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  1. Article: Intrathecal ziconotide and baclofen provide pain relief in seven patients with neuropathic pain and spasticity: case reports.

    Saulino, M / Burton, A W / Danyo, D A / Frost, S / Glanzer, J / Solanki, D R

    European journal of physical and rehabilitation medicine

    2009  Volume 45, Issue 1, Page(s) 61–67

    Abstract: Seven cases of combination of intrathecal (IT) ziconotide and baclofen therapy in patients with refractory neuropathic pain and spasticity were reviewed. Five of the seven adult patients were receiving IT baclofen treatment when ziconotide was initiated. ...

    Abstract Seven cases of combination of intrathecal (IT) ziconotide and baclofen therapy in patients with refractory neuropathic pain and spasticity were reviewed. Five of the seven adult patients were receiving IT baclofen treatment when ziconotide was initiated. All five patients had experienced at least one previous failed IT treatment regimen. Pain intensity scores improved by a mean of 50.3% with the use of ziconotide-baclofen therapy. Mean time to onset of pain relief was 15 weeks, at a mean ziconotide dose of 3.7 microg/day. Within this group of patients, adverse events were observed in one patient, but they were not considered to be ziconotide related and subsequently resolved. The remaining two patients were receiving ziconotide treatment when baclofen was initiated. Pain intensity scores improved by 75% and 30%, respectively. Pain relief was evident at two weeks and one week, with corresponding ziconotide doses of 2.4 microg/day and 14.4 microg/day, respectively. One patient in this group reported adverse events, but all resolved during continued treatment with the study drugs. Treatment regimens varied between patients in these case series; each regimen used a different titration strategy and different concentrations of ziconotide and baclofen. Combination IT ziconotide and baclofen therapy may be a treatment option for patients with neuropathic pain and spasticity. Future studies are warranted to determine the optimal dosing and titration schedules for ziconotide-baclofen usage.
    MeSH term(s) Adult ; Baclofen/therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Male ; Middle Aged ; Muscle Relaxants, Central/administration & dosage ; Muscle Relaxants, Central/therapeutic use ; Muscle Spasticity/drug therapy ; Neuralgia/drug therapy ; Neuroprotective Agents/administration & dosage ; Neuroprotective Agents/therapeutic use ; Pain/drug therapy ; Pain/etiology ; Pain Measurement ; Treatment Outcome ; omega-Conotoxins/administration & dosage ; omega-Conotoxins/therapeutic use
    Chemical Substances Muscle Relaxants, Central ; Neuroprotective Agents ; omega-Conotoxins ; ziconotide (7I64C51O16) ; Baclofen (H789N3FKE8)
    Language English
    Publishing date 2009-03
    Publishing country Italy
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2426908-6
    ISSN 1973-9095 ; 1973-9087
    ISSN (online) 1973-9095
    ISSN 1973-9087
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  2. Article: Expression profiling of small cellular samples in cancer: less is more.

    Glanzer, J G / Eberwine, J H

    British journal of cancer

    2004  Volume 90, Issue 6, Page(s) 1111–1114

    Abstract: Expression profiling of tumours from cancer patients has uncovered several genes that are critically important in the progression of a normal cell to an oncogenic phenotype. Leading the way in these discoveries is the use of microarrays, a technology ... ...

