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  1. Article ; Online: Sovateltide (ILR-1620) Improves Motor Function and Reduces Hyperalgesia in a Rat Model of Spinal Cord Injury.

    Mavridis, Theodoros / Mavridi, Artemis / Karampela, Eleftheria / Galanos, Antonis / Gkiokas, George / Iacovidou, Nicoletta / Xanthos, Theodoros

    Neurocritical care

    2024  

    Abstract: Background: Spinal cord injury (SCI) presents a major global health challenge, with rising incidence rates and substantial disability. Although progress has been made in understanding SCI's pathophysiology and early management, there is still a lack of ... ...

    Abstract Background: Spinal cord injury (SCI) presents a major global health challenge, with rising incidence rates and substantial disability. Although progress has been made in understanding SCI's pathophysiology and early management, there is still a lack of effective treatments to mitigate long-term consequences. This study investigates the potential of sovateltide, a selective endothelin B receptor agonist, in improving clinical outcomes in an acute SCI rat model.
    Methods: Thirty male Sprague-Dawley rats underwent sham surgery (group A) or SCI and treated with vehicle (group B) or sovateltide (group C). Clinical tests, including Basso, Beattie, and Bresnahan scoring, inclined plane, and allodynia testing with von Frey hair, were performed at various time points. Statistical analyses assessed treatment effects.
    Results: Sovateltide administration significantly improved motor function, reducing neurological deficits and enhancing locomotor recovery compared with vehicle-treated rats, starting from day 7 post injury. Additionally, the allodynic threshold improved, suggesting antinociceptive properties. Notably, the sovateltide group demonstrated sustained recovery, and even reached preinjury performance levels, whereas the vehicle group plateaued.
    Conclusions: This study suggests that sovateltide may offer neuroprotective effects, enhancing neurogenesis and angiogenesis. Furthermore, it may possess anti-inflammatory and antinociceptive properties. Future clinical trials are needed to validate these findings, but sovateltide shows promise as a potential therapeutic strategy to improve functional outcomes in SCI. Sovateltide, an endothelin B receptor agonist, exhibits neuroprotective properties, enhancing motor recovery and ameliorating hyperalgesia in a rat SCI model. These findings could pave the way for innovative pharmacological interventions for SCI in clinical settings.
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-024-01950-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Effect of Intraoperative Transversus Abdominis Plane Blocking on Postoperative Pain After Laparoscopic Transabdominal Pre-peritoneal (TAPP) Groin Hernia Repair.

    Chamzin, Alexandros / Frountzas, Maximos / Gkiokas, George / Kouskouni, Evaggelia / Xanthos, Theodoros / Michalopoulos, Nikolaos V

    Frontiers in surgery

    2022  Volume 9, Page(s) 834050

    Abstract: Background: Managing postoperative pain even after laparoscopic groin hernia repair still remains an interesting challenge for clinicians especially for patients of high risk. Plenty of operative techniques and analgesic methods have been proposed in ... ...

    Abstract Background: Managing postoperative pain even after laparoscopic groin hernia repair still remains an interesting challenge for clinicians especially for patients of high risk. Plenty of operative techniques and analgesic methods have been proposed in order to minimize postoperative pain after laparoscopic groin hernia repair. The aim of the present study is to compare transverse abdominis plane (TAP)-block with local analgesic infiltration at trocar entry sites in the terms of reducing postoperative pain.
    Methods: Patients that underwent laparoscopic trans-abdominal pre-peritoneal (TAPP) groin hernia repair in a high-volume university hospital were included. Patients were divided in two groups depending on the analgesic method used. Pain was assessed using Visual Numerical Scale (VNS) score.
    Results: Thirty patients were included. Intraoperative TAP-block seemed to be superior in terms of decreasing pain at the hernia area and at the trocar insertion site (
    Conclusion: Intraoperative TAP-block under direct vision seems to be an effective, fast and easy technique in order to reduce postoperative pain after laparoscopic groin hernia repair, but more studies are required to validate these results in a prospective and randomized context.
    Language English
    Publishing date 2022-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.834050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Giant Ovarian Thecoma Associated with Meigs Syndrome: A Striking Case.

