LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Gladkevich, Anatoliy V"
  2. AU="Xiao, Wen-Jie"
  3. AU="Gottsäter, Anders"
  4. AU="Yousaf, Anum"
  5. AU="Yoo, Soo-In"
  6. AU="Racine, Grégoire"
  7. AU="Lundtorp Olsen, Niels"
  8. AU="Davis, Onika"
  9. AU="Khare, Sanjay D"
  10. AU="Caruso, Angela"
  11. AU=Yeo Woon-Seok
  12. AU="Vijayan, Tara"
  13. AU="Wenjing Tu"
  14. AU="Aanchal Gupta"
  15. AU="Nguyen, Hang Minh"
  16. AU="Ceasar, M"
  17. AU="López-Cotarelo, Pilar"
  18. AU="Lenc, E"
  19. AU="Brabcova, Zuzana"
  20. AU="Bayırlı Turan, Derya"
  21. AU=Sleigh James N
  22. AU="Thanee, Malinee"
  23. AU="Watchara Fongkum"

Suchergebnis

Treffer 1 - 7 von insgesamt 7

Suchoptionen

  1. Artikel ; Online: Major depressive disorder is associated with changes in a cluster of serum and urine biomarkers.

    van Buel, Erin M / Meddens, Marcus J M / Arnoldussen, Eduard A / van den Heuvel, Edwin R / Bohlmeijer, Willem C / den Boer, Johan A / Muller Kobold, Anna / Boonman-de Winter, Leandra J M / van Rumpt, Dirk / Timmers, Lambertus F J / Veerman, Mattheus F A / Kamphuis, Johannes S / Gladkevich, Anatoliy V / Schoevers, Robert A / Luiten, Paul G M / Eisel, Ulrich L M / Bosker, Fokko J / Klein, Hans C

    Journal of psychosomatic research

    2019  Band 125, Seite(n) 109796

    Abstract: Major Depressive Disorder (MDD) is a heterogeneous disorder with a considerable symptomatic overlap with other psychiatric and somatic disorders. This study aims at providing evidence for association of a set of serum and urine biomarkers with MDD. We ... ...

    Abstract Major Depressive Disorder (MDD) is a heterogeneous disorder with a considerable symptomatic overlap with other psychiatric and somatic disorders. This study aims at providing evidence for association of a set of serum and urine biomarkers with MDD. We analyzed urine and serum samples of 40 MDD patients and 47 age- and sex-matched controls using 40 potential MDD biomarkers (21 serum biomarkers and 19 urine biomarkers). All participants were of Caucasian origin. We developed an algorithm to combine the heterogeneity at biomarker level. This method enabled the identification of correlating biomarkers based on differences in variation and distribution between groups, combined the outcome of the selected biomarkers, and calculated depression probability scores (the "bio depression score"). Phenotype permutation analysis showed a significant discrimination between MDD and euthymic (control) subjects for biomarkers in urine (P < .001), in serum (P = .02) and in the combined serum plus urine result (P < .001). Based on this algorithm, a combination of 8 urine biomarkers and 9 serum biomarkers were identified to correlate with MDD, enabling an area under the curve (AUC) of 0.955 in a Receiver Operating Characteristic (ROC) analysis. Selection of either urine biomarkers or serum biomarkers resulted in AUC values of 0.907 and 0.853, respectively. Internal cross-validation (5-fold) confirmed the association of this set of biomarkers with MDD.
    Mesh-Begriff(e) Adult ; Algorithms ; Area Under Curve ; Biomarkers/blood ; Biomarkers/urine ; Case-Control Studies ; Depressive Disorder, Major/blood ; Depressive Disorder, Major/urine ; Female ; Humans ; Male ; Middle Aged ; ROC Curve
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2019-08-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80166-5
    ISSN 1879-1360 ; 0022-3999
    ISSN (online) 1879-1360
    ISSN 0022-3999
    DOI 10.1016/j.jpsychores.2019.109796
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ui I Zs.233: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Biomarker approaches in major depressive disorder evaluated in the context of current hypotheses.

