Article ; Online: Web-Based Intervention Effects on Mild Cognitive Impairment Based on Apolipoprotein E Genotype: Quasi-Experimental Study.
Journal of medical Internet research
2020 Volume 22, Issue 5, Page(s) e14617
Abstract: Background: Apolipoprotein E (APOE) ε4 allele is a major genetic risk factor for Alzheimer disease and mild cognitive impairment (MCI). Computer-based training programs can improve cognitive performance in elderly populations. However, the effects of ... ...
| Abstract | Background: Apolipoprotein E (APOE) ε4 allele is a major genetic risk factor for Alzheimer disease and mild cognitive impairment (MCI). Computer-based training programs can improve cognitive performance in elderly populations. However, the effects of computer-based interventions on MCI APOE ε4 carriers have never been studied before. Objective: The effects of different web-based interventions and the APOE isoform-specific differences in training outcomes are investigated. Methods: Using a quasi-experimental study design, 202 participants with MCI aged 60 years and older took part in three different intervention programs (physical and cognitive [Long-Lasting Memories, or LLM], cognitive [Active Control, or AC], or physical intervention [Physical Training Control, or PTC]) via an innovative information and communication technologies exergaming platform. Participants in each interventional group were subdivided into APOE ε4 carriers and non-APOE ε4 carriers. All participants underwent an extensive neuropsychological evaluation before and after the training, blood tests, and brain imaging. Results: All interventions resulted in multiple statistically significant cognitive benefits after the intervention. Verbal learning (California Verbal Learning Test: immediate recall test score-LLM: P=.04; AC: P<.001), working memory (digit span forward and backward test scores-AC: P=.03; PTC: P=.02 and P=.006, respectively), and long-term memory (California Verbal Learning Test: delayed recall test score-LLM: P=.02; AC: P=.002; and PTC: P=.02) were improved. There was no statistically significant difference among the intervention effects. APOE ε4 presence moderates intervention effects as the LLM intervention improved only their task-switching processing speed (Trail Making Test, Part B: P=.03) and the PTC intervention improved only the working memory (digit span backward: P=.03). No significant performance alteration was noted for the APOE ε4+ cognitive AC training group. Conclusions: None of the applied interventions could be identified as the optimal one; it is suggested, however, that combined cognitive and physical training and physical training via exergaming may be more effective for the high-risk MCI ΑPOE ε4+ subgroup. |
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| MeSH term(s) | Apolipoproteins E/genetics ; Cognitive Dysfunction/therapy ; Female ; Genotype ; Humans ; Internet-Based Intervention/statistics & numerical data ; Male ; Middle Aged ; Neuropsychological Tests/standards ; Non-Randomized Controlled Trials as Topic ; Risk Factors |
| Chemical Substances | Apolipoproteins E |
| Language | English |
| Publishing date | 2020-05-07 |
| Publishing country | Canada |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2028830-X |
| ISSN | 1438-8871 ; 1439-4456 |
| ISSN (online) | 1438-8871 |
| ISSN | 1439-4456 |
| DOI | 10.2196/14617 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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