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  1. Article: Exoscope and operative microscope for training in microneurosurgery: A laboratory investigation on a model of cranial approach.

    Calloni, Tommaso / Antolini, Laura / Roumy, Louis-Georges / Nicolosi, Federico / Carrabba, Giorgio G / Di Cristofori, Andrea / Fontanella, Marco M / Giussani, Carlo G

    Frontiers in surgery

    2023  Volume 10, Page(s) 1150981

    Abstract: Objective: To evaluate the viability of exoscopes in the context of neurosurgical education and compare the use of a 4k3D exoscope to a traditional operative microscope in the execution of a task of anatomic structure identification on a model of ... ...

    Abstract Objective: To evaluate the viability of exoscopes in the context of neurosurgical education and compare the use of a 4k3D exoscope to a traditional operative microscope in the execution of a task of anatomic structure identification on a model of cranial approach.
    Material and methods: A cohort of volunteer residents performed a task of anatomical structure identification with both devices three times across an experimental period of 2 months. We timed the residents' performances, and the times achieved were analyzed. The volunteers answered two questionnaires concerning their opinions of the two devices.
    Results: Across tries, execution speed improved for the whole cohort. When using the exoscopes, residents were quicker to identify a single anatomical structure starting from outside the surgical field when deep structures were included in the pool. In all other settings, the two devices did not differ in a statistically significant manner. The volunteers described the exoscope as superior to the microscope in all the aspects the questionnaires inquired about, besides the depth of field perception, which was felt to be better with the microscope. Volunteers furthermore showed overwhelming support for training on different devices and with models of surgical approaches.
    Conclusion: The exoscope appeared to be non-inferior to the microscope in the execution of a task of timed identification of anatomical structures on a model of cranial approach carried out by our cohort of residents. In the questionnaires, the residents reported the exoscope to be superior to the microscope in eight of nine investigated domains. Further studies are needed to investigate the use of the exoscope in learning of microsurgical skills.
    Language English
    Publishing date 2023-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1150981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The exoscope as a promising tool to overcome the conflict between patient positioning and surgeon ergonomics in awake surgery.

    Calloni, Tommaso / Roumy, Louis-Georges / DI Cristofori, Andrea / Carrabba, Giovanni G / Nicolosi, Federico / Giussani, Carlo G

    Journal of neurosurgical sciences

    2023  Volume 67, Issue 4, Page(s) 537–539

    MeSH term(s) Humans ; Brain Neoplasms ; Wakefulness ; Neurosurgical Procedures ; Microsurgery ; Patient Positioning ; Ergonomics ; Surgeons
    Language English
    Publishing date 2023-07-23
    Publishing country Italy
    Document type Letter
    ZDB-ID 193139-8
    ISSN 1827-1855 ; 0390-5616 ; 0026-4881
    ISSN (online) 1827-1855
    ISSN 0390-5616 ; 0026-4881
    DOI 10.23736/S0390-5616.22.05954-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pathogenesis of spontaneous chronic subdural hematoma of the posterior fossa.

    Cristaldi, Paola M F / Di Cristofori, Andrea / Fiori, Leonardo / Giussani, Carlo G

    Acta neurologica Belgica

    2021  Volume 122, Issue 2, Page(s) 567–569

    MeSH term(s) Cranial Fossa, Posterior ; Head ; Hematoma, Subdural, Chronic/diagnostic imaging ; Hematoma, Subdural, Chronic/etiology ; Humans
    Language English
    Publishing date 2021-10-25
    Publishing country Italy
    Document type Letter
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-021-01827-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Epidemiology-based evaluation of trends in treatment for ruptured intracranial aneurysms in Italy.

    Bongetta, Daniele / Zoia, Cesare / Agosti, Edoardo / Doglietto, Francesco / Fiorindi, Alessandro / Spena, Giannantonio / Fontanella, Marco M / Giussani, Carlo G

    Journal of neurosurgical sciences

    2022  

    Abstract: Background: In recent years there have been significant advances in the diagnosis, management and treatment of intracranial aneurysms (IAs) in Italy. Changes in prevalence of several epigenetic risk factors in the population as well as in environmental ... ...

    Abstract Background: In recent years there have been significant advances in the diagnosis, management and treatment of intracranial aneurysms (IAs) in Italy. Changes in prevalence of several epigenetic risk factors in the population as well as in environmental factors may have influenced the epidemiological burden of this disease. No long-term, population-based study about the incidence of treated ruptured IAs (rIAs) in Italy has yet been reported in literature.
    Methods: A long-term (January 2015 - December 2020), nationwide epidemiology study was performed by using discharge data collected by the Italian National Agency for Regional Healthcare Services with a particular focus on the treatment incidence of rIAs. A sub-analysis per macro-areas (north, center, and south and islands) was also performed, including the data about regional healthcare systems organization. The prevalence of common epigenetic and environmental risk factors has been also assessed.
    Results: Over 6 years, the mean incidence of rIAs treatment was 2.7 x 100.000 per year (ds ± 0.1; range: 2.6-2.9). In 2020, there was a significant north-south decreasing gradient in incidence (north vs center vs south and islands: 3.4 vs 2.4 vs 1.8 x 100.000/year; all p<0.001). There were no meaningful differences between macro-areas in terms of access to emergency care and number of neurosurgical wards per population. The rate of unruptured IAs (uIAs) treatment did not show a correlation to that of ruptured ones. Minor regional differences were retrieved for high-risk hypertension as well as for alcohol abuse prevalence. Air pollutants and temperature charts showed a north-south gradient similar to that of the incidence in the treated rIAs.
    Conclusions: The mean incidence of treated rIAs was stable over the 2015-2020 period in Italy. A north-south decreasing gradient in rIAs treatment incidence was reported. Neither the Regional healthcare organizations nor the rate of uIAs treatment were significant factors explaining the regional differences in the incidence of rIAs treatment. Minor differences in epigenetic and environmental risk factors may be synergistically involved.
    Language English
    Publishing date 2022-04-13
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 193139-8
    ISSN 1827-1855 ; 0390-5616 ; 0026-4881
    ISSN (online) 1827-1855
    ISSN 0390-5616 ; 0026-4881
    DOI 10.23736/S0390-5616.22.05755-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Role of aquaporins in hydrocephalus: what do we know and where do we stand? A systematic review.

