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  1. Article: Calcium-Dependent Interaction of Nitric Oxide Synthase with Cytochrome

    Haynes, Virginia / Giulivi, Cecilia

    Brain sciences

    2023  Volume 13, Issue 11

    Abstract: Targeted nitric oxide production is relevant for maintaining cellular energy production, protecting against oxidative stress, regulating cell death, and promoting neuroprotection. This study aimed to characterize the putative interaction of nitric-oxide ... ...

    Abstract Targeted nitric oxide production is relevant for maintaining cellular energy production, protecting against oxidative stress, regulating cell death, and promoting neuroprotection. This study aimed to characterize the putative interaction of nitric-oxide synthase with mitochondrial proteins. The primary finding of this study is that cytochrome
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13111534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Starch treatment improves the salivary proteome for subject identification purposes.

    Smith, Hannah / Giulivi, Cecilia

    Forensic science, medicine, and pathology

    2023  Volume 20, Issue 1, Page(s) 117–128

    Abstract: Identification of subjects, including perpetrators, is one of the most crucial goals of forensic science. Saliva is among the most common biological fluids found at crime scenes, containing identifiable components. DNA has been the most prominent ... ...

    Abstract Identification of subjects, including perpetrators, is one of the most crucial goals of forensic science. Saliva is among the most common biological fluids found at crime scenes, containing identifiable components. DNA has been the most prominent identifier to date, but its analysis can be complex due to low DNA yields and issues preserving its integrity at the crime scene. Proteins are emerging as viable candidates for subject identification. Previous work has shown that the salivary proteome of the least-abundant proteins may be helpful for subject identification, but more optimized techniques are needed. Among them is removing the most abundant proteins, such as salivary α-amylase. Starch treatment of saliva samples elicited the removal of this enzyme and that of glycosylated, low-molecular-weight proteins, proteases, and immunoglobulins, resulting in a saliva proteome profile enriched with a subset of proteins, allowing a more reliable and nuanced subject identification.
    MeSH term(s) Humans ; Proteome/metabolism ; Starch/metabolism ; Saliva ; DNA ; Forensic Sciences
    Chemical Substances Proteome ; Starch (9005-25-8) ; DNA (9007-49-2)
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2195904-3
    ISSN 1556-2891 ; 1547-769X
    ISSN (online) 1556-2891
    ISSN 1547-769X
    DOI 10.1007/s12024-023-00629-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Recent advances and new perspectives in mitochondrial dysfunction.

    Giulivi, Cecilia / Zhang, Kezhong / Arakawa, Hirofumi

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 7977

    MeSH term(s) Humans ; Mitochondria/genetics ; Mitochondrial Diseases/genetics ; Mitochondrial Diseases/therapy ; DNA, Mitochondrial
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Editorial
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-34624-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Metabolomic Signatures of Brainstem in Mice following Acute and Subchronic Hydrogen Sulfide Exposure.

    Kim, Dong-Suk / Santana Maldonado, Cristina M / Giulivi, Cecilia / Rumbeiha, Wilson Kiiza

    Metabolites

    2024  Volume 14, Issue 1

    Abstract: Hydrogen sulfide ( ... ...

    Abstract Hydrogen sulfide (H
    Language English
    Publishing date 2024-01-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo14010053
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  5. Article ; Online: Factors influencing vitamin B6 status in domestic cats: age, disease, and body condition score.

    Chu, Vy / Fascetti, Andrea J / Larsen, Jennifer A / Montano, Maria / Giulivi, Cecilia

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2037

    Abstract: Limited studies are available on vitamin B6 status in domestic cats. To this end, we evaluated glutamate-oxaloacetate transaminase (GOT) activity in hemolysates with and without pyridoxal 5'-phosphate addition in two feline populations: a cohort of 60 ... ...

