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  1. AU="Giulio M. Pasinetti"
  2. AU="Ivan Arano"
  3. AU="Fujii, Denise Nami"
  4. AU="Marquer, L"
  5. AU="Rosa, Giuseppe La"
  6. AU="Honari, Niloofar"
  7. AU="Grant, Patrick A"
  8. AU="Hojski, Aljaz"
  9. AU="SUN Chuanrui"
  10. AU="Holt, Liam J"
  11. AU="Matthew Bell"
  12. AU="Cheng, Pu"
  13. AU="D'Souza, Jill N"
  14. AU="Terrone, Sophie"
  15. AU="Esmaily, Hadi"
  16. AU="Al-Ani, Gada"
  17. AU="Denys, Damiaan A J P"
  18. AU="Irigoin, Victoria"
  19. AU="Kim, Joo-Yun"
  20. AU="Albu, Simona Elena"
  21. AU="Monalisa Feliciano Figueiredo"
  22. AU="Zhao, Houhua"
  23. AU="Kern, Bastian Johannes"
  24. AU="Antonio Vitobello"
  25. AU="Paulus Rahardjo"
  26. AU="Geier, Martina"
  27. AU="Kwon, Tae-Hwan"
  28. AU="Christos Barboutis, "
  29. AU="Fayaz, U"
  30. AU="Ba, Yabo"
  31. AU="Stevens, Valerie A"
  32. AU="Kahouli, Sophia"
  33. AU="Sun, Chuanrui"
  34. AU="Carrera, Carlo Giovanni"
  35. AU="Secrieru, Oana Manuela"
  36. AU="Wang, Lanzhong"

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Treffer 1 - 10 von insgesamt 17

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  1. Artikel ; Online: The Use of Antimicrobial and Antiviral Drugs in Alzheimer’s Disease

    Umar H. Iqbal / Emma Zeng / Giulio M. Pasinetti

    International Journal of Molecular Sciences, Vol 21, Iss 4920, p

    2020  Band 4920

    Abstract: The aggregation and accumulation of amyloid-β plaques and tau proteins in the brain have been central characteristics in the pathophysiology of Alzheimer’s disease (AD), making them the focus of most of the research exploring potential therapeutics for ... ...

    Abstract The aggregation and accumulation of amyloid-β plaques and tau proteins in the brain have been central characteristics in the pathophysiology of Alzheimer’s disease (AD), making them the focus of most of the research exploring potential therapeutics for this neurodegenerative disease. With success in interventions aimed at depleting amyloid-β peptides being limited at best, a greater understanding of the physiological role of amyloid-β peptides is needed. The development of amyloid-β plaques has been determined to occur 10–20 years prior to AD symptom manifestation, hence earlier interventions might be necessary to address presymptomatic AD. Furthermore, recent studies have suggested that amyloid-β peptides may play a role in innate immunity as an antimicrobial peptide. These findings, coupled with the evidence of pathogens such as viruses and bacteria in AD brains, suggests that the buildup of amyloid-β plaques could be a response to the presence of viruses and bacteria. This has led to the foundation of the antimicrobial hypothesis for AD. The present review will highlight the current understanding of amyloid-β, and the role of bacteria and viruses in AD, and will also explore the therapeutic potential of antimicrobial and antiviral drugs in Alzheimer’s disease.
    Schlagwörter Alzheimer’s disease ; amyloid-β ; antimicrobial ; antiviral ; antimicrobial peptide ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process

    Maria Sebastian-Valverde / Giulio M. Pasinetti

    Cells, Vol 9, Iss 1552, p

    2020  Band 1552

    Abstract: As a consequence of the considerable increase in the human lifespan over the last century, we are experiencing the appearance and impact of new age-related diseases. The causal relationships between aging and an enhanced susceptibility of suffering from ... ...

    Abstract As a consequence of the considerable increase in the human lifespan over the last century, we are experiencing the appearance and impact of new age-related diseases. The causal relationships between aging and an enhanced susceptibility of suffering from a broad spectrum of diseases need to be better understood. However, one specific shared feature seems to be of capital relevance for most of these conditions: the low-grade chronic inflammatory state inherently associated with aging, i.e., inflammaging. Here, we review the molecular and cellular mechanisms that link aging and inflammaging, focusing on the role of the innate immunity and more concretely on the nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, as well as how the chronic activation of this inflammasome has a detrimental effect on different age-related disorders.
    Schlagwörter inflammaging ; NLRP3 ; innate immunity ; age-related diseases ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: The Viral Hypothesis in Alzheimer’s Disease

    Sean X Naughton / Urdhva Raval / Giulio M. Pasinetti

    Journal of Personalized Medicine, Vol 10, Iss 74, p

    Novel Insights and Pathogen-Based Biomarkers

    2020  Band 74

    Abstract: Early diagnosis of Alzheimer’s disease (AD) and the identification of significant risk factors are necessary to better understand disease progression, and to develop intervention-based therapies prior to significant neurodegeneration. There is thus a ... ...

