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  1. Article ; Online: Hands-on reservoir computing

    Matteo Cucchi / Steven Abreu / Giuseppe Ciccone / Daniel Brunner / Hans Kleemann

    Neuromorphic Computing and Engineering, Vol 2, Iss 3, p

    a tutorial for practical implementation

    2022  Volume 032002

    Abstract: This manuscript serves a specific purpose: to give readers from fields such as material science, chemistry, or electronics an overview of implementing a reservoir computing (RC) experiment with her/his material system. Introductory literature on the ... ...

    Abstract This manuscript serves a specific purpose: to give readers from fields such as material science, chemistry, or electronics an overview of implementing a reservoir computing (RC) experiment with her/his material system. Introductory literature on the topic is rare and the vast majority of reviews puts forth the basics of RC taking for granted concepts that may be nontrivial to someone unfamiliar with the machine learning field (see for example reference Lukoševičius (2012 Neural Networks: Tricks of the Trade (Berlin: Springer) pp 659–686). This is unfortunate considering the large pool of material systems that show nonlinear behavior and short-term memory that may be harnessed to design novel computational paradigms. RC offers a framework for computing with material systems that circumvents typical problems that arise when implementing traditional, fully fledged feedforward neural networks on hardware, such as minimal device-to-device variability and control over each unit/neuron and connection. Instead, one can use a random, untrained reservoir where only the output layer is optimized, for example, with linear regression. In the following, we will highlight the potential of RC for hardware-based neural networks, the advantages over more traditional approaches, and the obstacles to overcome for their implementation. Preparing a high-dimensional nonlinear system as a well-performing reservoir for a specific task is not as easy as it seems at first sight. We hope this tutorial will lower the barrier for scientists attempting to exploit their nonlinear systems for computational tasks typically carried out in the fields of machine learning and artificial intelligence. A simulation tool to accompany this paper is available online ^7 .
    Keywords physical reservoir computing ; hardware-based random neural networks ; tutorial review ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 006
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher IOP Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The Small RNA Landscape in NSCLC

    Giuseppe Ciccone / Maria Luigia Ibba / Gabriele Coppola / Silvia Catuogno / Carla Lucia Esposito

    International Journal of Molecular Sciences, Vol 24, Iss 6121, p

    Current Therapeutic Applications and Progresses

    2023  Volume 6121

    Abstract: Non-small-cell lung cancer (NSCLC) is the second most diagnosed type of malignancy and the first cause of cancer death worldwide. Despite recent advances, the treatment of choice for NSCLC patients remains to be chemotherapy, often showing very limited ... ...

    Abstract Non-small-cell lung cancer (NSCLC) is the second most diagnosed type of malignancy and the first cause of cancer death worldwide. Despite recent advances, the treatment of choice for NSCLC patients remains to be chemotherapy, often showing very limited effectiveness with the frequent occurrence of drug-resistant phenotype and the lack of selectivity for tumor cells. Therefore, new effective and targeted therapeutics are needed. In this context, short RNA-based therapeutics, including Antisense Oligonucleotides (ASOs), microRNAs (miRNAs), short interfering (siRNA) and aptamers, represent a promising class of molecules. ASOs, miRNAs and siRNAs act by targeting and inhibiting specific mRNAs, thus showing an improved specificity compared to traditional anti-cancer drugs. Nucleic acid aptamers target and inhibit specific cancer-associated proteins, such as “nucleic acid antibodies”. Aptamers are also able of receptor-mediated cell internalization, and therefore, they can be used as carriers of secondary agents giving the possibility of producing very highly specific and effective therapeutics. This review provides an overview of the proposed applications of small RNAs for NSCLC treatment, highlighting their advantageous features and recent advancements in the field.
    Keywords NSCLC ; aptamer ; ASO ; RNAi ; targeted therapy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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