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  1. Article ; Online: Rheumatic disease management in the Campania region of Italy during the COVID-19 pandemic.

    Masini, Francesco / Gjeloshi, Klodian / Ferrara, Roberta / Pinotti, Emanuele / Cuomo, Giovanna

    Rheumatology international

    2020  Volume 40, Issue 9, Page(s) 1537–1538

    MeSH term(s) Antirheumatic Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Delivery of Health Care ; Humans ; Italy/epidemiology ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Rheumatic Diseases/drug therapy ; SARS-CoV-2 ; Telemedicine
    Chemical Substances Antirheumatic Agents
    Keywords covid19
    Language English
    Publishing date 2020-07-14
    Publishing country Germany
    Document type Letter
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-020-04648-8
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  2. Article ; Online: MRI Digital Artery Volume Index (DAVIX) as a surrogate outcome measure of digital ulcer disease in patients with systemic sclerosis: a prospective cohort study.

    Hughes, Michael / Di Donato, Stefano / Gjeloshi, Klodian / Abignano, Giuseppina / Danzo, Fiammetta / Lettieri, Giovanni / De Lorenzis, Enrico / Bertham, Dominic / O'Connor, Philip / Kubassova, Olga / Dehmeshki, Jamshid / Del Galdo, Francesco

    The Lancet. Rheumatology

    2023  Volume 5, Issue 10, Page(s) e611–e621

    Abstract: Background: Vascular fibrosis is a key manifestation of systemic sclerosis that leads to the narrowing of small and medium arteries, causing vascular clinical manifestations including digital ulcers and pulmonary arterial hypertension. We investigated ... ...

    Abstract Background: Vascular fibrosis is a key manifestation of systemic sclerosis that leads to the narrowing of small and medium arteries, causing vascular clinical manifestations including digital ulcers and pulmonary arterial hypertension. We investigated the potential of the MRI-based Digital Artery Volume Index (DAVIX) as a surrogate outcome measure of vascular fibrosis by using it to quantify and predict the burden of digital ulcer disease in patients with systemic sclerosis.
    Methods: Two independent cohorts of patients participating in the prospective observational study STRIKE were consecutively enrolled from the Scleroderma Clinic of the Leeds Teaching Hospitals Trust, Leeds, UK. Eligible patients were aged 18 years or older and fulfilled the very early diagnosis of systemic sclerosis (VEDOSS) or the 2013 American College of Rheumatology (ACR)-European Alliance of Associations for Rheumatology (EULAR) systemic sclerosis classification criteria. DAVIX was calculated as the percentage mean of the ratio of digital artery volume to finger volume in the four fingers of the dominant hand. Data were collected at baseline and 12-month follow-up, and the primary outcome was the presence of digital ulcers at 12-month follow-up.
    Findings: Between Feb 7, 2018, and April 11, 2022, we included 85 patients in the exploratory cohort and 150 in the validation cohort. In the exploratory cohort, the mean age was 54·5 years (SD 11·6), 75 (88%) of 85 patients were women, ten (12%) were men, and 69 (82%) were White. In the validation cohort, the mean age was 53·5 years (SD 13·8), 136 (91%) of 150 patients were women, 14 (9%) were men, and 127 (85%) were White. In the exploratory cohort, DAVIX was significantly lower in patients with previous or active digital ulcers (0·34% [IQR 0·16-0·69]) than in those without digital ulcer disease (0·65% [0·42-0·88]; p=0·015); this finding was substantiated in the validation cohort (0·43% [0·20-0·73] vs 0·73% [0·53-0·97]; p<0·0001). Patients who developed new digital ulcers during 12-month follow-up had a lower DAVIX (0·23% [0·10-0·66]) than those who did not (0·65% [0·45-0·91]; p=0·0039). DAVIX was negatively correlated with disease duration (r=-0·415; p<0·0001), the ratio of forced vital capacity to the diffusing capacity of the lungs for carbon monoxide (r=-0·334; p=0·0091), nailfold capillaroscopy pattern (r=-0·447; p<0·0001), and baseline modified Rodnan skin score (r=-0·305; p=0·014) and was positively correlated with the diffusing capacity of carbon monoxide (r=0·368; p=0·0041). DAVIX was negatively correlated with change in score on the Scleroderma Health Assessment Questionnaire-Disability Index (r=-0·308; p=0·024), Visual Analogue Scale (VAS) Raynaud's (r=-0·271; p=0·044), and VAS digital ulcers (r=-0·291; p=0·044).
    Interpretation: DAVIX is a promising surrogate outcome measure of digital ulcer disease in patients with systemic sclerosis. The ability of DAVIX to non-invasively predict future digital ulcers and worsening of patient-reported outcomes could aid patient enrichment and stratification in clinical trials. Clinically, DAVIX could offer insights into the assessment of vascular activity. The sensitivity of DAVIX to change over time and with treatment will establish its value as an imaging outcome measure of vascular disease.
    Funding: National Institute for Health Research Biomedical Research Centre and University of Leeds Industry Engagement Accelerator Fund.
    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Carbon Monoxide ; Prospective Studies ; Scleroderma, Systemic/complications ; Ulnar Artery ; Magnetic Resonance Imaging ; Scleroderma, Localized ; Outcome Assessment, Health Care ; Fibrosis ; Skin Ulcer
    Chemical Substances Carbon Monoxide (7U1EE4V452)
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Observational Study ; Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(23)00189-3
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  3. Article: Rheumatic disease management in the Campania region of Italy during the COVID-19 pandemic

