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Article: Quality of Life in Patients With Well-Differentiated Thyroid Carcinoma After Total Thyroidectomy in Greece.

Agglopoulou, Olga / Gkrinia, Eleni / Bizaki-Vallaskangas, Argyro / Hajiioannou, Jiannis / Bizakis, Ioannis

2024 Volume 16, Issue 1, Page(s) e53304

Abstract: Introduction: Well-differentiated thyroid cancer is among the most common types of endocrine cancer. Despite its increasing prevalence, the prognosis of thyroid cancer is rather good, with a five-year survival rate ranging between 80% and 90%, depending ...

Abstract	Introduction: Well-differentiated thyroid cancer is among the most common types of endocrine cancer. Despite its increasing prevalence, the prognosis of thyroid cancer is rather good, with a five-year survival rate ranging between 80% and 90%, depending on the histological type. Not only the post-treatment complications and the side effects of the lifelong medication but also the possibility of a recurrence may have a negative impact on the patient's quality of life (QoL). Objective: The aim of this study is to investigate the impact of total thyroidectomy on the QoL of patients with well-differentiated thyroid carcinoma. Methods: A prospective study was performed in patients who underwent total thyroidectomy due to well-differentiated thyroid carcinoma in the Otolaryngology-Head and Neck Surgery Department at the University Hospital of Larissa, Greece. The QoL was evaluated based on the "Quality of Life (Thyroid Version)" questionnaire. Results: One hundred patients participated in the study, with a mean age of 51.24±15.33 years. Of these, 63 (63%) were females and 37 (37%) were males. Social concerns, physical well-being, and psychological well-being presented a gradual positive alteration during the first 12 months after the surgery, with psychological well-being reporting the most significant progress of 15.3%. However, spiritual well-being appeared to decline over time. The younger patients progressively improved their physical, psychological, and mental well-being; however, the older patients showed an amelioration of their social skills. Female patients reported higher levels of spiritual well-being, whereas males developed better social skills. Conclusions: In the long term, total thyroidectomy can ameliorate patients' physical status, psychological well-being, and social concerns. However, it might have a negative effect on their mental health during the first 12 months postoperatively. In addition, QoL is directly influenced by demographic characteristics such as age and gender.
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.53304
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Otogenic brain complications: a systematic review and meta-analysis.

Gkrinia, Eleni / Brotis, Alexandros G / Vallianou, Kyriaki / Ntziovara, Anna Maria / Hajiioannou, Jiannis

The Journal of laryngology and otology

2024 , Page(s) 1–10

Abstract: Objective: This study aimed to form astute deductions regarding the presentation, treatment and mortality of otogenic brain complications.: Methods: A systematic literature search of four medical databases (PubMed, Embase, Web of Science and Scopus) ... ...

Abstract	Objective: This study aimed to form astute deductions regarding the presentation, treatment and mortality of otogenic brain complications. Methods: A systematic literature search of four medical databases (PubMed, Embase, Web of Science and Scopus) was conducted. Studies associated with otogenic brain complications were considered eligible. Fixed- and random-effects model meta-analysis was developed to assess the proportion estimate for each outcome individually. Results: Twenty-eight studies, with 1650 patients in total, were included. In 66 per cent of patients there was a known history of chronic otitis media. The most common symptoms were purulent otorrhoea (84 per cent), headache (65 per cent) and otalgia (45 per cent). A brain abscess was observed in 49 per cent of patients, followed by meningitis (34 per cent) and sinus thrombosis (22 per cent). A combination of surgical and conservative therapy was chosen in 84.3 per cent of cases and the mortality rate approached 11.1 per cent. Conclusion: Otogenic brain complications are a possibly life-threatening condition. Prompt imaging examination may set the final diagnosis and lead to an effective treatment.
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215124000343
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Article: Diagnostic accuracy of fine needle aspiration cytology in parotid gland lesions.

Hajiioannou, J / Gkrinia, E / Brotis, G A / Saratziotis, A / Nepka, C / Korais, C / Skoulakis, C

Hippokratia

2022 Volume 26, Issue 1, Page(s) 25–31

Abstract: Background: This study aimed to estimate the fine needle aspiration cytology's (FNAC) diagnostic accuracy in differentiating neoplastic from inflammatory lesions (Q1) and malignant from their benign counterparts (Q2).: Methods: We present a ... ...

