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  1. Article: Detection of Asian genetic components in autochthonous human

    Gładysz, Paweł / Lass, Anna

    One health (Amsterdam, Netherlands)

    2023  Volume 17, Page(s) 100623

    Abstract: Alveolar echinococcosis is a life-threatening zoonotic disease caused by the larval stage of the ... ...

    Abstract Alveolar echinococcosis is a life-threatening zoonotic disease caused by the larval stage of the cestode
    Language English
    Publishing date 2023-08-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2023.100623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cutaneous myiasis caused by Dermatobia hominis (Diptera: Oestridae) in a Polish traveller to South America - a case report.

    Biernat, Beata / Gładysz, Paweł / Sulima, Małgorzata / Sikorska, Katarzyna

    International maritime health

    2024  Volume 75, Issue 1, Page(s) 61–63

    Abstract: Myiasis, an infestation caused by dipteran larvae, commonly known as maggots, is one of the most common parasitic skin disorders in the tropical regions. Authors report a case of cutaneous myiasis caused by Dermatobia hominis (Diptera: Oestridae) in a ... ...

    Abstract Myiasis, an infestation caused by dipteran larvae, commonly known as maggots, is one of the most common parasitic skin disorders in the tropical regions. Authors report a case of cutaneous myiasis caused by Dermatobia hominis (Diptera: Oestridae) in a Polish traveller returning from a self-organized trip to South America. Species biology, prophylaxis, and medical implications of this tropical parasitosis are discussed.
    MeSH term(s) Myiasis/diagnosis ; Myiasis/parasitology ; Humans ; Animals ; Poland ; Diptera ; Travel ; South America ; Male ; Larva ; Adult ; Middle Aged
    Language English
    Publishing date 2024-05-01
    Publishing country Poland
    Document type Case Reports ; Journal Article
    ZDB-ID 2032821-7
    ISSN 2081-3252 ; 1641-9251
    ISSN (online) 2081-3252
    ISSN 1641-9251
    DOI 10.5603/imh.99548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1742: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Rethinking premedical education.

    Gladysz, John A

    Science (New York, N.Y.)

    2022  Volume 378, Issue 6622, Page(s) 809

    Abstract: The world needs more physicians. Increasing their numbers alone won't solve the many problems associated with improving health care. But it doesn't help to have a dearth of doctors, who were generally in short supply before COVID-19 struck. The pandemic ... ...

    Abstract The world needs more physicians. Increasing their numbers alone won't solve the many problems associated with improving health care. But it doesn't help to have a dearth of doctors, who were generally in short supply before COVID-19 struck. The pandemic has only exacerbated doctor shortages everywhere. This doesn't bode well for a world that must prepare for future pandemics and for populations that are both growing and aging. Better health outcomes require more physicians. So, where are the bottlenecks?
    MeSH term(s) Humans ; Delivery of Health Care ; Education, Premedical/methods ; Education, Premedical/organization & administration ; Physicians/statistics & numerical data ; United States
    Language English
    Publishing date 2022-11-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adf8727
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

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  4. Article ; Online: The role of QRFP43 in the secretory activity of the gonadotrophic axis in female sheep.

    Przybył, Bartosz Jarosław / Szlis, Michał / Wysoczański, Bartłomiej / Wójcik-Gładysz, Anna

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8989

    Abstract: In mammals reproduction is regulated by many factors, among others by the peptides belonging to the RFamide peptide family. However, the knowledge concerning on the impact of recently identified member of this family (QRFP43) on the modulation of the ... ...