    Jentsch, Mike C / Van Buel, Erin M / Bosker, Fokko J / Gladkevich, Anatoliy V / Klein, Hans C / Oude Voshaar, Richard C / Ruhé, Eric G / Eisel, Uli L M / Schoevers, Robert A

    Biomarkers in medicine

    2015  Band 9, Heft 3, Seite(n) 277–297

    Abstract: Major depressive disorder is a heterogeneous disorder, mostly diagnosed on the basis of symptomatic criteria alone. It would be of great help when specific biomarkers for various subtypes and symptom clusters of depression become available to assist in ... ...

    Abstract Major depressive disorder is a heterogeneous disorder, mostly diagnosed on the basis of symptomatic criteria alone. It would be of great help when specific biomarkers for various subtypes and symptom clusters of depression become available to assist in diagnosis and subtyping of depression, and to enable monitoring and prognosis of treatment response. However, currently known biomarkers do not reach sufficient sensitivity and specificity, and often the relation to underlying pathophysiology is unclear. In this review, we evaluate various biomarker approaches in terms of scientific merit and clinical applicability. Finally, we discuss how combined biomarker approaches in both preclinical and clinical studies can help to make the connection between the clinical manifestations of depression and the underlying pathophysiology.
    Mesh-Begriff(e) Animals ; Biomarkers/metabolism ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/etiology ; Depressive Disorder, Major/metabolism ; Depressive Disorder, Major/physiopathology ; Humans
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2015
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm.14.114
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6985: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: Changes in winter depression phenotype correlate with white blood cell gene expression profiles: a combined metagene and gene ontology approach.

    Bosker, Fokko J / Terpstra, Peter / Gladkevich, Anatoliy V / Janneke Dijck-Brouwer, D A / te Meerman, Gerard / Nolen, Willem A / Schoevers, Robert A / Meesters, Ybe

    Progress in neuro-psychopharmacology & biological psychiatry

    2015  Band 58, Seite(n) 8–14

    Abstract: In the present study we evaluate the feasibility of gene expression in white blood cells as a peripheral marker for winter depression. Sixteen patients with winter type seasonal affective disorder were included in the study. Blood was taken by venous ... ...

    Abstract In the present study we evaluate the feasibility of gene expression in white blood cells as a peripheral marker for winter depression. Sixteen patients with winter type seasonal affective disorder were included in the study. Blood was taken by venous puncture at three time points; in winter prior and following bright light therapy and in summer. RNA was isolated, converted into cRNA, amplified and hybridized on Illumina® gene expression arrays. The raw optical array data were quantile normalized and thereafter analyzed using a metagene approach, based on previously published Affymetrix gene array data. The raw data were also subjected to a secondary analysis focusing on circadian genes and genes involved in serotonergic neurotransmission. Differences between the conditions were analyzed, using analysis of variance on the principal components of the metagene score matrix. After correction for multiple testing no statistically significant differences were found. Another approach uses the correlation between metagene factor weights and the actual expression values, averaged over conditions. When comparing the correlations of winter vs. summer and bright light therapy vs. summer significant changes for several metagenes were found. Subsequent gene ontology analyses (DAVID and GeneTrail) of 5 major metagenes suggest an interaction between brain and white blood cells. The hypothesis driven analysis with a smaller group of genes failed to demonstrate any significant effects. The results from the combined metagene and gene ontology analyses support the idea of communication between brain and white blood cells. Future studies will need a much larger sample size to obtain information at the level of single genes.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Gene Expression Profiling ; Gene Ontology ; Humans ; Microarray Analysis ; Middle Aged ; Phenotype ; Phototherapy ; Psychiatric Status Rating Scales ; Seasonal Affective Disorder/blood ; Seasonal Affective Disorder/genetics ; Seasonal Affective Disorder/therapy ; Seasons ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2015-04-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 781181-0
    ISSN 1878-4216 ; 0278-5846
    ISSN (online) 1878-4216
    ISSN 0278-5846
    DOI 10.1016/j.pnpbp.2014.10.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1342: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel ; Online: Comparison of brain and blood gene expression in an animal model of negative symptoms in schizophrenia.