Abstract	Background: This study aimed to estimate the fine needle aspiration cytology's (FNAC) diagnostic accuracy in differentiating neoplastic from inflammatory lesions (Q1) and malignant from their benign counterparts (Q2). Methods: We present a retrospective case series covering a single University Hospital and six attending head and neck surgeons over eight years (January 2011 to July 2017). We concentrated on adults with clinically suspected parotid gland lesions. We offered all patients FNAC biopsy preoperatively, and the final diagnosis was established based on the findings of the final histology. The FNAC and histology results were cross-tabulated in a 2 x 2 contingency table, from which we calculated the diagnostic accuracy, sensitivity, specificity, and positive and negative predictive values. Results: From 212 consecutive patients reviewed, and after excluding thirteen cases (8 %) of valid but non-diagnostic FNAC, 161 cases (50 females and 111 males) fulfilled set eligibility criteria. The most common diagnosis was Warthin tumors (53 patients, 34 %), followed by pleomorphic adenomas (52 patients, 33.5 %). The sensitivity and specificity of FNAC in differentiating neoplastic from non-neoplastic lesions and in segregating malignant from benign conditions were estimated to be as high as 50 % and 97 %, and 98 % and 93 %, respectively. Conclusion: FNAC is moderately effective in differentiating non-neoplastic from neoplastic disease and highly accurate in selecting malignant lesions from benign ones. Although the lack of FNAC sensitivity can occasionally be problematic, it still comprises a valuable tool in salivary gland surgery. HIPPOKRATIA 2022, 26 (1):25-31.
Language	English
Publishing date	2022-04-04
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2491943-3
ISSN	1790-8019 ; 1108-4189
ISSN (online)	1790-8019
ISSN	1108-4189
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Article ; Online: Anatomical variations of the recurrent laryngeal nerve according to the inferior thyroid artery and their clinical impact in patients undergoing thyroidectomy.

Gkrinia, E / Nana, P / Spanos, K / Fiska, A / Hajiioannou, J / Skoulakis, C / Zibis, A H

The Journal of laryngology and otology

2022 Volume 137, Issue 6, Page(s) 673–677

Abstract: Background: Recurrent laryngeal nerve identification is the 'gold standard' in thyroidectomy, to determine nerve function security and prevent severe complications. This study assessed the topographical relationship between the recurrent laryngeal nerve ...

Abstract	Background: Recurrent laryngeal nerve identification is the 'gold standard' in thyroidectomy, to determine nerve function security and prevent severe complications. This study assessed the topographical relationship between the recurrent laryngeal nerve and the inferior thyroid artery in patients undergoing total thyroidectomy, and determined its clinical impact. Methods: A retrospective study was performed of patients undergoing total thyroidectomy in a single tertiary centre over a six-month period. Results: Sixty-four patients were included. Among the 128 recurrent laryngeal nerve dissections, the nerve was identified traversing the inferior thyroid artery anteriorly in 27.3 per cent, with equal distribution between the two sides. No significant sex association was reported. One patient had transient vocal fold palsy, and hypocalcaemia was observed in 21.9 per cent, yet there was no statistical association with the topographical variation of the recurrent laryngeal nerve. Conclusion: Almost one-third of patients had an anatomical variation in which the recurrent laryngeal nerve ran superiorly to the inferior thyroid artery. Recurrent laryngeal nerve variation had no clinical impact on local complications or hypocalcaemia.
MeSH term(s)	Humans ; Thyroid Gland/surgery ; Thyroidectomy/adverse effects ; Recurrent Laryngeal Nerve ; Retrospective Studies ; Hypocalcemia ; Arteries/surgery
Language	English
Publishing date	2022-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215122001360
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Article ; Online: Microscopic versus endoscopic stapes surgery: systematic review and meta-analysis.

Hajiioannou, J / Gkrinia, E / Tzimkas-Dakis, K / Palla, E / Brotis, A / Korais, C / Saratziotis, A / Lachanas, V / Skoulakis, C

The Journal of laryngology and otology

2022 Volume 136, Issue 11, Page(s) 1014–1022

Abstract: Objective: To compare the efficacy and safety characteristics of endoscopic and microscopic stapes surgery based on current evidence.: Methods: A systematic literature search was conducted of three medical databases, focusing on randomised, ... ...