    Abstract In mammals reproduction is regulated by many factors, among others by the peptides belonging to the RFamide peptide family. However, the knowledge concerning on the impact of recently identified member of this family (QRFP43) on the modulation of the gonadotrophic axis activity is still not fully understood and current research results are ambiguous. In the present study we tested the in vivo effect of QRFP43 on the secretory activity of the gonadotrophic axis at the hypothalamic-pituitary level in Polish Merino sheep. The animals (n = 48) were randomly divided into three experimental groups: controls receiving an icv infusion of Ringer-Locke solution, group receiving icv infusion of QRFP43 at 10 μg per day and 50 μg per day. All sheep received four 50 min icv infusions at 30 min intervals, on each of three consecutive days. Hypothalamic and pituitaries were collected and secured for further immunohistochemical and molecular biological analysis. In addition, during the experiment a blood samples have been collected for subsequent RIA determinations. QRFP43 was found to downregulate Kiss mRNA expression in the MBH and reduce the level of IR material in ME. This resulted in a reduction of GnRH IR material in the ME. QRFP43 increased plasma FSH levels while decreasing LH levels. Our findings indicate that QRFP43 inhibits the activity of the gonadotropic axis in the ovine at the level of the hypothalamus and may represent another neuromodulator of reproductive processes in animals.
    MeSH term(s) Female ; Sheep ; Animals ; Luteinizing Hormone ; Gonadotropin-Releasing Hormone/metabolism ; Hypothalamus/metabolism ; Pituitary Gland/metabolism ; Gonadotrophs/metabolism ; Follicle Stimulating Hormone ; Mammals/metabolism
    Chemical Substances Luteinizing Hormone (9002-67-9) ; Gonadotropin-Releasing Hormone (33515-09-2) ; Follicle Stimulating Hormone (9002-68-0)
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59801-1
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  5. Article ; Online: Detection of Asian genetic components in autochthonous human Echinococcus multilocularis infections from endemic Warmia-Masuria (north-eastern Poland)

    Paweł Gładysz / Anna Lass

    One Health, Vol 17, Iss , Pp 100623- (2023)

    2023  

    Abstract: Alveolar echinococcosis is a life-threatening zoonotic disease caused by the larval stage of the cestode Echinococcus multilocularis. People are aberrant intermediate hosts accidentally infected with the parasite eggs via faecal-oral route, usually by ... ...

    Abstract Alveolar echinococcosis is a life-threatening zoonotic disease caused by the larval stage of the cestode Echinococcus multilocularis. People are aberrant intermediate hosts accidentally infected with the parasite eggs via faecal-oral route, usually by the consumption of unwashed fruit and vegetable or direct contact with definitive hosts. The recently reported presence of Asian admixture in E. multilocularis tapeworms from Polish red foxes prompted the question of metacestode descent in the human population. In this study, a Maximum Likelihood tree based on partial sequences of E. multilocularis mitochondrial genes cox1, cob, and nad2 coupled with a hierarchical clustering analysis of microsatellite EmsB profiles and supplemented by Sammon's nonlinear mapping with k-means clustering revealed Asian genetic components, to date associated only with the sylvatic cycle, in two autochthonous samples from alveolar echinococcosis patients living in endemic Warmia-Masuria, north-eastern Poland. The red fox is the most likely source of contamination in the environment shared by people and wildlife that led to these infections. Our results confirm that Asian genetic variants participate in the synanthropic cycle in north-eastern Poland and indicate that they may be present in the human population in other areas where Asian genetic variants were detected in red foxes.
    Keywords Human alveolar echinococcosis ; Poland ; Asian origin ; Microsatellite EmsB ; Mitochondrial sequencing ; Medicine (General) ; R5-920
    Subject code 590
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Exogenous Melatonin Protects against Oxidative Damage to Membrane Lipids Caused by Some Sodium/Iodide Symporter Inhibitors in the Thyroid.

    Gładysz, Aleksandra K / Stępniak, Jan / Karbownik-Lewińska, Małgorzata

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: The thyroid gland is the primary site of sodium/iodide symporter (NIS), an intrinsic plasma membrane protein responsible for the active uptake of iodine, which is indispensable for thyroid hormone synthesis. Since exposure of the thyroid to NIS ... ...

    Abstract The thyroid gland is the primary site of sodium/iodide symporter (NIS), an intrinsic plasma membrane protein responsible for the active uptake of iodine, which is indispensable for thyroid hormone synthesis. Since exposure of the thyroid to NIS inhibitors can potentially have harmful effects on the entire organism, it is important to investigate the potential protective effects of known antioxidants, such as melatonin and indole-3-propionic acid (IPA), against pro-oxidative action of classic NIS inhibitors. The study aimed to check if and to what extent melatonin and IPA interact with some confirmed NIS inhibitors regarding their effects on oxidative damage to membrane lipids in the thyroid. For comparison with the thyroid gland, in which NIS is typically present, the liver tissue-not possessing NIS-was applied in the present study. Thyroid and liver homogenates were incubated in the presence of tested NIS inhibitors (i.e., NaClO
    Language English
    Publishing date 2023-08-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12091688
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  7. Article ; Online: Hybrid graphene - silver nanoantenna to control THz emission from polar quantum systems.