    Abstract Expression profiling of tumours from cancer patients has uncovered several genes that are critically important in the progression of a normal cell to an oncogenic phenotype. Leading the way in these discoveries is the use of microarrays, a technology that is currently in transition from basic science applications to use in the clinic. Microarrays can determine the global gene regulation of an individual cancer, which may be useful in formulating an individualised therapy for the patient. Currently, cells used in breast cancer microarray studies often come from either homogenous cultures or heterogeneous biopsy samples. Both cell sources are at a disadvantage in determining the most accurate gene profile of cancer, which often consists of multiple subspecies of cancerous cells within a background of normal cells. Therefore, acquisition of small, but highly specific biopsies for analysis may be required for an accurate expression analysis of the disease. Amplification methods, such as polymerase chain reaction (PCR) and amplified antisense RNA (aRNA) amplification, have been used to amplify the mRNA signal from very small samples, which can then be used for microarray analysis. In this study, we describe the acquisition, amplification, and analysis of very small samples (<10000 cells) for expression analysis and demonstrate that the ultimate resolution of cancer expression analysis, one cell, is both feasible and practical.
    MeSH term(s) Breast Neoplasms/diagnosis ; Breast Neoplasms/genetics ; Cell Transformation, Neoplastic ; Female ; Gene Expression Profiling ; Humans ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Polymerase Chain Reaction ; RNA, Antisense ; Specimen Handling
    Chemical Substances RNA, Antisense
    Language English
    Publishing date 2004-03-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/sj.bjc.6601668
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  3. Article: RNA splicing capability of live neuronal dendrites.

    Glanzer, J / Miyashiro, K Y / Sul, J-Y / Barrett, L / Belt, B / Haydon, P / Eberwine, J

    Proceedings of the National Academy of Sciences of the United States of America

    2005  Volume 102, Issue 46, Page(s) 16859–16864

    Abstract: Dendrites are specialized extensions of the neuronal soma that contain components of the cellular machinery involved in RNA and protein metabolism. Several dendritically localized proteins are associated with the precursor-mRNA (pre-mRNA) splicing ... ...

    Abstract Dendrites are specialized extensions of the neuronal soma that contain components of the cellular machinery involved in RNA and protein metabolism. Several dendritically localized proteins are associated with the precursor-mRNA (pre-mRNA) splicing complex, or spliceosome. Although some spliceosome-related, RNA-binding proteins are known to subserve separate cytoplasmic functions when moving between the nucleus and cytoplasm, little is known about the pre-mRNA splicing capacity of intact dendrites. Here, we demonstrate the presence and functionality of pre-mRNA-splicing components in dendrites. When isolated dendrites are transfected with a chicken delta-crystallin pre-mRNA or luciferase reporter pre-mRNA, splicing junctions clustered at or near expected splice sites are observed. Additionally, in vitro synaptoneurosome experiments show that this subcellular fraction contains a similar complement of splicing factors that is capable of splicing chicken delta-crystallin pre-mRNA. These observations suggest that pre-mRNA-splicing factors found in the dendroplasm retain the potential to promote pre-mRNA splicing.
    MeSH term(s) Animals ; Chickens ; Dendrites/physiology ; Hippocampus/cytology ; Hippocampus/embryology ; Immunohistochemistry ; In Situ Hybridization ; Neurons/physiology ; Protein Biosynthesis ; RNA Precursors/genetics ; RNA Splicing ; Rats ; delta-Crystallins/genetics
    Chemical Substances RNA Precursors ; delta-Crystallins
    Language English
    Publishing date 2005-11-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.0503783102
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  4. Article: Wild-type and Ras-transformed fibroblasts display differential mitogenic responses to transient sodium arsenite exposure.

    Trouba, K J / Glanzer, J G / Vorce, R L

    Toxicological sciences : an official journal of the Society of Toxicology

    1999  Volume 50, Issue 1, Page(s) 72–81

    Abstract: Arsenic is a human carcinogen whose mechanism of action remains undefined. Based on the hypothesis that arsenic sensitizes cells to mitogenic stimulation by affecting the receptor tyrosine kinase (RTK) signal transduction pathway, these studies first ... ...