Abstract	Objective: To compare the efficacy and safety characteristics of endoscopic and microscopic stapes surgery based on current evidence. Methods: A systematic literature search was conducted of three medical databases, focusing on randomised, controlled studies or observational studies. Data related to the efficacy and safety of each technique were extracted. Outcome data were summarised using the pooled mean differences or pooled odds ratios, along with their 95 per cent confidence intervals. Results: Thirteen studies were included in the meta-analysis. Success rate was evaluated by estimating air-bone gap improvement; this revealed comparable outcomes for the two techniques (mean difference = -0.20; 95 per cent confidence interval = -0.53, 0.14). No statistically significant difference was detected concerning post-operative complications, except for dysgeusia (odds ratio = -1.12; 95 per cent confidence interval = -1.97, -0.28) and pain (odds ratio = -2.00; 95 per cent confidence interval = -2.97, -1.04), which favoured the endoscopic approach. Conclusion: Though both techniques result in commensurate outcomes concerning success rate, post-operative pain and dysgeusia favour the endoscopic approach. Further high-quality studies are needed to adequately compare the two methods.
MeSH term(s)	Humans ; Dysgeusia ; Stapes Surgery/methods ; Stapes ; Endoscopy/adverse effects ; Endoscopy/methods ; Ossicular Prosthesis
Language	English
Publishing date	2022-01-11
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215121004436
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Article ; Online: Nocardia Farcinica Mastoiditis and Epidural Abscess in an Immunocompetent Patient: A Rare Entity.

Gkrinia, Eleni / Bizaki-Vallaskangas, Argyro / Rautiainen, Markus / Kivekäs, Ilkka

Ear, nose, & throat journal

2022 , Page(s) 1455613221139400

Abstract: Nocardia is regarded as an opportunistic pathogen primarily affecting the respiratory system, ... ...

Abstract	Nocardia is regarded as an opportunistic pathogen primarily affecting the respiratory system, whereas
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/01455613221139400
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Article ; Online: Endoscopic Versus Microscopic Tympanoplasty: A Systematic Review and Metanalysis.

Gkrinia, Eleni / Ntziovara, Anna Maria / Brotis, Alexandros G / Tzimkas-Dakis, Konstantinos / Saratziotis, Athanasios / Korais, Christos / Hajiioannou, Jiannis

The Laryngoscope

2024

Abstract: Objective: Endoscopic ear surgery is no longer a promising technique, but a well-established one. This study aims to compare endoscopic and microscopic tympanoplasty based on current literature evidence, in terms of their efficacy and safety ... ...

Abstract	Objective: Endoscopic ear surgery is no longer a promising technique, but a well-established one. This study aims to compare endoscopic and microscopic tympanoplasty based on current literature evidence, in terms of their efficacy and safety characteristics. Data sources: We conducted a systematic literature search of four medical databases (Pubmed, Cochrane Library, Scopus, ClinicalTrials.gov), focusing on randomized controlled or observational studies comparing microscopic to endoscopic tympanoplasty. Review methods: Data related to the efficacy and safety of each technique were extracted. Outcome data were summarized using pooled mean differences or pooled odds ratio along with their 95% confidence intervals. The risk of bias was estimated, by using the ROBINS-I and RoB-II assessment tools, while the overall quality of evidence was evaluated according to the GRADE working group. Results: Thirty-three studies, with 2646 patients in total, were included in the meta-analysis. Success rate was evaluated by estimating tympanic graft failure (pooled mean difference:-0.23; 95% CI: -0.61, 0.14, I Conclusion: Endoscopic tympanoplasty is an innovative alternative to the microscopic technique, resulting in commensurate outcomes regarding success rate. Furthermore, it offers superior results concerning postoperative complications, while it presents a significant reduction in the duration of surgery, mainly when it is compared to the postauricular microscopic approach. Level of evidence: NA Laryngoscope, 2024.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.31365
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Article ; Online: Frontal Sinus Metastasis from Colonic Adenocarcinoma: a Case Report and Review of the Literature.

Fountarlis, Athanasios Luca / Saini, Fani / Nepka, Charitini / Gkrinia, Eleni / Hajiioannou, Jiannis / Terzoudis, Christos / Kotsakis, Athanasios / Skoulakis, Charalampos

Journal of gastrointestinal cancer

2023 Volume 54, Issue 4, Page(s) 1356–1358

MeSH term(s)	Humans ; Frontal Sinus/pathology ; Head and Neck Neoplasms ; Tomography, X-Ray Computed ; Colonic Neoplasms/pathology ; Adenocarcinoma/diagnosis ; Adenocarcinoma/therapy ; Adenocarcinoma/pathology
Language	English
Publishing date	2023-03-20
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2452514-5
ISSN	1941-6636 ; 1559-0739 ; 1941-6628 ; 1537-3649
ISSN (online)	1941-6636 ; 1559-0739
ISSN	1941-6628 ; 1537-3649
DOI	10.1007/s12029-023-00917-4
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Article: Asymptomatic unilateral aplasia of the left parotid gland: an unusual entity and case report.

