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  1. Article ; Online: Beyond the labyrinth: Reevaluating contralateral hearing impacts in Ménière's disease.

    Alfonso, Scarpa / Mario, Carucci / Massimo, Ralli / Claudia, Cassandro / Pietro, De Luca / Giovanni, Salzano / Pasquale, Viola / Giuseppe, Chiarella / Antonio, Salzano Francesco

    American journal of otolaryngology

    2024  Volume 45, Issue 2, Page(s) 104224

    MeSH term(s) Humans ; Meniere Disease ; Ear, Inner ; Hearing
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Letter
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2024.104224
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  2. Article ; Online: Brain Correlates of Persistent Postural-Perceptual Dizziness

    Iole Indovina / Luca Passamonti / Viviana Mucci / Giuseppe Chiarella / Francesco Lacquaniti / Jeffrey P. Staab

    Journal of Clinical Medicine, Vol 10, Iss 4274, p

    A Review of Neuroimaging Studies

    2021  Volume 4274

    Abstract: Persistent postural-perceptual dizziness (PPPD), defined in 2017, is a vestibular disorder characterized by chronic dizziness that is exacerbated by upright posture and exposure to complex visual stimuli. This review focused on recent neuroimaging ... ...

    Abstract Persistent postural-perceptual dizziness (PPPD), defined in 2017, is a vestibular disorder characterized by chronic dizziness that is exacerbated by upright posture and exposure to complex visual stimuli. This review focused on recent neuroimaging studies that explored the pathophysiological mechanisms underlying PPPD and three conditions that predated it. The emerging picture is that local activity and functional connectivity in multimodal vestibular cortical areas are decreased in PPPD, which is potentially related to structural abnormalities (e.g., reductions in cortical folding and grey-matter volume). Additionally, connectivity between the prefrontal cortex, which regulates attentional and emotional responses, and primary visual and motor regions appears to be increased in PPPD. These results complement physiological and psychological data identifying hypervigilant postural control and visual dependence in patients with PPPD, supporting the hypothesis that PPPD arises from shifts in interactions among visuo-vestibular, sensorimotor, and emotional networks that overweigh visual over vestibular inputs and increase the effects of anxiety-related mechanisms on locomotor control and spatial orientation.
    Keywords persistent postural-perceptual dizziness ; phobic postural vertigo ; chronic subjective dizziness ; visually induced dizziness ; visual dependency ; neuroimaging ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Vestibular Disorders after Kidney Transplantation

    Pasquale Viola / Vincenzo Marcelli / Domenico Sculco / Davide Pisani / Alfredo Caglioti / Filippo Ricciardiello / Alfonso Scarpa / Alessia Astorina / Giuseppe Tortoriello / Luca Gallelli / Giovambattista De Sarro / Giuseppe Chiarella

    International Journal of Environmental Research and Public Health, Vol 19, Iss 2260, p

    Focus on the Pathophysiological Mechanisms Underlying the Vertical Nystagmus Associated with Tacrolimus-Related Hypomagnesamia

    2022  Volume 2260

    Abstract: The purpose of this paper is to present the case of a patient undergoing kidney transplantation who developed limb tremor dizziness and vertical nystagmus (ny) during Tacrolimus (TAC) therapy and to investigate the pathophysiological mechanisms ... ...

    Abstract The purpose of this paper is to present the case of a patient undergoing kidney transplantation who developed limb tremor dizziness and vertical nystagmus (ny) during Tacrolimus (TAC) therapy and to investigate the pathophysiological mechanisms underlying the balance disorder. This case study regards a 51-year old kidney transplant male patient with hand tremors and lower limbs asthenia associated with dizziness and nausea. The symptoms started two months after the beginning of intravenous TAC for renal transplantation. The pure-tone audiometry showed a mild symmetrical high-frequencies down-sloping sensorineural hearing loss. Acoustic emittance measures showed a normal tympanogram; stapedial reflexes were normally elicited. The Auditory Brainstem Responses (ABR) and Cervical Vestibular Evoked Myogenic Potentials (c-VEMPs) were bilaterally normally evoked. The bedside vestibular examination showed spontaneous down-beating stationary persistent, omni-positional nystagmus, not inhibited by fixation. The Head-Shaking Test accentuates the spontaneous ny. The horizontal clinical head impulse test was negative, bilaterally. A biochemical blood test revealed a decrease in Magnesium (Mg) levels (0.8 mg/dL; normal range 1.58–2.55). The integration of Mg induced both a plasma levels normalization and an improvement of clinical symptoms. This case suggests that TAC treatment can induce a Mg depletion that caused the transient cerebellar lesion. Therefore, the monitoring of serum electrolytes during immunosuppressive treatment appears to be a useful tool in order to reduce the central system symptomatology.
    Keywords vertical nystagmus ; hypomagnesemia ; tacrolimus ; kidney transplantation ; vestibular disorder ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Sudden sensorineural hearing loss and COVID-19

    Pietro De Luca / Ettore Cassandro / Alfonso Scarpa / Claudia Cassandro / Massimo Ralli / Federico Maria Gioacchini / Massimo Re / Giuseppe Chiarella

    International Journal of Infectious Diseases, Vol 101, Iss , Pp 201-

    2020  Volume 202

    Keywords Sudden sensorineural hearing loss ; COVID-19 ; Pandemic ; Sudden deafness ; PCR ; Infectious and parasitic diseases ; RC109-216 ; covid19
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Drug–Drug Interactions in Vestibular Diseases, Clinical Problems, and Medico-Legal Implications

    Giulio Di Mizio / Gianmarco Marcianò / Caterina Palleria / Lucia Muraca / Vincenzo Rania / Roberta Roberti / Giuseppe Spaziano / Amalia Piscopo / Valeria Ciconte / Nunzio Di Nunno / Massimiliano Esposito / Pasquale Viola / Davide Pisani / Giovambattista De Sarro / Milena Raffi / Alessandro Piras / Giuseppe Chiarella / Luca Gallelli

    International Journal of Environmental Research and Public Health, Vol 18, Iss 12936, p

    2021  Volume 12936

    Abstract: Peripheral vestibular disease can be treated with several approaches (e.g., maneuvers, surgery, or medical approach). Comorbidity is common in elderly patients, so polytherapy is used, but it can generate the development of drug–drug interactions (DDIs) ... ...

    Abstract Peripheral vestibular disease can be treated with several approaches (e.g., maneuvers, surgery, or medical approach). Comorbidity is common in elderly patients, so polytherapy is used, but it can generate the development of drug–drug interactions (DDIs) that play a role in both adverse drug reactions and reduced adherence. For this reason, they need a complex kind of approach, considering all their individual characteristics. Physicians must be able to prescribe and deprescribe drugs based on a solid knowledge of pharmacokinetics, pharmacodynamics, and clinical indications. Moreover, full information is required to reach a real therapeutic alliance, to improve the safety of care and reduce possible malpractice claims related to drug–drug interactions. In this review, using PubMed, Embase, and Cochrane library, we searched articles published until 30 August 2021, and described both pharmacokinetic and pharmacodynamic DDIs in patients with vestibular disorders, focusing the interest on their clinical implications and on risk management strategies.
    Keywords polytherapy ; elderly ; vestibular disease ; vertigo ; drug interactions ; clinical practice ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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