    Abstract Arsenic is a human carcinogen whose mechanism of action remains undefined. Based on the hypothesis that arsenic sensitizes cells to mitogenic stimulation by affecting the receptor tyrosine kinase (RTK) signal transduction pathway, these studies first examined the response of fibroblasts to specific mitogens using a defined media system. In both rodent and human fibroblasts, DNA synthesis was found to be stimulated in cells exposed to a transient, sub-lethal concentration of sodium arsenite followed by stimulation with known RTK pathway activators. This effect is observed for up to 32 h after removal of arsenic, suggesting that the RTK pathway is affected in a sustained manner. In contrast, transient arsenic exposure of ras-transformed cells results in decreased mitogen-stimulated DNA synthesis. Flow cytometry indicates that arsenic increases the percentage of wild-type cells in the S-phase of the cell cycle; conversely, the percentage of ras-transformed cells in S-phase is decreased by arsenic. No evidence of arsenic-induced cytotoxicity was detected using the neutral red assay, ensuring that decreased DNA synthesis in ras-transformed cells is not due to cell death. Taken together, the results of experiments presented herein indicate that arsenic produces sustained alterations in the growth characteristics of rodent and human fibroblasts. It is postulated that the proliferation-enhancing effect of arsenic on wild-type cells contributes to its ability to cause cancer.
    MeSH term(s) Animals ; Arsenites/toxicity ; Carcinogens/toxicity ; Cell Line, Transformed ; DNA/biosynthesis ; Fibroblasts/drug effects ; Flow Cytometry ; Genes, ras/genetics ; Humans ; Mice ; Mitogens/pharmacology ; Protein-Tyrosine Kinases/metabolism ; S Phase/drug effects ; Sodium Compounds/toxicity ; Time Factors
    Chemical Substances Arsenites ; Carcinogens ; Mitogens ; Sodium Compounds ; sodium arsenite (48OVY2OC72) ; DNA (9007-49-2) ; Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 1999-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1420885-4
    ISSN 1096-0929 ; 1096-6080
    ISSN (online) 1096-0929
    ISSN 1096-6080
    DOI 10.1093/toxsci/50.1.72
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  5. Article: Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases.

    Kadiu, I / Glanzer, J G / Kipnis, J / Gendelman, H E / Thomas, M P

    Neurotoxicity research

    2005  Volume 8, Issue 1-2, Page(s) 25–50

    Abstract: Brain mononuclear phagocytes (MP, bone marrow monocyte-derived macrophages, perivascular macrophages, and microglia) function to protect the nervous system by acting as debris scavengers, killers of microbial pathogens, and regulators of immune responses. ...

    Abstract Brain mononuclear phagocytes (MP, bone marrow monocyte-derived macrophages, perivascular macrophages, and microglia) function to protect the nervous system by acting as debris scavengers, killers of microbial pathogens, and regulators of immune responses. MP are activated by a variety of environmental cues and such inflammatory responses elicit cell injury and death in the nervous system. MP immunoregulatory responses include secretion of neurotoxic factors, mobilization of adaptive immunity, and cell chemotaxis. This incites tissue remodelling and blood-brain barrier dysfunction. As disease progresses, MP secretions engage neighboring cells in a vicious cycle of autocrine and paracrine amplification of inflammation leading to tissue injury and ultimately destruction. Such pathogenic processes tilt the balance between the relative production of neurotrophic and neurotoxic factors and to disease progression. The ultimate effects that brain MP play in disease revolves "principally" around their roles in neurodegeneration. Importantly, common functions of brain MP in neuroimmunity link highly divergent diseases (for example, human immunodeficiency virus type-one associated dementia, Alzheimer's disease and Parkinson's disease). Research into this process from our own laboratories and those of others seek to harness MP inflammatory processes with the intent of developing therapeutic interventions that block neurodegenerative processes and improve the quality of life in affected people.
    MeSH term(s) AIDS Dementia Complex/pathology ; AIDS Dementia Complex/therapy ; Alzheimer Disease/pathology ; Alzheimer Disease/therapy ; Animals ; Astrocytes/pathology ; Brain/pathology ; Humans ; Inflammation/pathology ; Macrophages/physiology ; Microglia/physiology ; Monocytes/pathology ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/therapy ; Phagocytes/pathology
    Language English
    Publishing date 2005-09-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2036826-4
    ISSN 1476-3524 ; 1029-8428
    ISSN (online) 1476-3524
    ISSN 1029-8428
    DOI 10.1007/bf03033818
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    Zs.A 5749: Show issues Location:
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  6. Article: Single neurons as experimental systems in molecular biology.