    Masini, Francesco / Gjeloshi, Klodian / Ferrara, Roberta / Pinotti, Emanuele / Cuomo, Giovanna

    Rheumatol Int

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #646678
    Database COVID19

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  4. Article ; Online: Rheumatic disease management in the Campania region of Italy during the COVID‐19 pandemic

    Masini, Francesco / Gjeloshi, Klodian / Ferrara, Roberta / Pinotti, Emanuele / Cuomo, Giovanna

    2020  

    Keywords covid19
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Rheumatic disease management in the Campania region of Italy during the COVID-19 pandemic

    Masini, Francesco / Gjeloshi, Klodian / Ferrara, Roberta / Pinotti, Emanuele / Cuomo, Giovanna

    Rheumatology International

    2020  Volume 40, Issue 9, Page(s) 1537–1538

    Keywords Immunology ; Immunology and Allergy ; Rheumatology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-020-04648-8
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Coronary Microvascular Dysfunction in Diabetes Mellitus: Pathogenetic Mechanisms and Potential Therapeutic Options.

    Salvatore, Teresa / Galiero, Raffaele / Caturano, Alfredo / Vetrano, Erica / Loffredo, Giuseppe / Rinaldi, Luca / Catalini, Christian / Gjeloshi, Klodian / Albanese, Gaetana / Di Martino, Anna / Docimo, Giovanni / Sardu, Celestino / Marfella, Raffaele / Sasso, Ferdinando Carlo

    Biomedicines

    2022  Volume 10, Issue 9

    Abstract: Diabetic patients are frequently affected by coronary microvascular dysfunction (CMD), a condition consisting of a combination of altered vasomotion and long-term structural change to coronary arterioles leading to impaired regulation of blood flow in ... ...

