and in particular anticancer drug development. Compared to commonly utilized mouse models, companion animals, specifically dogs and cats, share a closer phylogenetical distance, body size, and genome organization. Most importantly, pets develop spontaneous, rather than artificially induced, cancers. The incidence of cancer in people and companion animals is quite similar and cancer is the leading cause of death in dogs over 10 years of age. Many cancer types in dogs and cats have similar pathological, molecular, and clinical features to their human counterparts. Drug toxicity and response to anti-cancer treatment in dogs and cats are also similar to those in people. Companion animals share their lives with their owners, including the environmental and socioeconomic cancer-risk factors. In contrast to humans, pets have a shorter life span and cancer progression is often more rapid. Clinical trials in companion animals are cheaper and less time consuming compared to human trials. Dogs and cats with naturally occurring cancers are an ideal and unique model for human cancer research. Model selection for the specific type of cancer is of pivotal importance. Although companion animal models for translational research have been reviewed previously, this review will try to summarize the most important advantages and disadvantages of this model. Feline oral squamous cell carcinoma as a model for head and neck squamous cell carcinoma and canine oral melanoma as a model for mucosal melanoma and immunotherapy in people will be discussed as examples.
    Language English
    Publishing date 2021-12-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11010054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Companion Animal Model in Translational Oncology; Feline Oral Squamous Cell Carcinoma and Canine Oral Melanoma

    Giuliano, Antonio

    Biology. 2021 Dec. 31, v. 11, no. 1

    2021  

    Abstract: Companion animals with naturally occurring cancers can provide an advantageous model for cancer research and in particular anticancer drug development. Compared to commonly utilized mouse models, companion animals, specifically dogs and cats, share a ... ...

    Abstract Companion animals with naturally occurring cancers can provide an advantageous model for cancer research and in particular anticancer drug development. Compared to commonly utilized mouse models, companion animals, specifically dogs and cats, share a closer phylogenetical distance, body size, and genome organization. Most importantly, pets develop spontaneous, rather than artificially induced, cancers. The incidence of cancer in people and companion animals is quite similar and cancer is the leading cause of death in dogs over 10 years of age. Many cancer types in dogs and cats have similar pathological, molecular, and clinical features to their human counterparts. Drug toxicity and response to anti-cancer treatment in dogs and cats are also similar to those in people. Companion animals share their lives with their owners, including the environmental and socioeconomic cancer-risk factors. In contrast to humans, pets have a shorter life span and cancer progression is often more rapid. Clinical trials in companion animals are cheaper and less time consuming compared to human trials. Dogs and cats with naturally occurring cancers are an ideal and unique model for human cancer research. Model selection for the specific type of cancer is of pivotal importance. Although companion animal models for translational research have been reviewed previously, this review will try to summarize the most important advantages and disadvantages of this model. Feline oral squamous cell carcinoma as a model for head and neck squamous cell carcinoma and canine oral melanoma as a model for mucosal melanoma and immunotherapy in people will be discussed as examples.
    Keywords animal models ; antineoplastic agents ; body size ; cats ; death ; dogs ; drug development ; drug toxicity ; genome ; head and neck squamous cell carcinoma ; humans ; immunotherapy ; longevity ; melanoma ; mice ; neoplasm progression ; people ; pets ; squamous cell carcinoma
    Language English
    Dates of publication 2021-1231
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11010054
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Retrospective Evaluation of a Combination of Carboplatin and Bleomycin for the Treatment of Canine Carcinomas.

    Giuliano, Antonio / Almendros, Angel

    Animals : an open access journal from MDPI

    2022  Volume 12, Issue 18

    Abstract: Carboplatin is a chemotherapy agent widely used in veterinary oncology to treat various types of tumors including carcinomas. Carboplatin has previously been used in combination with 5-Fluoro uracil (5-FU) or gemcitabine for the treatment of various ... ...