    Hinkle, David / Glanzer, Jason / Sarabi, Arezou / Pajunen, Tiina / Zielinski, Jennifer / Belt, Brian / Miyashiro, Kevin / McIntosh, Tracy / Eberwine, James

    Progress in neurobiology

    2004  Volume 72, Issue 2, Page(s) 129–142

    Abstract: The cellular and the inter-connective complexity of the central nervous system (CNS) necessitate's analysis of functioning at both the system and single cell levels. Systems neuroscience has developed procedures that facilitate the analysis of ... ...

    Abstract The cellular and the inter-connective complexity of the central nervous system (CNS) necessitate's analysis of functioning at both the system and single cell levels. Systems neuroscience has developed procedures that facilitate the analysis of multicellular systems including multielectrode arrays, dye tracings and lesioning assays, and at the single cell level there have been significant strides in assessing the physiology and morphology of individual cells. Until recently little progress had been made in understanding the molecular biology of single neuronal cells. This review will highlight the development of PCR and aRNA procedures for analysis of mRNA abundances in single cells. Also, other procedures for the analysis of protein abundances as well as the association of RNA with proteins will also be summarized. These procedures promise to provide experimental insights that will help unravel the functional mechanisms regulating the cellular components of the CNS.
    MeSH term(s) Animals ; Cells, Cultured ; Central Nervous System/physiology ; Gene Expression Profiling/methods ; Humans ; In Vitro Techniques ; Molecular Biology/methods ; Neurons/physiology ; Polymerase Chain Reaction ; RNA, Messenger/analysis
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2004-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 185535-9
    ISSN 1873-5118 ; 0301-0082
    ISSN (online) 1873-5118
    ISSN 0301-0082
    DOI 10.1016/j.pneurobio.2004.01.001
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  7. Article: Factors related to accuracy in office cholesterol testing. Iowa Academy of Family Physicians Research Network.

    Erickson, R / Driscoll, C / Dvorak, L / Gjerde, C / Glanzer, J / Arteaga, M / Pisney, F / Williamson, P

    The Journal of family practice

    1991  Volume 33, Issue 5, Page(s) 457–461

    Abstract: Background: There has been growing interest in the performance of diagnostic testing in physician office laboratories (POLs). Since the measurement of cholesterol is a well-defined and standardized laboratory test, it was selected to assess factors ... ...

    Abstract Background: There has been growing interest in the performance of diagnostic testing in physician office laboratories (POLs). Since the measurement of cholesterol is a well-defined and standardized laboratory test, it was selected to assess factors related to test accuracy in POLs.
    Methods: One hundred thirty-one family practice offices were eligible to participate in the survey. Each was mailed a cholesterol specimen with a standardized value in October 1988. The laboratory characteristics of those POLs with results that were within 10% of the true specimen value were compared with those with results that were greater than 10% in error.
    Results: Of the 131 POLs, 122 returned an answer for the unknown specimen. Ninety-eight (80%) were within 10% of the true value, and 114 (93%) were within 15%. Factors that were related to lower error rates (more likely to be within 10% total error) were whether the laboratory performed more than 25 laboratory tests per day, participated in a proficiency testing program, and ran daily quality controls, as well as the type of instrument the laboratory used.
    Conclusions: Overall performance of the POLs compared favorably with reference laboratories; however, running controls and participating in a proficiency testing program may further improve POL test accuracy.
    MeSH term(s) Cholesterol/blood ; Clinical Laboratory Techniques/standards ; Clinical Laboratory Techniques/utilization ; Family Practice ; Humans ; Iowa ; Physicians' Offices ; Quality Assurance, Health Care
    Chemical Substances Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 1991-11
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197883-4
    ISSN 0094-3509
    ISSN 0094-3509
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  8. Article: Kawasaki disease in a 28-year-old man.