    Dellaportas, Dionysios / Kollia, Dimitra / Myoteri, Despoina / Nastos, Constantinos / Gkiokas, George / Carvounis, Eleni / Theodosopoulos, Theodosios

    Chirurgia (Bucharest, Romania : 1990)

    2021  Volume 116, Issue eCollection, Page(s) 1–5

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Ascites/etiology ; CA-125 Antigen ; Female ; Humans ; Meigs Syndrome/complications ; Meigs Syndrome/diagnosis ; Meigs Syndrome/surgery ; Middle Aged ; Ovarian Neoplasms/complications ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/surgery ; Thecoma/complications ; Thecoma/diagnosis ; Thecoma/surgery ; Treatment Outcome
    Chemical Substances CA-125 Antigen
    Language English
    Publishing date 2021-08-31
    Publishing country Romania
    Document type Case Reports ; Journal Article
    ZDB-ID 419244-8
    ISSN 1842-368X ; 1221-9118 ; 0009-4730 ; 0377-5003
    ISSN (online) 1842-368X
    ISSN 1221-9118 ; 0009-4730 ; 0377-5003
    DOI 10.21614/chirurgia.116.eC.1912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1352: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 620: Show issues

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  4. Article: Polymorphisms of the BARX1 and ADAMTS17 Locus Genes in Individuals With Gastroesophageal Reflux Disease.

    Argyrou, Alexandra / Legaki, Evangelia / Koutserimpas, Christos / Gazouli, Maria / Papaconstantinou, Ioannis / Gkiokas, George / Karamanolis, George

    Journal of neurogastroenterology and motility

    2019  Volume 25, Issue 3, Page(s) 436–441

    Abstract: Background/aims: Gastroesophageal reflux disease (GERD) represents a common condition having a substantial impact on the patients' quality of life, as well as the health system. According to many studies, the : Methods: The present is a prospective ... ...

    Abstract Background/aims: Gastroesophageal reflux disease (GERD) represents a common condition having a substantial impact on the patients' quality of life, as well as the health system. According to many studies, the
    Methods: The present is a prospective cohort study of 160 GERD patients and 180 healthy control subjects of Greek origin, examined for BARX1 and ADAMTS17 polymorphisms (rs11789015 and rs4965272) and a potential correlation to GERD.
    Results: The rs11789015 AG and GG genotypes were found to be significantly associated with GERD (
    Conclusions: This is a study investigating the potential correlation between
    Language English
    Publishing date 2019-04-24
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2573719-3
    ISSN 2093-0887 ; 2093-0879
    ISSN (online) 2093-0887
    ISSN 2093-0879
    DOI 10.5056/jnm18183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Risk factors for gastroesophageal reflux disease and analysis of genetic contributors.

    Argyrou, Alexandra / Legaki, Evangelia / Koutserimpas, Christos / Gazouli, Maria / Papaconstantinou, Ioannis / Gkiokas, George / Karamanolis, George

    World journal of clinical cases

    2018  Volume 6, Issue 8, Page(s) 176–182

    Abstract: Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder with an increasing prevalence. GERD develops when the reflux of stomach contents causes troublesome typical and atypical symptoms and/or complications. Several risk factors of ... ...

    Abstract Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder with an increasing prevalence. GERD develops when the reflux of stomach contents causes troublesome typical and atypical symptoms and/or complications. Several risk factors of GERD have been identified and evaluated over the years, including a considerable amount of genetic factors. Multiple mechanisms are involved in the pathogenesis of GERD including: (1) motor abnormalities, such as impaired lower esophageal sphincter (LES) resting tone, transient LES relaxations, impaired esophageal acid clearance and delayed gastric emptying; and (2) anatomical factors, such as hiatal hernia and obesity. Genetic contribution seems to play a major role in GERD and GERD- related disorders development such Barrett's esophagus and esophageal adenocarcinoma. Twin and family studies have revealed an about 31% heritability of the disease. Numerous single-nucleotide polymorphisms in various genes like
    Language English
    Publishing date 2018-07-30
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v6.i8.176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Declaration on infection prevention and management in global surgery.