    Abstract Early diagnosis of Alzheimer’s disease (AD) and the identification of significant risk factors are necessary to better understand disease progression, and to develop intervention-based therapies prior to significant neurodegeneration. There is thus a critical need to establish biomarkers which can predict the risk of developing AD before the onset of cognitive decline. A number of studies have indicated that exposure to various microbial pathogens can accelerate AD pathology. Additionally, several studies have indicated that amyloid-β possess antimicrobial properties and may act in response to infection as a part of the innate immune system. These findings have led some to speculate that certain types of infections may play a significant role in AD pathogenesis. In this review, we will provide an overview of studies which suggest pathogen involvement in AD. Additionally, we will discuss a number of pathogen-associated biomarkers which may be effective in establishing AD risk. Infections that increase the risk of AD represent a modifiable risk factor which can be treated with therapeutic intervention. Pathogen-based biomarkers may thus be a valuable tool for evaluating and decreasing AD risk across the population.
    Schlagwörter Alzheimer’s disease ; virus ; bacteria ; dementia ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Anti-aggregation Effects of Phenolic Compounds on α-synuclein

    Kenjiro Ono / Mayumi Tsuji / Tritia R. Yamasaki / Giulio M. Pasinetti

    Molecules, Vol 25, Iss 2444, p

    2020  Band 2444

    Abstract: The aggregation and deposition of α-synuclein (αS) are major pathologic features of Parkinson’s disease, dementia with Lewy bodies, and other α-synucleinopathies. The propagation of αS pathology in the brain plays a key role in the onset and progression ... ...

    Abstract The aggregation and deposition of α-synuclein (αS) are major pathologic features of Parkinson’s disease, dementia with Lewy bodies, and other α-synucleinopathies. The propagation of αS pathology in the brain plays a key role in the onset and progression of clinical phenotypes. Thus, there is increasing interest in developing strategies that attenuate αS aggregation and propagation. Based on cumulative evidence that αS oligomers are neurotoxic and critical species in the pathogenesis of α-synucleinopathies, we and other groups reported that phenolic compounds inhibit αS aggregation including oligomerization, thereby ameliorating αS oligomer-induced cellular and synaptic toxicities. Heterogeneity in gut microbiota may influence the efficacy of dietary polyphenol metabolism. Our recent studies on the brain-penetrating polyphenolic acids 3-hydroxybenzoic acid (3-HBA), 3,4-dihydroxybenzoic acid (3,4-diHBA), and 3-hydroxyphenylacetic acid (3-HPPA), which are derived from gut microbiota-based metabolism of dietary polyphenols, demonstrated an in vitro ability to inhibit αS oligomerization and mediate aggregated αS-induced neurotoxicity. Additionally, 3-HPPA, 3,4-diHBA, 3-HBA, and 4-hydroxybenzoic acid significantly attenuated intracellular αS seeding aggregation in a cell-based system. This review focuses on recent research developments regarding neuroprotective properties, especially anti-αS aggregation effects, of phenolic compounds and their metabolites by the gut microbiome, including our findings in the pathogenesis of α-synucleinopathies.
    Schlagwörter Parkinson’s disease ; α-synuclein ; phenolic compounds ; gut microbiome ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2020-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Efficient Chemical Synthesis of (Epi)catechin Glucuronides

    Maite L. Docampo-Palacios / Anislay Alvarez-Hernández / Ângelo de Fátima / Luciano Morais Lião / Giulio M. Pasinetti / Richard A. Dixon

    ACS Omega, Vol 5, Iss 46, Pp 30095-

    Brain-Targeted Metabolites for Treatment of Alzheimer’s Disease and Other Neurological Disorders

    2020  Band 30110

    Schlagwörter Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2020-11-01T00:00:00Z
    Verlag American Chemical Society
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Dietary polyphenols enhance optogenetic recall of fear memory in hippocampal dentate gyrus granule neuron subpopulations

    Chad Smith / Tal Frolinger / Justin Brathwaite / Steven Sims / Giulio M. Pasinetti

    Communications Biology, Vol 1, Iss 1, Pp 1-

    2018  Band 8

    Abstract: Chad Smith et al. show that dietary polyphenols, compounds found in grapes, enable mice to remember fearful events more effectively and map this function to the hippocampal dentate gyrus neurons. This study offers a way to identify the cellular ... ...