    Glanzer, J M / Galbraith, W B / Jacobs, J P

    JAMA

    1980  Volume 244, Issue 14, Page(s) 1604–1606

    MeSH term(s) Adult ; Age Factors ; Colorado ; Diagnosis, Differential ; Humans ; Lupus Erythematosus, Systemic/diagnosis ; Lymphatic Diseases/diagnosis ; Male ; Measles/diagnosis ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Scarlet Fever/diagnosis ; Stevens-Johnson Syndrome/diagnosis
    Language English
    Publishing date 1980-10-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0098-7484 ; 0254-9077 ; 0002-9955
    ISSN (online) 1538-3598
    ISSN 0098-7484 ; 0254-9077 ; 0002-9955
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  9. Article ; Online: Search for Subsolar-Mass Binaries in the First Half of Advanced LIGO's and Advanced Virgo's Third Observing Run.

    Abbott, R / Abbott, T D / Acernese, F / Ackley, K / Adams, C / Adhikari, N / Adhikari, R X / Adya, V B / Affeldt, C / Agarwal, D / Agathos, M / Agatsuma, K / Aggarwal, N / Aguiar, O D / Aiello, L / Ain, A / Ajith, P / Albanesi, S / Allocca, A /
    Altin, P A / Amato, A / Anand, C / Anand, S / Ananyeva, A / Anderson, S B / Anderson, W G / Andrade, T / Andres, N / Andrić, T / Angelova, S V / Ansoldi, S / Antelis, J M / Antier, S / Appert, S / Arai, K / Araya, M C / Areeda, J S / Arène, M / Arnaud, N / Aronson, S M / Arun, K G / Asali, Y / Ashton, G / Assiduo, M / Aston, S M / Astone, P / Aubin, F / Austin, C / Babak, S / Badaracco, F / Bader, M K M / Badger, C / Bae, S / Baer, A M / Bagnasco, S / Bai, Y / Baird, J / Ball, M / Ballardin, G / Ballmer, S W / Balsamo, A / Baltus, G / Banagiri, S / Bankar, D / Barayoga, J C / Barbieri, C / Barish, B C / Barker, D / Barneo, P / Barone, F / Barr, B / Barsotti, L / Barsuglia, M / Barta, D / Bartlett, J / Barton, M A / Bartos, I / Bassiri, R / Basti, A / Bawaj, M / Bayley, J C / Baylor, A C / Bazzan, M / Bécsy, B / Bedakihale, V M / Bejger, M / Belahcene, I / Benedetto, V / Beniwal, D / Bennett, T F / Bentley, J D / BenYaala, M / Bergamin, F / Berger, B K / Bernuzzi, S / Berry, C P L / Bersanetti, D / Bertolini, A / Betzwieser, J / Beveridge, D / Bhandare, R / Bhardwaj, U / Bhattacharjee, D / Bhaumik, S / Bilenko, I A / Billingsley, G / Bini, S / Birney, R / Birnholtz, O / Biscans, S / Bischi, M / Biscoveanu, S / Bisht, A / Biswas, B / Bitossi, M / Bizouard, M-A / Blackburn, J K / Blair, C D / Blair, D G / Blair, R M / Bobba, F / Bode, N / Boer, M / Bogaert, G / Boldrini, M / Bonavena, L D / Bondu, F / Bonilla, E / Bonnand, R / Booker, P / Boom, B A / Bork, R / Boschi, V / Bose, N / Bose, S / Bossilkov, V / Boudart, V / Bouffanais, Y / Bozzi, A / Bradaschia, C / Brady, P R / Bramley, A / Branch, A / Branchesi, M / Brau, J E / Breschi, M / Briant, T / Briggs, J H / Brillet, A / Brinkmann, M / Brockill, P / Brooks, A F / Brooks, J / Brown, D D / Brunett, S / Bruno, G / Bruntz, R / Bryant, J / Bulik, T / Bulten, H J / Buonanno, A / Buscicchio, R / Buskulic, D / Buy, C / Byer, R L / Cadonati, L / Cagnoli, G / Cahillane, C / Bustillo, J Calderón / Callaghan, J D / Callister, T A / Calloni, E / Cameron, J / Camp, J B / Canepa, M / Canevarolo, S / Cannavacciuolo, M / Cannon, K