    Abstract Diabetic patients are frequently affected by coronary microvascular dysfunction (CMD), a condition consisting of a combination of altered vasomotion and long-term structural change to coronary arterioles leading to impaired regulation of blood flow in response to changing cardiomyocyte oxygen requirements. The pathogenesis of this microvascular complication is complex and not completely known, involving several alterations among which hyperglycemia and insulin resistance play particularly central roles leading to oxidative stress, inflammatory activation and altered barrier function of endothelium. CMD significantly contributes to cardiac events such as angina or infarction without obstructive coronary artery disease, as well as heart failure, especially the phenotype associated with preserved ejection fraction, which greatly impact cardiovascular (CV) prognosis. To date, no treatments specifically target this vascular damage, but recent experimental studies and some clinical investigations have produced data in favor of potential beneficial effects on coronary micro vessels caused by two classes of glucose-lowering drugs: glucagon-like peptide 1 (GLP-1)-based therapy and inhibitors of sodium-glucose cotransporter-2 (SGLT2). The purpose of this review is to describe pathophysiological mechanisms, clinical manifestations of CMD with particular reference to diabetes, and to summarize the protective effects of antidiabetic drugs on the myocardial microvascular compartment.
    Language English
    Publishing date 2022-09-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10092274
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  7. Article ; Online: Platypnea-orthodeoxia syndrome in SARS-CoV-2 related ARDS: a case report.

    Aprea, Concetta / Imbriani, Simona / Cirigliano, Giovanna / Gjeloshi, Klodian / Meo, Luciana Agnese / Padula, Andrea / Ranieri, Roberta / Ricozzi, Carmen / Ruosi, Carolina / Cozzolino, Domenico / Adinolfi, Luigi Elio / Nevola, Riccardo

    Acta bio-medica : Atenei Parmensis

    2022  Volume 93, Issue S1, Page(s) e2022102

    Abstract: Platypnea-Orthodeoxia Syndrome (POS) is an often misdiagnosed clinical condition characterized by dyspnea and hypoxia in sitting or semi-sitting position, reversible in supine position. Although POS is typically associated with intracardiac shunts, it ... ...

    Abstract Platypnea-Orthodeoxia Syndrome (POS) is an often misdiagnosed clinical condition characterized by dyspnea and hypoxia in sitting or semi-sitting position, reversible in supine position. Although POS is typically associated with intracardiac shunts, it seems frequent also in SARS-CoV-2 related Acute Respiratory Distress Syndrome (ARDS). In fact, the prevalent involvement of the lung bases due to interstitial pneumonia can determine refractory positional hypoxemia, with marked desaturation in the sitting position and regression or improvement in the supine position, configuring the clinical picture of the POS. We present a clinical case of POS associated with acute respiratory distress from SARS-CoV-2 pneumonia in which refractory hypoxia would have required support by invasive mechanical ventilation if the syndrome had not been identified.
    MeSH term(s) COVID-19/complications ; Dyspnea/diagnosis ; Dyspnea/etiology ; Humans ; Hypoxia/diagnosis ; Hypoxia/etiology ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2
    Language English
    Publishing date 2022-06-07
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v93iS1.12824
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    Zs.B 925: Show issues Location:
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  8. Article ; Online: Gender Differences in the Pathogenesis and Risk Factors of Hepatocellular Carcinoma

    Nevola, Riccardo / Tortorella, Giovanni / Rosato, Valerio / Rinaldi, Luca / Imbriani, Simona / Perillo, Pasquale / Mastrocinque, Davide / La Montagna, Marco / Russo, Antonio / Di Lorenzo, Giovanni / Alfano, Maria / Rocco, Maria / Ricozzi, Carmen / Gjeloshi, Klodian / Sasso, Ferdinando Carlo / Marfella, Raffaele / Marrone, Aldo / Kondili, Loreta Anesti / Esposito, Nicolino /
    Claar, Ernesto / Cozzolino, Domenico

    Biology (Basel). 2023 July 11, v. 12, no. 7

    2023  

    Abstract: Several chronic liver diseases are characterized by a clear gender disparity. Among them, hepatocellular carcinoma (HCC) shows significantly higher incidence rates in men than in women. The different epidemiological distribution of risk factors for liver ...