    Abstract Chad Smith et al. show that dietary polyphenols, compounds found in grapes, enable mice to remember fearful events more effectively and map this function to the hippocampal dentate gyrus neurons. This study offers a way to identify the cellular subpopulations regulated by dietary polyphenols.
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2018-05-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: An Efficient Synthesis of Deoxyrhapontigenin-3‑O‑β‑d‑glucuronide, a Brain-Targeted Derivative of Dietary Resveratrol, and Its Precursor 4′‑O‑Me-Resveratrol

    Ângelo de Fátima / Maite Docampo-Palacios / Anislay Alvarez-Hernandez / Giulio M. Pasinetti / Richard A. Dixon

    ACS Omega, Vol 4, Iss 5, Pp 8222-

    2019  Band 8230

    Schlagwörter Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2019-05-01T00:00:00Z
    Verlag American Chemical Society
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: The gut microbiota composition affects dietary polyphenols-mediated cognitive resilience in mice by modulating the bioavailability of phenolic acids

    Tal Frolinger / Steven Sims / Chad Smith / Jun Wang / Haoxiang Cheng / Jeremiah Faith / Lap Ho / Ke Hao / Giulio M. Pasinetti

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Band 10

    Abstract: Abstract Dietary polyphenols promote memory in models of sleep deprivation (SD), stress, and neurodegeneration. The biological properties of dietary polyphenols greatly depend upon the bioavailability of their phenolic metabolites derivatives, which are ... ...

    Abstract Abstract Dietary polyphenols promote memory in models of sleep deprivation (SD), stress, and neurodegeneration. The biological properties of dietary polyphenols greatly depend upon the bioavailability of their phenolic metabolites derivatives, which are modulated by gut microbiota. We recently demonstrated that supplementation with grape-derived bioactive dietary polyphenol preparation (BDPP) improves SD-induced cognitive impairment. This study examined the role of the gut microbiota in the ability of BDPP to prevent memory impairment in response to SD. C57BL6/J mice, treated with antibiotics mix (ABX) or BDPP or both, were sleep-deprived at the end of a fear conditioning training session and fear memory was assessed the next day. Gut microbiota composition was analyzed in fecal samples and BDPP-driven phenolic acid metabolites extraction was measured in plasma. We report that the beneficial effect of BDPP on memory in SD is attenuated by ABX-induced dysbiosis. We identified specific communities of fecal microbiota that are associated with the bioavailability of BDPP-derived phenolic acids, which in turn, are associated with memory promotion. These results suggest the gut microbiota composition significantly affects the bioavailability of phenolic acids that drive the dietary polyphenols’ cognitive resilience property. Our findings provide a preclinical model with which to test the causal association of gut microbiota-polyphenols, with the ultimate goal of potential developing dietary polyphenols for the prevention/treatment of cognitive impairment.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-03-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Correction to “An Efficient Synthesis of Deoxyrhapontigenin-3‑O‑β‑d‑glucuronide, a Brain-Targeted Derivative of Dietary Resveratrol, and Its Precursor 4′‑O‑Me-Resveratrol”

    Ângelo de Fátima / Maite Docampo-Palacios / Anislay Alvarez-Hernandez / Giulio M. Pasinetti / Richard A. Dixon

    ACS Omega, Vol 4, Iss 6, Pp 10301-

    2019  Band 10301

    Schlagwörter Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2019-06-01T00:00:00Z
    Verlag American Chemical Society
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Correction

    Alon Lai / Lap Ho / Thomas W Evashwick-Rogler / Hironobu Watanabe / Jonathan Salandra / Beth A Winkelstein / Damien Laudier / Andrew C Hecht / Giulio M Pasinetti / James C Iatridis

    PLoS ONE, Vol 14, Iss 11, p e

    Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model.

    2019  Band 0225674

    Abstract: This corrects the article DOI:10.1371/journal.pone.0223435.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0223435.].
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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