C / Cao, H / Capote, E / Carapella, G / Carbognani, F / Carlin, J B / Carney, M F / Carpinelli, M / Carrillo, G / Carullo, G / Carver, T L / Diaz, J Casanueva / Casentini, C / Castaldi, G / Caudill, S / Cavaglià, M / Cavalier, F / Cavalieri, R / Ceasar, M / Cella, G / Cerdá-Durán, P / Cesarini, E / Chaibi, W / Chakravarti, K / Subrahmanya, S Chalathadka / Champion, E / Chan, C-H / Chan, C / Chan, C L / Chan, K / Chandra, K / Chanial, P / Chao, S / Charlton, P / Chase, E A / Chassande-Mottin, E / Chatterjee, C / Chatterjee, Debarati / Chatterjee, Deep / Chaturvedi, M / Chaty, S / Chatziioannou, K / Chen, H Y / Chen, J / Chen, X / Chen, Y / Chen, Z / Cheng, H / Cheong, C K / Cheung, H Y / Chia, H Y / Chiadini, F / Chiarini, G / Chierici, R / Chincarini, A / Chiofalo, M L / Chiummo, A / Cho, G / Cho, H S / Choudhary, R K / Choudhary, S / Christensen, N / Chu, Q / Chua, S / Chung, K W / Ciani, G / Ciecielag, P / Cieślar, M / Cifaldi, M / Ciobanu, A A / Ciolfi, R / Cipriano, F / Cirone, A / Clara, F / Clark, E N / Clark, J A / Clarke, L / Clearwater, P / Clesse, S / Cleva, F / Coccia, E / Codazzo, E / Cohadon, P-F / Cohen, D E / Cohen, L / Colleoni, M / Collette, C G / Colombo, A / Colpi, M / Compton, C M / Constancio, M / Conti, L / Cooper, S J / Corban, P / Corbitt, T R / Cordero-Carrión, I / Corezzi, S / Corley, K R / Cornish, N / Corre, D / Corsi, A / Cortese, S / Costa, C A / Cotesta, R / Coughlin, M W / Coulon, J-P / Countryman, S T / Cousins, B / Couvares, P / Coward, D M / Cowart, M J / Coyne, D C / Coyne, R / Creighton, J D E / Creighton, T D / Criswell, A W / Croquette, M / Crowder, S G / Cudell, J R / Cullen, T J / Cumming, A / Cummings, R / Cunningham, L / Cuoco, E / Curyło, M / Dabadie, P / Canton, T Dal / Dall'Osso, S / Dálya, G / Dana, A / DaneshgaranBajastani, L M / D'Angelo, B / Danilishin, S / D'Antonio, S / Danzmann, K / Darsow-Fromm, C 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/ Ward, R L / Warner, J / Was, M / Washington, N Y / Watchi, J / Weaver, B / Webster, S A / Weinert, M / Weinstein, A J / Weiss, R / Weller, C M / Wellmann, F / Wen, L / Weßels, P / Wette, K / Whelan, J T / White, D D / Whiting, B F / Whittle, C / Wilken, D / Williams, D / Williams, M J / Williamson, A R / Willis, J L / Willke, B / Wilson, D J / Winkler, W / Wipf, C C / Wlodarczyk, T / Woan, G / Woehler, J / Wofford, J K / Wong, I C F / Wu, D S / Wysocki, D M / Xiao, L / Yamamoto, H / Yang, F W / Yang, L / Yang, Yang / Yang, Z / Yap, M J / Yeeles, D W / Yelikar, A B / Ying, M / Yoo, J / Yu, Hang / Yu, Haocun / Zadrożny, A / Zanolin, M / Zelenova, T / Zendri, J-P / Zevin, M / Zhang, J / Zhang, L / Zhang, T / Zhang, Y / Zhao, C / Zhao, G / Zhao, Yue / Zhou, R / Zhou, Z / Zhu, X J / Zimmerman, A B / Zucker, M E / Zweizig, J / Jeong, Donghui / Shandera, Sarah

    Physical review letters

    2022  Volume 129, Issue 6, Page(s) 61104

    Abstract: We report on a search for compact binary coalescences where at least one binary component has a mass between 0.2  M_{⊙} and 1.0  M_{⊙} in Advanced LIGO and Advanced Virgo data collected between 1 April 2019 1500 UTC and 1 October 2019 1500 UTC. We extend ...