    Abstract Several chronic liver diseases are characterized by a clear gender disparity. Among them, hepatocellular carcinoma (HCC) shows significantly higher incidence rates in men than in women. The different epidemiological distribution of risk factors for liver disease and HCC only partially accounts for these gender differences. In fact, the liver is an organ with recognized sexual dysmorphism and is extremely sensitive to the action of androgens and estrogens. Sex hormones act by modulating the risk of developing HCC and influencing its aggressiveness, response to treatments, and prognosis. Furthermore, androgens and estrogens are able to modulate the action of other factors and cofactors of liver damage (e.g., chronic HBV infection, obesity), significantly influencing their carcinogenic power. The purpose of this review is to examine the factors related to the different gender distribution in the incidence of HCC as well as the pathophysiological mechanisms involved, with particular reference to the central role played by sex hormones.
    Keywords carcinogenicity ; gender ; hepatoma ; liver ; obesity ; pathogenesis ; prognosis ; risk
    Language English
    Dates of publication 2023-0711
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12070984
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Autonomic nervous system dysfunction correlates with microvascular damage in systemic sclerosis patients.

    Masini, Francesco / Galiero, Raffaele / Pafundi, Pia Clara / Gjeloshi, Klodian / Pinotti, Emanuele / Ferrara, Roberta / Romano, Ciro / Adinolfi, Luigi Elio / Sasso, Ferdinando Carlo / Cuomo, Giovanna

    Journal of scleroderma and related disorders

    2021  Volume 6, Issue 3, Page(s) 256–263

    Abstract: Objectives: Cardiac autonomic neuropathy is among the known cardiovascular complications of systemic sclerosis and may affect the whole prognosis of the disease. The aim of our study was to assess cardiac autonomic neuropathy prevalence in our cohort of ...

    Abstract Objectives: Cardiac autonomic neuropathy is among the known cardiovascular complications of systemic sclerosis and may affect the whole prognosis of the disease. The aim of our study was to assess cardiac autonomic neuropathy prevalence in our cohort of systemic sclerosis patients and compare its main features with clinical and epidemiological data, particularly with the severity of microvascular damage, as detected by nailfold videocapillaroscopy.
    Methods: Twenty-six patients with definite systemic sclerosis were consecutively enrolled at our outpatient rheumatology clinic. All patients underwent physical examination, nailfold videocapillaroscopy, and autonomic neuropathy diagnostic tests (orthostatic hypotension test, deep breathing test, lying-to-standing, and Valsalva maneuvers).
    Results: Cardiac autonomic neuropathy prevalence was 50% (13 cases). On univariate analysis, cardiac autonomic neuropathy was shown to be significantly associated with an active pattern on nailfold videocapillaroscopy (odds ratio 5.86, 95% confidence interval 1.59-9.24;
    Conclusions: Severe microvascular damage, as detected by nailfold videocapillaroscopy, may suggest the coexistence of autonomic dysfunction and should be considered as a red flag for the identification of patients particularly at risk of cardiac morbidity and mortality.
    Language English
    Publishing date 2021-06-07
    Publishing country England
    Document type Journal Article
    ISSN 2397-1991
    ISSN (online) 2397-1991
    DOI 10.1177/23971983211020617
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  10. Article ; Online: Very large abscesses of lower limbs by Nocardia farcinica requiring surgical management in patient with minimal change disease under chronic steroid treatment.

    Garofalo, Carlo / De Stefano, Filippo / Gjeloshi, Klodian / De Gregorio, Ilaria / Masini, Francesco / Ricozzi, Carmen / Sasso, Ferdinando Carlo / Sica, Antonello / Selvaggi, Lucio / Salvatore, Teresa

    Nephrology (Carlton, Vic.)

    2021  Volume 26, Issue 10, Page(s) 843–844

    MeSH term(s) Abscess/complications ; Abscess/pathology ; Abscess/surgery ; Aged ; Glucocorticoids/therapeutic use ; Humans ; Lower Extremity ; Male ; Nephrosis, Lipoid/complications ; Nephrosis, Lipoid/drug therapy ; Nocardia ; Nocardia Infections/complications ; Nocardia Infections/pathology ; Nocardia Infections/surgery ; Prednisone/therapeutic use
    Chemical Substances Glucocorticoids ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2021-05-31
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.13905
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