    Abstract Limited studies are available on vitamin B6 status in domestic cats. To this end, we evaluated glutamate-oxaloacetate transaminase (GOT) activity in hemolysates with and without pyridoxal 5'-phosphate addition in two feline populations: a cohort of 60 healthy, domestic (sexually intact and specific pathogen-free) cats maintained under strictly controlled conditions with appropriate diets housed at the Feline Nutrition and Pet Care Center, and a cohort of 57 cats randomly selected between December 2022 to January 2023 that visited the Veterinary Medicine Teaching Hospital to seek care under different circumstances. The GOT activity expressed as the ratio with and without pyridoxal 5'-phosphate addition (primary activation ratio; PAR) decreased significantly with age in the healthy cohort. The PAR values normalized to age established a cut-off for vitamin B6 deficiency in both cohorts, identifying 17 of 101 animals as vitamin B6 deficient. Using machine learning, a partition-based model (decision tree) was built to identify the most important factors that predicted vitamin B6 deficiency while using the resulting tree to make predictions for new observations. This analysis, performed with all 101 cats, revealed that the diagnosis of an infectious, chronic or acute condition (0.55) was the main contributor, followed by age (0.26), and body condition score (optimal-overweight; 0.19). Thus, our study supports that vitamin B6 supplementation may be indicated in junior to adult animals diagnosed with an infectious, chronic, or acute conditions or healthy cats with body weight ranging from optimal to overweight. In older cats, even if healthy, underweight to optimal cats appear to be at risk of vitamin B6 deficiency.
    MeSH term(s) Animals ; Cats ; Hospitals, Teaching ; Overweight ; Phosphates ; Pyridoxal Phosphate ; Pyridoxine ; Vitamin B 6 ; Vitamin B 6 Deficiency
    Chemical Substances Phosphates ; Pyridoxal Phosphate (5V5IOJ8338) ; Pyridoxine (KV2JZ1BI6Z) ; Vitamin B 6 (8059-24-3)
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52367-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Artificial neural network applied to fragile X-associated tremor/ataxia syndrome stage diagnosis based on peripheral mitochondrial bioenergetics and brain imaging outcomes.

    Giulivi, Cecilia / Wang, Jun Yi / Hagerman, Randi J

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 21382

    Abstract: No proven prognosis is available for the neurodegenerative disorder fragile X-associated tremor/ataxia syndrome (FXTAS). Artificial neural network analyses (ANN) were used to predict FXTAS progression using data from 127 adults (noncarriers and FMR1 ... ...

    Abstract No proven prognosis is available for the neurodegenerative disorder fragile X-associated tremor/ataxia syndrome (FXTAS). Artificial neural network analyses (ANN) were used to predict FXTAS progression using data from 127 adults (noncarriers and FMR1 premutation carriers with and without FXTAS) with five outcomes from brain MRI imaging and 22 peripheral bioenergetic outcomes from two cell types. Diagnosis accuracy by ANN predictions ranged from 41.7 to 86.3% (depending on the algorithm used), and those misclassified usually presented a higher FXTAS stage. ANN prediction of FXTAS stages was based on a combination of two imaging findings (white matter hyperintensity and whole-brain volumes adjusted for intracranial volume) and four bioenergetic outcomes. Those at Stage 3 vs. 0-2 showed lower mitochondrial mass, higher oxidative stress, and an altered electron transfer consistent with mitochondrial unfolded protein response activation. Those at Stages 4-5 vs. 3 had higher oxidative stress and glycerol-3-phosphate-linked ATP production, suggesting that targeting mGPDH activity may prevent a worse prognosis. This was confirmed by the bioenergetic improvement of inhibiting mGPDH with metformin in affected fibroblasts. ANN supports the prospect of an unbiased molecular definition in diagnosing FXTAS stages while identifying potential targets for personalized medicine.
    Language English
    Publishing date 2022-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-25615-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Grand challenges in cellular biochemistry: the "next-gen" biochemistry.

    Giulivi, Cecilia

    Frontiers in chemistry

    2014  Volume 2, Page(s) 22

    Language English
    Publishing date 2014-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2014.00022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Diagnosis of Wilson Disease and Its Phenotypes by Using Artificial Intelligence.