    Bosker, Fokko J / Gladkevich, Anatoliy V / Pietersen, Charmaine Y / Kooi, Krista A / Bakker, Petra L / Gerbens, Frans / den Boer, Johan A / Korf, Jakob / te Meerman, Gerard

    Progress in neuro-psychopharmacology & biological psychiatry

    2012  Band 38, Heft 2, Seite(n) 142–148

    Abstract: Objectives: To investigate the potential of white blood cells as probes for central processes we have measured gene expression in both the anterior cingulate cortex and white blood cells using a putative animal model of negative symptoms in ... ...

    Abstract Objectives: To investigate the potential of white blood cells as probes for central processes we have measured gene expression in both the anterior cingulate cortex and white blood cells using a putative animal model of negative symptoms in schizophrenia.
    Methods: The model is based on the capability of ketamine to induce psychotic symptoms in healthy volunteers and to worsen such symptoms in schizophrenic patients. Classical fear conditioning is used to assess emotional processing and cognitive function in animals exposed to sub-chronic ketamine vs. controls. Gene expression was measured using a commercially sourced whole genome rat gene array. Data analyses were performed using ANOVA (Systat 11).
    Results: In both anterior cingulate cortex and white blood cells a significant interaction between ketamine and fear conditioning could be observed. The outcome is largely supported by our subsequent metagene analysis. Moreover, the correlation between gene expression in brain and blood is about constant when no ketamine is present (r~0.4). With ketamine, however, the correlation becomes very low (r~0.2) when there is no fear, but it increases to ~0.6 when fear and ketamine are both present. Our results show that under normal conditions ketamine lowers gene expression in the brain, but this effect is completely reversed in combination with fear conditioning, indicating a stimulatory action.
    Conclusion: This paradoxical outcome indicates that extreme care must be taken when using gene expression data from white blood cells as marker for psychiatric disorders, especially when pharmacological and environmental interactions are at play.
    Mesh-Begriff(e) Animals ; Behavior, Animal/drug effects ; Brain/drug effects ; Brain/metabolism ; Conditioning (Psychology)/drug effects ; Disease Models, Animal ; Fear/drug effects ; Gene Expression/physiology ; Ketamine/pharmacology ; Rats ; Schizophrenia/blood ; Schizophrenia/genetics ; Schizophrenia/metabolism
    Chemische Substanzen Ketamine (690G0D6V8H)
    Sprache Englisch
    Erscheinungsdatum 2012-08-07
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 781181-0
    ISSN 1878-4216 ; 0278-5846
    ISSN (online) 1878-4216
    ISSN 0278-5846
    DOI 10.1016/j.pnpbp.2012.03.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1342: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel: Antagonism of 5-HT₁A receptors uncovers an excitatory effect of SSRIs on 5-HT neuronal activity, an action probably mediated by 5-HT₇ receptors

    Bosker, Fokko J / Folgering, Joost H.A / Gladkevich, Anatoliy V / Schmidt, Anne / van der Hart, Marieke C.G / Sprouse, Jeffrey / den Boer, Johan A / Westerink, Ben H.C / Cremers, Thomas I.F.H

    Journal of neurochemistry. 2009 Mar., v. 108, no. 5

    2009  

    Abstract: Both microdialysis and electrophysiology were used to investigate whether another serotonin (5-HT) receptor subtype next to the 5-HT₁A autoreceptor is involved in the acute effects of a selective serotonin reuptake inhibitor on 5-HT neuronal activity. On ...