    Abstract Carboplatin is a chemotherapy agent widely used in veterinary oncology to treat various types of tumors including carcinomas. Carboplatin has previously been used in combination with 5-Fluoro uracil (5-FU) or gemcitabine for the treatment of various carcinomas. Bleomycin is a chemotherapy drug commonly used in humans, but its use has been uncommonly reported in dogs. The combination of carboplatin and bleomycin chemotherapy treatment has never been reported in dogs. Dogs diagnosed with carcinoma and treated with a combination of carboplatin and bleomycin, at a single veterinary referral center, were retrospectively evaluated. Thirty patients met the inclusion criteria. The dose of carboplatin ranged from 200-250 mg/m
    Language English
    Publishing date 2022-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12182340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Retrospective Evaluation of a Combination of Carboplatin and Bleomycin for the Treatment of Canine Carcinomas

    Giuliano, Antonio / Almendros, Angel

    Animals. 2022 Sept. 08, v. 12, no. 18

    2022  

    Abstract: Carboplatin is a chemotherapy agent widely used in veterinary oncology to treat various types of tumors including carcinomas. Carboplatin has previously been used in combination with 5-Fluoro uracil (5-FU) or gemcitabine for the treatment of various ... ...

    Abstract Carboplatin is a chemotherapy agent widely used in veterinary oncology to treat various types of tumors including carcinomas. Carboplatin has previously been used in combination with 5-Fluoro uracil (5-FU) or gemcitabine for the treatment of various carcinomas. Bleomycin is a chemotherapy drug commonly used in humans, but its use has been uncommonly reported in dogs. The combination of carboplatin and bleomycin chemotherapy treatment has never been reported in dogs. Dogs diagnosed with carcinoma and treated with a combination of carboplatin and bleomycin, at a single veterinary referral center, were retrospectively evaluated. Thirty patients met the inclusion criteria. The dose of carboplatin ranged from 200–250 mg/m² (median 240 mg/m²) and the dose of bleomycin from 15–20 IU/m² (median 15 IU/m²). The treatment with carboplatin and bleomycin was well tolerated, with sixteen patients (53%) developing side effects. Thirteen patients (46%) developed gastrointestinal signs and nine dogs (30%) developed hematological abnormalities. The most common side effects were grade-1 hyporexia and grade-1 neutropenia. Grade-2 neutropenia was rarely observed, and only one patient developed grade-3 neutropenia. None of the dogs developed grade-4 adverse events, or required hospitalization, or died due to the treatment. No signs of chronic side effects, including pulmonary toxicity, were observed. Objective response was observed in 24% of the cases (six partial responses) and 76% of cases achieved clinical benefit (partial response+ stable disease). Clinical signs improved in 24 of the 30 cases (80%). The main aim of this study was to evaluate the safety of bleomycin and carboplatin in combination for the treatment of various types of carcinomas. The combination of bleomycin and carboplatin appears safe and potentially effective for some types of carcinomas. Larger prospective studies are needed to confirm the safety and efficacy of combined carboplatin and bleomycin.
    Keywords carcinoma ; dogs ; drug therapy ; fluorouracil ; gastrointestinal system ; neutropenia ; patients ; retrospective studies ; toxicity ; uracil
    Language English
    Dates of publication 2022-0908
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12182340
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Case report: Suspected plasmablastic lymphoma in a dog resembling the clinical presentation in humans.

    Giuliano, Antonio / Lam, Sin Yan / Flecher, Mayra C / Horta, Rodrigo S

    Frontiers in veterinary science

    2023  Volume 10, Page(s) 1100942

    Abstract: Plasmablastic lymphoma (PBL) is a rare form of lymphoma in people. PBL originates from plasmablasts and usually presents with swelling/mass in the mouth/neck. A 7-year-old Mongrel dog was presented for a large oral and neck mass. Cytology and ... ...