    Sartelli, Massimo / Coccolini, Federico / Ansaloni, Luca / Biffl, Walter L / Blake, David P / Boermeester, Marja A / Coimbra, Raul / Evans, Heather L / Ferrada, Paula / Gkiokas, George / Jeschke, Marc G / Hardcastle, Timothy / Hinson, Chandler / Labricciosa, Francesco M / Marwah, Sanjay / Marttos, Antonio C / Quiodettis, Martha / Rasa, Kemal / Ren, Jianan /
    Rubio-Perez, Ines / Sawyer, Robert / Shelat, Vishal / Upperman, Jeffrey S / Catena, Fausto

    World journal of emergency surgery : WJES

    2023  Volume 18, Issue 1, Page(s) 56

    Abstract: Surgeons in their daily practice are at the forefront in preventing and managing infections. However, among surgeons, appropriate measures of infection prevention and management are often disregarded. The lack of awareness of infection and prevention ... ...

    Abstract Surgeons in their daily practice are at the forefront in preventing and managing infections. However, among surgeons, appropriate measures of infection prevention and management are often disregarded. The lack of awareness of infection and prevention measures has marginalized surgeons from this battle. Together, the Global Alliance for Infections in Surgery (GAIS), the World Society of Emergency Surgery (WSES), the Surgical Infection Society (SIS), the Surgical Infection Society-Europe (SIS-E), the World Surgical Infection Society (WSIS), the American Association for the Surgery of Trauma (AAST), and the Panamerican Trauma Society (PTS) have jointly completed an international declaration, highlighting the threat posed by antimicrobial resistance globally and the need for preventing and managing infections appropriately across the surgical pathway. The authors representing these surgical societies call all surgeons around the world to participate in this global cause by pledging support for this declaration for maintaining the effectiveness of current and future antibiotics.
    MeSH term(s) Humans ; United States ; Anti-Bacterial Agents/therapeutic use ; Surgeons
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Letter
    ZDB-ID 2233734-9
    ISSN 1749-7922 ; 1749-7922
    ISSN (online) 1749-7922
    ISSN 1749-7922
    DOI 10.1186/s13017-023-00526-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Surgical Antibiotic Prophylaxis: A Proposal for a Global Evidence-Based Bundle.

    Sartelli, Massimo / Coccolini, Federico / Labricciosa, Francesco M / Al Omari, AbdelKarim H / Bains, Lovenish / Baraket, Oussama / Catarci, Marco / Cui, Yunfeng / Ferreres, Alberto R / Gkiokas, George / Gomes, Carlos Augusto / Hodonou, Adrien M / Isik, Arda / Litvin, Andrey / Lohsiriwat, Varut / Kotecha, Vihar / Khokha, Vladimir / Kryvoruchko, Igor A / Machain, Gustavo M /
    O'Connor, Donal B / Olaoye, Iyiade / Al-Omari, Jamal A K / Pasculli, Alessandro / Petrone, Patrizio / Rickard, Jennifer / Sall, Ibrahima / Sawyer, Robert G / Téllez-Almenares, Orlando / Catena, Fausto / Siquini, Walter

    Antibiotics (Basel, Switzerland)

    2024  Volume 13, Issue 1

    Abstract: In the multimodal strategy context, to implement healthcare-associated infection prevention, bundles are one of the most commonly used methods to adapt guidelines in the local context and transfer best practices into routine clinical care. One of the ... ...

    Abstract In the multimodal strategy context, to implement healthcare-associated infection prevention, bundles are one of the most commonly used methods to adapt guidelines in the local context and transfer best practices into routine clinical care. One of the most important measures to prevent surgical site infections is surgical antibiotic prophylaxis (SAP). This narrative review aims to present a bundle for the correct SAP administration and evaluate the evidence supporting it. Surgical site infection (SSI) prevention guidelines published by the WHO, CDC, NICE, and SHEA/IDSA/APIC/AHA, and the clinical practice guidelines for SAP by ASHP/IDSA/SIS/SHEA, were reviewed. Subsequently, comprehensive searches were also conducted using the PubMed
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics13010100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The battle of marathon

    Livas, Christos / Gkiokas, George / Yousafzai, Shumaila

    Marketing and management sciences : proceedings of the International Conference on ICMMS 2008 , p. 7-9

    segmenting, targeting and positioning in the ancient and contemporary Greece

    2010  , Page(s) 7–9

    Author's details Christos Livas, George Gkiokas & Shumaila Yousafzai
    Language English
    Size graph. Darst.
    Publisher Imperial College Pr.
    Publishing place Singapore [u.a.]
    Document type Article
    ISBN 1-8481-6509-9 ; 978-1-8481-6509-0
    Database ECONomics Information System

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  9. Article: Six Long-Standing Questions about Antibiotic Prophylaxis in Surgery.