    Abstract We report on a search for compact binary coalescences where at least one binary component has a mass between 0.2  M_{⊙} and 1.0  M_{⊙} in Advanced LIGO and Advanced Virgo data collected between 1 April 2019 1500 UTC and 1 October 2019 1500 UTC. We extend our previous analyses in two main ways: we include data from the Virgo detector and we allow for more unequal mass systems, with mass ratio q≥0.1. We do not report any gravitational-wave candidates. The most significant trigger has a false alarm rate of 0.14  yr^{-1}. This implies an upper limit on the merger rate of subsolar binaries in the range [220-24200]  Gpc^{-3} yr^{-1}, depending on the chirp mass of the binary. We use this upper limit to derive astrophysical constraints on two phenomenological models that could produce subsolar-mass compact objects. One is an isotropic distribution of equal-mass primordial black holes. Using this model, we find that the fraction of dark matter in primordial black holes in the mass range 0.2  M_{⊙}<m_{PBH}<1.0  M_{⊙} is f_{PBH}≡Ω_{PBH}/Ω_{DM}≲6%. This improves existing constraints on primordial black hole abundance by a factor of ∼3. The other is a dissipative dark matter model, in which fermionic dark matter can collapse and form black holes. The upper limit on the fraction of dark matter black holes depends on the minimum mass of the black holes that can be formed: the most constraining result is obtained at M_{min}=1  M_{⊙}, where f_{DBH}≡Ω_{DBH}/Ω_{DM}≲0.003%. These are the first constraints placed on dissipative dark models by subsolar-mass analyses.<br />
    Language English
    Publishing date 2022-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.129.061104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: GW190521: A Binary Black Hole Merger with a Total Mass of 150  M_{⊙}.

    Abbott, R / Abbott, T D / Abraham, S / Acernese, F / Ackley, K / Adams, C / Adhikari, R X / Adya, V B / Affeldt, C / Agathos, M / Agatsuma, K / Aggarwal, N / Aguiar, O D / Aich, A / Aiello, L / Ain, A / Ajith, P / Akcay, S / Allen, G /
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    Physical review letters

    2021  Volume 125, Issue 10, Page(s) 101102

    Abstract: On May 21, 2019 at 03:02:29 UTC Advanced LIGO and Advanced Virgo observed a short duration gravitational-wave signal, GW190521, with a three-detector network signal-to-noise ratio of 14.7, and an estimated false-alarm rate of 1 in 4900 yr using a search ... ...

    Abstract On May 21, 2019 at 03:02:29 UTC Advanced LIGO and Advanced Virgo observed a short duration gravitational-wave signal, GW190521, with a three-detector network signal-to-noise ratio of 14.7, and an estimated false-alarm rate of 1 in 4900 yr using a search sensitive to generic transients. If GW190521 is from a quasicircular binary inspiral, then the detected signal is consistent with the merger of two black holes with masses of 85_{-14}^{+21}  M_{⊙} and 66_{-18}^{+17}  M_{⊙} (90% credible intervals). We infer that the primary black hole mass lies within the gap produced by (pulsational) pair-instability supernova processes, with only a 0.32% probability of being below 65  M_{⊙}. We calculate the mass of the remnant to be 142_{-16}^{+28}  M_{⊙}, which can be considered an intermediate mass black hole (IMBH). The luminosity distance of the source is 5.3_{-2.6}^{+2.4}  Gpc, corresponding to a redshift of 0.82_{-0.34}^{+0.28}. The inferred rate of mergers similar to GW190521 is 0.13_{-0.11}^{+0.30}  Gpc^{-3} yr^{-1}.
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.125.101102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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