    de Laurentis, Camilla / Cristaldi, Paola / Arighi, Andrea / Cavandoli, Clarissa / Trezza, Andrea / Sganzerla, Erik P / Giussani, Carlo G / Di Cristofori, Andrea

    Journal of neurology

    2020  Volume 268, Issue 11, Page(s) 4078–4094

    Abstract: Introduction: Glymphatic fluid circulation may be considered the lymphatic system of the brain and the main role of such system seems to be played by aquaporins (AQPs), a family of proteins which regulates water exchange, in particular AQP4 and 1. ... ...

    Abstract Introduction: Glymphatic fluid circulation may be considered the lymphatic system of the brain and the main role of such system seems to be played by aquaporins (AQPs), a family of proteins which regulates water exchange, in particular AQP4 and 1. Alterations of glymphatic fluid circulation through AQPs variations are now emerging as central elements in the pathophysiology of different brain conditions, like hydrocephalus. This systematic review provides an insight about the role of AQPs in hydrocephalus establishment and compensation, investigating their possible role as diagnostic tools or therapeutic targets.
    Methods: PubMed database was screened searching for the relevant existing literature in English language published until February 29th 2020, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement.
    Results: A total of 40 articles met the inclusion criteria for our systematic analysis. AQP4 resulted the most studied water channel, followed by AQP1. The changes in cerebrospinal fluid (CSF), brain parenchyma and choroid plexus (CP) in different hydrocephalus type were analyzed. Moreover, important pharmacological interactions regarding AQP and molecules or conditions were discussed. A very interesting result is the general consensus on increase of AQP4 in hydrocephalic patients, unless in patients suffering from idiopathic normal pressure hydrocephalus, where AQP4 shows a tendency in reduction.
    Conclusion: AQP seem to play a central role in the pathophysiology of hydrocephalus and in its compensation mechanisms. Further studies are required to definitively establish their precise roles and their quantitative changes to allow their utilization as diagnostic tools or therapeutic targets.
    MeSH term(s) Aquaporin 4/metabolism ; Aquaporins/metabolism ; Brain/metabolism ; Humans ; Hydrocephalus
    Chemical Substances Aquaporin 4 ; Aquaporins
    Language English
    Publishing date 2020-08-03
    Publishing country Germany
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-020-10122-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intraoperative ultrasound in the neurosurgical management of intracranial bleedings in newborns.

    DE Laurentis, Camilla / Trezza, Andrea / Calloni, Tommaso / Paterlini, Giuseppe / Malguzzi, Silvia / Moretto, Alessandra / Sganzerla, Erik P / Giussani, Carlo G

    Journal of neurosurgical sciences

    2020  Volume 65, Issue 4, Page(s) 462–464

    MeSH term(s) Humans ; Infant, Newborn ; Intracranial Hemorrhages/diagnostic imaging ; Intracranial Hemorrhages/surgery ; Neurosurgical Procedures ; Ultrasonography
    Language English
    Publishing date 2020-09-28
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 193139-8
    ISSN 1827-1855 ; 0390-5616 ; 0026-4881
    ISSN (online) 1827-1855
    ISSN 0390-5616 ; 0026-4881
    DOI 10.23736/S0390-5616.20.05090-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Surgical management of pediatric intracranial CCM: a 10-year single center experience.

    Calloni, Tommaso / Carai, Andrea / Lioi, Francesco / Cavaliere, Marilou / DE Benedictis, Alessandro / Rossi, Sabrina / Randi, Franco / Rossi Espagnet, Maria C / Trivisano, Marina / Cesario, Claudia / Pisaneschi, Elisa / Marasi, Alessandra / Savioli, Alessandra / Giussani, Carlo G / Marras, Carlo E

    Journal of neurosurgical sciences

    2022  

    Abstract: Background: Cerebral cavernous malformations (CCMs) are low-flow vascular malformations made up of dilated vascular spaces without intervening parenchyma that can occur throughout the central nervous system. CCMs can occur sporadically or in familial ... ...

    Abstract Background: Cerebral cavernous malformations (CCMs) are low-flow vascular malformations made up of dilated vascular spaces without intervening parenchyma that can occur throughout the central nervous system. CCMs can occur sporadically or in familial forms. Presentation is diverse, ranging from asymptomatic discoveries to drug-resistant epilepsy and hemorrhages.
    Methods: We describe the surgical management of CCMs in pediatric patients at Bambino Gesù Children's Hospital in Rome over the last 10 years. The cases have been stratified based on the clinical presentation and the relevant literature is discussed accordingly.
    Results: We discuss the rationale and technique used in these cases based on their presentation, as well as the generally positive outcomes we achieved with early surgical management, use of intra-operative ultrasound (ioUS) and intraoperative neuromonitoring.
    Conclusions: Surgical management of pediatric CCMs is a safe and effective strategy, low rates of postoperative morbidity and partial resection were observed.
    Language English
    Publishing date 2022-04-13
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 193139-8
    ISSN 1827-1855 ; 0390-5616 ; 0026-4881
    ISSN (online) 1827-1855
    ISSN 0390-5616 ; 0026-4881
    DOI 10.23736/S0390-5616.22.05574-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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