Sgantzou, Ioanna-Konstantina / Vassiou, Katerina / Gkrinia, Eleni / Maiou, Chariklia / Agrotis, Georgios / Vlychou, Marianna

Radiology case reports

2021 Volume 16, Issue 11, Page(s) 3453–3456

Abstract: Congenital agenesis of major salivary glands is considered a very infrequent condition and typically appears to be a coincidental finding. It can be present as sporadic case or may be combined with aplasia or hypoplasia of other salivary glands or the ... ...

Abstract	Congenital agenesis of major salivary glands is considered a very infrequent condition and typically appears to be a coincidental finding. It can be present as sporadic case or may be combined with aplasia or hypoplasia of other salivary glands or the lacrimal glands, or as a part of syndromes. Only 23 cases documented in the literature to date, while the youngest patient was 50 days old. Plenty of radiographic useful techniques and treatment is closely related to the clinical manifestations; therefore. We present a case of 52 year old female who was referred to our radiology department for recurrent numbness of the left upper limb, experienced over the previous three months. Complete absence of the left parotid gland was incidentally demonstrated at the brain MRI scan. Based on the patient's past medical history, physical examination and demonstrated radiographic techniques it was an asymptomatic, no-syndromic and no-familious unilateral aplasia of the parotid gland. In the present report, we aimed to underline that this rare condition may be asymptomatic and co-exist with other medical conditions and syndromes.
Language	English
Publishing date	2021-09-06
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2021.07.096
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Article ; Online: Management of external jugular vein aneurysm: a systematic review.

Nana, Petroula / Gkrinia, Eleni / Maiou, Chara / Karyda, Ourania / Korais, Christos / Spanos, Konstantinos / Kouvelos, Georgios

Vascular

2021 Volume 30, Issue 3, Page(s) 590–595

Abstract: Introduction: Aneurysms of the jugular vein system are rare and high clinical suspicion is needed for diagnosis. External jugular vein aneurysms (EJVA) are considered innocent lesions that need treatment mainly for aesthetic reasons. The aim of this ... ...

Abstract	Introduction: Aneurysms of the jugular vein system are rare and high clinical suspicion is needed for diagnosis. External jugular vein aneurysms (EJVA) are considered innocent lesions that need treatment mainly for aesthetic reasons. The aim of this systematic review was to present current literature regarding diagnosis and management of EJVAs. Methods: A literature review was conducted through the Pubmed/Medline and Scopus regarding articles referring on EJVA from 2000 to 2020. Using the PRISMA guidelines (Preferred Reporting Items for Systematic reviews and Meta-Analyses), 30 articles were identified, according to inclusion criteria. Demographics, clinical characteristics, etiology, diagnostic imaging, complications, treatment, and histopathological findings were recorded and analyzed. Results: Twenty-seven case reports and one case series were identified, including 30 patients and 31 EJVAs. One-third of patients (30.3%) were < 18 years old (mean age 32 years, range 1-72 years) and 54% of them were females. In 51% of the cases, the lesion was characterized as a true aneurysm after histological evaluation. The presence of a soft cervical mass was the most common clinical symptom, while Valsalva maneuver pointed out the presence of an EJVA in 66.7% of patients. Diagnosis was achieved using ultrasonography, computed tomography, or magnetic resonance imaging. Forty-three percent of the patients underwent more than one radiological examination. Twenty patients underwent surgical management. The primary indication of surgical treatment was aesthetic reasons (11/20, 55%). Thrombosis was the most common EJVA complication (11/30, 36.3%). Conclusions: Differential diagnosis of neck mass should include EJVA. High clinical suspicion and adequate imaging are important for diagnosis. Open surgical approach is the more commonly applied therapeutic strategy.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aneurysm/diagnostic imaging ; Aneurysm/surgery ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Jugular Veins/diagnostic imaging ; Jugular Veins/surgery ; Male ; Middle Aged ; Subclavian Vein ; Thrombosis/complications ; Valsalva Maneuver ; Young Adult
Language	English
Publishing date	2021-05-22
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	2137151-9
ISSN	1708-539X ; 1708-5381
ISSN (online)	1708-539X
ISSN	1708-5381
DOI	10.1177/17085381211013950
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Zs.A 4277: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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