    Abstract Both microdialysis and electrophysiology were used to investigate whether another serotonin (5-HT) receptor subtype next to the 5-HT₁A autoreceptor is involved in the acute effects of a selective serotonin reuptake inhibitor on 5-HT neuronal activity. On the basis of a previous study, we decided to investigate the involvement of the 5-HT₇ receptors. Experiments were performed with the specific 5-HT₇ antagonist SB 258741 and the putative 5-HT₇ agonist AS19. In this study WAY 100.635 was used to block 5-HT₁A receptors. Systemic administration of SB 258741 significantly reduced the effect of combined selective serotonin reuptake inhibitor and WAY 100.635 administration on extracellular 5-HT in the ventral hippocampus as well as 5-HT neuronal firing in the dorsal raphe nucleus. In the microdialysis study, co-administration of AS19 and WAY 100.635 showed a biphasic effect on extracellular 5-HT in ventral hippocampus, hinting at opposed 5-HT₇ receptor mediated effects. In the electrophysiological experiments, systemic administration of AS19 alone displayed a bell-shaped dose-effect curve: moderately increasing 5-HT neuronal firing at lower doses while decreasing it at higher doses. SB 258741 was capable of blocking the effect of AS19 at a low dose. This is consistent with the pharmacological profile of AS19, displaying high affinity for 5-HT₇ receptors and moderate affinity for 5-HT₁A receptors. The data are in support of an excitatory effect of selective serotonin reuptake inhibitors on 5-HT neuronal activity mediated by 5-HT₇ receptors. It can be speculated, that the restoration of 5-HT neuronal firing upon chronic antidepressant treatment, which is generally attributed to desensitization of 5-HT₁A receptors alone, in fact results from a shift in balance between 5-HT₁A and 5-HT₇ receptor function.
    Schlagwörter hippocampus
    Sprache Englisch
    Erscheinungsverlauf 2009-03
    Umfang p. 1126-1135.
    Verlag Blackwell Publishing Ltd
    Erscheinungsort Oxford, UK
    Dokumenttyp Artikel
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/j.1471-4159.2008.05850.x
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ui II Zs.170: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  6. Artikel ; Online: Antagonism of 5-HT(1A) receptors uncovers an excitatory effect of SSRIs on 5-HT neuronal activity, an action probably mediated by 5-HT(7) receptors.

    Bosker, Fokko J / Folgering, Joost H A / Gladkevich, Anatoliy V / Schmidt, Anne / van der Hart, Marieke C G / Sprouse, Jeffrey / den Boer, Johan A / Westerink, Ben H C / Cremers, Thomas I F H

    Journal of neurochemistry

    2009  Band 108, Heft 5, Seite(n) 1126–1135

    Abstract: Both microdialysis and electrophysiology were used to investigate whether another serotonin (5-HT) receptor subtype next to the 5-HT(1A) autoreceptor is involved in the acute effects of a selective serotonin reuptake inhibitor on 5-HT neuronal activity. ... ...

    Abstract Both microdialysis and electrophysiology were used to investigate whether another serotonin (5-HT) receptor subtype next to the 5-HT(1A) autoreceptor is involved in the acute effects of a selective serotonin reuptake inhibitor on 5-HT neuronal activity. On the basis of a previous study, we decided to investigate the involvement of the 5-HT(7) receptors. Experiments were performed with the specific 5-HT(7) antagonist SB 258741 and the putative 5-HT(7) agonist AS19. In this study WAY 100.635 was used to block 5-HT(1A) receptors. Systemic administration of SB 258741 significantly reduced the effect of combined selective serotonin reuptake inhibitor and WAY 100.635 administration on extracellular 5-HT in the ventral hippocampus as well as 5-HT neuronal firing in the dorsal raphe nucleus. In the microdialysis study, co-administration of AS19 and WAY 100.635 showed a biphasic effect on extracellular 5-HT in ventral hippocampus, hinting at opposed 5-HT(7) receptor mediated effects. In the electrophysiological experiments, systemic administration of AS19 alone displayed a bell-shaped dose-effect curve: moderately increasing 5-HT neuronal firing at lower doses while decreasing it at higher doses. SB 258741 was capable of blocking the effect of AS19 at a low dose. This is consistent with the pharmacological profile of AS19, displaying high affinity for 5-HT(7) receptors and moderate affinity for 5-HT(1A) receptors. The data are in support of an excitatory effect of selective serotonin reuptake inhibitors on 5-HT neuronal activity mediated by 5-HT(7) receptors. It can be speculated, that the restoration of 5-HT neuronal firing upon chronic antidepressant treatment, which is generally attributed to desensitization of 5-HT(1A) receptors alone, in fact results from a shift in balance between 5-HT(1A) and 5-HT(7) receptor function.
    Mesh-Begriff(e) Action Potentials/drug effects ; Action Potentials/physiology ; Analysis of Variance ; Animals ; Brain/cytology ; Chromatography, High Pressure Liquid/methods ; Citalopram/pharmacology ; Drug Interactions ; Electrochemistry/methods ; Male ; Microdialysis/methods ; Neurons/drug effects ; Neurons/physiology ; Piperazines/pharmacology ; Piperidines/pharmacology ; Pyrazoles/pharmacology ; Pyridines/pharmacology ; Pyrrolidines/pharmacology ; Rats ; Rats, Wistar ; Receptor, Serotonin, 5-HT1A/physiology ; Receptors, Serotonin/physiology ; Serotonin/metabolism ; Serotonin 5-HT1 Receptor Antagonists ; Serotonin Agents/pharmacology ; Serotonin Uptake Inhibitors/pharmacology ; Tetrahydronaphthalenes/pharmacology ; Tosyl Compounds/pharmacology ; Wakefulness
    Chemische Substanzen 5-HT(7) receptor, rat ; AS 19 compound ; Piperazines ; Piperidines ; Pyrazoles ; Pyridines ; Pyrrolidines ; Receptors, Serotonin ; SB258741 ; Serotonin 5-HT1 Receptor Antagonists ; Serotonin Agents ; Serotonin Uptake Inhibitors ; Tetrahydronaphthalenes ; Tosyl Compounds ; Citalopram (0DHU5B8D6V) ; Receptor, Serotonin, 5-HT1A (112692-38-3) ; Serotonin (333DO1RDJY) ; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide (71IH826FEG)
    Sprache Englisch
    Erscheinungsdatum 2009-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/j.1471-4159.2008.05850.x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ui II Zs.170: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  7. Artikel ; Online: Biochemical and behavioral effects of long-term citalopram administration and discontinuation in rats: role of serotonin synthesis.