    Abstract Plasmablastic lymphoma (PBL) is a rare form of lymphoma in people. PBL originates from plasmablasts and usually presents with swelling/mass in the mouth/neck. A 7-year-old Mongrel dog was presented for a large oral and neck mass. Cytology and histopathology were suggestive of a round cell tumor that was suspected to be lymphoma. An immunohistochemical (IHC) stain panel showed positive for CD18, thus supporting the diagnosis of round cell tumor, but negative for T- and B-cell lymphomas, CD3, CD20, and PAX-5. Other markers including cytokeratin AE1/3 (for epithelial cell origin), CD31 (for endothelial cells), SOX10 (for melanoma), IBa-1 (for histiocytic sarcoma), and CD117 (for mast cell tumor) were all negative. MUM-1 (for plasma cell differentiation) was strongly positive and CD79a (B cell and plasma cells) was also scantly positive. Based on the histopathology and immunohistochemistry results in combination with the clinical presentation, a suspected diagnosis of PBL was made. As per available literature, this is perhaps the first highly suspected case of PBL in a dog.
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1100942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Clinical response and survival time of cats with carcinoma of the nasal cavity treated with palliative coarse fractionated radiotherapy.

    Giuliano, Antonio / Dobson, Jane

    Journal of feline medicine and surgery

    2020  Volume 22, Issue 10, Page(s) 922–927

    Abstract: Objectives: Carcinoma is the second most common tumour of the nasal cavity in cats. Few studies assessing the response and survival of cats with carcinoma of the nasal cavity treated with palliative coarse fractionated radiotherapy have been published.!# ...

    Abstract Objectives: Carcinoma is the second most common tumour of the nasal cavity in cats. Few studies assessing the response and survival of cats with carcinoma of the nasal cavity treated with palliative coarse fractionated radiotherapy have been published.
    Methods: Twenty-eight cats were diagnosed with histologically confirmed carcinoma of the nasal cavity. All patients treated with a coarse fractionated radiotherapy protocol were retrospectively reviewed.
    Results: Improvement of the clinical signs were reported in 24 cases; median survival time (MST) was 342 days; and cats with Adams modified stage IV and facial deformity had a significantly reduced MST of 152 days (
    Conclusions and relevance: Coarse fractionated radiotherapy treatment for carcinoma of the nasal cavity in cats is effective in relieving clinical signs. Long survival times can be achieved, in particular in cases with a less advanced stage of the tumour.
    MeSH term(s) Animals ; Carcinoma/radiotherapy ; Carcinoma/veterinary ; Cat Diseases/radiotherapy ; Cats ; Dose Fractionation, Radiation ; Female ; Male ; Nasal Cavity/pathology ; Nose Neoplasms/radiotherapy ; Nose Neoplasms/veterinary ; Palliative Care ; Retrospective Studies
    Language English
    Publishing date 2020-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049047-1
    ISSN 1532-2750 ; 1098-612X
    ISSN (online) 1532-2750
    ISSN 1098-612X
    DOI 10.1177/1098612X19893445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Clinical response and survival time of cats with carcinoma of the nasal cavity treated with palliative coarse fractionated radiotherapy

    Giuliano, Antonio / Dobson, Jane

    Journal of feline medicine and surgery. 2020 Oct., v. 22, no. 10

    2020  

    Abstract: Carcinoma is the second most common tumour of the nasal cavity in cats. Few studies assessing the response and survival of cats with carcinoma of the nasal cavity treated with palliative coarse fractionated radiotherapy have been published. Twenty-eight ... ...

    Abstract Carcinoma is the second most common tumour of the nasal cavity in cats. Few studies assessing the response and survival of cats with carcinoma of the nasal cavity treated with palliative coarse fractionated radiotherapy have been published. Twenty-eight cats were diagnosed with histologically confirmed carcinoma of the nasal cavity. All patients treated with a coarse fractionated radiotherapy protocol were retrospectively reviewed. Improvement of the clinical signs were reported in 24 cases; median survival time (MST) was 342 days; and cats with Adams modified stage IV and facial deformity had a significantly reduced MST of 152 days (P = 0.0013) and 67 days (P = 0.0002), respectively. Severe radiotherapy-related clinical signs were not reported and alopecia and leukotrichia were the most common side effects reported in ten cases. Coarse fractionated radiotherapy treatment for carcinoma of the nasal cavity in cats is effective in relieving clinical signs. Long survival times can be achieved, in particular in cases with a less advanced stage of the tumour.
    Keywords adverse effects ; alopecia ; carcinoma ; cats ; fractionation ; medicine ; nasal cavity ; patients ; protocols ; radiotherapy ; signs and symptoms (animals and humans) ; surgery
    Language English
    Dates of publication 2020-10
    Size p. 922-927.
    Publishing place SAGE Publications
    Document type Article
    Note NAL-light
    ZDB-ID 2049047-1
    ISSN 1532-2750 ; 1098-612X
    ISSN (online) 1532-2750
    ISSN 1098-612X
    DOI 10.1177/1098612X19893445
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Testicular torsion in a normally descended testicle in a cat.