    Sartelli, Massimo / Boermeester, Marja A / Cainzos, Miguel / Coccolini, Federico / de Jonge, Stijn W / Rasa, Kemal / Dellinger, E Patchen / McNamara, Deborah A / Fry, Donald E / Cui, Yunfeng / Delibegovic, Samir / Demetrashvili, Zaza / De Simone, Belinda / Gkiokas, George / Hardcastle, Timothy C / Itani, Kamal M F / Isik, Arda / Labricciosa, Francesco Maria / Lohsiriwat, Varut /
    Marwah, Sanjay / Pintar, Tadeja / Rickard, Jennifer / Shelat, Vishal G / Catena, Fausto / Barie, Philip S

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 5

    Abstract: Surgical site infections (SSIs) are the most common adverse event occurring in surgical patients. Optimal prevention of SSIs requires the bundled integration of a variety of measures before, during, and after surgery. Surgical antibiotic prophylaxis (SAP) ...

    Abstract Surgical site infections (SSIs) are the most common adverse event occurring in surgical patients. Optimal prevention of SSIs requires the bundled integration of a variety of measures before, during, and after surgery. Surgical antibiotic prophylaxis (SAP) is an effective measure for preventing SSIs. It aims to counteract the inevitable introduction of bacteria that colonize skin or mucosa into the surgical site during the intervention. This document aims to guide surgeons in appropriate administration of SAP by addressing six key questions. The expert panel identifies a list of principles in response to these questions that every surgeon around the world should always respect in administering SAP.
    Language English
    Publishing date 2023-05-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12050908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Pancreatic Remnant Occlusion after Whipple's Procedure: An Alternative Oncologically Safe Method.

    Theodosopoulos, Theodosios / Dellaportas, Dionysios / Yiallourou, Anneza I / Gkiokas, George / Polymeneas, George / Fotopoulos, Alexios

    ISRN surgery

    2013  Volume 2013, Page(s) 960424

    Abstract: Introduction. To present our experience regarding the use of pancreatic stump occlusion technique as an alternative management of the pancreatic remnant after pancreatoduodenectomy (PD). Methods. Between 2002 and 2009, hospital records of 93 patients who ...

    Abstract Introduction. To present our experience regarding the use of pancreatic stump occlusion technique as an alternative management of the pancreatic remnant after pancreatoduodenectomy (PD). Methods. Between 2002 and 2009, hospital records of 93 patients who had undergone a Whipple's procedure for either pancreatic-periampullary cancer or chronic pancreatitis were retrospectively studied. In 37 patients the pancreatic duct was occluded by stapling and running suture without anastomosis of the pancreatic remnant, whereas in 56 patients a pancreaticojejunostomy was performed. Operative data, postoperative complications, oncological parameters, and survival rates were recorded. Results. 2/37 patients of the occlusion group and 9/56 patients of the anastomosis group were treated for chronic pancreatitis, whereas 35/37 and 47/56 patients for periampullary malignancies. The duration of surgery for the anastomosis group was significantly longer (mean time 220 versus 180 minutes). Mean hospitalization time was 6 days for both groups. The occlusion group had a lower morbidity rate (24% versus 32%). With regard to postoperative complications, a slightly higher incidence of pancreatic fistulas was observed in the anastomosis group. Conclusions. Pancreatic remnant occlusion is a safe, technically feasible, and reducing postoperative complications alternative approach of the pancreatic stump during Whipple's procedure.
    Language English
    Publishing date 2013-08-05
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2612998-X
    ISSN 2090-5793 ; 2090-5785
    ISSN (online) 2090-5793
    ISSN 2090-5785
    DOI 10.1155/2013/960424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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