    Medici, Valentina / Czlonkowska, Anna / Litwin, Tomasz / Giulivi, Cecilia

    Biomolecules

    2021  Volume 11, Issue 8

    Abstract: WD is caused ... ...

    Abstract WD is caused by
    MeSH term(s) Adult ; Algorithms ; Artificial Intelligence ; Brain/embryology ; Ceruloplasmin/metabolism ; Copper/metabolism ; Copper-Transporting ATPases/biosynthesis ; DNA, Mitochondrial/metabolism ; Diagnosis, Computer-Assisted ; Female ; Fuzzy Logic ; Glutamic Acid/metabolism ; Hepatolenticular Degeneration/diagnosis ; Hepatolenticular Degeneration/genetics ; Hepatolenticular Degeneration/physiopathology ; Humans ; Liver/metabolism ; Male ; Medical Informatics/methods ; Middle Aged ; Mutation ; Neural Networks, Computer ; Phenotype ; Principal Component Analysis
    Chemical Substances DNA, Mitochondrial ; Glutamic Acid (3KX376GY7L) ; Copper (789U1901C5) ; Ceruloplasmin (EC 1.16.3.1) ; ATP7B protein, human (EC 7.2.2.8) ; Copper-Transporting ATPases (EC 7.2.2.8)
    Language English
    Publishing date 2021-08-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11081243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Disrupted brain mitochondrial morphology after in vivo hydrogen sulfide exposure.

    Rumbeiha, Wilson K / Kim, Dong-Suk / Min, Angela / Nair, Maya / Giulivi, Cecilia

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 18129

    Abstract: Changes in mitochondrial dynamics are often associated with dietary patterns, medical treatments, xenobiotics, and diseases. Toxic exposures to hydrogen sulfide ( ... ...

    Abstract Changes in mitochondrial dynamics are often associated with dietary patterns, medical treatments, xenobiotics, and diseases. Toxic exposures to hydrogen sulfide (H
    MeSH term(s) Mice ; Animals ; Hydrogen Sulfide/metabolism ; Mitochondria/metabolism ; Electron Transport Complex IV/metabolism ; Brain/metabolism
    Chemical Substances Hydrogen Sulfide (YY9FVM7NSN) ; Electron Transport Complex IV (EC 1.9.3.1)
    Language English
    Publishing date 2023-10-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44807-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults.

    Dhir, Shibani / Tarasenko, Maya / Napoli, Eleonora / Giulivi, Cecilia

    Frontiers in psychiatry

    2019  Volume 10, Page(s) 207

    Abstract: Thiamine (vitamin B1) is an essential nutrient that serves as a cofactor for a number of enzymes, mostly with mitochondrial localization. Some thiamine-dependent enzymes are involved in energy metabolism and biosynthesis of nucleic acids whereas others ... ...

    Abstract Thiamine (vitamin B1) is an essential nutrient that serves as a cofactor for a number of enzymes, mostly with mitochondrial localization. Some thiamine-dependent enzymes are involved in energy metabolism and biosynthesis of nucleic acids whereas others are part of the antioxidant machinery. The brain is highly vulnerable to thiamine deficiency due to its heavy reliance on mitochondrial ATP production. This is more evident during rapid growth (i.e., perinatal periods and children) in which thiamine deficiency is commonly associated with either malnutrition or genetic defects. Thiamine deficiency contributes to a number of conditions spanning from mild neurological and psychiatric symptoms (confusion, reduced memory, and sleep disturbances) to severe encephalopathy, ataxia, congestive heart failure, muscle atrophy, and even death. This review discusses the current knowledge on thiamine deficiency and associated morbidity of neurological and psychiatric disorders, with special emphasis on the pediatric population, as well as the putative beneficial effect of thiamine supplementation in autism spectrum disorder (ASD) and other neurological conditions.
    Language English
    Publishing date 2019-04-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2019.00207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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