    Giuliano, Antonio

    The Journal of small animal practice

    2013  Volume 54, Issue 3, Page(s) 164

    MeSH term(s) Animals ; Cat Diseases/diagnosis ; Cat Diseases/surgery ; Cats ; Incidental Findings ; Male ; Spermatic Cord Torsion/diagnosis ; Spermatic Cord Torsion/surgery ; Spermatic Cord Torsion/veterinary ; Treatment Outcome
    Language English
    Publishing date 2013-03
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 410743-3
    ISSN 1748-5827 ; 0022-4510 ; 1748-5827
    ISSN (online) 1748-5827
    ISSN 0022-4510 ; 1748-5827
    DOI 10.1111/jsap.12030
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 590: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Suspected chlorambucil-related neurotoxicity with seizures in a dog.

    Giuliano, Antonio

    The Journal of small animal practice

    2013  Volume 54, Issue 8, Page(s) 437

    MeSH term(s) Animals ; Antineoplastic Agents, Alkylating/adverse effects ; Chlorambucil/adverse effects ; Dog Diseases/chemically induced ; Dog Diseases/drug therapy ; Dogs ; Lymphoma/drug therapy ; Lymphoma/veterinary ; Seizures/chemically induced ; Seizures/veterinary
    Chemical Substances Antineoplastic Agents, Alkylating ; Chlorambucil (18D0SL7309)
    Language English
    Publishing date 2013-08
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 410743-3
    ISSN 1748-5827 ; 0022-4510 ; 1748-5827
    ISSN (online) 1748-5827
    ISSN 0022-4510 ; 1748-5827
    DOI 10.1111/jsap.12110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 590: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Molecular Profile of Canine Hemangiosarcoma and Potential Novel Therapeutic Targets.

    Pimentel, Pedro Antônio Bronhara / Giuliano, Antonio / Bęczkowski, Paweł Marek / Horta, Rodrigo Dos Santos

    Veterinary sciences

    2023  Volume 10, Issue 6

    Abstract: Canine hemangiosarcoma (HSA) is a relatively common neoplasia, occurring mainly in the skin, spleen, liver and right atrium. Despite the numerous studies investigating the treatment of canine HSA, no significant improvement in survival has been achieved ... ...

    Abstract Canine hemangiosarcoma (HSA) is a relatively common neoplasia, occurring mainly in the skin, spleen, liver and right atrium. Despite the numerous studies investigating the treatment of canine HSA, no significant improvement in survival has been achieved in the last 20 years. Advancements in genetic and molecular profiling presented molecular similarities between canine HSA and human angiosarcoma. It could therefore serve as a valuable model for investigating new and more effective treatments in people and dogs. The most common genetic abnormalities in canine HSA have been found in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and neuroblastoma RAS viral oncogene homolog (NRAS) pathways. Mutations are also found in tumor protein p53 (TP53), phosphatase and tensin homolog (PTEN) and cyclin dependent kinase inhibitor 2A (CDKN2A). Known abnormal protein expression could be exploited to trial new target treatments that could be beneficial for both canine and human patients. Despite the high expression of vascular endothelial growth factor (VEGF) and its receptor (VEGFR), no correlation with overall survival time has ever been found. In this review, we explore the most recent developments in molecular profiling in canine HSA and discuss their possible applications in the prognosis and treatment of this fatal disease.
    Language English
    Publishing date 2023-06-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci10060387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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