    Izadshenas, Saeid / Gładysz, Piotr / Słowik, Karolina

    Optics express

    2023  Volume 31, Issue 18, Page(s) 29037–29050

    Abstract: Fluorescent light emission from atomic quantum systems routinely occurs at the illumination frequency. If the system is polar, an additional fluorescence peak appears at a much lower Rabi frequency, which scales with the illumination field amplitude. ... ...

    Abstract Fluorescent light emission from atomic quantum systems routinely occurs at the illumination frequency. If the system is polar, an additional fluorescence peak appears at a much lower Rabi frequency, which scales with the illumination field amplitude. This opens the possibility of spectrally controlling the emission, promising tunable coherent radiation sources. However, typically the emission occurs in the MHz to GHz regimes, and its intensity from a single quantum system is relatively low. Here, we propose a hybrid nanoantenna combining noble-metal and graphene elements, exploited for an unusual goal: The silver elements spectrally tune the emission frequency of the molecule and shift it to the THz band, where novel sources of coherent radiation are still desired. Additionally, the graphene elements are used to plasmonically enhance the emission intensity. Their tunability allows for adjustment of the operational frequencies of the device to the illumination conditions and to counteract the fluctuations related to the field modulations in space. All these features are discussed based on the real-life example of a polar molecule of barium monofluoride (BaF).
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.496435
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  8. Article ; Online: ASSESSING THE KNOWLEDGE OF CERVICAL CANCER BY WOMEN FROM BIAŁA PODLASKA, LUBELSKIE VOIVODESHIP

    Iwona Anna Gładysz

    Health Problems of Civilization, Vol 15, Iss 1, Pp 17-

    2021  Volume 22

    Keywords cervical cancer ; knowledge ; women ; Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Sustainable Metrics in Project Financial Risk Management

    Barbara Gładysz / Dorota Kuchta

    Sustainability, Vol 14, Iss 14247, p

    2022  Volume 14247

    Abstract: The objective of this study is to propose an approach that would increase the efficiency and efficacy of project financial risk management. The starting point of this research is an original detailed list of project financial risk categories, as it was ... ...

    Abstract The objective of this study is to propose an approach that would increase the efficiency and efficacy of project financial risk management. The starting point of this research is an original detailed list of project financial risk categories, as it was observed that financial risk is described in the literature far too generally. Following a survey of project managers, it is shown that all the identified project financial risk categories are significant and early warning signals may play an important role in their prevention or mitigation. Additionally, the main causes for project financial risks are identified and their importance assessed. Following a literature review on metrics-based and financial risk management in projects, as well as an analysis of the causes assessed in the survey, it is hypothesised that sustainability principles, combined with metrics-based management, may increase the efficiency and efficacy of project financial risk management. A corresponding method is proposed, which should be embedded into the traditional process of project financial risk management. This method consists of generating metrics with a warning and preventive potential for each combination of three elements (financial risk category, risk cause, sustainability principle). This approach introduces into project financial risk management elements going beyond the financial optics, which may considerably increase its potential.
    Keywords project risk ; project cost ; project revenues ; metrics-based project management ; sustainable project management ; project financial management ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 332 ; 690
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Aggregated Power Indices for Measuring Indirect Control in Complex Corporate Networks with Float Shareholders.

    Stach, Izabella / Mercik, Jacek / Bertini, Cesarino / Gładysz, Barbara / Staudacher, Jochen

    Entropy (Basel, Switzerland)

    2023  Volume 25, Issue 3

    Abstract: The purpose of this paper is to introduce new methods to measure the indirect control power of firms in complex corporate shareholding structures using the concept of power indices from cooperative game theory. The proposed measures vary in desirable ... ...

    Abstract The purpose of this paper is to introduce new methods to measure the indirect control power of firms in complex corporate shareholding structures using the concept of power indices from cooperative game theory. The proposed measures vary in desirable properties satisfied, as well as in the bargaining models of power indices used to construct them. Hence, they can be used to produce different pictures of the coalitional strength of firms in control of other firms in mutual shareholding networks with the presence of cycles. Precisely, in the framework of Karos and Peters from 2015, ten power indices substitute the original Shapley and Shubik power index in a modular fashion. In this way, we obtain a set of new measures called aggregated indices. The float shareholders typically hold less than 5 percent of the outstanding shares, which is an uncertain element of indirect control in complex shareholding structures. The fuzzy number seems appropriate to model these shareholders' behavior. The novelty is that we model the behavior of float using
    Language English
    Publishing date 2023-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e25030429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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