    Bosker, Fokko J / Tanke, Marit A C / Jongsma, Minke E / Cremers, Thomas I F H / Jagtman, Evelien / Pietersen, Charmaine Y / van der Hart, Marieke G C / Gladkevich, Anatoliy V / Kema, Ido P / Westerink, Ben H C / Korf, Jakob / den Boer, Johan A

    Neurochemistry international

    2010  Band 57, Heft 8, Seite(n) 948–957

    Abstract: We have investigated effects of continuous SSRI administration and abrupt discontinuation on biochemical and behavioral indices of rat brain serotonin function, and attempted to identify underlying mechanisms. Biochemistry of serotonin was assessed with ... ...

    Abstract We have investigated effects of continuous SSRI administration and abrupt discontinuation on biochemical and behavioral indices of rat brain serotonin function, and attempted to identify underlying mechanisms. Biochemistry of serotonin was assessed with brain tissue assays and microdialysis; behavior was assessed as the acoustic startle reflex. Long-term SSRI administration to rats reduced the content of 5-HT and its main metabolite shortly after inhibition of 5-HT synthesis in many brain areas with more than 50%. Turnover was not appreciably decreased, but significantly increased within 48h of drug discontinuation. The microdialysis experiments indicate that neuronal release of 5-HT depends strongly on new synthesis and emphasize the role of 5-HT(1B) receptors in the regulation of these processes. Discontinuation of the SSRI rapidly increased behavioral reactivity to the external stimulus. Additional startle experiments suggest that the increased reactivity is more likely related to the reduced extracellular 5-HT levels than to impaired synthesis. The combination of the marked reduction of serotonin content and limited synthesis may destabilize brain serotonin transmission during long-term SSRI treatment. These combined effects may compromise the efficacy of an SSRI therapy and facilitate behavioral changes following non-compliance.
    Mesh-Begriff(e) Animals ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Brain Chemistry/drug effects ; Brain Chemistry/physiology ; Citalopram/pharmacology ; Depressive Disorder/drug therapy ; Depressive Disorder/metabolism ; Depressive Disorder/psychology ; Male ; Rats ; Rats, Wistar ; Serotonin/biosynthesis ; Serotonin/deficiency ; Serotonin Uptake Inhibitors/pharmacology ; Substance Withdrawal Syndrome/metabolism ; Substance Withdrawal Syndrome/psychology ; Time Factors
    Chemische Substanzen Serotonin Uptake Inhibitors ; Citalopram (0DHU5B8D6V) ; Serotonin (333DO1RDJY)
    Sprache Englisch
    Erscheinungsdatum 2010-12
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 283190-9
    ISSN 1872-9754 ; 0197-0186
    ISSN (online) 1872-9754
    ISSN 0197-0186
    DOI 10.1016/j.neuint.2010.10.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1610: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang